{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:00:26Z","timestamp":1775926826835,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[1986]]},"DOI":"10.1007\/bf00688042","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T08:14:44Z","timestamp":1101716084000},"page":"216-223","source":"Crossref","is-referenced-by-count":113,"title":["Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes"],"prefix":"10.1007","volume":"71","author":[{"given":"D. W.","family":"Dickson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. -H.","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. I.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00005072-197501000-00002","volume":"34","author":"JM Andrews","year":"1975","unstructured":"Andrews JM (1975) The fine structure of the cervical spinal cord, ventral root and brachial plexus in the Wobbler (wr) mouse. J Neuropathol Exp Neurol 34:12?27","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR2","first-page":"421","volume-title":"Progress in neuropathology, vol 2","author":"S Brion","year":"1973","unstructured":"Brion S, Mikol J, Psimaras A (1973) Recent findings in Pick's disease. In: Zimmermen HM (ed) Progress in neuropathology, vol 2. Grune and Stratton, New York, pp 421?425"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0006-8993(76)90751-4","volume":"117","author":"BS Bunney","year":"1976","unstructured":"Bunney BS, Aghajanian GK (1976) The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Res 117:423?435","journal-title":"Brain Res"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1056\/NEJM198509193131208","volume":"313","author":"Case Records of Massachusetts General Hospital","year":"1985","unstructured":"Case Records of Massachusetts General Hospital (83-1985) (1985) Corticonigral degeneration with neuronal achromasia. N Engl J Med 313:739?748","journal-title":"N Engl J Med"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00005072-198605000-00011","volume":"45","author":"AW Clark","year":"1986","unstructured":"Clark AW, Manz HJ, White CL, III, Lehman J, Miller D, Coyle JT (1986) Cortical degeneration with swollen chromatolytic neurons: its relationship to Pick's disease. J Neuropathol Exp Neurol 45:268?284","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR6","first-page":"72","volume-title":"Modern approaches to the dementias, part I: etiology and pathophysiology","author":"J Constantinidis","year":"1985","unstructured":"Constantinidis J (1985) Pick dementia: anatomoclinical correlations and pathophysiological considerations. In: Rose FC (ed) Modern approaches to the dementias, part I: etiology and pathophysiology. Karger, Basel, pp 72?97"},{"key":"CR7","first-page":"292","volume":"120","author":"DW Dickson","year":"1985","unstructured":"Dickson DW, Kress Y, Crowe A, Yen S-H (1985) Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am J Pathol 120:292?303","journal-title":"Am J Pathol"},{"key":"CR8","first-page":"381","volume":"85","author":"DW Dickson","year":"1986","unstructured":"Dickson DW, Yen S-H, Davies P (1986) Alzheimer neurofibrillary tangles (ANT) contain phosphorylated and nonphosphorylated neurofilament (NF) epitopes recognized by monoclonal antibodies. Am J Clin Pathol 85:381 [abstr]","journal-title":"Am J Clin Pathol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1001\/archneur.1974.00490310072012","volume":"30","author":"EC Dooling","year":"1974","unstructured":"Dooling EC, Schoene WC, Richardson EP Jr (1974) Hallevorden-Spatz syndrome. Arch Neurol 30:70?83","journal-title":"Arch Neurol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/309624a0","volume":"309","author":"UC Drager","year":"1983","unstructured":"Drager UC, Hofbauer A (1983) Antibodies to heavy neurofilament subunit detect a subpopulation of damaged ganglion cells in the retina. Nature 309:624?626","journal-title":"Nature"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/brain\/82.2.203","volume":"82","author":"WK Engel","year":"1959","unstructured":"Engel WK, Kurland LT, Klatzo I (1959) An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement: an intermediate form? Brain 82:203?220","journal-title":"Brain"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1056\/NEJM198503143121110","volume":"312","author":"DC Gajdusek","year":"1985","unstructured":"Gajdusek DC (1985) Hypothesis: interference with axonal transport of neurofilaments as a common pathogenetic mechanism in certain diseases of the central nervous system. N Engl J Med 312:714?719","journal-title":"N Engl J Med"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00005072-198301000-00006","volume":"42","author":"P Gambetti","year":"1983","unstructured":"Gambetti P, Shecket G, Ghetti B, Hirano A, Dahl D (1983) Neurofibrillary changes in human brain: an immunocytochemical study with a neurofilament antiserum. J Neuropathol Exp Neurol 42:69?79","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1985.tb50400.x","volume":"455","author":"R Goldman","year":"1985","unstructured":"Goldman R, Goldman A, Green K, Jones J, Lieska N, Yang H-Y (1985) Intermediate filaments: possible function as cytoskeletal connecting links between the nucleus and the cell surface. Ann NY Acad Sci 455:1?17","journal-title":"Ann NY Acad Sci"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1001\/archneur.1967.00470210008002","volume":"16","author":"A Hirano","year":"1967","unstructured":"Hirano A, Kurland LT, Sayre GP (1967) Familial amyotrophic lateral sclerosis. A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells. Arch Neurol 16:232?243","journal-title":"Arch Neurol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00005072-198409000-00001","volume":"43","author":"A Hirano","year":"1984","unstructured":"Hirano A, Donnenfeld H, Sasaki S, Nakani I (1984) Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 43:461?470","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR17","first-page":"155","volume-title":"Neurofilaments","author":"KS Kosik","year":"1983","unstructured":"Kosik KS, Selkoe DJ (1983) Experimental models of neurofilamentous pathology. In: Marotta C (ed) Neurofilaments. University of Minnesota Press, Minneapolis, pp 155?195"},{"key":"CR18","doi-asserted-by":"crossref","unstructured":"Ksiezak-Reding H, Yen S-H (1986) Two monoclonal antibodies recognize Alzheimer's neurofibrillary tangles, neurofilament, and microtubule associated proteins. J Neurochem (in press)","DOI":"10.1111\/j.1471-4159.1987.tb04114.x"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0074-7742(08)60183-X","volume":"14","author":"AR Lieberman","year":"1971","unstructured":"Lieberman AR (1971) The axonal reaction: a review of the principal features of perikaryal responses to axon injury. Int Rev Neurobiol 14:49?124b","journal-title":"Int Rev Neurobiol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ana.410190108","volume":"19","author":"H Mitsumoto","year":"1986","unstructured":"Mitsumoto H, Gambetti P (1986) Impaired slow axonal transport in Wobbler mouse neuron disease. Ann Neurol 19:36?43","journal-title":"Ann Neurol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0022-510X(83)90068-0","volume":"60","author":"TH Moss","year":"1983","unstructured":"Moss TH, Lewkowicz SJ (1983) The axon reaction in motor and sensory neurons of mice studied by a monoclonal antibody marker of neurofilament protein. J Neurol Sci 60:267?280","journal-title":"J Neurol Sci"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/oxfordjournals.jbchem.a135625","volume":"99","author":"N Nukina","year":"1986","unstructured":"Nukina N, Ihara Y (1986) One of the antigenic determinats of paired helical filaments is related to tau proteins. J Biochem 99:1541?1544","journal-title":"J Biochem"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1056\/NEJM198503143121107","volume":"321","author":"CG Rasool","year":"1985","unstructured":"Rasool CG, Selkoe DJ (1985) Sharing of specific antigens by degenerating neurons in Pick's disease and Alzheimer's disease. N Engl J Med 321:700?705","journal-title":"N Engl J Med"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1001\/archneur.1968.00470310034003","volume":"18","author":"JJ Rebeiz","year":"1968","unstructured":"Rebeiz JJ, Kolodny EH, Richardson EP Jr (1968) Corticodentationigral degeneration with neuronal achromasia. Arch Neurol 18:20?33","journal-title":"Arch Neurol"},{"key":"CR25","first-page":"2","volume":"11","author":"J Rosenfeld","year":"1985","unstructured":"Rosenfeld J, Dorman ME, Sternberger NH, Sternberger LA, Hoffman PN, Price DL (1985) In situ distribution of phosphorylated and nonphosphorylated neurofilament epitopes following axotomy and neurectomy of sensory neurons. Soc Neurosci Abstr, vol 11, part 1:2","journal-title":"Soc Neurosci Abstr"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0165-0173(85)90008-6","volume":"10","author":"LM Sayre","year":"1985","unstructured":"Sayre LM, Autilio-Gambetti L, Gambetti P (1985) Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modifications of neurofilaments. Brain Res Rev 10:69?83","journal-title":"Brain Res Rev"},{"key":"CR27","first-page":"87","volume-title":"Neuropsychiatric disorders in the elderly","author":"F Seitelberger","year":"1981","unstructured":"Seitelberger F, Gross H, Pilz P (1981) Pick's disease: a neuropathologic study. In: Hirano A, Miyoshi K (eds) Neuropsychiatric disorders in the elderly. Igaku-Shoin, New York, pp 87?117"},{"key":"CR28","first-page":"104","volume-title":"Immunocytochemistry","author":"LA Sternberger","year":"1979","unstructured":"Sternberger LA (1979) Immunocytochemistry, 2nd edn. Wiley, New York, pp 104?169","edition":"2nd edn"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1073\/pnas.80.19.6126","volume":"80","author":"LA Sternberger","year":"1983","unstructured":"Sternberger LA, Sternberger NH (1983) Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci USA 80:6126?6130","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1073\/pnas.82.12.4274","volume":"82","author":"NH Sternberger","year":"1985","unstructured":"Sternberger NH, Sternberger LA, Ulrich J (1985) Aberrant neurofilament phosphorylation in Alzheimers disease. Proc Natl Acad Sci USA 82:4174?4276","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2990.1985.tb00037.x","volume":"11","author":"LC Triarhou","year":"1985","unstructured":"Triarhou LC, Norton J, Bugiani O, Ghetti B (1985) Ventral root axonopathy and its relation to neurofibrillary degeneration of lower motor neurons in aluminum-induced encephalomyelopathy. Neuropathol Appl Neurobiol 11:407?430","journal-title":"Neuropathol Appl Neurobiol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1523\/JNEUROSCI.06-03-00650.1986","volume":"6","author":"JQ Trojanowski","year":"1986","unstructured":"Trojanowski JQ, Wakenstein N, Lee V M-Y (1986), Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunocytochemical study with monoclonal antibodies. J Neurosci 6:650?660","journal-title":"J Neurosci"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00005072-198505000-00190","volume":"44","author":"J Ulrich","year":"1985","unstructured":"Ulrich J, Haugh M, Anderton BH, Probst A (1985) Phosphorylated epitopes on Pick bodies (PB) and Alzheimer neurofibrillary tangles (NFT) (abstract). J Neuropathol Exp Neurol 44:367","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1749-6632.1985.tb50402.x","volume":"455","author":"E Wang","year":"1985","unstructured":"Wang E (1985) Intermediate filament associated proteins. Ann NY Acad Sci 455:32?56","journal-title":"Ann NY Acad Sci"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/archneurpsyc.1935.02250210029002","volume":"34","author":"HW Williams","year":"1935","unstructured":"Williams HW (1935) The peculiar cells of Pick's disease: their pathogenesis and distribution in disease. Arch Neurol Psychiatry 34:508?519","journal-title":"Arch Neurol Psychiatry"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archneur.1972.00490080015001","volume":"26","author":"HM Wisniewski","year":"1972","unstructured":"Wisniewski HM, Coblentz JM, Terry RD (1972) Pick's disease: a clinical and ultrastructural study. Arch Neurol 26:97?108","journal-title":"Arch Neurol"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1749-6632.1985.tb50432.x","volume":"455","author":"RC Williams Jr","year":"1985","unstructured":"Williams RC Jr, Aamodt EJ (1985) Interaction between microtubules and neurofilaments in vitro. Ann NY Acad Sci 455:509?524","journal-title":"Ann NY Acad Sci"},{"key":"CR38","first-page":"282","volume":"120","author":"S-H Yen","year":"1985","unstructured":"Yen S-H, Crowe A, Dickson DW (1985) Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides. Am J Pathol 120:282?291","journal-title":"Am J Pathol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00688042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00688042\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00688042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T11:12:09Z","timestamp":1585998729000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00688042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986]]},"references-count":38,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1986]]}},"alternative-id":["BF00688042"],"URL":"https:\/\/doi.org\/10.1007\/bf00688042","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986]]}}}