{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:05:29Z","timestamp":1761523529950},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[1995,6]]},"DOI":"10.1007\/bf00872864","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T15:39:06Z","timestamp":1104161946000},"page":"149-155","source":"Crossref","is-referenced-by-count":2,"title":["A phase II and pharmacokinetic study of 6S-leucovorin plus 5-fluorouracil in patients with colorectal carcinoma"],"prefix":"10.1007","volume":"13","author":[{"given":"Neal J.","family":"Meropol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Petrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youcef M.","family":"Rustum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Rodriguez-Bigas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie E.","family":"Blumenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmer","family":"Berghorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Creaven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00872864_CR1","first-page":"180","volume-title":"Cancer Chemotherapy: Principles and Practice","author":"JL Grem","year":"1990","unstructured":"Grem JL: Fluoropyrimidines. In: Chabner BA and Collins JM (eds) Cancer Chemotherapy: Principles and Practice. JB Lippinott Company, Philadelphia, pp 180\u2013224, 1990"},{"key":"BF00872864_CR2","first-page":"896","volume":"6","author":"P Piedbois","year":"1992","unstructured":"Piedbois P, Buyse M, Rustum YM, Machover D, Erlichman C, Carlson RW, Valone F, Labianca R, Doroshow JH, Petrelli N: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 6:896\u2013903, 1992","journal-title":"J Clin Oncol"},{"key":"BF00872864_CR3","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1200\/JCO.1991.9.11.1967","volume":"9","author":"MA Poon","year":"1991","unstructured":"Poon MA, O'Connell MJ, Wieand HS, Krook JE, Gerstner JB, Tschetter LK, Levitt R, Kardinal CG, Mailliard JA: Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal carcinoma. J Clin Oncol 9:1967\u20131972, 1991","journal-title":"J Clin Oncol"},{"key":"BF00872864_CR4","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1200\/JCO.1993.11.10.1879","volume":"11","author":"N Wolmark","year":"1993","unstructured":"Wolmark N, Rockette H, Fisher B, Wickerham DL, Redmond C, Fisher ER, Jones J, Mamounas EP, Ore L, Petrelli NJ, Spurr CL, Dimitrov N, Romond EH, Sutherland CM, Kardinal CG, DeFusco PA, Jochimsen P: The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-03. J Clin Oncol 11:1879\u20131887, 1993","journal-title":"J Clin Oncol"},{"key":"BF00872864_CR5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF02897229","volume":"26","author":"PP Lee","year":"1990","unstructured":"Lee PP, Schilsky RL: Inhibition of thymidylate synthase by the diastereoisomers of leucovorin. Cancer Chemother Pharmacol 26:273\u2013277, 1990","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF00872864_CR6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0021-9258(17)38295-9","volume":"253","author":"JC White","year":"1978","unstructured":"White JC, Bailey BD, Goldman ID: Lack of stereospecificity at carbon 6 of methyltetrahydrofolate. Transport in Ehrlich ascites tumor cells. J Biol Chem 253:242\u2013245, 1978","journal-title":"J Biol Chem"},{"key":"BF00872864_CR7","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1016\/0006-2952(79)90599-9","volume":"28","author":"FM Sirotnak","year":"1979","unstructured":"Sirotnak FM, Chello PL, Moccio DM, Kisliuk RL, Combepine G, Gaumont Y, Montgomery JA: Stereo-specificity at carbon 6 of formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexatein vitro. Biochem Pharmacol 28:2993\u20132997, 1979","journal-title":"Biochem Pharmacol"},{"key":"BF00872864_CR8","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/jnci\/82.17.1411","volume":"82","author":"RL Schilsky","year":"1990","unstructured":"Schilsky RL, Ratain MJ: Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. J Nat Cancer Inst 82:1411\u20131415, 1990","journal-title":"J Nat Cancer Inst"},{"key":"BF00872864_CR9","unstructured":"Creaven PJ, Petrelli NJ, Rustum YM, George M, Letvak L, Solomon J: Initial clinical trial of weekly 5-fluorouracil plus 6S-leucovorin. 7th NCI-EORTC Symposium on New Drugs in Cancer Therapy, Amsterdam, The Netherlands, 195, 1992"},{"key":"BF00872864_CR10","unstructured":"Cancer Therapy Evaluation Program: Common toxicity criteria. In: NCI decision of cancer treatment guidelines for reporting of adverse drug reactions. Bethesda: NIH Publications, pp 6\u20139, 1989"},{"key":"BF00872864_CR11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0010-468X(83)90082-X","volume":"16","author":"ML Rocci","year":"1983","unstructured":"Rocci ML, Jusko WJ: LAGRAN program for area and moments in pharmacokinetic analysis. Computer Programs in Biomedicine 16:203\u2013216, 1983","journal-title":"Computer Programs in Biomedicine"},{"key":"BF00872864_CR12","unstructured":"Schefler W: Statistics for the biological sciences. Addison-Wesley Publishing Co., Inc., 1979"},{"key":"BF00872864_CR13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1200\/JCO.1994.12.1.14","volume":"12","author":"TR Buroker","year":"1994","unstructured":"Buroker TR, O'Connell MJ, Wieand HS, Krook JE, Gerstner JB, Mailliard JA, Schaefer PL, Levitt R, Kardinal CG, Gesme DH: Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 12:14\u201320, 1994","journal-title":"J Clin Oncol"},{"key":"BF00872864_CR14","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1200\/JCO.1987.5.10.1559","volume":"10","author":"N Petrelli","year":"1987","unstructured":"Petrelli N, Herrera L, Rustum YM, Burke P, Creaven PJ, Stulc J, Emrich LJ, Mittelman A: A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 10:1559\u20131565, 1987","journal-title":"J Clin Oncol"},{"key":"BF00872864_CR15","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1200\/JCO.1989.7.10.1419","volume":"7","author":"N Petrelli","year":"1989","unstructured":"Petrelli N, Douglass HO, Herrera L, Russell D, Stablein DM, Bruckner HW, Mayer RJ, Schinella R, Green MD, Muggia FM, Megibow A, Greenwald ES, Bukovvski RM, Harris J, Levin B, Gaynor E, Loutfi A, Kalser MH, Barkin JS, Benedetto P, Woolley PV, Nauta R, Weaver DW, Leichman LP: The modulation of flourouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. J Clin Oncol 7: 1419\u20131426, 1989","journal-title":"J Clin Oncol"},{"key":"BF00872864_CR16","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/jnci\/81.15.1175","volume":"81","author":"R Bertrand","year":"1989","unstructured":"Bertrand R, Jolivet J: Lack of interference by the unnatural isomer of 5-formyltetrahydrofolate with the effects of the natural isomer in leucovorin preparations. J Natl Cancer Inst 81:1175\u20131178, 1989","journal-title":"J Natl Cancer Inst"},{"key":"BF00872864_CR17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/1097-0142(19890315)63:6+<1013::AID-CNCR2820631304>3.0.CO;2-9","volume":"63","author":"YM Rustum","year":"1989","unstructured":"Rustum YM: Toxicity and antitumor activity of 5-fluorouracil in combination with leucovorin. Cancer 63: 1013\u20131017, 1989","journal-title":"Cancer"},{"key":"BF00872864_CR18","first-page":"36","volume":"19","author":"JL Grem","year":"1992","unstructured":"Grem JL, Chu E, Boarman D, Balsi FM, Murphy RF, McAtee N, Allegra CJ: Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations. Sem Oncol 19:36\u201344, 1992","journal-title":"Sem Oncol"},{"key":"BF00872864_CR19","first-page":"36","volume":"52","author":"DM Boarman","year":"1992","unstructured":"Boarman DM, Allegra CJ: Intracellular metabolism of 5-formyltetrahydrofolate in human breast and colon cell lines. Cancer Res 52:36\u201344, 1992","journal-title":"Cancer Res"},{"key":"BF00872864_CR20","first-page":"3476","volume":"51","author":"Z-G Zhang","year":"1991","unstructured":"Zhang Z-G, Rustum YM: Effects of diastereoisomers of 5-formyltetrahydrofolate on cellular growth. Sensitivity to 5-fluoro-2\u2032-deoxyuridine, and methyleneterrahydrofolate polyglutamate levels in HCT-8 cells. Cancer Res 51:3476\u20133481, 1991","journal-title":"Cancer Res"},{"key":"BF00872864_CR21","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1200\/JCO.1993.11.9.1737","volume":"11","author":"JL Grem","year":"1993","unstructured":"Grem JL, Jordan E, Robson ME, Binder RA, Hamilton JM, Steinberg SM, Arbuck SG, Beveridge RA, Kales AN, Miller JA, Weiss RB, McAtee N, Chen A, Goldspiel B, Sover E, Allegra CJ: Phase II study of fluorouracil, leucovorin, and interferon alfal-2a in metastatic colorectal carcinoma. J Clin Oncol 11:1737\u20131745, 1993","journal-title":"J Clin Oncol"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00872864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF00872864\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00872864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00872864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T17:44:53Z","timestamp":1678556693000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF00872864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["BF00872864"],"URL":"https:\/\/doi.org\/10.1007\/bf00872864","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}