{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:28:22Z","timestamp":1776263302570,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[1984,6,1]],"date-time":"1984-06-01T00:00:00Z","timestamp":454896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[1984,6]]},"DOI":"10.1007\/bf00915708","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T15:18:43Z","timestamp":1104679123000},"page":"S3-S14","source":"Crossref","is-referenced-by-count":57,"title":["Rheumatoid arthritis"],"prefix":"10.1007","volume":"8","author":[{"given":"Gerald","family":"Weissmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Korchak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1172\/JCI109760","volume":"65","author":"J. E. Smolen","year":"1980","unstructured":"Smolen, J. E., H. M. Korchak, andG. Weissmann. 1980. Increased levels of cyclic adenosine-3?, 5?-monophosphate in human polymorphonuclear leukocytes after surface stimulation.J. Clin. Invest. 65:1077?1085.","journal-title":"J. Clin. Invest."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1172\/JCI109007","volume":"61","author":"H. J. Cohen","year":"1978","unstructured":"Cohen, H. J. andM. E. Chovaniec. 1978. Superoxide anion generation by digitonin-stimulated guinea-pig granulocytes. A basis for a continuous assay for monitoring Superoxide production and for the study of the activation of the generating systems.J. Clin. Invest. 61:1081?1087.","journal-title":"J. Clin. Invest."},{"key":"CR3","doi-asserted-by":"crossref","unstructured":"Smolen, J. E., H. M.Korchak, and G.Weissmann. 1983. Kinetics of degranulation of human neutrophils as measured by self-quenching of 9-aminoacridine.Biochim. Biophys. Acta (in press).","DOI":"10.1016\/0167-4889(83)90066-6"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1016\/S0021-9258(19)83801-2","volume":"257","author":"L. A. Sklae","year":"1982","unstructured":"Sklae, L. A., V. M. McNeil, A. J. Jesaitis, R. G. Painter, andC. G. Cochrane. 1982. A continuous, spectroscopic analysis of the kinetics of elastase secretion by neutrophils.J. Biol. Chem. 257:5471?5475.","journal-title":"J. Biol. Chem."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0167-4889(82)90023-4","volume":"721","author":"H. B. Kaplan","year":"1982","unstructured":"Kaplan, H. B., H. S. Edelson, R. Freidman, andG. Weissmann. 1982. The roles of degranulation and Superoxide anion generation in neutrophil aggregation.Biochem. Biophys. Acta 721:55?63.","journal-title":"Biochem. Biophys. Acta"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.1073\/pnas.78.12.7540","volume":"78","author":"L. A. Sklar","year":"1981","unstructured":"Sklar, L. A., Z. G. Oades, A. J. Jesaitis, R. G. Painter, andC. G. Cochrane. 1981. Fluoresceinated chemotactic peptide and high-affinity antifluorescein antibody as a probe of the temporal characteristics of neutrophil stimulation.Proc. Natl. Acad. Sci. U.S.A. 78:7540?7544.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"CR7","first-page":"520A","volume":"30","author":"A. R. Radin","year":"1982","unstructured":"Radin, A. R., H. M. Korchak, C. Wilkenfeld, L. E. Rutherford, andG. Weissmann. 1982. Differential requirements for receptor occupancy in neutrophil responses to a chemoattractant.Clin. Res. 30:520A.","journal-title":"Clin. Res."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0006-291X(82)80076-4","volume":"108","author":"H. M. Korchak","year":"1982","unstructured":"Korchak, H. M., A. M. Rich, C. Wilkenfeld, L. E. Rutherford, andG. Weissmann, 1982. A carbocyanine dye, DiOC6(3), acts as a mitochondrial probe in human neutrophils.Biochem. Biophys. Res. Comm. 108:1495?1501.","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF01869194","volume":"52","author":"B. E. Seligmann","year":"1980","unstructured":"Seligmann, B. E., E. K. Gallin, D. L. Martin, W. Shain, andJ. I. Gallin. 1980. Interaction of chemotactic factors with human polymorphonuclear leukocytes: Studies using a membrane potential sensitive cyanide dye.J. Memb. Biol. 52:257?272.","journal-title":"J. Memb. Biol."},{"key":"CR10","first-page":"90","volume":"91","author":"G. Weissmann","year":"1979","unstructured":"Weissmann, G., S. Hoffstein, H. Kochak, andJ. E. Smolen. 1979. The earliest membrane responses to phagocytosis: Membrane potential changes and Canloss in human granulocytes.Trans. Am. Assoc. Physicians 91:90?101.","journal-title":"Trans. Am. Assoc. Physicians"},{"key":"CR11","first-page":"G269","volume":"238","author":"J. A. Williams","year":"1980","unstructured":"Williams, J. A. 1980. Regulation of pancreatic acinar cell function by intracellular calcium.Am. J. Physiol. 238:G269-G279.","journal-title":"Am. J. Physiol."},{"key":"CR12","first-page":"1","volume":"39","author":"W. W. Douglas","year":"1974","unstructured":"Douglas, W. W. 1974. Involvement of calcium in exocytosis and the exocytosisvesiculation sequence.Biochem. Soc. Symp. 39:1?28.","journal-title":"Biochem. Soc. Symp."},{"key":"CR13","first-page":"209","volume":"30","author":"J. E. Putney","year":"1979","unstructured":"Putney, J. E. 1979. Stimulus-permeability coupling; role of calcium in the receptor regulation of membrane permeability.Pharmacol. Rev. 30:209?245.","journal-title":"Pharmacol. Rev."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0006-291X(74)90312-X","volume":"60","author":"I. M. Goldstein","year":"1974","unstructured":"Goldstein, I. M., J. K. Horn, H. B. Kaplan, andG. Weissmann. 1974. Calcium induced lysozyme secretion from human polymorphonuciear leukocytes.Biochem. Biophys. Res. Comm. 60:807?812.","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"CR15","first-page":"155","volume":"92","author":"J. T. O'Flaherty","year":"1978","unstructured":"O'Flaherty, J. T., H. J. Showell, E. L. Beckee, andP. A. Ward, 1978. Substances which activate neutrophils. Mechanism of action.Am. J. Path. 92:155?166.","journal-title":"Am. J. Path."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF00916046","volume":"4","author":"R. J. Smith","year":"1980","unstructured":"Smith, R. J., andS. S. Iden. 1980. Properties of concanavalin A-elicited granule exocytosis from human polymorphonuclear neutrophils.Inflammation.4:343?358.","journal-title":"Inflammation"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00914105","volume":"4","author":"R. J. Smith","year":"1980","unstructured":"Smith, R. J., W. Wierenga, andS. Iden. 1980. Characteristics of N-fromyl-methionylleucyaphenylalanine as an inducer of lysosomal enzyme release from human neutrophils.Inflammation.4:73?88.","journal-title":"Inflammation"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0304-4165(81)90267-1","volume":"677","author":"J. E. Smolex","year":"1981","unstructured":"Smolex, J. E., H. M. Korchak, andG. Weissmann. 1981. The roles of extracellular and intraceliular calcium in lysosomal enzyme release and Superoxide anion generation by human neutrophils.Biochim. Biophys. Acta 677:512?520.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-2999(74)90198-8","volume":"27","author":"M. H. Malagodi","year":"1974","unstructured":"Malagodi, M. H., andC. Y. Chiou. 1974. Pharmacological evaluation of a new calcium antagonist 8-(N,N-diethyIamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8): Studies in smooth muscle.Eur. J. Pharmacol. 27:25?33.","journal-title":"Eur. J. Pharmacol."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.75.3.635","volume":"75","author":"P. H. Naccache","year":"1979","unstructured":"Naccache, P. H., H. J. Showell, E. L. Becker, andR. I. Sha'afi 1979. Changes in ionic movements across rabbit polymorphonuclear leukocyte membranes during lysosomal enzyme release.J. Cell. Biol. 75:635?664.","journal-title":"J. Cell. Biol."},{"key":"CR21","first-page":"317","volume-title":"The Secretory Process, Vol. 1","author":"H. M. Korchak","year":"1982","unstructured":"Korchak, H. M., S. T. Hoffstein, andG. Weissmann. 1982.In The neutrophil granules. A. M. Poisner and J. M. Trifaro, editors. The Secretory Process, Vol. 1, Elsevier Biomedical Press, New York. 317?355."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0167-4889(83)90007-1","volume":"762","author":"C. Serhan","year":"1983","unstructured":"Serhan, C., H. M. Korchak, J. Broekman, J. E. Smolen, A. Marcus, andG. Weissmann. 1983. Phosphatidyl inositol breakdown and phosphatidic acid accumulation in stimulated human neutrophils: Relationship to calcium mobilization and calcium uptake.Biochim. Biophys. Acta 762:420?428.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0143-4160(80)90039-1","volume":"1","author":"C. Mottola","year":"1980","unstructured":"Mottola, C., L. Dolzani, andD. Romeo. 1980. The peripheral Ca2+ pump activity of macrophages and neutrophils.Cell Calcium 1:371?379.","journal-title":"Cell Calcium"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-291X(82)92067-8","volume":"106","author":"M. Volpi","year":"1982","unstructured":"Volpi, M., P. H. Naccache, andR. I. Sha'afi. 1982. Preparation of inside-out membrane vesicles from neutrophils capable of actively transporting calcium.Biochem. Biophys. Res. Comm. 106:123?130.","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1083\/jcb.94.2.325","volume":"94","author":"R. Y. Tsein","year":"1983","unstructured":"Tsein, R. Y., T. Pozzan, andT. J. Rink. 1983. Calcium homeostasis in intact lymphocytes: Cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.J. Cell. Biol. 94:325?334.","journal-title":"J. Cell. Biol."},{"key":"CR26","first-page":"320","volume":"31","author":"T. Pozzan","year":"1983","unstructured":"Pozzan, T., P. D. Lew, C. G. Wollheim, andR. Y. Tsien. 1983. Monitoring cytoplasmic free calcium concentrations (Ca2+) in living polymorphonuclear leukocytes.Clin. Res. 31:320.","journal-title":"Clin. Res."},{"key":"CR27","first-page":"410","volume":"31","author":"H. Lagast","year":"1983","unstructured":"Lagast, H., T. Pozzan, P. D. Lew, andF. A. Waldvogel. 1983. Phorbol myristate acetate stimulates the plasma membrane pump of human and guinea pig neutrophils without raising cytoplasmic free calcium.Clin. Res. 31:410.","journal-title":"Clin. Res."},{"key":"CR28","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1073\/pnas.80.9.2642","volume":"80","author":"J. J. Sando","year":"1983","unstructured":"Sando, J. J., andM. C. Young, 1983. Identification of high-affinity phorbol ester receptorin cytosol of EL-4 thyoma cells: Requirement for calcium, magnesium, and phospholipids.Proc. Natl. Acad. Sci. U.S.A. 80:2642?2646.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4049\/jimmunol.123.3.1395","volume":"123","author":"S. T. Hoffstein","year":"1979","unstructured":"Hoffstein, S. T. 1979. Ultrastructural demonstration of calcium loss from local regions of the plasma membrane of surface-stimulated human granulocytes.J. Immunol. 123:1395?1402.","journal-title":"J. Immunol."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0021-9258(19)85963-X","volume":"255","author":"J. C. Whitin","year":"1980","unstructured":"Whitin, J. C., C. E. Chapman, E. R. Simons, M. E. Chovaniec, andH. J. Cohen, 1980. Correlation between membrane potential changes and Superoxide anion production in human granulocytes stimulated by phorbol myristate acetate.J. Biol. Chem. 255:1874?1878.","journal-title":"J. Biol. Chem."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.83.1.179","volume":"83","author":"P. H. Naccache","year":"1979","unstructured":"Naccache, P. H., J. H. Showell, E. Becker, andR. I. Sha'afi. 1979. Involvement of membrane calcium in the response of rabbit neutrophils to chemotactic factors as evidenced by the fluorescence of chlorotetracycline.J. Cell Biol. 83:179?186.","journal-title":"J. Cell Biol."},{"key":"CR32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0167-4889(82)90009-X","volume":"720","author":"J. E. Smolen","year":"1982","unstructured":"Smolen, J. E., andG. Weissmann. 1982. The effect of various stimuli and calcium antagonists on the fluorescence response of chlorotetracycline-loaded human neutrophils.Biochim. Biophys. Acta 720:172?180.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0304-4165(78)90233-7","volume":"542","author":"T. Herlin","year":"1978","unstructured":"Herlin, T., C. S. Petersen, andV. Esmann. 1978. The role of calcium and cyclic adenosin3?, 5?-monophosphate in the regulation of glycogen metabolism in phagocytosing human polymorphonuclear leukocytes.Biochim. Biophys. Acta. 542:63?76.","journal-title":"Biochim. Biophys. Acta."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-4165(78)90234-9","volume":"542","author":"C. S. Petersen","year":"1978","unstructured":"Petersen, C. S., T. Herlin, andV. Esmann. 1978. Effects of catecholamines and glucagon on glycogen metabolism in human polymorphonuclear leukocytes.Biochim. Biophys. Acta 542:77?87.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR35","first-page":"473","volume":"16","author":"S. Jackowski","year":"1979","unstructured":"Jackowski, S., andR. I. Sha'afi. 1979. Response of adenosine cyclic-3?, 5?-monophosphate level in rabbit neutrophiis to the chemotactic peptide formylmethionyl-leucyl-phenyalanine.Molec. Pharmacol 16:473?481.","journal-title":"Molec. Pharmacol"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0309-1651(79)90082-1","volume":"3","author":"H. U. Keller","year":"1979","unstructured":"Keller, H. U., G. Gerisch, andJ. H. Wissler. 1979. A transient rise in cyclic AMP levels following chemotactic stimulation of neutrophil granulocytes.Cell Biol. Internal. Reports 3:759?765.","journal-title":"Cell Biol. Internal. Reports"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.4049\/jimmunol.124.3.1482","volume":"124","author":"L. Simchowitz","year":"1980","unstructured":"Simchowitz, L., L. C. Fischbein, I. Spilberg, andJ. P. Atkinson. 1980. Induction of a transient elevation in intracellular levels of adenosine 3?, 5?-cyclic monophosphate by chemotactic factors: An early event in human neutrophil activation.J. Immunol. 124:1482?1491.","journal-title":"J. Immunol."},{"key":"CR38","first-page":"1080","volume":"42","author":"L. Simchowitz","year":"1983","unstructured":"Simchowitz, L., I. Spilberg, andJ. P. Atkinson. 1983. Evidence that the functional responses of human neutrophils occur independently of transient elevations in cAMP levels.Fed. Proc. 42:1080.","journal-title":"Fed. Proc."},{"key":"CR39","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1172\/JCI107550","volume":"43","author":"R. B. Zurier","year":"1974","unstructured":"Zurier, R. B., G. Weissmann, S. Hoffstein, S. Kammerman, andH. Tai 1974. Mechanisms of lysosomal enzyme release from human leukocytes II. Effects of cAMP and cGMP, autonomic agonists and agents which affect microtubule function.J. Clin. Invest. 43:297?309.","journal-title":"J. Clin. Invest."},{"key":"CR40","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/bj1450437","volume":"145","author":"P.-K. TsunG","year":"1975","unstructured":"TsunG, P.-K., T. Sakamoto, andG. Weissmann. 1975. Protein kinase and phosphatases from human polymorphonuclear leukocytes.Biochem. J. 145:437?448.","journal-title":"Biochem. J."},{"key":"CR41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V61.2.333.333","volume":"61","author":"P. C. Andrews","year":"1983","unstructured":"Andrews, P. C., andB. M. Babior. 1983. Endogenous protein phosphorylation by resting and activated human neutrophils.Blood 61:333?340.","journal-title":"Blood"},{"key":"CR42","first-page":"1080","volume":"42","author":"C. K. Huang","year":"1983","unstructured":"Huang, C. K., J. Hill, Jr.,W. M. Mackin, B. J. Bormann, andE. L. Becker. 1983. Effects of chemotactic factors on the protein phosphorylation of rabbit peritoneal neurophils.Fed. Proc. 42:1080.","journal-title":"Fed. Proc."},{"key":"CR43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1073\/pnas.80.1.36","volume":"80","author":"J. E. Niedel","year":"1983","unstructured":"Niedel, J. E., L. J. Kuhn, andG. R. Vandenbark. 1983. Phorboldiester receptor copurifies with protein kinase C.Proc. Natl. Acad. Sci. U.S.A. 80:36?40.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"CR44","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/S0021-9258(19)69677-8","volume":"256","author":"C. Serhan","year":"1981","unstructured":"Serhan, C., P. Anderson, E. Goodman, P. Dunham, andG. Weissmann. 1981. Phosphatidate and oxidized fatty acids are calcium ionophors. Studies employing arsenazo III in liposomes.J. Biol. Chem 256:2736?2741.","journal-title":"J. Biol. Chem"},{"key":"CR45","first-page":"1080","volume":"42","author":"C. W. Lee","year":"1983","unstructured":"Lee, C. W., K. F. Lewis, F. K. Austen, andE. J. Corey. 1983. Oxidative inactivation of the sulfidopeptide leukotrienes by human polymorphonuclear leukocytes (PMNs).Fed. Proc. 42:1080.","journal-title":"Fed. Proc."},{"key":"CR46","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.4049\/jimmunol.125.4.1789","volume":"125","author":"E. L. Goetzel","year":"1980","unstructured":"Goetzel, E. L., andW. C. Pickett. 1980.J. Immunol. 125:1789?1791.","journal-title":"J. Immunol."}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00915708.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00915708\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00915708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T10:34:54Z","timestamp":1682937294000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00915708"}},"subtitle":["The role of neutrophil activation"],"short-title":[],"issued":{"date-parts":[[1984,6]]},"references-count":46,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[1984,6]]}},"alternative-id":["BF00915708"],"URL":"https:\/\/doi.org\/10.1007\/bf00915708","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,6]]}}}