{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:41:41Z","timestamp":1768808501237,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother. Pharmacol."],"published-print":{"date-parts":[[1995]]},"DOI":"10.1007\/bf00689193","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T16:27:54Z","timestamp":1101745674000},"page":"107-114","source":"Crossref","is-referenced-by-count":47,"title":["Metabolism of taxol by human and rat liver in vitro: A screen for drug interactions and interspecies differences"],"prefix":"10.1007","volume":"36","author":[{"given":"Carlos A.","family":"Jamis-Dow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond W.","family":"Klecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aspandiar G.","family":"Katki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry M.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248","journal-title":"Anal Biochem"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1200\/JCO.1991.9.7.1261","volume":"9","author":"T Brown","year":"1991","unstructured":"Brown T, Havlin K, Weiss G, Cagnola J, Koeller J, Kuhn J, Rizzo J, Craig J, Phillips J, Von Hoff D (1991) A phase I trial of taxol given by a 6-hour intravenous infusion. J Clin Oncol 9: 1261","journal-title":"J Clin Oncol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/cpt1978234375","volume":"23","author":"SG Carruthers","year":"1978","unstructured":"Carruthers SG, Shoeman DW, Hignite CE, Azarnoff DL (1978) Correlation between plasma diphenhydramine level and sedative and antihistamine effects. Clin Pharmacol Ther 23:375","journal-title":"Clin Pharmacol Ther"},{"key":"CR4","first-page":"233","volume":"3","author":"GM Cragg","year":"1991","unstructured":"Cragg GM, Snader KM (1991) Taxol: the supply issue. Cancer Cells 3:233","journal-title":"Cancer Cells"},{"key":"CR5","first-page":"386","volume":"54","author":"T Cresteil","year":"1994","unstructured":"Cresteil T, Monsarrat B, Alvinerie P, Tr\u00e9luyer JM, Vieira I, Wright M (1994) Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation. Cancer Res 54:386","journal-title":"Cancer Res"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00003088-198814010-00002","volume":"14","author":"TK Daneshmend","year":"1988","unstructured":"Daneshmend TK, Warnock DW (1988) Clinical pharmacokinetics of ketoconazole. Clin Pharmacokinet 14:13","journal-title":"Clin Pharmacokinet"},{"key":"CR7","first-page":"605","volume-title":"The Pharmacological basis of therapeutics","author":"WW Douglas","year":"1985","unstructured":"Douglas WW (1985) Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. In: Gilman AG, Goodman LS, Rall TW, Murad F (eds) The Pharmacological basis of therapeutics, 7th edn, Macmillan, New York, p 605","edition":"7th edn"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00194546","volume":"9","author":"AI Einzig","year":"1991","unstructured":"Einzig AI, Hochster H, Wiernik PH, Trump DL, Dutcher JP, Garowski E, Sasloff J, Smith TJ (1991) A phase II study of taxol in patients with malignant melanoma. Invest New Drugs 9:59","journal-title":"Invest New Drugs"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(89)91802-3","volume":"2","author":"MR First","year":"1989","unstructured":"First MR, Schroeder TJ, Weiskittel P, Myre SA, Alexander JW, Pesce AJ (1989) Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients. Lancet 2:1198","journal-title":"Lancet"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2165\/00003088-198308010-00004","volume":"8","author":"F Follath","year":"1983","unstructured":"Follath F, Ganzinger U, Schuetz E (1983) Reliability of antiarrhythmic drug plasma concentration monitoring. Clin Pharmacokinet 8:63","journal-title":"Clin Pharmacokinet"},{"key":"CR11","first-page":"287","volume":"30","author":"FP Guengerich","year":"1986","unstructured":"Guengerich FP, Muller-Enoch D, Blair IA (1986) Oxidation of quinidine by human liver cytochrome P-450. Mol Pharmacol 30:287","journal-title":"Mol Pharmacol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1021\/jm00031a022","volume":"37","author":"JW Harris","year":"1994","unstructured":"Harris JW, Katki A, Anderson LW, Chmurny GN, Paukstelis JV, Collins JM (1994) Isolation, structural determination, and biological activity of 6?-hydroxytaxol, the principal human metabolite of taxol. J Med Chem 37:706","journal-title":"J Med Chem"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/jnci\/83.24.1797-a","volume":"83","author":"FA Holmes","year":"1991","unstructured":"Holmes FA, Walters RS, Theriault RL, Forman AD, Newton LK, Raber MN, Buzdar AU, Frye DK, Hortobagyi GN (1991) Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J Natl Cancer Inst 83:1797","journal-title":"J Natl Cancer Inst"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1021\/ja00083a066","volume":"116","author":"RA Holton","year":"1994","unstructured":"Holton RA, Somoza C, Kim HB, Liang F, Biediger RJ, Boatman PD, Shindo M, Smith CC, Kim SC, Nadizadeh H, Suzuki Y, Tao CL, Vu P, Tang SH, Zhang PS, Murthi KK, Gentile LN, Liu JH (1994) First total synthesis of taxol. 1. Functionalization of the B ring. J Am Chem Soc 116:1597","journal-title":"J Am Chem Soc"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1021\/ja00083a067","volume":"116","author":"RA Holton","year":"1994","unstructured":"Holton RA, Kim HB, Somoza C, Liang F, Biediger RJ, Boatman PD, Shindo M, Smith CC, Kim SC, Nadizadeh H, Suzuki Y, Tao CL, Vu P, Tang SH, Zhang PS, Murthi KK, Gentile LN, Liu JH (1994) First total synthesis of taxol. 2. Completion of the C and D rings. J Am Chem Soc 116:1599","journal-title":"J Am Chem Soc"},{"key":"CR16","first-page":"254","volume":"22","author":"RW Klecker","year":"1994","unstructured":"Klecker RW, Jamis-Dow CA, Egorin MJ, Erkmen K, Parker RJ, Stevens R, Collins JM (1994) Effect of cimetidine, probenecid and ketoconazole on the distribution, biliary secretion and metabolism of3H-taxol in the sprague-dawley rat. Drug Metab Dispos 22:254","journal-title":"Drug Metab Dispos"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/0016-5085(91)90408-D","volume":"101","author":"RG Knodell","year":"1991","unstructured":"Knodell RG, Browne DG, Gwozdz GP, Brian WR, Guengerich FP (1991) Differential inhibition of individual human liver cytochromes P-450 by cimetidine. Gastroenterology 101:1680","journal-title":"Gastroenterology"},{"key":"CR18","first-page":"177","volume":"22","author":"GN Kumar","year":"1994","unstructured":"Kumar GN, Oatis JEJ, Thornburg KR, Heldich FJ, Hazard ESI, Walle T (1994) 6?-Hydroxytaxol: isolation and identification of the major metabolite of taxol in human liver microsomes. Drug Metab Dispos 22:177","journal-title":"Drug Metab Dispos"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1096\/fasebj.6.2.1371482","volume":"6","author":"M Maurice","year":"1992","unstructured":"Maurice M, Pichard L, Daujat M, Fabre I, Joyeux H, Domergue J, Maurel P (1992) Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture. FASEB J 6:752","journal-title":"FASEB J"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7326\/0003-4819-111-4-273","volume":"111","author":"WP McGuire","year":"1989","unstructured":"McGuire WP, Rowinsky EK, Rosenshein NB, Grumbine FC, Ettinger DS, Armstrong DK, Donehower RC (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann Intern Med 111:273","journal-title":"Ann Intern Med"},{"key":"CR21","first-page":"895","volume":"18","author":"B Monsarrat","year":"1990","unstructured":"Monsarrat B, Mariel E, Cros S, Gar\u00e8s M, Gu\u00e9nard D, Gu\u00e9ritte-Voegelein F, Wright M (1990) Taxol metabolism. Isolation and identification of three major metabolites of taxol in rat bile. Drug Metab Dispos 18:895","journal-title":"Drug Metab Dispos"},{"key":"CR22","first-page":"39","volume":"15","author":"B Monsarrat","year":"1993","unstructured":"Monsarrat B, Alvinerie P, Wright M, Dubois J, Gu\u00e9ritte-Voegelein F, Gu\u00e9nard D, Donehower RC, Rowinsky EK (1993) Hepatic metabolism and biliary excretion of taxol in rats and humans. J Natl Cancer Inst Monogr 15:39","journal-title":"J Natl Cancer Inst Monogr"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/367630a0","volume":"367","author":"KC Nicolaou","year":"1994","unstructured":"Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K, Sorensen EJ (1994) Total synthesis of taxol. Nature 367:630","journal-title":"Nature"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1200\/JCO.1993.11.5.885","volume":"11","author":"DM Peereboom","year":"1993","unstructured":"Peereboom DM, Donehower RC, Eisenhauer EA, McGuire WP, Onetto N, Hubbard JL, Piccart M, Gianni L, Rowinsky EK (1993) Successful re-treatment with taxol after major hypersensitivity reactions. J Clin Oncol 11:885","journal-title":"J Clin Oncol"},{"key":"CR25","first-page":"1047","volume":"41","author":"L Pichard","year":"1992","unstructured":"Pichard L, Fabre I, Daujat M, Domergue J, Joyeux H, Maurel P (1992) Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes. Mol Pharmacol 41:1047","journal-title":"Mol Pharmacol"},{"key":"CR26","first-page":"395","volume":"34","author":"E Reed","year":"1993","unstructured":"Reed E, Sarosy G, Jamis-Dow CA, Klecker R, Kohn E, Link C, Christian M, Davis P, Collins J (1993) Cimetidine does not influence taxol steady-state plasma levels. Proc Am Assoc Cancer Res 34:395","journal-title":"Proc Am Assoc Cancer Res"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1021\/ja00738a045","volume":"93","author":"MC Wani","year":"1971","unstructured":"Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:2325","journal-title":"J Am Chem Soc"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/jnci\/85.20.1685","volume":"85","author":"L Webster","year":"1993","unstructured":"Webster L, Linsenmeyer M, Millward M, Morton C, Bishop J, Woodcock D (1993) Measurement of Cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype. J Natl Cancer Inst 85: 1685","journal-title":"J Natl Cancer Inst"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1200\/JCO.1990.8.7.1263","volume":"8","author":"RB Weiss","year":"1990","unstructured":"Weiss RB, Donehower RC, Wiernik PH, Ohnuma T, Gralla RJ, Trump DL, Baker J Jr, Van Echo DA, Von Hoff DD, Leyland-Jones B (1990) Hypersensitivity reactions from taxol. J Clin Oncol 8:1263","journal-title":"J Clin Oncol"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1200\/JCO.1994.12.8.1621","volume":"12","author":"WH Wilson","year":"1994","unstructured":"Wilson WH, Berg SL, Bryant G, Wittes RE, Bates S, Fojo A, Steinberg SM, Goldspiel BR, Herdt J, O'Shavghnessy J, Balis FM, Chabner BA (1994) Paclitaxel in doxorubicin-refractory or mitoxantrone-refractory breast cancer: a phase I\/II trial of 96-hour infusion. J Clin Oncol 12:1621","journal-title":"J Clin Oncol"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00689193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00689193\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00689193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T18:40:47Z","timestamp":1554835247000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00689193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995]]}},"alternative-id":["BF00689193"],"URL":"https:\/\/doi.org\/10.1007\/bf00689193","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995]]}}}