{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:36:58Z","timestamp":1779345418353,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Metast Rev"],"published-print":{"date-parts":[[1995,3]]},"DOI":"10.1007\/bf00690209","type":"journal-article","created":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T09:48:59Z","timestamp":1101894539000},"page":"31-41","source":"Crossref","is-referenced-by-count":52,"title":["Cell cycle checkpoints and DNA repair preserve the stability of the human genome"],"prefix":"10.1007","volume":"14","author":[{"given":"William K.","family":"Kaufmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","volume-title":"DNA Repair","author":"EC Freidberg","year":"1986","unstructured":"Freidberg EC:DNA Repair, Plenum Press, NY 1986"},{"key":"CR2","volume-title":"Dermatology in General Medicine","author":"KH Kraemer","year":"1987","unstructured":"Kraemer KH: Heritable diseases with increased sensitivity to cellular injury.In: Fitzpatrick, Eisen, Wolff, Freedberg, Austen (eds) Dermatology in General Medicine. McGraw Hill, NY 1987, Chapter 50"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0005-2787(76)90063-0","volume":"418","author":"RB Painter","year":"1976","unstructured":"Painter RB, Young BR: Formation of nascent DNA molecules during inhibition of replicon initiation in mammalian cells. Biochim Biophys Acta 418: 146?153, 1976","journal-title":"Biochim Biophys Acta"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1073\/pnas.88.10.4066","volume":"88","author":"B Thony","year":"1991","unstructured":"Thony B, Hwang DS, Fradkin L, Kornberg A:iciA, anEscherichia coli gene encloding a specific inhibitor of chromosomal initiation of replicationin vitro. Proc Natl Acad Sci USA 88: 4066?4070, 1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR5","first-page":"45","volume-title":"Critical Molecular Determinants of Carcinogenesis","author":"JC Barrett","year":"1987","unstructured":"Barrett JC, Oshimura M, Koi M: Role of oncogenes and tumor suppressor genes in a multistep model of carcinogenesis.In: Beckeriand FF, Slaga TJ (eds) Critical Molecular Determinants of Carcinogenesis. Univ. of Texas Press, Austin TX, 45?56, 1987"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/10408448409021603","volume":"12","author":"P Nettesheim","year":"1984","unstructured":"Nettesheim P, Barrett JC: Tracheal epithelial cell transformation: A model system for studies on neoplastic progression. CRC Crit Rev Toxicol 12: 215?240, 1984","journal-title":"CRC Crit Rev Toxicol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0092-8674(92)90586-2","volume":"71","author":"L Hartwell","year":"1992","unstructured":"Hartwell L: Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71: 543?546, 1992","journal-title":"Cell"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1096\/fasebj.7.12.8375618","volume":"7","author":"WK Kaufmann","year":"1993","unstructured":"Kaufmann WK, Kaufman DG: Cell cycle control, DNA repair and initiation of carcinogenesis. FASEB J 7: 1188?1191, 1993","journal-title":"FASEB J"},{"key":"CR9","first-page":"6304","volume":"51","author":"MB Kastan","year":"1991","unstructured":"Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular responses to DNA damage. Cancer Res 51: 6304?6311, 1991","journal-title":"Cancer Res"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0092-8674(94)90379-4","volume":"76","author":"V Dulic","year":"1994","unstructured":"Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI: p53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76: 1013?1023, 1994","journal-title":"Cell"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0092-8674(92)90244-7","volume":"70","author":"Y Yin","year":"1992","unstructured":"Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM: Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70: 937?948, 1992","journal-title":"Cell"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0092-8674(92)90243-6","volume":"70","author":"LR Livingstone","year":"1992","unstructured":"Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD: Altered cell cycle arrest and gene amplification potential accompany loss of wild type p53. Cell 70: 923?935, 1992","journal-title":"Cell"},{"key":"CR13","first-page":"1263","volume":"47","author":"WK Kaufmann","year":"1987","unstructured":"Kaufmann WK, Rice JM, Wenk ML, Devor D, Kaufman DG: Cell cycle-dependent initiation of hepatocarcinogenesis in rats by methyl(acetoxymethyl)nitrosamine. Cancer Res 47: 1263?1266, 1987","journal-title":"Cancer Res"},{"key":"CR14","first-page":"3771","volume":"47","author":"WK Kaufman","year":"1987","unstructured":"Kaufman WK, Rahija RJ, MacKenzie SA, Kaufman DG: Cell cycle-dependent initiation of hepatocarcinogenesis in rats by (\u00b1)- 7r,8t-dihydroxy- 9t,10t-epoxy- 7,8,9,10-tetrahy-drobenzo[a]pyrene. Cancer Res 47: 3771?3775, 1987","journal-title":"Cancer Res"},{"key":"CR15","first-page":"7","volume":"125","author":"PC Nowell","year":"1986","unstructured":"Nowell PC, Croce CM: Chromosomes, genes and cancer. Am J Pathol 125: 7?15, 1986","journal-title":"Am J Pathol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0921-8777(94)90062-0","volume":"314","author":"WK Kaufmann","year":"1994","unstructured":"Kaufmann WK, Wilson SJ: G1 arrest and cell cycle-dependent clastogenesis in UV-irradiated human fibroblasts. Mutat Res 314: 67?76, 1994","journal-title":"Mutat Res"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0921-8777(90)90038-7","volume":"236","author":"WK Kaufmann","year":"1990","unstructured":"Kaufmann WK, Wilson SR: DNA repair endonuclease activity during synchronous proliferation of diploid human fibroblasts. Mutat Res 236: 107?117, 1990","journal-title":"Mutat Res"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4613-0785-3_2","volume":"18","author":"MM Cohen","year":"1989","unstructured":"Cohen MM, Levy HP: Chromosomal instability syndromes. Adv Human Genet 18: 43?149, 1989","journal-title":"Adv Human Genet"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0092-8674(92)90593-2","volume":"71","author":"MB Kastan","year":"1992","unstructured":"Kastan MB, Zhan Q, El-Deirey WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ, Jr: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell 71: 587?597, 1992","journal-title":"Cell"},{"key":"CR20","first-page":"1169","volume":"54","author":"WS El-Deiry","year":"1994","unstructured":"El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW, Vogelstein B: WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169?1174, 1994","journal-title":"Cancer Res"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0022-2836(81)90297-7","volume":"149","author":"WK Kaufmann","year":"1981","unstructured":"Kaufmann WK, Cleaver JE: Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts. J Mol Biol 149: 171?187, 1981","journal-title":"J Mol Biol"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0167-4781(85)90091-0","volume":"824","author":"WK Kaufmann","year":"1985","unstructured":"Kaufmann WK, Boyer JC, Smith BA, Cordeiro-Stone M: DNA repair and replication in human fibroblasts treated with (\u00b1)r-7,t-8-dihydroxy-t-9,10- epoxy-7,8,9,10- tetrahy-drobenzo[a]pyrene. Biochim Biophys Acta 824: 146?151, 1985","journal-title":"Biochim Biophys Acta"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1128\/MCB.11.7.3711","volume":"11","author":"WK Kaufmann","year":"1991","unstructured":"Kaufmann WK, Boyer JC, Estabrooks LE, Wilson SR: Inhibition of replicon initiation in human cells following transient stabilization of topoisomerase-DNA complexes. Mol Cell Biol 11: 3711?3718, 1991","journal-title":"Mol Cell Biol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1073\/pnas.77.12.7315","volume":"77","author":"RB Painter","year":"1980","unstructured":"Painter RB, Young BR: Radiosensitivity in ataxia telangiectasia: a new explanation. Proc Natl Acad Sci USA 77: 7315?7317, 1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0167-8817(85)90041-0","volume":"145","author":"RB Painter","year":"1985","unstructured":"Painter RB: Inhibition and recovery of DNA synthesis in human cells after exposure to ultraviolet light. Mutation Res 145: 63?69, 1985","journal-title":"Mutation Res"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/10.1.1","volume":"10","author":"WK Kaufmann","year":"1989","unstructured":"Kaufmann WK: Pathways of human cell postreplication repair. Carcinogenesis 10: 1?11, 1989","journal-title":"Carcinogenesis"},{"key":"CR27","first-page":"2960","volume":"51","author":"JC Boyer","year":"1991","unstructured":"Boyer JC, Kaufmann WK, Cordeiro-Stone M: Role of postreplication repair in transformation of human fibroblasts to anchorage independence. Cancer Res 51: 2960?2964, 1991","journal-title":"Cancer Res"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1016\/S0021-9258(18)53096-9","volume":"268","author":"PM O'Connor","year":"1993","unstructured":"O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW: G2 delay induced by nitrogen mustard in human cells affects cyclin A\/cdk2 and cyclin B\/cdc2 complexes differently. J Biol Chem 268: 8298?8308, 1993","journal-title":"J Biol Chem"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0165-7992(83)90144-6","volume":"122","author":"G Olivieri","year":"1983","unstructured":"Olivieri G, Micheli A: Mitotic delay and repair in human lymphocytes. Mutat Res 122: 65?72, 1983","journal-title":"Mutat Res"},{"key":"CR30","first-page":"547","volume":"39","author":"F Zampetti-Bosseler","year":"1981","unstructured":"Zampetti-Bosseler F, Scott D: Cell death, chromosome damage, and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation. Inter J Radiat Biol 39: 547?558, 1981","journal-title":"Inter J Radiat Biol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0027-5107(85)90044-2","volume":"152","author":"MA Bender","year":"1985","unstructured":"Bender MA, Rary JM, Kale PR: G2 chromosomal radiosensitivity in ataxia-telangiectasia lymphocytes. Mutat Res 152: 39?47, 1985","journal-title":"Mutat Res"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0027-5107(78)90045-3","volume":"50","author":"AMR Taylor","year":"1978","unstructured":"Taylor AMR: Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations. Mutat Res 50: 407?418, 1978","journal-title":"Mutat Res"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0027-5107(86)90120-X","volume":"159","author":"Y Ejima","year":"1986","unstructured":"Ejima Y, Sasaki MS: Enhanced expression of X-ray- and UV-induced chromosome aberrations by cytosine arabinoside in ataxia telangiectasia cells. Mutat Res 159: 117?123, 1986","journal-title":"Mutat Res"},{"key":"CR34","first-page":"285","volume":"146","author":"M Watanabe","year":"1985","unstructured":"Watanabe M, Maher VM, McCormick JJ: Excision repair of UV-of benzo[a]pyrene diolepoxide-induced lesions in xeroderma pigmentosum variant cells is ?error-free?. Mutat Res 146: 285?294, 1985","journal-title":"Mutat Res"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0027-5107(73)90060-2","volume":"20","author":"MA Bender","year":"1973","unstructured":"Bender MA, Griggs HG, Walker PL: Mechanisms of chromosomal aberration production. I. Aberration induction by ultraviolet light. Mutat Res 20: 387?402, 1973","journal-title":"Mutat Res"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/carcin\/7.3.389","volume":"7","author":"TCV Wang","year":"1986","unstructured":"Wang TCV, Smith KC: Postreplication repair in ultraviolet-irradiated human fibroblasts: formation and repair of DNA double strand breaks. Carcinogenesis 7: 389?392, 1986","journal-title":"Carcinogenesis"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0921-8777(90)90066-E","volume":"235","author":"F Darroudi","year":"1990","unstructured":"Darroudi F, Natarajan AT, van der Schans GP: Biochemical and cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6. VI. The correlation between UV-induced DNA lesions and chromosomal aberrations, and their modulations with inhibitors of DNA repair synthesis. Mutat Res 235: 129?135, 1990","journal-title":"Mutat Res"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"11034","DOI":"10.1073\/pnas.90.23.11034","volume":"90","author":"V Dulic","year":"1993","unstructured":"Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH: Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin D1\/Cdk2 and cyclin E\/Cdk2 complexes. Proc Natl Acad Sci USA 90: 11034?11038, 1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1073\/pnas.89.21.10114","volume":"89","author":"RC Allsop","year":"1992","unstructured":"Allsop RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB: Telomere length predicts the replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89: 10114?10118, 1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/carcin\/12.9.1587","volume":"12","author":"WK Kaufmann","year":"1991","unstructured":"Kaufmann WK, Rice JM, MacKenzie SA, Smith GJ, Wenk ML, Devor D, Qaqish BF, Kaufman DG: Proliferation of carcinogen-damaged hepatocytes during cell-cycle-dependent initiation of hepatocarcinogenesis in the rat. Carcinogenesis 12: 1587?1593, 1991","journal-title":"Carcinogenesis"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"12642","DOI":"10.1016\/S0021-9258(18)67110-8","volume":"261","author":"VS Goldmacher","year":"1986","unstructured":"Goldmacher VS, Cuzick RA Jr, Thilly WG: Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. J Biol Chem 261: 12642?12471, 1986","journal-title":"J Biol Chem"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.1073\/pnas.90.14.6424","volume":"90","author":"A Kat","year":"1993","unstructured":"Kat A, Thilly WG, Fang W-H, Longley MJ, Li G-M, Modrich P: An alkylation-tolerant mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci USA 90: 6424?6428, 1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"14367","DOI":"10.1016\/S0021-9258(17)36630-9","volume":"269","author":"A Umar","year":"1994","unstructured":"Umar A, Boyer JC, Thomas DC, Nguyen DC, Risinger JI, Boyd J, Ionov Y, Perucho M, Kunkel TA: Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem 269: 14367?14370, 1994","journal-title":"J Biol Chem"}],"container-title":["Cancer and Metastasis Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00690209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00690209\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00690209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T04:42:51Z","timestamp":1625028171000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00690209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["BF00690209"],"URL":"https:\/\/doi.org\/10.1007\/bf00690209","relation":{},"ISSN":["0167-7659","1573-7233"],"issn-type":[{"value":"0167-7659","type":"print"},{"value":"1573-7233","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}