{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:41:07Z","timestamp":1762864867386},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[1989]]},"DOI":"10.1007\/bf00931271","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:00:32Z","timestamp":1104598832000},"page":"178-182","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of experimental trypanocidal compounds against a multiple drug-resistantTrypanosoma brucei brucei stock in mice"],"prefix":"10.1007","volume":"75","author":[{"given":"E.","family":"Zweygarth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"R\ufffdttcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.6775372","volume":"210","author":"CJ Bacchi","year":"1980","unstructured":"Bacchi CJ, Nathan HC, Hutner SH, McCann PP, Sjoerdsma A (1980) Polyamine metabolism: a potential therapeutic target in trypanosomes. Science 210:332?334","journal-title":"Science"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4269\/ajtmh.1987.36.46","volume":"36","author":"CJ Bacchi","year":"1987","unstructured":"Bacchi CJ, Nathan HC, Clarkson AB Jr, Bienen EJ, Bitonti AJ, McCann PP, Sjoerdsma A (1987) Effects of the ornithine decarboxylase inhibitors DL-?-difluoromethylornithine and ?-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin againstTrypanosoma brucei brucei central nervous system models. Am J Trop Med Hyg 36:46?52","journal-title":"Am J Trop Med Hyg"},{"key":"CR3","first-page":"287","volume":"42","author":"NK Borowy","year":"1985","unstructured":"Borowy NK, Fink E, Hirumi H (1985a) In vitro activity of the trypanocidal diamidine DAPI on animal-infectiveTrypanosoma brucei brucei. Acta Trop (Basel) 42:287?298","journal-title":"Acta Trop (Basel)"},{"key":"CR4","first-page":"155","volume":"11","author":"NK Borowy","year":"1985","unstructured":"Borowy NK, Hirumi H, Waithaka HK, Mkoji G (1985b) An assay for screening drugs against animal-infective blood-stream forms ofTrypanosoma brucei brucei in vitro. Drugs Exp Clin Res 11:155?161","journal-title":"Drugs Exp Clin Res"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jlac.19717490110","volume":"749","author":"O Dann","year":"1971","unstructured":"Dann O, Bergen G, Demant E, Volz G (1971) Trypanocide Diamidine des 2-Phenyl-benzo-furans, 2-Phenyl-indens und 2-Phenyl-indols. Liebigs Ann Chem 749:68?89","journal-title":"Liebigs Ann Chem"},{"key":"CR6","first-page":"332","volume":"32","author":"DK Dube","year":"1983","unstructured":"Dube DK, Mpimbaza G, Allison AC, Lederer E, Rovis L (1983) Antitrypanosomal activity of sinefungin. Am J Trop Med Hyg 32:332?334","journal-title":"Am J Trop Med Hyg"},{"key":"CR7","first-page":"628","volume":"43","author":"P Ehrlich","year":"1909","unstructured":"Ehrlich P (1909) \u00dcber die neuesten Ergebnisse auf dem Gebiete der Trypanosomenforschung. Zentralbl Bakteriol Parasitenkde Infektionskr Abt Ref 43:628?629","journal-title":"Zentralbl Bakteriol Parasitenkde Infektionskr Abt Ref"},{"key":"CR8","first-page":"118","volume-title":"International Scientific Council for Trypanosomiasis Research and Control, 15th Meeting","author":"F Finelle","year":"1977","unstructured":"Finelle F (1977) Revue de la situation actuelle de la trypanosomiase animale. In: International Scientific Council for Trypanosomiasis Research and Control, 15th Meeting. Eleza Services, Nairobi, Kenya, pp 118?128"},{"key":"CR9","first-page":"281","volume":"39","author":"L Jenni","year":"1982","unstructured":"Jenni L, Brun R (1982) A new in vitro test for human serum resistance ofTrypanosoma (T.) brucei. Acta Trop (Basel) 39:281?284","journal-title":"Acta Trop (Basel)"},{"key":"CR10","first-page":"161","volume":"33","author":"E Karbe","year":"1982","unstructured":"Karbe E, B\u00f6ttger M, McCann PP, Sjoerdsma A, Freitas EK (1982) Curative effects of ?-difluoromethylornithine on fatalTrypanosoma congolense infection in mice. Tropenmed Parasitol 33:161?162","journal-title":"Tropenmed Parasitol"},{"key":"CR11","first-page":"434","volume":"59","author":"PP McCann","year":"1981","unstructured":"McCann PP, Bacchi CJ, Clarkson AB Jr, Seed JR, Nathan HC, Amole BO, Hutner SH, Sjoerdsma A (1981a) Further studies on difluoromethylornithine in African trypanosomes. Med Biol 59:434?440","journal-title":"Med Biol"},{"key":"CR12","first-page":"97","volume-title":"Advances in polyamine research, vol III","author":"PP McCann","year":"1981","unstructured":"McCann PP, Bacchi CJ, Hanson WL, Cain GD, Nathan HC, Hutner SH, Sjoerdsma A (1981b) Effect on parasitic protozoa of ?-difluoromethylornithine?an inhibitor of ornithine decarboxylase. In: Caldarera CM, Zappia V, Bachrach U (eds) Advances in polyamine research, vol III. Raven Press, New York, pp 97?110"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1021\/ja00476a050","volume":"100","author":"BW Metcalf","year":"1978","unstructured":"Metcalf BW, Bey P, Danzin C, Jung MJ, Casara P, Vevert JP (1978) Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogues. J Am Chem Soc 100:2551?2553","journal-title":"J Am Chem Soc"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0166-6851(87)90064-8","volume":"22","author":"MA Phillips","year":"1987","unstructured":"Phillips MA, Wang CC (1987) ATrypanosoma brucei mutant resistant to ?-difluoromethylornithine. Mol Biochem Parasitol 22:9?17","journal-title":"Mol Biochem Parasitol"},{"key":"CR15","first-page":"143","volume":"5","author":"R Richle","year":"1983","unstructured":"Richle R, Hofheinz W (1983) Chemotherapeutische Wirksamkeit von 2 neuen 2-Nitroimidazolderivaten gegenTrypanosoma brucei rhodesiense bei der experimentellen Schlafkrankheit von Maus und Kaninchen. Mitt Oesterr Ges Tropenmed Parasitol 5:143?149","journal-title":"Mitt Oesterr Ges Tropenmed Parasitol"},{"key":"CR16","first-page":"894","volume":"40","author":"D Schillinger","year":"1985","unstructured":"Schillinger D (1985) Ursachen von Therapieversagern bei der Behandlung der Naganaseuche des Rindes. Tieraerztl Umschau 40:894?904","journal-title":"Tieraerztl Umschau"},{"key":"CR17","first-page":"677","volume":"10","author":"D Schillinger","year":"1984","unstructured":"Schillinger D, Gorton E (1984) Efficacy of difluoromethylornithine upon a drug-resistantTrypanosoma congolense strain in mice. Drugs Exp Clin Res 10:677?679","journal-title":"Drugs Exp Clin Res"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0002-9343(87)90107-0","volume":"82","author":"H Taelman","year":"1987","unstructured":"Taelman H, Schechter PJ, Marcelis L, Sonnet J, Kazyumba G, Dasnoy J, Haegele KD, Sjoerdsma A, Wery M (1987) Difluoromethylornithine, an effective new treatment of Gambian trypanosomiasis. Am J Med 82:607?614","journal-title":"Am J Med"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1021\/jm00367a007","volume":"27","author":"P Ulrich","year":"1984","unstructured":"Ulrich P, Cerami A (1984) Trypanocidal 1,3-arylene diketone bis(guanylhydrazone)s. Structure-activity relationships among substituted and heterocyclic analogues. J Med Chem 27:35?40","journal-title":"J Med Chem"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/0035-9203(85)90195-6","volume":"79","author":"S Nieuwenhove Van","year":"1985","unstructured":"Van Nieuwenhove S, Schechter PJ, Declercq J, Bon\u00e9 G, Burke J, Sjoerdsma A (1985) Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-?-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial. Trans R Soc Trop Med Hyg 79:692?698","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"CR21","first-page":"171","volume":"38","author":"E Zweygarth","year":"1987","unstructured":"Zweygarth E, R\u00f6ttcher D (1987) Trypanocidal activity of a 5-substituted 2-nitroimidazole compound (Ro 15-0216) in mice. Trop Med Parasitol 38:171?174","journal-title":"Trop Med Parasitol"},{"key":"CR22","first-page":"255","volume":"37","author":"E Zweygarth","year":"1986","unstructured":"Zweygarth E, Schillinger D, Kaufmann W, R\u00f6ttcher D (1986) Evaluation of sinefungin for the treatment ofTrypanosoma (Nannomonas) congolense infections in goats. Trop Med Parasitol 37:255?257","journal-title":"Trop Med Parasitol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00931271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00931271\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00931271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T17:44:44Z","timestamp":1556559884000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00931271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989]]}},"alternative-id":["BF00931271"],"URL":"https:\/\/doi.org\/10.1007\/bf00931271","relation":{},"ISSN":["0044-3255","1432-1955"],"issn-type":[{"value":"0044-3255","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989]]}}}