{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:42:13Z","timestamp":1770478933026,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[1996,7]]},"DOI":"10.1007\/bf00817918","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T00:38:05Z","timestamp":1104194285000},"page":"213-220","source":"Crossref","is-referenced-by-count":12,"title":["Mercury distribution and renal metallothionein induction after subchronic oral exposure in rats"],"prefix":"10.1007","volume":"9","author":[{"given":"Miguel \ufffdngel","family":"Morcillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\ufffds","family":"Santamaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","volume-title":"Handbook on The Toxicology of Metals, Vol II","author":"M. Berlin","year":"1986","unstructured":"Berlin M. 1986 Mercury. In: Friberg L, Nordberg GF, Vouk VB, eds.Handbook on The Toxicology of Metals, Vol II. Amsterdam: Elsevier."},{"issue":"Suppl. 3","key":"CR2","first-page":"305","volume":"102","author":"M Blanusa","year":"1994","unstructured":"Blanusa M, Prester L, Radic S, Kargacin B. 1994 Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.Environ Health Perspect 102 (Suppl. 3), 305?307.","journal-title":"Environ Health Perspect"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0013-9351(80)90037-7","volume":"21","author":"JD Bodgen","year":"1980","unstructured":"Bodgen JD, Kemp FW, Troiano RA, Jortner BS, Timpone C, Giuliani D. 1980 Effect of mercuric chloride and methylmercury chloride exposure on tissue concentrations of six essential minerals.Environ Res 21, 350?359.","journal-title":"Environ Res"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0076-6879(91)05080-F","volume":"205","author":"I Bremner","year":"1991","unstructured":"Bremner I. 1991 Nutritional and physiological significance of metallothionein.Methods Enzimol 205, 25?35.","journal-title":"Methods Enzimol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.nu.10.070190.000431","volume":"10","author":"I Bremner","year":"1990","unstructured":"Bremner I, Beattie JH. 1990 Metallothionein and the trace minerals.Annu Rev Nutr 10, 63?83.","journal-title":"Annu Rev Nutr"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0041-008X(76)90146-0","volume":"38","author":"MG Cherian","year":"1976","unstructured":"Cherian MG, Goger RA, Delaguerriere-Richardson. 1976 Cadmiummetallothionein-induced nephropathy.Toxicol Appl Pharmacol 38, 399?408.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1042\/bj0990062","volume":"99","author":"TW Clarkson","year":"1966","unstructured":"Clarkson TW, Magos L. 1966 Studies on the binding of mercury in tissue homogenates.Biochem J 99, 62?69.","journal-title":"Biochem J"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0041-008X(86)90385-6","volume":"85","author":"GP Daston","year":"1983","unstructured":"Daston GP, Kulock RJ, Rogers EM, Carver B. 1983 Toxicity of mercuric chloride to the developing rat kidney. I. Postnatal ontogeny of renal sensitivity.Toxicol Appl Pharmacol 85, 39?48.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL. 1959 Tissue sulphydryl groups.Arch Biochem Biophys 82, 70?77.","journal-title":"Arch Biochem Biophys"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1016\/S0021-9258(19)39356-1","volume":"265","author":"N Jahroudi","year":"1990","unstructured":"Jahroudi N, Foster R, Haughey JP, Beitel G, Gedamu L. 1990 Cell-type specific and differential regulation of the human metallothionein genes.J Biol Chem 265, 6506?6511.","journal-title":"J Biol Chem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0041-008X(70)90080-3","volume":"16","author":"M Jakubowski","year":"1970","unstructured":"Jakubowski M, Piotrowski J, Trojanowska B. 1970 Binding of mercury in the rat: studies using203HgCl2 and gel filtration.Toxicol Appl Pharmacol 16, 743?753.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0092-8674(85)90051-0","volume":"41","author":"M Karin","year":"1985","unstructured":"Karin M. 1985 Metallothioneins: proteins in search of function.Cell 41, 9?10.","journal-title":"Cell"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0041-008X(78)90303-4","volume":"46","author":"R Kishi","year":"1978","unstructured":"Kishi R, Hashimoto K, Shimizu S, Kobayashi M. 1978 Behavioral changes and mercury concentrations in tissues of rats exposed to mercury vapor.Toxicol Appl Pharmacol 46, 555?566.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0041-008X(87)90005-6","volume":"88","author":"LD Lehman-McKeeman","year":"1987","unstructured":"Lehman-McKeeman LD, Klaassen CD. 1987 Induction to metallothionein-I and metallothionein-II in rats by cadmium and zinc.Toxicol Appl Pharmacol 88, 195?202.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01079693","volume":"5","author":"X Liu","year":"1992","unstructured":"Liu X, Nordberg GF, Jin T. 1992 Increased urinary excretion of zinc and copper by mercuric chloride injection in rats.BioMetals 5, 17?22.","journal-title":"BioMetals"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0272-0590(88)90255-2","volume":"10","author":"T Maitani","year":"1988","unstructured":"Maitani T, Cuppage FE, Klaassen CD. 1988 Nephrotoxicity of intravenously injected cadmium-metallothionein: critical concentration and tolerance.Fundam Appl Toxicol 10, 98?108.","journal-title":"Fundam Appl Toxicol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-0773.1980.tb02413.x","volume":"46","author":"H Mengel","year":"1980","unstructured":"Mengel H, Karlog O. 1980 Studies on the interaction and distribution of selenite, mercuric, methoxyethyl mercuric and methyl mercuric chloride in rats. I. Analysis of brain, liver, kidney and faeces.Acta Pharmacol Toxicol 46, 14?24.","journal-title":"Acta Pharmacol Toxicol"},{"key":"CR18","first-page":"163","volume":"8","author":"Y Mitane","year":"1988","unstructured":"Mitane Y, Tohyama C. 1988 Urinary excretion of metallothionein in cadmium- and mercury-treated rats.Environ Occup Chem Hazards 8, 163?169.","journal-title":"Environ Occup Chem Hazards"},{"key":"CR19","series-title":"Doctoral Thesis","volume-title":"Metallothionein as a biological indicator in rats chronically exposed to inorganic mercury","author":"MA Morcillo","year":"1992","unstructured":"Morcillo MA. 1992 Metallothionein as a biological indicator in rats chronically exposed to inorganic mercury.Doctoral Thesis, Faculty of Sciences, Universidad Aut\u00f3noma de Madrid, Spain."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0021-9673(93)87013-C","volume":"655","author":"MA Morcillo","year":"1993","unstructured":"Morcillo MA, Santamaria J. 1993 Separation and characterization of rat kidney isometallothioneins induced by exposure to inorganic mercury.J. Chrom A 655, 77?83.","journal-title":"J. Chrom A"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00141603","volume":"8","author":"MA Morcillo","year":"1995","unstructured":"Morcillo MA, Santamaria J. 1995 Whole-body retention, urinary and fecal excretion of mercury after subchronic oral exposure to mercuric chloride in rats.BioMetals 8, 301?308.","journal-title":"BioMetals"},{"key":"CR22","first-page":"88","volume":"10","author":"MA Morcillo","year":"1993","unstructured":"Morcillo MA, Santamaria J, S\u00e1nchez F. 1993 La metalotioneina como proteina destoxificante del mercurio inorg\u00e1nico.Rev Toxicol 10, 88.","journal-title":"Rev Toxicol"},{"key":"CR23","volume-title":"Metal Compounds in Environment and Life, 4","author":"MA Morcillo","year":"1992","unstructured":"Morcillo MA, Santamaria J, S\u00e1nchez F, Ribas B, Bando I. 1992 Rat kidney metallothionein induced by subchronic exposure to inorganic mercury. In: Merian E, Haerdi W, eds.Metal Compounds in Environment and Life, 4. Northwood-Wilmington: Science and Technology Letters-Science Reviews Inc."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/15287399209531659","volume":"111","author":"JB Nielsen","year":"1992","unstructured":"Nielsen JB. 1992 Toxicokinetics of mercuric chloride and methylmercuric chloride in mice.J Toxicol Environ Health 111, 85?122.","journal-title":"J Toxicol Environ Health"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-483X(89)90152-2","volume":"59","author":"JB Nielsen","year":"1989","unstructured":"Nielsen JB, Andersen O. 1989 Oral mercuric chloride exposure in mice: effects of dose on intestinal absorption and relative organ distribution.Toxicology 59, 1?10.","journal-title":"Toxicology"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/15287399009531420","volume":"30","author":"JB Nielsen","year":"1990","unstructured":"Nielsen JB, Andersen O. 1990 Disposition and retention of mercuric chloride in mice after oral and parenteral administration.J Toxicol Environ Health 30, 167?180.","journal-title":"J Toxicol Environ Health"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF02796698","volume":"1","author":"CV Nolan","year":"1987","unstructured":"Nolan CV, Shaikh ZA. 1987 Induction of metallothionein in rat tissues following subchronic exposure to mercury shown by radioimmunoassay.Biol Trace Elem Res 1, 419?428.","journal-title":"Biol Trace Elem Res"},{"key":"CR28","first-page":"149","volume":"4","author":"M Nordberg","year":"1974","unstructured":"Nordberg M, Trojanowska B, Nordberg GF. 1974 Studies on metal-binding proteins of low molecular weight from renal tissue of rabbits exposed to cadmium or mercury.Environ Physiol Biochem 4, 149?158.","journal-title":"Environ Physiol Biochem"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0079-6468(08)70292-3","volume-title":"Progress in Medicinal Chemistry, Vol. 27","author":"K Nordlind","year":"1990","unstructured":"Nordlind K. 1990 Biological effects of mercuric chloride, nickel sulphate and nickel chloride. In: Ellis GP, West GB, eds.Progress in Medicinal Chemistry, Vol. 27. Amsterdam: Elsevier; 189?233."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF00295161","volume":"56","author":"F Planas-Bohne","year":"1985","unstructured":"Planas-Bohne F, Taylor DM, Walser R. 1985 The influence of administered mass on the subcellular distribution and binding of mercury in rat liver and kidney.Arch Toxicol 56, 242?246.","journal-title":"Arch Toxicol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0041-008X(74)90169-0","volume":"27","author":"JK Piotrowski","year":"1974","unstructured":"Piotrowski JK, Trojanowska B, Wisniewska-Knypl JM, Bolanowska W. 1974 Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: induction of metallothionein by mercury and cadmium.Toxicol Appl Pharmacol 27, 11?19.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0014-5793(74)80472-2","volume":"48","author":"G Sokolowski","year":"1974","unstructured":"Sokolowski G, Pilz W, Weser U. 1974 X-Ray photoelectron spectroscopic properties of Hg-thionein.FEBS Lett 48, 222?225.","journal-title":"FEBS Lett"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1289\/ehp.845431","volume":"54","author":"KS Squibb","year":"1984","unstructured":"Squibb KS, Fowler BA. 1984 Intracellular metabolism and effects of circulating cadmium-metallothionein in the kidney.Environ Health Perspect 54, 31?35.","journal-title":"Environ Health Perspect"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0076-6879(91)05085-A","volume":"205","author":"KH Summer","year":"1991","unstructured":"Summer KH, Klein D. 1991 Determination of metallothionein in biological materials.Methods Enzymol 205, 57?60.","journal-title":"Methods Enzymol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0076-6879(91)05079-B","volume":"205","author":"DM Templeton","year":"1991","unstructured":"Templeton DM, Cherian MG. 1991 Toxicological significance of metallothionein.Methods Enzymol 205, 11?24.","journal-title":"Methods Enzymol"},{"key":"CR36","volume-title":"Metallothionein II","author":"M Webb","year":"1987","unstructured":"Webb M. 1987 Toxicological significance of metallothionein. In: K\u00e4gi JHR, Koyima Y, eds.Metallothionein II. Boston: Birkha\u00fcser Verlag Basel."},{"key":"CR37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0009-2797(78)90020-0","volume":"21","author":"M Webb","year":"1980","unstructured":"Webb M, Magos L. 1980 Maleate induced change in the kidney binding of mercury in rats pretreated with cadmium.Chem-Biol Interact 21, 215?226.","journal-title":"Chem-Biol Interact"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0013-9351(83)90222-0","volume":"30","author":"PD Whanger","year":"1983","unstructured":"Whanger PD, Deagen JT. 1983 Effects of dietary mercury level and cadmium on rat tissue metallothionein: mercury binding and influences on zinc.Environ Res 30, 372?380.","journal-title":"Environ Res"},{"key":"CR39","first-page":"333","volume":"19","author":"PE Wilcox","year":"1960","unstructured":"Wilcox PE, Lisowski J. 1960 Application of gel filtration in studies of protein-metal complexes.Fedn Proc 19, 333?343.","journal-title":"Fedn Proc"},{"key":"CR40","volume-title":"Environmental Health Criteria 118","author":"World Health Organization","year":"1991","unstructured":"World Health Organization. 1991 Inorganic mercury. In:Environmental Health Criteria 118. Geneva: World Health Organization."},{"key":"CR41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0014-4800(91)90039-Z","volume":"54","author":"RK Zalups","year":"1991","unstructured":"Zalups RK. 1991 Autometallographic localization of inorganic mercury in the kidneys of rats: effect of unilateral nephrectomy and compensatory renal growth.Exp Mol Pathol 54, 10?21.","journal-title":"Exp Mol Pathol"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0041-008X(90)90244-O","volume":"106","author":"RK Zalups","year":"1990","unstructured":"Zalups RK, Barfuss D. 1990 Accumulation of inorganic mercury along the renal proximal tubule of the rabbit.Toxicol Appl Pharmacol 106, 245?253.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/BF02890261","volume":"53","author":"RK Zalups","year":"1987","unstructured":"Zalups RK, Diamond JM. 1987 Mercuric chloride-induced nephrotoxicity in the rat following unilateral nephrectomy and compensatory renal growth.Virchows Arch B 53, 336?346.","journal-title":"Virchows Arch B"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0041-008X(87)90043-3","volume":"89","author":"RK Zalups","year":"1987","unstructured":"Zalups RK, Klotzbach JM, Diamond JM. 1987 Enhanced accumulation of injected inorganic mercury in renal outer medulla after unilateral nephrectomy.Toxicol Appl Pharmacol 89, 226?236.","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0005-2795(80)90111-7","volume":"625","author":"AJ Zelazowski","year":"1980","unstructured":"Zelazowski AJ, Piotrowski JK. 1980 Mercury-binding, copper-zinc proteins from rat kidney. Amino acid composition, molecular weight and metal content.Biochim Biophys Acta 625, 89?99.","journal-title":"Biochim Biophys Acta"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00817918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00817918\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00817918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T18:14:34Z","timestamp":1625249674000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00817918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["BF00817918"],"URL":"https:\/\/doi.org\/10.1007\/bf00817918","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}