{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:52:11Z","timestamp":1761807131007},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1992,7,2]],"date-time":"1992-07-02T00:00:00Z","timestamp":710035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We analysed the distribution of mutant mitochondrial DNA (mtDNA) with A\u2010to\u2010G substitution mutation of tRNA<jats:sup>Leu(UUR)<\/jats:sup> in various autopsied tissues from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke\u2010like episodes (MELAS). There was no significant difference in the proportion (76\u201386%) of mutant mtDNA in many tissues, except in the lung and spleen. Unequal partitioning of mtDNA in somatic cells appears less prominent than that in germ cells.<\/jats:p>","DOI":"10.1007\/bf00711311","type":"journal-article","created":{"date-parts":[[2004,11,30]],"date-time":"2004-11-30T08:37:33Z","timestamp":1101803853000},"page":"27-30","source":"Crossref","is-referenced-by-count":13,"title":["Tissue distribution of mutant mitochondrial DNA in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke\u2010like episodes (MELAS)"],"prefix":"10.1002","volume":"16","author":[{"given":"Y.","family":"Shoji","sequence":"first","affiliation":[{"name":"Department of Pediatrics Akita University School of Medicine  1\u20101\u20101 Hondo Akita 010 Japan"},{"name":"Department of Pediatrics Senboku Kumiai General Hospital  Akita 014 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Akita University School of Medicine  1\u20101\u20101 Hondo Akita 010 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hayasaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Akita University School of Medicine  1\u20101\u20101 Hondo Akita 010 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Akita University School of Medicine  1\u20101\u20101 Hondo Akita 010 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,7,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.10.1663"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310408"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00206080"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/348651a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.545"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10614"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80599-2"},{"key":"e_1_2_1_9_1","article-title":"33th Ann Mtg, Japanese Society of Child Neurology.","volume":"24","author":"Ito S","year":"1991","journal-title":"No To Hattatsu"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(88)90272-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160409"},{"key":"e_1_2_1_12_1","first-page":"655","article-title":"Genetic analysis of three pedigrees of mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS)","volume":"50","author":"Sato W","year":"1992","journal-title":"Am J Hum Genet"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF00711311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF00711311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T10:23:56Z","timestamp":1694859836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF00711311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7,2]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1007\/BF00711311"],"URL":"https:\/\/doi.org\/10.1007\/bf00711311","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7,2]]}}}