{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:45:44Z","timestamp":1775540744314,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[1991,7]]},"DOI":"10.1007\/bf00917423","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T07:45:44Z","timestamp":1104651944000},"page":"175-183","source":"Crossref","is-referenced-by-count":8,"title":["Defective T-lymphocyte signal transduction and function in leukocyte adhesion deficiency"],"prefix":"10.1007","volume":"11","author":[{"given":"Lesley M.","family":"Voss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy H.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee A.","family":"Schoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Leibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-065X.1990.tb00565.x","volume":"114","author":"RS Larson","year":"1990","unstructured":"Larson RS, Springer TA: Structure and function of leukocyte integrins. Immunol Rev 114:181?217, 1990","journal-title":"Immunol Rev"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0167-5699(89)90039-X","volume":"10","author":"MW Makgoba","year":"1989","unstructured":"Makgoba MW, Sanders ME, Shaw S: The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T cell recognition. Immunol Today 10:417?422, 1989","journal-title":"Immunol Today"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1096\/fasebj.2.10.2838364","volume":"2","author":"BE Bierer","year":"1988","unstructured":"Bierer BE, Burakoff SJ: T cell adhesion molecules. FASEB J 2:2584?2590, 1988","journal-title":"FASEB J"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0952-7915(88)90045-3","volume":"1","author":"PA Detmers","year":"1988","unstructured":"Detmers PA, Wright SD: Adhesion-promoting receptors on leukocytes. Curr Opin Immunol 1:10?15, 1988","journal-title":"Curr Opin Immunol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1084\/jem.158.6.1785","volume":"158","author":"F Sanchez-Madrid","year":"1983","unstructured":"Sanchez-Madrid F, Nagy JA, Robbins E, Simon P, Springer TA: A human leukocyte differentiation antigen family with distinct alpha subunits and a common beta subunit: The lymphocyte function-associated antigen (LFA-1), the C3bi complement receptors (OKM1\/Mac-1), and the p150,95 molecule. J Exp Med 158:1785?1803, 1983","journal-title":"J Exp Med"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-065X.1990.tb00560.x","volume":"114","author":"I Dransfield","year":"1990","unstructured":"Dransfield I, Buckle AM, Hogg N: Early events of the immune response mediated by leukocyte integrins. Immunol Rev 114:29?44, 1990","journal-title":"Immunol Rev"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-065X.1990.tb00562.x","volume":"114","author":"M Patarroyo","year":"1990","unstructured":"Patarroyo M, Prieto J, Rincon J, Timonen T, Lundberg C, Lindbom L, Asjo B, Gahmberg CG: Leukocyte-cell adhesion: A molecular process fundamental in leukocyte physiology. Immunol Rev 114:67?108, 1990","journal-title":"Immunol Rev"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0092-8674(89)90620-X","volume":"56","author":"LM Stoolman","year":"1989","unstructured":"Stoolman LM: Adhesion molecules controlling lymphocyte migration. Cell 56:907?910, 1989","journal-title":"Cell"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.4049\/jimmunol.137.9.2901","volume":"137","author":"D Haskard","year":"1986","unstructured":"Haskard D, Cavender D, Beatty P, Springer T, Ziff M: T lymphocyte adhesion to endothelial cells: Mechanisms demonstrated by anti-LFA-1 monoclonal antibodies. J Immunol 137:2901?2906, 1986","journal-title":"J Immunol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.107.1.321","volume":"107","author":"ML Dustin","year":"1988","unstructured":"Dustin ML, Springer TA: Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol 107:321?331, 1988","journal-title":"J Cell Biol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4049\/jimmunol.139.4.1037","volume":"139","author":"S Shaw","year":"1987","unstructured":"Shaw S, Luce GG: The lymphocyte function-associated antigen (LFA)-1 and CD2\/LFA-3 pathways of antigen-independent human T cell adhesion. J Immunol 139:1037?1045, 1987","journal-title":"J Immunol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4049\/jimmunol.127.2.590","volume":"127","author":"D Davignon","year":"1981","unstructured":"Davignon D, Martz E, Reynolds T, Kurzinger K, Springer TA: Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): Mechanisms of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions. J Immunol 127:590?595, 1981","journal-title":"J Immunol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/eji.1830130514","volume":"13","author":"P Bongrand","year":"1983","unstructured":"Bongrand P, Pierres M, Golstein P: T-cell mediated cytolysis: On the strength of effector-target cell interaction. Eur J Immunol 13:424?429, 1983","journal-title":"Eur J Immunol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0198-8859(86)90280-6","volume":"17","author":"SJ Mentzer","year":"1986","unstructured":"Mentzer SJ, Krensky AM, Burakoff SJ: Mapping functional epitopes of the human LFA-1 glycoprotein: Monoclonal antibody inhibition of NK and CTL effectors. Hum Immunol 17:288?296, 1986","journal-title":"Hum Immunol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.4049\/jimmunol.141.3.1041","volume":"141","author":"T Timononen","year":"1988","unstructured":"Timononen T, Patarroyo M, Gahmberg CG: CD11a-c\/CD18 and GP84 (LB-2) adhesion molecules on human large granular lymphocytes and their participation in natural killing. J Immunol 141:1041?1046, 1988","journal-title":"J Immunol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.4049\/jimmunol.137.4.1270","volume":"137","author":"R Rothlein","year":"1986","unstructured":"Rothlein R, Dustin ML, Marlin SD, Springer TA: A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137:1270?1274, 1986","journal-title":"J Immunol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/339061a0","volume":"339","author":"DE Staunton","year":"1989","unstructured":"Staunton DE, Dustin ML, Springer TA: Functional Cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 339:61?64, 1989","journal-title":"Nature"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/eji.1830120112","volume":"12","author":"M Pierres","year":"1982","unstructured":"Pierres M, Goridis C, Golstein P: Inhibition of murine T cell-mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94,000 and 180,000 molecular weight. Eur J Immunol 12:60?69, 1982","journal-title":"Eur J Immunol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/eji.1830130305","volume":"13","author":"JEK Hildreth","year":"1983","unstructured":"Hildreth JEK, Gotch FM, Hildreth PDK, McMichael AJ: A human lymphocyte-associated antigen involved in cell-mediated lympholysis. Eur J Immunol 13:202?208, 1983","journal-title":"Eur J Immunol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/333850a0","volume":"333","author":"C Noesel van","year":"1988","unstructured":"van Noesel C, Miedema F, Brouwer M, De Rie MA, Aarden LA, van Lier RAW: Regulatory properties of LFA-1 alpha and beta chains in human T-lymphocyte activation. Nature 333:850?852, 1988","journal-title":"Nature"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1084\/jem.170.2.431","volume":"170","author":"MC Wacholtz","year":"1989","unstructured":"Wacholtz MC, Patel SS, Lipsky PE: Leukocyte function-associated antigen 1 is an activation molecule for human T cells. J Exp Med 170:431?448, 1989","journal-title":"J Exp Med"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.4049\/jimmunol.143.10.3157","volume":"143","author":"R Pardi","year":"1989","unstructured":"Pardi R, Bender JR, Dettori C, Giannazza E, Engleman EG: Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets. J Immunol 143:3157?3166, 1989","journal-title":"J Immunol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.4049\/jimmunol.144.12.4579","volume":"144","author":"GA Seventer van","year":"1990","unstructured":"van Seventer GA, Shimizu Y, Hogan KJ, Shaw S: The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cell receptor-mediated activation of resting T cells. J Immunol 144:4579?4586, 1990","journal-title":"J Immunol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.me.38.020187.001135","volume":"38","author":"DC Anderson","year":"1987","unstructured":"Anderson DC, Springer TA: Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 38:175?194, 1987","journal-title":"Annu Rev Med"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4612-3234-6_7","volume-title":"Leukocyte Adhesion Molecules","author":"A Fischer","year":"1990","unstructured":"Fischer A, Lisowska-Grospierre B, Mazerolles F, Le Deist F, Perez N, Dimanche-Boitrel MT, Griscelli C: Leukocyte adhesion deficiency as a model for the study of the functional role of LFA-1.In Leukocyte Adhesion Molecules, TA Springer, DC Anderson, AS Rosenthal, R Rothlein (eds). New York, Springer-Verlag, 1990, pp 95?100"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1084\/jem.160.6.1901","volume":"160","author":"TA Springer","year":"1984","unstructured":"Springer TA, Thompson WS, Miller LJ, Schmalstieg FC, Anderson DC: Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis. J Exp Med 160:1901?1918, 1984","journal-title":"J Exp Med"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI112868","volume":"79","author":"N Dana","year":"1987","unstructured":"Dana N, Clayton LK, Tennon DG, Pierce MW, Lachman PJ, Law SA, Arnaout MA: Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common ? subunit precursor and ?-subunit messenger RNA. J Clin Invest 79:1010?1015, 1987","journal-title":"J Clin Invest"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0092-8674(87)90215-7","volume":"50","author":"TK Kishimoto","year":"1987","unstructured":"Kishimoto TK, Hollander N, Roberts TM, Anderson DC, Springer TA: Heterogeneous mutations in the ? subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell 50:193?202, 1987","journal-title":"Cell"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1172\/JCI114491","volume":"85","author":"ML Hibbs","year":"1990","unstructured":"Hibbs ML, Wardlaw AJ, Stacker SA, Anderson DC, Lee A, Roberts TM, Springer TA: Transfection of cells from patients with leukocyte adhesion deficiency with an integrin ? subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function. J Clin Invest 85:674?681, 1990","journal-title":"J Clin Invest"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0022-1759(84)90340-5","volume":"56","author":"RJ Griend Van de","year":"1984","unstructured":"Van de Griend RJ, van Krimpen BA, Bol SJL, Thompson A, Bolhuis RLH: Rapid expansion of human cytotoxic T cell clones: Growth promotion by a heat-labile serum component and by various types of feeder cells. J Immunol Methods 56:285?298, 1984","journal-title":"J Immunol Methods"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.4049\/jimmunol.141.11.3951","volume":"141","author":"KP Windebank","year":"1988","unstructured":"Windebank KP, Abraham RT, Powis G, Olsen RA, Barna TJ, Leibson PJ: Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP. J Immunol 141:3951?3957, 1988","journal-title":"J Immunol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/S0021-9258(18)61566-2","volume":"262","author":"RT Abraham","year":"1987","unstructured":"Abraham RT, Ho SN, Barna TJ, McKean DJ: Transmembrane signaling during interleukin 1-dependent T cell activation. J Biol Chem 262:2719?2728, 1987","journal-title":"J Biol Chem"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0092-8674(85)80080-5","volume":"41","author":"MK Bijsterbosch","year":"1985","unstructured":"Bijsterbosch MK, Meade CJ, Turner GA, Klaus GG: B lymphocyte receptors and polyphosphoinositide degradation. Cell 41:999?1006, 1985","journal-title":"Cell"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1084\/jem.161.3.446","volume":"161","author":"BJ Imboden","year":"1985","unstructured":"Imboden BJ, Stobo JD: Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med 161:446?456, 1985","journal-title":"J Exp Med"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/341619a0","volume":"341","author":"ML Dustin","year":"1989","unstructured":"Dustin ML, Springer TA: T cell receptor crosslinking transiently stimulates adhesiveness through LFA-1. Nature 341:619?624, 1989","journal-title":"Nature"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.4049\/jimmunol.138.6.1660","volume":"138","author":"TD Geppert","year":"1987","unstructured":"Geppert TD, Lipsky PE: Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3. J Immunol 138:1660?1666, 1987","journal-title":"J Immunol"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1073\/pnas.87.11.4358","volume":"87","author":"LE Samelson","year":"1990","unstructured":"Samelson LE, Phillips AF, Luong ET, Klausner RD: Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci USA 87:4358?4362, 1990","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00917423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00917423\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00917423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T10:06:34Z","timestamp":1682935594000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00917423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["BF00917423"],"URL":"https:\/\/doi.org\/10.1007\/bf00917423","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}