{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:29:03Z","timestamp":1791905343855,"version":"4.3.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1987,1,1]],"date-time":"1987-01-01T00:00:00Z","timestamp":536457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[1987]]},"DOI":"10.1007\/bf00718020","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T06:58:51Z","timestamp":1102057131000},"page":"105-108","source":"Crossref","is-referenced-by-count":28,"title":["Intraventricular morphine produces pain relief, hypothermia, hyperglycaemia and increased prolactin and growth hormone levels in patients with cancer pain"],"prefix":"10.1007","volume":"235","author":[{"given":"C. F.","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0006-8993(75)90062-1","volume":"94","author":"H Akil","year":"1975","unstructured":"Akil H, Liebeskind JC (1975) Monoaminergic mechanisms of stimulation-induced analgesia. Brain Res 94:279?296","journal-title":"Brain Res"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-8993(73)90796-8","volume":"60","author":"S Baragura","year":"1973","unstructured":"Baragura S, Ralph T (1973) The analgesic effect of electrical stimulation of the diencephalon and mesencephalon. Brain Res 60:369?379","journal-title":"Brain Res"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1210\/jcem-50-6-1021","volume":"50","author":"DH Catlin","year":"1980","unstructured":"Catlin DH, Poland RE, Gorelick DA, Gerner RH, Hui KK, Rubin RT, Li CH (1980) Intravenous infusion of ?-endorphin increases serum prolactin, but not growth hormone or cortisol, in depressed subjects and withdrawing methadone addicts. J Clin Endocrinol Metab 50:1021?1025","journal-title":"J Clin Endocrinol Metab"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/endo-102-1-281","volume":"102","author":"K Chihara","year":"1978","unstructured":"Chihara K, Arimura A, Coy DH, Schally V (1978) Studies of the interaction of endorphins, substance P and endogenous somatostatin in growth hormone and prolactin release in rats. Endocrinology 102:281?286","journal-title":"Endocrinology"},{"key":"CR5","first-page":"164","volume":"17","author":"PI Collins","year":"1974","unstructured":"Collins PI, Wei E, Way EL (1974) Central sites of morphine analgesia. Proc West Pharmacol Soc 17:164?167","journal-title":"Proc West Pharmacol Soc"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1073\/pnas.74.1.358","volume":"74","author":"A Dupont","year":"1977","unstructured":"Dupont A, Cusan L, Garon M, Labrie F, Li CH (1977) ?-endorphin: stimulation of growth hormone release in vivo. Proc Natl Acad Sci USA 74:358?362","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0006-291X(77)91291-8","volume":"75","author":"A Dupont","year":"1977","unstructured":"Dupont A, Cusan L, Labrie F, Coy DH, Li CH (1977) Stimulation of prolactin release in the rat by intraventricular injection of ?-endorphin and methionine-enkephalin. Biochem Biophys Res Commun 75:76?81","journal-title":"Biochem Biophys Res Commun"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/clinchem\/20.3.365","volume":"20","author":"LB Foster","year":"1974","unstructured":"Foster LB, Dunn RT (1974) Single-antibody technique of radio-immunoassay of cortisol in unextracted serum or plasma. Clin Chem 20:365?372","journal-title":"Clin Chem"},{"key":"CR9","first-page":"198","volume-title":"Agonists and antagonists action of narcotic analgesic drugs","author":"LS Harris","year":"1973","unstructured":"Harris LS, Dewey WL (1973) Role of cholinergic systems in the central action of narcotic agonists and antagonists. In: Kosterlitz HW, Collier HOJ, Villarreal JE (eds) Agonists and antagonists action of narcotic analgesic drugs. University Park Press, Baltimore, pp 198?206"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.185.4156.1055","volume":"185","author":"YF Jacquet","year":"1974","unstructured":"Jacquet YF, Lajtha A (1974) Paradoxical effects after microinjection of morphine in the periaqueductal gray matter in the rat. Science 185:1055?1057","journal-title":"Science"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1210\/endo-90-3-735","volume":"90","author":"N Kokka","year":"1972","unstructured":"Kokka N, Garcia JF, George R, Elliott HW (1972) Growth hormone and ACTH secretion: evidence for an inverse relationship in rats. Endocrinology 90:735?742","journal-title":"Endocrinology"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3171\/jns.1982.56.2.0241","volume":"56","author":"ME Leavens","year":"1982","unstructured":"Leavens ME, Hui CS, Cech DH, Weyland JB, Weston JS (1982) Intrathecal and intraventricular morphine for pain in cancer patients: initial study. J Neurosurg 56:241?245","journal-title":"J Neurosurg"},{"key":"CR13","first-page":"142","volume-title":"Agonists and antagonists actions of narcotic analgesic durgs","author":"GM Lees","year":"1973","unstructured":"Lees GM, Kosterlitz HW, Waterfield AA (1973) Characteristics of morphine-sensitive release of neurotransmitter substances. In: Kosterlitz HW, Collier HDJ, Villarreal JE (eds) Agonists and antagonists actions of narcotic analgesic durgs. University Park Press, Baltimore, pp 142?152"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1227\/00006123-198507000-00002","volume":"17","author":"A Lenzi","year":"1985","unstructured":"Lenzi A, Galli G, Gandolfini M, Marini G (1985) Intraventricular morphine in paraneoplastic painful syndrome of the cervicofacial region: experience in thirty-eight cases. Neurosurgery 17:6?11","journal-title":"Neurosurgery"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0006-8993(73)90748-8","volume":"50","author":"JC Liebeskind","year":"1973","unstructured":"Liebeskind JC, Guilbaud G, Besson JM, Oliveras JL (1973) Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioural observations and inhibitory effects on spinal cord interneurons. Brain Res 50:441?446","journal-title":"Brain Res"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1113\/jphysiol.1979.sp012960","volume":"295","author":"MT Lin","year":"1979","unstructured":"Lin MT, Su CY (1979) Metabolic, respiratory, vasomotor and body temperature responses to ?-endorphin and morphine in rabbits. J Physiol (Lond) 295:179?189","journal-title":"J Physiol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3171\/jns.1983.59.4.0627","volume":"59","author":"RD Lobato","year":"1983","unstructured":"Lobato RD, Madrid JL, Fatela LV, Rivas JJ, Reig E, Lamas E (1983) Intraventricular morphine for control of pain in terminal cancer patients. J Neurosurg 59:627?633","journal-title":"J Neurosurg"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0006-8993(74)90534-4","volume":"68","author":"DJ Mayer","year":"1974","unstructured":"Mayer DJ, Liebeskind JC (1974) Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis. Brain Res 68:73?93","journal-title":"Brain Res"},{"key":"CR19","first-page":"121","volume-title":"Narcotics and the hypothalamus","author":"SM McCann","year":"1974","unstructured":"McCann SM, Ojeda SR, Libertun C, Harms PG, Krulich I (1974) Drug-induced alterations in gonadotropin and prolactin release in the rat. In: Zimmermann E, George R (eds) Narcotics and the hypothalamus. Raven Press, New York, pp 121?129"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3959(77)90083-5","volume":"4","author":"RB Messing","year":"1977","unstructured":"Messing RB, Lytle LD (1977) Serotonin-containing neurons: their possible role in pain and analgesia. Pain 4:1?24","journal-title":"Pain"},{"key":"CR21","first-page":"495","volume-title":"Advances in pain research and therapy, vol 5","author":"BA Meyerson","year":"1983","unstructured":"Meyerson BA (1983) Electrostimulation procedures: effects, presumed rationale, and possible mechanisms. In: Bonica JJ, Lindblom U, Iggo A (eds) Advances in pain research and therapy, vol 5. Raven, New York, pp 495?534"},{"key":"CR22","first-page":"801","volume":"15","author":"G Nurchi","year":"1984","unstructured":"Nurchi G (1984) Use of intraventricular and intrathecal morphine in intractable pain associated with cancer. Neurosurgery 15:801?803","journal-title":"Neurosurgery"},{"key":"CR23","first-page":"973","volume":"70","author":"WD Odell","year":"1967","unstructured":"Odell WD, Rayford DL, Ross GT (1967) Simplified, partially automated method for radioimmunoassay of human thyroid stimulating, growth, luteinizing and follicle stimulating hormone. J Lab Clin Med 70:973?978","journal-title":"J Lab Clin Med"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0006-8993(74)90875-0","volume":"72","author":"JL Oliveras","year":"1974","unstructured":"Oliveras JL, Woda A, Guilbaud G, Besson JM (1974) Inhibition of the jaw opening reflex by electrical stimulation of the periaqueductal gray matter in the awake, unrestrained cat. Brain Res 72:328?331","journal-title":"Brain Res"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(74)90731-8","volume":"80","author":"A Pert","year":"1974","unstructured":"Pert A, Yaksh T (1974) Sites of morphine induced analgesia in the primate brain: relation to pain pathway. Brain Res 80:135?140","journal-title":"Brain Res"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1210\/endo-100-1-238","volume":"100","author":"C Rivier","year":"1977","unstructured":"Rivier C, Vale W, Ling N, Brown M, Guillemin R (1977) Stimulation in vivo of the secretion of prolactin and growth hormone by ?-endorphin. Endocrinology 100:238?241","journal-title":"Endocrinology"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0090-3019(84)90334-3","volume":"21","author":"B Roquefeuil","year":"1984","unstructured":"Roquefeuil B, Benezech J, Batier C, Frerebeau P, Gros C (1984) Intraventricular administration of morphine in patients with neoplastic intractable pain. Surg Neurol 21:155?158","journal-title":"Surg Neurol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0024-3205(77)90415-5","volume":"21","author":"CJ Shaar","year":"1977","unstructured":"Shaar CJ, Frederickson RCA, Dininger NB, Jackson L (1977) Enkephalin analogue and naloxone modulate the release of growth hormone and prolactin ? evidence for regulation by an endogenous opioid peptide in brain. Life Sci 21:853?860","journal-title":"Life Sci"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3171\/jns.1980.53.5.0684","volume":"53","author":"CJ Shih","year":"1980","unstructured":"Shih CJ, Lin MT (1980) Effects of cholinomimetic drugs on sudomotor, metabolic, respiratory, vasomotor and temperature response in palmar hyperhidrosis. J Neurosurg 53:684?689","journal-title":"J Neurosurg"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1210\/jcem-36-3-509","volume":"36","author":"YN Sinha","year":"1973","unstructured":"Sinha YN, Selby FW, Lewis UJ, Vanderlick WP (1973) A homologous radioimmunoassay for human prolactin. J Clin Endocrinol Metab 36:509?514","journal-title":"J Clin Endocrinol Metab"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.ne.02.030179.000343","volume":"2","author":"SH Snyder","year":"1979","unstructured":"Snyder SH, Childers SR (1979) Opiate receptors and opiate peptides. Rev Neurosci 2:35?64","journal-title":"Rev Neurosci"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1210\/jcem-41-4-797","volume":"41","author":"G Tolis","year":"1975","unstructured":"Tolis G, Hickey J, Guyda H (1975) Effects of morphine on serum growth hormone, cortisol, prolactin and thyroid stimulating hormone in man. J Clin Endocrinol Metab 41:797?803","journal-title":"J Clin Endocrinol Metab"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/0024-3205(79)90534-4","volume":"24","author":"DA Vugt Van","year":"1979","unstructured":"Van Vugt DA, Bruni JF, Sylvester PW, Chen HT, Ieiri T, Meites J (1979) Interaction between opiates and hypothalamic dopamine on prolactin release. Life Sci 24:2361?2368","journal-title":"Life Sci"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4684-1869-9_10","volume-title":"Narcotic drugs: biochemical pharmacology","author":"EL Way","year":"1971","unstructured":"Way EL, Shen F (1971) Catecholamines and 5-hydroxytryptamine. In: Clouet DH (ed) Narcotic drugs: biochemical pharmacology. Plenum Press, New York, pp 229?253"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0006-8993(79)90616-4","volume":"160","author":"TL Yaksh","year":"1979","unstructured":"Yaksh TL (1979) Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray. Brain Res 160:180?185","journal-title":"Brain Res"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00718020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00718020\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00718020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T13:25:47Z","timestamp":1586006747000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00718020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987]]}},"alternative-id":["BF00718020"],"URL":"https:\/\/doi.org\/10.1007\/bf00718020","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987]]}}}