{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T11:10:20Z","timestamp":1726139420413},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Conclusion<\/jats:title><jats:p>We propose that the most likely location for CLN3 is within the interval between loci D16S297 and D16S57 on the proximal portion of the short arm of chromosome 16. The position of the CLN3 gene could be further refined by the use of new polymorphic markers isolated within this interval.<\/jats:p><jats:p>We have preliminary data indicating strong linkage disequilibrium with the disease for two markers, D16S298 and D16S299, and we find no recombination between these loci in the CEPH pedigrees (Thompson, Callen, Mitchison and Gardiner, unpublished). We therefore have a good indication that within our expected interval CLN3 is within close proximity of the locus D16S298\/299.<\/jats:p>","DOI":"10.1007\/bf00710278","type":"journal-article","created":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T12:15:16Z","timestamp":1101903316000},"page":"339-341","source":"Crossref","is-referenced-by-count":10,"title":["Refined genetic mapping of juvenile\u2010onset neuronal ceroid\u2010lipofuscinosis on chromosome 16"],"prefix":"10.1002","volume":"16","author":[{"given":"H. M.","family":"Mitchison","sequence":"first","affiliation":[{"name":"Department of Paediatrics UCL Medical School, The Rayne Institute  5 University Street London WC1E 6JJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Paediatrics UCL Medical School, The Rayne Institute  5 University Street London WC1E 6JJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. R.","family":"McKay","sequence":"additional","affiliation":[{"name":"Department of Paediatrics UCL Medical School, The Rayne Institute  5 University Street London WC1E 6JJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F.","family":"Callen","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics and Molecular Genetics Adelaide Children's Hospital  72 King William Road North Adelaide SA 5006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics and Molecular Genetics Adelaide Children's Hospital  72 King William Road North Adelaide SA 5006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Mulley","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics and Molecular Genetics Adelaide Children's Hospital  72 King William Road North Adelaide SA 5006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. L.","family":"Stallings","sequence":"additional","affiliation":[{"name":"Centre for Human Genome Studies Los Alamos National Laboratory  MS M880 Los Alamos NM 87545 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Centre for Human Genome Studies Los Alamos National Laboratory  MS M880 Los Alamos NM 87545 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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M.","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Department of Paediatrics UCL Medical School, The Rayne Institute  5 University Street London WC1E 6JJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"235","article-title":"A mouse\u2010human hybrid cell panel for mapping human chromosome 16","volume":"29","author":"Callen DF","year":"1986","journal-title":"Ann Genet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90341-8"},{"key":"e_1_2_1_4_1","first-page":"1372","article-title":"Regional mapping of the Batten disease locus (CLN3) to human chromosome 16p12","volume":"49","author":"Callen DF","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1989.tb03193.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.19.5449"},{"key":"e_1_2_1_7_1","first-page":"482","article-title":"Multilocus analysis in humans: Detection of linkage and estimation of recombination","volume":"37","author":"Lathrop GM","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","first-page":"2002","article-title":"Integration of a cosmid contig map with cytogenetic and genetic linkage maps of human chromosome 16. 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