{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:25:19Z","timestamp":1770963919289,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Metast Rev"],"published-print":{"date-parts":[[1993,3]]},"DOI":"10.1007\/bf00689786","type":"journal-article","created":{"date-parts":[[2004,12,2]],"date-time":"2004-12-02T03:19:27Z","timestamp":1101957567000},"page":"11-19","source":"Crossref","is-referenced-by-count":9,"title":["Rodent models for targeted oncogenesis of the prostate gland"],"prefix":"10.1007","volume":"12","author":[{"given":"Ralph","family":"Buttyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Slawin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/canjclin.40.1.9","volume":"40","author":"ES Silverberg","year":"1990","unstructured":"Silverberg ES, Boring CC, Squires TS: Cancer statistics, 1990. CA Cancer J Clin 40: 9?26, 1990","journal-title":"CA Cancer J Clin"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60220-1","volume":"51","author":"MC Bosland","year":"1988","unstructured":"Bosland MC: The etiopathogenesis of prostate cancer with special reference to environmental factors. Adv Cancer Res 51: 1?106, 1988","journal-title":"Adv Cancer Res"},{"key":"CR3","first-page":"379","volume":"37","author":"DS Coffey","year":"1980","unstructured":"Coffey DS, Isaacs JT: Requirements for an idealized animal model of prostate cancer. Prog Clin Biol Res 37: 379?391, 1980","journal-title":"Prog Clin Biol Res"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/jnci\/51.4.1235","volume":"51","author":"M Pollard","year":"1973","unstructured":"Pollard M: Spontaneous prostate adenocarcinomas in aged germfree Wistar rats. J Natl Can Inst 51: 1235?1241, 1973","journal-title":"J Natl Can Inst"},{"key":"CR5","first-page":"517","volume":"43","author":"JM Ward","year":"1980","unstructured":"Ward JM, Reznik G, Stinson SF, Lattirada CP, Longfellow DG, Cameron TP: Lab Invest 43: 517?522, 1980","journal-title":"Lab Invest"},{"key":"CR6","first-page":"195","volume-title":"Prostate Cancer","author":"JT Isaacs","year":"1979","unstructured":"Isaacs JT, Coffey DS: Spontaneous animal models for prostate cancer. In: Coffey DS, Isaacs JT (eds) Prostate Cancer, pp 195?219. Geneva: International Union Against Cancer, 1979"},{"key":"CR7","unstructured":"Isaacs JT: The aging ACI\/Seg rat versus Copenhagen male rat as a model for the study of prostatic carcinogenesis. Cancer Res 44: 5785-5769"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","volume":"61","author":"ER Fearon","year":"1990","unstructured":"Fearon ER, Vogelstein B: A genetic model of colorectal tumorigenesis. Cell 61: 759?765, 1990","journal-title":"Cell"},{"key":"CR9","first-page":"3232","volume":"42","author":"BE Henderson","year":"1982","unstructured":"Henderson BE, Ross RK, Pike MC: Endogenous hormones as a major factor in human cancer. Cancer Res 42: 3232?3239, 1982","journal-title":"Cancer Res"},{"key":"CR10","first-page":"45","volume":"76","author":"R Ross","year":"1986","unstructured":"Ross R, Bernstein L, Judd H, Hanisch R, Pike M, Henderson B: Serum testosterone levels in healthy young black and white men. JNCI 76: 45?48, 1986","journal-title":"JNCI"},{"key":"CR11","first-page":"113","volume":"23","author":"RL Nobel","year":"1982","unstructured":"Nobel RL: Prostate Cancer of the Nb rat in relation to hormones. Int Rev Exp Pathol 23: 113?159, 1982","journal-title":"Int Rev Exp Pathol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/pros.2990030605","volume":"3","author":"M Pollard","year":"1982","unstructured":"Pollard M, Luckert PH, Schmidth MA: Induction of prostate adenocarcinomas in Lobund Wistar rats by testosterone. Prostate 3: 563?568, 1982","journal-title":"Prostate"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/carcin\/4.1.49","volume":"4","author":"PM Pour","year":"1983","unstructured":"Pour PM: Prostate cancer induced in MRC rats byN-nitrosobis(2-oxopropyl)amine andN-nitrosobis(2-hydroxypropyl)amine. Carcin (London) 4: 49?55, 1983","journal-title":"Carcin (London)"},{"key":"CR14","unstructured":"Shirai T, Tukushima S, Ikawa E, Tagawa Y, Ito N: Induction of prostate carcinomain situ at high incidence in F344 rats by a combination of 3, 2'-dimethyl-4-aminobiphenyl and ethinyl estradiol. Cancer Res 6423-6426, 1986"},{"key":"CR15","first-page":"691","volume":"50","author":"MC Bosland","year":"1990","unstructured":"Bosland MC, Prinsen MK: Induction of dorsolateral prostate adenocarcinomas and other accessory sex gland lesions in male Wistar rats by a single administration ofN-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl after sequential treatment with cyproterone acetate and testosterone propionate. Can Res 50: 691?699, 1990","journal-title":"Can Res"},{"key":"CR16","first-page":"700","volume":"50","author":"MC Bosland","year":"1990","unstructured":"Bosland MC, Prinsen MK, Dirksen TJM, Spit BJ: Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistar rats byN-methyl-N-nitrosourea, 7,12-dimethylbenz(a)antracene, and 3,2'-dimethyl-4-aminobiphenyl, following sequential treatment with cyproterone acetate and testosterone propionate. Can Res 50: 700?709, 1990","journal-title":"Can Res"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/mc.2940040507","volume":"4","author":"S Sukumar","year":"1991","unstructured":"Sukumar S, Armstrong B, Bruyntjes JP, Leav I, Bosland MC: Frequent activation of the Ki-ras oncogene at codon 12 inN-methyl-Nnitrosurea-induced rat prostate adenocarcinomas and neurogenic sarcomas. Mol Carcin 4: 362?368, 1991","journal-title":"Mol Carcin"},{"key":"CR18","first-page":"6830","volume":"50","author":"BS Carter","year":"1990","unstructured":"Carter BS, Epstein JE, Isaacs WB:Ras gene mutations in prostate cancer. Can Res 50: 6830?6832, 1990","journal-title":"Can Res"},{"key":"CR19","first-page":"1632","volume":"51","author":"PH Gumerlock","year":"1991","unstructured":"Gumerlock PH, Poonamallee UR, Meyers FJ, deVere-White RW: Activatedras alleles in human carcinoma of the prostate are rare. Can Res 51: 1632?1637, 1991","journal-title":"Can Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0092-8674(89)90625-9","volume":"56","author":"TC Thompson","year":"1989","unstructured":"Thompson TC, Southgate J, Kitchener G, Land H: Multistage carcinogenesis induced byras andmyc oncogenes in a reconstituted organ. Cell 56: 917?930, 1989","journal-title":"Cell"},{"key":"CR21","first-page":"559","volume":"39","author":"GR Cunha","year":"1983","unstructured":"Cunha GR, Chung LWK, Shannon JM, Taguchi O, Fujii H: Hormone-induced morphogenesis and growth: role of mesenchymal-epithelial interactions. Rec Prog Horm Res 39: 559?598, 1983","journal-title":"Rec Prog Horm Res"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1083\/jcb.96.6.1662","volume":"96","author":"GR Chunha","year":"1983","unstructured":"Chunha GR, Rujii H, Neubauer BL, Shannon JM, Sawyer L, Reese BA: Epithelial-mesenchymal interactions in prostatic development. I. Morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder. J Cell Biol 96: 1662?1670, 1983","journal-title":"J Cell Biol"},{"key":"CR23","first-page":"337","volume-title":"Molecular and Cellular Biology of Cancer","author":"TC Thompson","year":"1991","unstructured":"Thompson TC, Kadmon D, Arnall MF, Flanagan WF, Egawa S, Scardino PT, Park S, Merz VW: Evidence for the involvement of genetic difference and mesenchymal factors in the progression of oncogene-induced prostate cander in reconstituted mouse prostate. In: Karr JP, Coffey DS, Smith RG, Tindall DJ (eds) Molecular and Cellular Biology of Cancer, 1991, Plenum Press, New York, NY, pp 337?344"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1210\/mend-5-4-503","volume":"5","author":"VW Merz","year":"1991","unstructured":"Merz VW, Miller GJ, Krebs T, Timme TL, Kadmon D, Park SH, Egawa S, Scardino PT, Thompson TC: Transforming factor-?1 and ?3 mRNA levels are associated withras +myc-induced carcinomas in reconstituted mouse prostate: Evidence for a paracrine role during progression. Mol Endocrin 5: 503?513, 1991","journal-title":"Mol Endocrin"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/mc.2940050110","volume":"5","author":"S Egawa","year":"1992","unstructured":"Egawa S, Kadmon D, Miller GJ, Scardino PT, Thompson TC: Alterations in mRNA levels for growth-related genes after transplantation into castrated hosts in oncogene-induced clonal mouse prostate carcinoma. Mol Carcinogenesis 5: 52?61, 1992","journal-title":"Mol Carcinogenesis"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0092-8674(92)90541-J","volume":"70","author":"X Lu","year":"1992","unstructured":"Lu X, Park SH, Thompson TC, Lane DP:ras-induced hyperplasia occurs with mutation ofp53, but activatedras andmyc together can induce carcinoma withoutp53 mutation. Cell 70: 153?161, 1992","journal-title":"Cell"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0022-5347(17)37287-7","volume":"147","author":"K Mellon","year":"1992","unstructured":"Mellon K, Thompson S, Charlton RG, Marsh C, Robinson M, Lane DP, Harris AL, Horne CH, Neal DE: p53, c-erbB-2 and the epidermal growth factor receptor in the benign and malignant prostate. J Urol 147: 496?499, 1992","journal-title":"J Urol"},{"key":"CR28","first-page":"389","volume":"33","author":"HJ Voeller","year":"1992","unstructured":"Voeller HJ, Carroll AG, Winkfield B, Paik S, Gelman EP: The analysis of p53 gene mutations in prostate cancer. Proc Am Ass Cancer Res 33: 389, 1992","journal-title":"Proc Am Ass Cancer Res"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.1957168","volume":"254","author":"JM Adams","year":"1991","unstructured":"Adams JM, Cory S: Transgenic models of tumor development. Science 254: 1161?1167, 1991","journal-title":"Science"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0092-8674(89)90770-8","volume":"59","author":"FV Chisari","year":"1989","unstructured":"Chisari FV, Klopchin K, Moriyama T, Pasquinelli C, Dunsford HA, Sell S, Pinkert CA, Brinster RL, Palmiter RD: Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59: 1145?1156, 1989","journal-title":"Cell"},{"key":"CR31","first-page":"3400","volume":"50","author":"HA Dunsford","year":"1990","unstructured":"Dunsford HA, Sell S, Chisari FV: Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res 50: 3400?3407, 1990","journal-title":"Cancer Res"},{"key":"CR32","first-page":"9","volume":"1072","author":"M Adams","year":"1991","unstructured":"Adams M, Cory S: Transgenic models for haematopoetic malignancies. Biochim Biophys Acta 1072: 9?31, 1991","journal-title":"Biochim Biophys Acta"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0092-8674(87)90710-0","volume":"48","author":"CJ Quaife","year":"1987","unstructured":"Quaife CJ, Pinkert CA, Ornitz DM, Palmiter RD, Brintster RL: Pancreatic neoplasia induced byras expression in acinar cells of transgenic mice. Cell 48: 1023?1034, 1987","journal-title":"Cell"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.2821617","volume":"238","author":"DM Ornitz","year":"1987","unstructured":"Ornitz DM, Hammer RE, Messing A, Palmiter RD, Brinster RL: Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science 238: 188?193, 1987","journal-title":"Science"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0092-8674(88)90220-6","volume":"55","author":"AS Tsukamoto","year":"1988","unstructured":"Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varumus HE: Expression of theint-1 gene in transgenic mice in association with hyperplasia and mammary gland adenocarcinoma in male and female mice. Cell 55: 619?625, 1988","journal-title":"Cell"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"9178","DOI":"10.1073\/pnas.87.23.9178","volume":"87","author":"A Leder","year":"1990","unstructured":"Leder A, Kuo A, Cardiff RD, Sinn E, Leder P: v-Ha-ras transgene abbrogates the initiator step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc Natl Acad Sci USA 87: 9178?9182, 1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0092-8674(90)90115-U","volume":"62","author":"B Bailleul","year":"1990","unstructured":"Bailleul B, Surani MA, White S, Barton SC, Brown K, Blessing K, Jorcano J, Balmain A: Skin hyperkeratosis and papilloma formation in transgenic mice expressing aras oncogene from a suprabasal keratin promotor. Cell 62: 697?708, 1990","journal-title":"Cell"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1101\/gad.5.5.714","volume":"5","author":"R Vassar","year":"1991","unstructured":"Vassar R, Fuchs E: Transgenic mice provide new insights into the role of TGF-? during epidermal development and differentiation. Genes Dev 5: 714?727, 1991","journal-title":"Genes Dev"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1073\/pnas.88.1.93","volume":"88","author":"EP Sandgren","year":"1991","unstructured":"Sandgren EP, Quaife CJ, Paulovitch AG, Palmiter RD, Brinster RL: Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer. Proc. Natl Acad Sci USA, 88: 6427?6431, 1991","journal-title":"Proc. Natl Acad Sci USA"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1128\/MCB.11.9.4518","volume":"11","author":"DG Skalnik","year":"1991","unstructured":"Skalnik DG, Dorman DM, Williams DA, Orkin SH: Restriction of neuroblastoma to the prostate gland in transgenic mice. Mol Cell Biol 11: 4518?1527, 1991","journal-title":"Mol Cell Biol"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/j.1460-2075.1990.tb08188.x","volume":"9","author":"WJ Muller","year":"1990","unstructured":"Muller WJ, Lee FS, Dickson C, Peters G, Pattengale P, Leder P: Theint-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J 9: 907?913, 1990","journal-title":"EMBO J"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0022-4731(88)90075-1","volume":"30","author":"MG Parker","year":"1988","unstructured":"Parker MG, Webb P, Mills JS, Needham M, White R: Analysis of regulatory sequences in androgen-responsive genes. J Steroid Biochem 30: 47?51, 1988","journal-title":"J Steroid Biochem"},{"key":"CR43","first-page":"697","volume":"42","author":"RF Tutrone Jr","year":"1991","unstructured":"Tutrone Jr RF, Ball RA, Ornitz DM, Leder P, Richie JP: Benign prostatic hyperplasia in a transgenic mouse: a hormonally responsive investigatory model. Surg Forum 42: 697?701, 1991","journal-title":"Surg Forum"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1128\/JVI.62.8.3046-3049.1988","volume":"62","author":"D Henrard","year":"1988","unstructured":"Henrard D, Ross SR: Endogeneous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland. J Virol 62: 3046?3049, 1988","journal-title":"J Virol"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/j.1460-2075.1983.tb01498.x","volume":"2","author":"HC Hurst","year":"1983","unstructured":"Hurst HC, Parker MG: Rat prostatic steroid binding protein: DNA sequence and transcript maps of the two C3 genes. EMBO J 2: 769?774, 1983","journal-title":"EMBO J"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"8861","DOI":"10.1016\/S0021-9258(18)32135-5","volume":"258","author":"DH Viskochil","year":"1983","unstructured":"Viskochil DH, Perry ST, Lea OA, Stafford DW, Wilson EM, French FS: Isolation of two genomic sequences encoding that Mr = 14,000 subunit of rat prostatein. J. Biol Chem 258: 8861?8866, 1983","journal-title":"J. Biol Chem"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1016\/S0021-9258(18)43674-5","volume":"255","author":"MG Parker","year":"1980","unstructured":"Parker MG, White R, Williams JG: Cloning and characterization of androgen-dependent mRNA from rat ventral prostate. J Biol Chem 255: 6996?7001, 1980","journal-title":"J Biol Chem"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0303-7207(82)90099-5","volume":"27","author":"MJ Page","year":"1982","unstructured":"Page MJ, Parker MG: Effect of androgen on the transcription of rat prostatic binding protein genes. Mol Cell Endocrin 27: 343?355, 1982","journal-title":"Mol Cell Endocrin"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0022-4731(86)90840-X","volume":"24","author":"D Bossyns","year":"1986","unstructured":"Bossyns D, Delaey B, Rombauts W, Heyns W: Influence of castration and androgen treatment on the synthesis of prostatic binding protein and the concentration of its mRNA in the rat ventral prostate. J Steroid Biochem 24: 661?668, 1986","journal-title":"J Steroid Biochem"},{"key":"CR50","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1128\/MCB.9.5.2254","volume":"9","author":"J Allison","year":"1989","unstructured":"Allison J, Zhang YL, Parker MG: Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice. Mol Cell Biol 9: 2254?2257, 1989","journal-title":"Mol Cell Biol"},{"key":"CR51","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1093\/nar\/17.6.2365","volume":"17","author":"GR MacGregor","year":"1989","unstructured":"MacGregor GR, Caskey CT: Construction of plasmids that express E. coli ?-galactosidase in mammalian cells. Nuc Acids Res 17: 2365, 1989","journal-title":"Nuc Acids Res"}],"container-title":["Cancer and Metastasis Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00689786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00689786\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00689786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T06:38:34Z","timestamp":1625035114000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00689786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["BF00689786"],"URL":"https:\/\/doi.org\/10.1007\/bf00689786","relation":{},"ISSN":["0167-7659","1573-7233"],"issn-type":[{"value":"0167-7659","type":"print"},{"value":"1573-7233","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}