{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:18:32Z","timestamp":1791256712247,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1980,1,1]],"date-time":"1980-01-01T00:00:00Z","timestamp":315532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[1980,1]]},"DOI":"10.1007\/bf00688530","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T08:05:32Z","timestamp":1101715532000},"page":"19-24","source":"Crossref","is-referenced-by-count":193,"title":["Intranuclear aluminum content in Alzheimer's disease, dialysis encephalopathy, and experimental aluminum encephalopathy"],"prefix":"10.1007","volume":"50","author":[{"given":"D. R.","family":"Crapper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Quittkat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"De Boni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1056\/NEJM197601222940402","volume":"294","author":"AC Alfrey","year":"1976","unstructured":"Alfrey AC, Le Gendre GR, Kaehny WD (1976) The dialysis encephalopathy syndrome: possible aluminum intoxication. N Engl J Med 294:184?188","journal-title":"N Engl J Med"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.7326\/0003-4819-90-5-741","volume":"90","author":"AI Arieff","year":"1979","unstructured":"Arieff AI, Cooper JD, Armstrong D, Lazaromitz BS (1979) Dementia, renal failure, and brain aluminum. Ann Intern Med 90:741?747","journal-title":"Ann Intern Med"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1021\/bi00653a013","volume":"15","author":"SE Bryan","year":"1976","unstructured":"Bryan SE, Simons SJ, Vizard DL, Hardy KJ (1976) Interactions of mercury and copper with constitutive heterochromatin and euchromatin in vivo and in vitro. Biochemistry 15:1667?1671","journal-title":"Biochemistry"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0013-4694(73)90211-3","volume":"35","author":"DR Crapper","year":"1973","unstructured":"Crapper DR (1973) Experimental neurofibrillary degeneration and altered electrical activity. Electroencephalogr Clin Neurophysiol 35:575?588","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0031-9384(73)90063-2","volume":"10","author":"DR Crapper","year":"1973","unstructured":"Crapper DR, Dalton AJ (1973) Alterations in short-term retention, conditioned avoidance response acquisition and motivation following aluminum induced neurofibrillary degeneration. Physiol Behav 10:925?933","journal-title":"Physiol Behav"},{"key":"CR6","first-page":"97","volume-title":"Frontiers in neurology and neuroscience research","author":"DR Crapper","year":"1974","unstructured":"Crapper DR (1974) Dementia: Recent observations in Alzheimer's disease and experimental aluminum encephalopathy. In: Seeman P, Brown GM (eds) Frontiers in neurology and neuroscience research. University of Toronto Press, Toronto, pp 97?111"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archneur.1975.00490510074006","volume":"3","author":"DR Crapper","year":"1975","unstructured":"Crapper DR, Dalton AJ, Skopitz M, Scott JW, Hachinski VC (1975) Alzheimer degeneration in Down syndrome. Electrophysiologic alterations and histopathologic findings. Arch Neurol 3:618?623","journal-title":"Arch Neurol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/brain\/99.1.67","volume":"99","author":"DR Crapper","year":"1976","unstructured":"Crapper DR, Krishnan SS, Quittkat S (1976) Aluminum, neurofibrillary degeneration, and Alzheimer's disease. Brain 99:67?80","journal-title":"Brain"},{"key":"CR9","first-page":"471","volume-title":"Alzheimer's disease, senile dementia, and related disorders, vol 7, Aging","author":"DR Crapper","year":"1978","unstructured":"Crapper DR, Karlik S, De Boni U (1978) Aluminum and other metals in senile (Alzheimer) dementia. In: Katzman R, Terry RD, Beck KL (eds) Alzheimer's disease, senile dementia, and related disorders, vol 7, Aging. Raven Press, New York, pp 471?485"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/brain\/102.3.483","volume":"102","author":"DR Crapper","year":"1979","unstructured":"Crapper DR, Quittkat S, De Boni U (1979) Altered chromatin conformation in Alzheimer's disease. Brain 102:483?495","journal-title":"Brain"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00490271","volume":"40","author":"U Boni De","year":"1974","unstructured":"De Boni U, Scott JW, Crapper DR (1974) Intracellular aluminum binding: a histochemical study. Histochemistry 40:31?37","journal-title":"Histochemistry"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/271566a0","volume":"271","author":"U Boni De","year":"1978","unstructured":"De Boni U, Crapper DR (1978) Paired helical filaments of the Alzheimer type in cultured neurons. Nature 271:566?568","journal-title":"Nature"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1073\/pnas.73.6.1897","volume":"73","author":"JT Finch","year":"1976","unstructured":"Finch JT, Klug A (1976) Solenoidal model for super-structure in chromatin. Proc Natl Acad Sci USA 73:1897?1901","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0041-008X(75)90244-6","volume":"33","author":"KJ Hardy","year":"1975","unstructured":"Hardy KJ, Bryan SE (1975) Localization and uptake of copper into chromatin. Toxicol Appl Pharmacol 33:62?69","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/brain\/87.2.307","volume":"87","author":"M Kidd","year":"1964","unstructured":"Kidd M (1964) Alzheimer's disease, an electron microscopical study. Brain 87:308?319","journal-title":"Brain"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0091-3057(75)90008-8","volume":"3","author":"GA King","year":"1975","unstructured":"King GA, De Boni U, Crapper DR (1975) Effect of aluminum upon conditioned avoidance response acquisition in the absence of neurofibrillary degeneration. Pharmacol Biochem Behav 3:1003?1009","journal-title":"Pharmacol Biochem Behav"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005072-196504000-00002","volume":"24","author":"I Klatzo","year":"1965","unstructured":"Klatzo I, Wisiniewski H, Streicher E (1965) Experimental production of neurofibrillary degeneration. J Neuropathol Exp Neurol 24:187?199","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR18","first-page":"25","volume":"21","author":"SS Krishnan","year":"1976","unstructured":"Krishnan SS, Quittkat S, Crapper DR (1976) Atomic absorption analysis for traces of aluminum and vanadium in biological tissue. A critical evaluation of the graphite furnace atomizer. Can J Spectrosc 21:25?30","journal-title":"Can J Spectrosc"},{"key":"CR19","first-page":"59","volume":"25","author":"A Kushelevsky","year":"1976","unstructured":"Kushelevsky A, Yagil R, Alfosi Z, Berlyne GM (1976) Uptake of aluminum ion by the liver. Biomedicine 25:59?60","journal-title":"Biomedicine"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-4827(72)90257-1","volume":"71","author":"RE Leake","year":"1972","unstructured":"Leake RE, Trench ME, Barry JM (1972) Effect of cations in the condensation of hen erythrocyte nuclei and its relation to gene activation. Exp Cell Res 71:17?26","journal-title":"Exp Cell Res"},{"key":"CR21","first-page":"287","volume-title":"Alzheimer's disease: senile dementia and realed disorders, vol 7, Aging","author":"H Matsuyama","year":"1978","unstructured":"Matsuyama H, Nakamura S (1978) Senile changes in the brain in the Japanese: incidence of Alzheimer's neurofibrillary change and senile plaques. In: Katzman R, Terry RD, Beck KL (eds) Alzheimer's disease: senile dementia and realed disorders, vol 7, Aging. Raven Press, New York, pp 287?297"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1126\/science.897661","volume":"197","author":"GH Mayor","year":"1977","unstructured":"Mayor GH, Keiser JA, Makdoni D, Ku P (1977) Aluminum absorption and distribution: effect of parathyroid hormone. Science 197:1187?1189","journal-title":"Science"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0140-6736(77)90516-5","volume":"II","author":"JR McDermott","year":"1977","unstructured":"McDermott JR, Smith AI, Iqbal K, Wisniewski HM (1977) Aluminum and Alzheimer's disease. Lancet II:710?711","journal-title":"Lancet"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(78)90681-5","volume":"I","author":"JR McDermott","year":"1978","unstructured":"McDermott JR, Smith AI, Ward MK, Parkinson IS, Kerr D (1978) Brain ? aluminum concentration in dialysis encephalopathy. Lancet I:901?904","journal-title":"Lancet"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00005072-197905000-00111","volume":"38","author":"DP Perl","year":"1979","unstructured":"Perl DP, Brody AR (1979) Detection of focal accumulations of aluminum (Al) and silicon (Si) with neurofibrillary tangle bearing neurons of Alzheimer's disease. J Neuropathol Exp Neurol 38:335 (Abstract 102)","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0009-8981(66)90029-5","volume":"14","author":"N Robinson","year":"1966","unstructured":"Robinson N (1966) Composition of deoxyribonucleoprotein in human brain. Clin Chim Acta 14:429?434","journal-title":"Clin Chim Acta"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF01176996","volume":"7","author":"T Ryan","year":"1978","unstructured":"Ryan T, Potter HD (1978) A Mg2+ dependent class of thick filaments and correlated nuclear chromatin in cat-fish photoreceptors. J Neurocytol 7:313?321","journal-title":"J Neurocytol"},{"key":"CR28","first-page":"269","volume":"44","author":"RD Terry","year":"1964","unstructured":"Terry RD, Gonatas NK, Weiss M (1964) Ultrastructural studies in Alzheimer's pre-senile dementia. Am J Pathol 44:269?297","journal-title":"Am J Pathol"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00005072-196504000-00003","volume":"24","author":"RD Terry","year":"1965","unstructured":"Terry RD, Pena C (1965) Experimental production of neurofibrillary degeneration. Electron microscopy, phosphatase histochemistry and electron-probe analysis. J Neuropathol Exp Neurol 24:200?210","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR30","first-page":"709","volume":"13","author":"GA Trapp","year":"1978","unstructured":"Trapp GA, Miner GD, Zimmerman RL, Mastri RA, Heston LL (1978) Aluminum levels in brain in Alzheimer disease. Biol Psychol 13:709?718","journal-title":"Biol Psychol"},{"key":"CR31","first-page":"220","volume-title":"Electronmicroscopy, vol II, Biology. Ninth International Congress on Electron microscopy","author":"F Thoma","year":"1978","unstructured":"Thoma F, Koller TH (1978) The ionic strength dependence of chromatin folding. In: Sturgess JM (ed) Electronmicroscopy, vol II, Biology. Ninth International Congress on Electron microscopy. The Microscopical Society of Canada, Toronto, pp 220?221"},{"key":"CR32","first-page":"413","volume":"43","author":"Y Yase","year":"1977","unstructured":"Yase Y (1977) The basic process of amyotrophic lateral sclerosis as reflected in Kii peninsula and Guam. Excerpt Med Internat Cong Series 434. Neurology 43:413?427","journal-title":"Neurology"},{"key":"CR33","unstructured":"Yase Y (1978) Kii peninsula amyotrophic lateral sclerosis. USPHS, NIW CS, NJH Guam Alz\/PD Workshop"},{"key":"CR34","first-page":"49","volume":"30","author":"F Yoshimasu","year":"1976","unstructured":"Yoshimasu F, Uebayaski Y, Yase Y, Iwata S, Sasajima K (1976) Studies on amytrophic lateral sclerosis by neutron activation analysis. Folia Psychiatr Neurol Jpn 30:49?55","journal-title":"Folia Psychiatr Neurol Jpn"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00688530.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00688530\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00688530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T18:40:34Z","timestamp":1554835234000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00688530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["BF00688530"],"URL":"https:\/\/doi.org\/10.1007\/bf00688530","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}