{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:39:01Z","timestamp":1772991541637,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1986,6,1]],"date-time":"1986-06-01T00:00:00Z","timestamp":517968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[1986,6]]},"DOI":"10.1007\/bf00915999","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T03:51:28Z","timestamp":1104637888000},"page":"175-182","source":"Crossref","is-referenced-by-count":23,"title":["Bee venom melittin blocks neutrophil O2 ? production"],"prefix":"10.1007","volume":"10","author":[{"given":"Stanley D.","family":"Somerfield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean -Louis","family":"Stach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Mraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Gervais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Skamene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","volume-title":"Bee Venom Therapy","author":"B. Beck","year":"1935","unstructured":"Beck, B. 1935. Bee Venom Therapy. Appleton-Century Company, New York."},{"key":"CR2","volume-title":"The Curative Properties of Honey and Bee Venom","author":"N. Yoirish","year":"1977","unstructured":"Yoirish, N. 1977. The Curative Properties of Honey and Bee Venom. New Glide Publications, San Francisco."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF02024736","volume":"9","author":"Y. H. Chang","year":"1979","unstructured":"Chang, Y. H., andM. L. Bliven. 1979. Antiarthritic effect of bee venom.Agents Actions 9:205?211.","journal-title":"Agents Actions"},{"key":"CR4","first-page":"399","volume":"4","author":"O. J. Lorenzetti","year":"1972","unstructured":"Lorenzetti, O. J., B. Fortenberry, andE. Busby. 1972. Influence of bee venom in the adjuvant induced arthritic rat model.Res. Commun. Chem. Pathol. Pharmacol 4:399?352.","journal-title":"Res. Commun. Chem. Pathol. Pharmacol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/art.1780240912","volume":"24","author":"M. D. Lockshin","year":"1981","unstructured":"Lockshin, M. D. 1981. Special article. The unproven remedies committee.Arthritis Rheum. 24:1188?1190.","journal-title":"Arthritis Rheum."},{"key":"CR6","first-page":"25","volume":"494","author":"J. M. McCord","year":"1980","unstructured":"McCord, J. M., K. Wong, S. H. Stokes, W. F. Petrone, andD. English. 1980. Superoxide and inflammation: A mechanism for the antiinflammatory activity of superoxide dismutase.Acta Physiol. Scand. Suppl. 494:25?30.","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"CR7","first-page":"343","volume":"65","author":"J. M. McCord","year":"1979","unstructured":"McCord, J. M. andK. Wong. 1979. Phagocyte production free radicals: Roles in cytotoxicity and inflammation.Ciba Found. Symp. 65:343?369.","journal-title":"Ciba Found. Symp."},{"issue":"4","key":"CR8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00918214","volume":"8","author":"S. D. Somerfield","year":"1984","unstructured":"Somerfield, S. D., J. L. Stach, C. Mraz, F. Gervais, andE. Skamene. 1984. Bee venom inhibits superoxide production by human neutrophils.Inflammation 8, (4):385?391.","journal-title":"Inflammation"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1139\/y82-207","volume":"60","author":"P. K. Singal","year":"1982","unstructured":"Singal, P. K., N. Kapur, andK. S. Dhillon. 1982. Role of free radicals in catecholamine-induced cardiomyopathy.Can. J. Physiol. Pharmacol. 60:1390?1387.","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"CR10","first-page":"443","volume":"9","author":"J. Donaldson","year":"1982","unstructured":"Donaldson, J., D. McGregor, andF. La Bella. 1982. Manganese Neurotoxicity: A model for free radical-mediated neurodegeneration.Can. J. Physiol. Pharmacol. 9:443?445.","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1161\/01.STR.9.5.443","volume":"9","author":"J. D. Butterfield","year":"1978","unstructured":"Butterfield, J. D., andC. P. McGraw. 1978. Free radical pathology.Stroke 9:443?445.","journal-title":"Stroke"},{"key":"CR12","first-page":"91","volume":"492","author":"H. B. Demopoulos","year":"1980","unstructured":"Demopoulos, H. B., E. S. Flamm, andD. D. Pietronigro. 1980. The free radical pathology and the microcirculation in the major central nervous system disorders.Acta Physiol. Scand. Suppl. 492:91?119.","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"CR13","first-page":"233","volume":"8","author":"J. Lunec","year":"1981","unstructured":"Lunec, J., S. P. Halloran, R. G. White, andT. L. Dormandy. 1981. Free radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis.J. Rheumatol. 8:233?245.","journal-title":"J. Rheumatol."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1126\/science.185.4150.529","volume":"185","author":"J. M. McCord","year":"1974","unstructured":"McCord, J. M. 1974. Free radicals and inflammation: Protection of synovial fluid by superoxide dismutase.Science 185:529?531.","journal-title":"Science"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/ard.43.1.28","volume":"43","author":"N. P. Hyrst","year":"1984","unstructured":"Hyrst, N. P., B. Bessac, andG. Nuki. 1984. Monocyte superoxide anion production in rheumatoid arthritis: Preliminary evidence for enhanced rates of superoxide anion production by monocytes from patients receiving penicillamine, sodium aurothiomalate, and corticosteroids.Ann. Rheum. Dis. 43:28?33.","journal-title":"Ann. Rheum. Dis."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0022-1759(80)90036-8","volume":"36","author":"A. Ferrante","year":"1980","unstructured":"Ferrante, A., andY. H. Thong. 1980. Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leukocytes from human peripheral blood by HypaqueFicoll method.J. Immunol. Methods 36:109?117.","journal-title":"J. Immunol. Methods"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.142.3589.228","volume":"142","author":"A. W. Benton","year":"1963","unstructured":"Benton, A. W., R. A. Morse, andJ. D. Stewart. 1963. Venom collection from honey bees.Science 142:228?230.","journal-title":"Science"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0022-2828(83)90335-8","volume":"15","author":"A. Bobik","year":"1983","unstructured":"Bobik, A., J. Campbell, P. Snow, andP. J. Little. 1983. The effects of endogenous phospholipase A2 activation on beta adrenoceptor function in cardiac cells.J. Mol. Cell. Cardiol. 15:759?768.","journal-title":"J. Mol. Cell. Cardiol."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1172\/JCI109007","volume":"61","author":"H. J. Cohen","year":"1978","unstructured":"Cohen, H. J., andM. E. Chovaniec. 1978. Superoxide generation by digitonin stimulated guinea pig granulocytes. A basis for a continuous assay monitoring superoxide production and for the study of the activation of the generating system.J. Clin. Invest. 61:1081?1087.","journal-title":"J. Clin. Invest."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1016\/S0021-9258(18)62884-4","volume":"215","author":"I. Fridovich","year":"1970","unstructured":"Fridovich, I. 1970. Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase.J. Biol. Chem. 215:4053?4057.","journal-title":"J. Biol. Chem."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0006-291X(81)91770-8","volume":"99","author":"K. Takeshige","year":"1981","unstructured":"Takeshige, K., andS. Minakami. 1981. Involvement of calmodulin in phagocytic respiratory burst of leukocytes.Biochem. Biophys. Res. Commun. 99:484?490.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"CR22","first-page":"677","volume":"44","author":"R. J. Smith","year":"1981","unstructured":"Smith, R. J., B. J. Bowman, andS. S. Iden. 1981. Effects of trifluoperazine on human neutrophil function.Immunology 44:677?684.","journal-title":"Immunology"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0304-4165(81)90267-1","volume":"677","author":"J. E. Smolen","year":"1981","unstructured":"Smolen, J. E. andG. Weissmann. 1981. The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes.Biochim. Biophys. Acta 677:512?520.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR24","first-page":"408","volume-title":"Biological and Clinical Aspects of superoxide and superoxide Dismutase","author":"K. B. Menander-Huber","year":"1980","unstructured":"Menander-Huber, K. B. 1980. Double-blind controlled clinical trials in man with bovine copper-zinc superoxide dismutase (Orgotein).In Biological and Clinical Aspects of superoxide and superoxide Dismutase. W. H. Bannister, J. V. Bannister, editors. Elsevier\/North Holland, Amsterdam. 408?423."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/bj2090269","volume":"209","author":"M. Comte","year":"1983","unstructured":"Comte, M., Y. Maulet, andJ. A. Cox, 1983. Ca2+-dependent high-affinity complex formation between calmodulin and melittin.Biochem. J. 209:269?272.","journal-title":"Biochem. J."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1172\/JCI111249","volume":"73","author":"B. M. Barbior","year":"1984","unstructured":"Barbior, B. M. 1984. The respiratory burst of phagocytes.J. Clin. Invest. 73:599?601.","journal-title":"J. Clin. Invest."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/bj2020217","volume":"202","author":"N. Katoh","year":"1982","unstructured":"Katoh, N., R. L. Raynor, B. C. Wise, R. C. Schatzman, R. S. Turner, D. M. Helfman, J. N. Fain, andJ. Kuo 1982. Inhibition by melittin of phospholipid-sensitive and calmodulinsensitive Ca2+ -dependent protein kinases.Biochem. J. 202:217?224.","journal-title":"Biochem. J."},{"key":"CR28","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1016\/S0021-9258(18)43501-6","volume":"255","author":"T. Mori","year":"1980","unstructured":"Mori, T., Y. Takai, R. Minakuchi, B. Yu, andY. Nishizuka. 1980. Inhibitory action of chlorpromazine, dibucaine and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinases.J. Biol Chem. 255:8378?8380.","journal-title":"J. Biol Chem."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0304-4165(82)90137-4","volume":"714","author":"H. P. Jones","year":"1982","unstructured":"Jones, H. P., G. Chai, W. F. Petrone, andJ. M. McCord. 1982. Calmodulin-dependent stimulation of the NADPH oxidase of human neutrophils.Biochim. Biophys. Acta 714:152?156.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/BF01114895","volume":"2","author":"S. MacNeil","year":"1982","unstructured":"MacNeil, S., S. W. Walker, B. L. Brown, andS. Tomlinson. 1982. Evidence that calmodulin may be involved in phytohaemagglutinin-stimulated lymphocyte division.Biosci. Rep. 2:891?897.","journal-title":"Biosci. Rep."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.1016\/S0021-9258(18)34459-4","volume":"257","author":"M. Castagna","year":"1982","unstructured":"Castagna, M., Y. Takai, K. Kaibucht, K. Sano, U. Kikkawa, andY. Nishizuka. 1982. Direct activation of calcium activated phospholipid-dependent protein kinase by tumour producing phorbol esters.J. Biol. Chem. 257:7847?7851.","journal-title":"J. Biol. Chem."}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00915999.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00915999\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00915999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T12:45:46Z","timestamp":1625316346000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00915999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["BF00915999"],"URL":"https:\/\/doi.org\/10.1007\/bf00915999","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}