{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T08:29:52Z","timestamp":1680164992635},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[1995,9]]},"DOI":"10.1007\/bf00873805","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T20:03:48Z","timestamp":1105128228000},"page":"229-233","source":"Crossref","is-referenced-by-count":5,"title":["A Phase II trial of weekly infusional 5-fluorouracil in combination with lowdose leucovorin in patients with advanced colorectal cancer"],"prefix":"10.1007","volume":"13","author":[{"given":"Naomi B.","family":"Haas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell J.","family":"Schilder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry","family":"Nash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Ozols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"O'Dwyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00873805_CR1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1200\/JCO.1992.10.6.896","volume":"10","author":"Advanced colorectal cancer metaanalysis project. ACCNAP","year":"1992","unstructured":"Advanced colorectal cancer metaanalysis project. ACCNAP. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 10:896\u2013903, 1992","journal-title":"J Clin Oncol"},{"key":"BF00873805_CR2","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1200\/JCO.1989.7.10.1407","volume":"7","author":"MA Poon","year":"1989","unstructured":"Poon MA, O'Connell MJ, Moertel CG,et al.: Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 7: 1407\u20131418, 1989","journal-title":"J Clin Oncol"},{"key":"BF00873805_CR3","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1200\/JCO.1989.7.10.1419","volume":"7","author":"N Petrelli","year":"1989","unstructured":"Petrelli N, Douglass HO, Herrera L,et al.: The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma. A prospective randomized phase III trial. J Clin Oncol 7:1419\u20131426, 1989","journal-title":"J Clin Oncol"},{"key":"BF00873805_CR4","first-page":"371","volume":"7","author":"MT Nobile","year":"1988","unstructured":"Nobile MT, Vidili MG, Sobrero A,et al.: 5-fluorouracil alone or combined with high-dose folinic acid in advanced colorectal cancer patients. Proc Am Soc Clin Oncol 7:371 (abstr), 1988","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF00873805_CR5","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1200\/JCO.1987.5.10.1559","volume":"5","author":"N Petrelli","year":"1987","unstructured":"Petrelli N, Herrera L, Rustum Y,et al.: A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5:1559\u20131565, 1987","journal-title":"J Clin Oncol"},{"key":"BF00873805_CR6","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1200\/JCO.1988.6.6.1053","volume":"6","author":"B Ardalan","year":"1988","unstructured":"Ardalan B, Singh G, Silberman H: A randomized Phase I and II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers. J Clin Oncol 6:1053\u20131058, 1988","journal-title":"J Clin Oncol"},{"key":"BF00873805_CR7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00874152","volume":"11","author":"NB Haas","year":"1993","unstructured":"Haas NB, Hines JB, Hudes GR, Johnston W, Ozols RF, O'Dwyer PJ: Phase I trial of 5-fluorouracil by 24-hour infusion weekly. Investigational New Drugs 11:181\u2013185, 1993","journal-title":"Investigational New Drugs"},{"key":"BF00873805_CR8","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1200\/JCO.1990.8.9.1497","volume":"8","author":"PJ O'Dwyer","year":"1990","unstructured":"O'Dwyer PJ, Paul AR, Walczak J, Weiner LM, Litwin S, Comis RL: Phase II study of biochemical modulation of 5-fluorouracil by low-dose PALA in patients with colorectal cancer. J Clin Oncol 8:1497\u20131503, 1990","journal-title":"J Clin Oncol"},{"key":"BF00873805_CR9","first-page":"2408","volume":"52","author":"EM Newman","year":"1992","unstructured":"Newman EM, Akman SA, Harrison JS,et al.: Pharmacokinetics and toxicity of continuous infusion (6S)-folinic acid and bolus 5-fluorouracil in patients with advanced cancer. Cancer Res 52:2408\u20132412, 1992","journal-title":"Cancer Res"},{"key":"BF00873805_CR10","doi-asserted-by":"crossref","first-page":"14402","DOI":"10.1016\/S0021-9258(18)68234-1","volume":"263","author":"K Keyomarsi","year":"1988","unstructured":"Keyomarsi K, Moran RG: Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem 263:14402\u201314409, 1988","journal-title":"J Biol Chem"},{"key":"BF00873805_CR11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/jnci\/80.7.496","volume":"80","author":"DS Martin","year":"1988","unstructured":"Martin DS, Stolfi RL, Colofiore JR: Failure of high dose leucovorin to improve therapy with the maximally tolerated dose of 5-fluorouracil: A murine study with clinical relevance? J Natl Cancer Inst 80:496\u2013501, 1988","journal-title":"J Natl Cancer Inst"},{"key":"BF00873805_CR12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6","volume":"47","author":"AB Miller","year":"1981","unstructured":"Miller AB, Hoogstraten B, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer 47:207\u2013214, 1981","journal-title":"Cancer"},{"key":"BF00873805_CR13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1981","unstructured":"Kaplan EL, Meier P: Non-parametric estimation from incomplete observations. J Am Stat Assoc 53:457\u2013481, 1981","journal-title":"J Am Stat Assoc"},{"issue":"Suppl. 1","key":"BF00873805_CR14","first-page":"16","volume":"17","author":"S Wadler","year":"1990","unstructured":"Wadler S, Wiernik PH: Clinical update on the role of fluorouracil and recombinant interferon alfa-2a in the treatment of colorectal cancer. Semin Oncol 17 (Suppl. 1):16\u201321, 1990","journal-title":"Semin Oncol"},{"key":"BF00873805_CR15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00686549","volume":"35","author":"A Hageboutros","year":"1995","unstructured":"Hageboutros A, Rogatko, Newman EM, McAleer C, Brennan J, LaCreta FP, Ozols RF, O'Dwyer PJ: Phase I study of phosphonacetyl-L-aspartate (PALA), 5-fluorouracil, and leucovorin in patients with advanced cancer. Cancer Chemother Pharmacol 35:205\u2013212, 1995","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF00873805_CR16","first-page":"4618","volume":"51","author":"RG Moran","year":"1991","unstructured":"Moran RG, Scanlon KL: Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid. Cancer Res 51:4618\u20134623, 1991","journal-title":"Cancer Res"},{"key":"BF00873805_CR17","first-page":"160","volume":"10","author":"M Tempero","year":"1991","unstructured":"Tempero M, Mitchell M, Higginbottom P: Tolerance of protracted infusion 5-fluorouracil and oral leucovorin. Proc Am Soc Clin Oncol 10:160, 1991","journal-title":"Proc Am Soc Clin Oncol"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00873805.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF00873805\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00873805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00873805.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T17:46:25Z","timestamp":1678556785000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF00873805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["BF00873805"],"URL":"https:\/\/doi.org\/10.1007\/bf00873805","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}