{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:11:32Z","timestamp":1789384292469,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother. Pharmacol."],"published-print":{"date-parts":[[1989]]},"DOI":"10.1007\/bf00694339","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T18:20:35Z","timestamp":1101752435000},"page":"55-61","source":"Crossref","is-referenced-by-count":323,"title":["Pharmacokinetics of busulfan: correlation with veno-occlusive disease in patients undergoing bone marrow transplantation"],"prefix":"10.1007","volume":"25","author":[{"given":"Louise B.","family":"Grochow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Brundrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden G.","family":"Braine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rein","family":"Saral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. Michael","family":"Colvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.7326\/0003-4819-90-2-158","volume":"90","author":"PO Berk","year":"1979","unstructured":"Berk PO, Popper H, Krueger GRF, Decter J, Herzig G, Graw RG (1979) Veno-occlusive disease of the liver after allogeneic bone marrow transplantation. Possible association with graftversus-host disease. Ann Intern Med 90: 158","journal-title":"Ann Intern Med"},{"key":"CR2","first-page":"369","volume":"99","author":"WE Beschorner","year":"1980","unstructured":"Beschorner WE, Pino J, Boitnott JK, Tutschka PJ, Santos GW (1980) Pathology of the liver with bone marrow transplantation. Effects of busulfan, carmustine, acute graft-versus-host disease, and cytomegalovirus infection. Am J Pathol 99: 369","journal-title":"Am J Pathol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0165-1110(86)90020-5","volume":"168","author":"JB Bishop","year":"1986","unstructured":"Bishop JB, Wassom JS (1986) Toxicologic review of busulfan (Myleran). Mutat Res 168: 15","journal-title":"Mutat Res"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0308-2261(21)00552-X","volume":"6","author":"GP Canellos","year":"1977","unstructured":"Canellos GP (1977) The treatment of chronic granulocytic leukemia. Clin Haematol 6: 113","journal-title":"Clin Haematol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.2042-7158.1984.tb04847.x","volume":"36","author":"H Ehrsson","year":"1984","unstructured":"Ehrsson H, Hassan M (1984) Binding of busulfan to plasma proteins and blood cells. J Pharm Pharmacol 36: 694","journal-title":"J Pharm Pharmacol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/clpt.1983.134","volume":"34","author":"H Ehrsson","year":"1983","unstructured":"Ehrsson H, Hassan M, Ehrnebo M, Beran M (1983) Busulfan kinetics. Clin Pharmacol Ther 34: 86","journal-title":"Clin Pharmacol Ther"},{"key":"CR7","first-page":"132","volume-title":"Pharmacokinetics","year":"1982","unstructured":"Gibaldi M, Perrier D (eds) (1982) Pharmacokinetics. Marcel Dekker, New York, p 132"},{"key":"CR8","first-page":"399","volume":"15","author":"M Hassan","year":"1987","unstructured":"Hassan M, Ehrsson J (1987) Urinary metabolites of busulfan in the rat. Drug Metab Dispos 15: 399","journal-title":"Drug Metab Dispos"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03189864","volume":"12","author":"M Hasson","year":"1987","unstructured":"Hasson M, Ehrsson H (1987) Metabolism of*14C-busulfan in isolated perfused rat liver. Eur J Drug Metab Pharmacokinet 12: 71","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"CR10","first-page":"440","volume":"90","author":"GW Hepner","year":"1977","unstructured":"Hepner GW, Vesell ES, Lipton A, Harvey HA, Wilkinson GR, Schenker S (1977) Disposition of aminopyrine, antipyrine diazepam and indocyanine green in patients with liver disease or on anticonvulsant therapy: diazepam breath test and correlations in drug elimination. J Lab Clin Med 90: 440","journal-title":"J Lab Clin Med"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0006-2952(58)90007-8","volume":"1","author":"RF Hudson","year":"1958","unstructured":"Hudson RF, Timmis GM, Marshall RD (1958) A physicochemical investigation into the biological action of Myleran and related sulphonic acid esters. Biochem Pharmacol 1: 48","journal-title":"Biochem Pharmacol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00007890-198712000-00011","volume":"44","author":"RJ Jones","year":"1987","unstructured":"Jones RJ, Lee KSK, Beschorner WE, Vogel VG, Grochow LB, Braine HG, Vogelsang GB, Sensenbrenner LL, Santos GW, Saral R (1987) Veno-occlusive disease of the liver following bone marrow transplantation. Transplantation 44: 778","journal-title":"Transplantation"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1039\/JR9620003686","volume":"3","author":"AT Kader","year":"1962","unstructured":"Kader AT, Stirling CJM (1962) Elimination-addition: I. Displacement of sulphonyl groups from diarylsulphonylalkanes. J Chem Soc 3: 3686","journal-title":"J Chem Soc"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.1840040121","volume":"4","author":"GB McDonald","year":"1984","unstructured":"McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED (1984) Veno-occlusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 4: 116","journal-title":"Hepatology"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/00007890-198506000-00005","volume":"39","author":"GB McDonald","year":"1985","unstructured":"McDonald GB, Sharma P, Matthews DE, Schulman HM, Thomas ED (1985) The clinical course of 53 patients with veno-occlusive disease of the liver after marrow transplantation. Transplantation 39: 603","journal-title":"Transplantation"},{"key":"CR16","first-page":"713","volume":"19","author":"MV Nadkarni","year":"1959","unstructured":"Nadkarni MV, Trams EG, Smith PK (1959) Preliminary studies on the distribution and fate of TEM, TEPA and myleran in the human. Cancer Res 19: 713","journal-title":"Cancer Res"},{"key":"CR17","first-page":"6402","volume":"47","author":"WP Peters","year":"1987","unstructured":"Peters WP, Henner WD, Grochow LB, Olsen G, Edwards S, Stanbuck H, Stuart A, Gockerman J, Moore J, Bast RC Jr, Seigler HF, Colvin OM (1987) Clinical and pharmacologic effects of high dose single agent busulfan with autologous bone marrow support in the treatment of solid tumors. Cancer Res 47: 6402","journal-title":"Cancer Res"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0006-2952(61)90133-2","volume":"6","author":"JJ Roberts","year":"1961","unstructured":"Roberts JJ, Warwick GP (1961) The mode of action of alkylating agents: III. The formation of 3-hydroxytetra-hydrothiophene-1?1-dioxide from 1?4-dimethane sulphonyloxybutane (Myleran),S-B-alanyl-tetrahydrothiophenium mesylate, tetrahydrothiophene-1?1 dioxide in the rat, rabbit and mouse. Biochem Pharmacol 6: 217","journal-title":"Biochem Pharmacol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0002-9343(86)90266-4","volume":"81","author":"BJ Rollins","year":"1986","unstructured":"Rollins BJ (1986) Hepatic veno-occlusive disease. Am J Med 81: 297","journal-title":"Am J Med"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1056\/NEJM198312013092202","volume":"309","author":"GW Santos","year":"1983","unstructured":"Santos GW, Tutschka PJ, Brookmeyer R, Saral R, Beschorner WE, Bias WB, Braine HG, Burns WH, Elfenbein GJ, Kaizer H, Mellits D, Sensenbrenner LL, Stuart RK, Yeager AM (1983) Marrow transplantation for acute non-lymphocytic leukemia after treatment with busulfan and cyclophosphamide. New Engl J Med 309: 1347","journal-title":"New Engl J Med"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0006-2952(59)90052-8","volume":"2","author":"EG Trams","year":"1959","unstructured":"Trams EG, Nadkarni MV, de Quattro V, Maengwyn-Davies GD, Smith PK (1959) Dimethane sulphonoxybutane (myleran): preliminary studies and metabolic fate in the rat. Biochem Pharmacol 2: 7","journal-title":"Biochem Pharmacol"},{"key":"CR22","first-page":"266","volume":"73","author":"H Vodopick","year":"1969","unstructured":"Vodopick H, Hamilton HE, Jackson HL, Peng CT, Sheets RF (1969) Metabolic fate of busulfan in man. J Lab Clin Med 73: 266","journal-title":"J Lab Clin Med"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00694339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00694339\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00694339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T01:42:18Z","timestamp":1625017338000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00694339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989]]}},"alternative-id":["BF00694339"],"URL":"https:\/\/doi.org\/10.1007\/bf00694339","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989]]}}}