{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:21:17Z","timestamp":1773058877211,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1984,2,1]],"date-time":"1984-02-01T00:00:00Z","timestamp":444441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[1984,2]]},"DOI":"10.1007\/bf00964170","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T16:46:34Z","timestamp":1105634794000},"page":"225-231","source":"Crossref","is-referenced-by-count":38,"title":["Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities"],"prefix":"10.1007","volume":"9","author":[{"given":"Leontino","family":"Battistin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Varotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Berlese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/oxfordjournals.jbchem.a131372","volume":"80","author":"M. Abe","year":"1976","unstructured":"Abe, M., andMatsuda, M. 1976. A correlation between changes in ?-aminobutyric acid metabolism and seizures induced by antivitamin B6. J. Biochem. 80:1165?1171.","journal-title":"J. Biochem."},{"key":"CR2","first-page":"125","volume":"284","author":"C. C. Aickin","year":"1978","unstructured":"Aickin, C. C., Deisz, R. A., andLux, H. D. 1978. The effect of diphenylhydantoin and picrotoxin on post-synaptic inhibition. J. Physiol. 284:125?126P.","journal-title":"J. Physiol."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(75)90714-3","volume":"89","author":"L. Battistin","year":"1975","unstructured":"Battistin, L., Varotto, M., andDe Lorenzi, A. 1975. Amino acid uptake in vivo by the mouse brain and by various regions of the rabbit brain after drug-induced convulsions. Brain Res. 89:215?224.","journal-title":"Brain Res."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/978-1-4684-3264-0_34","volume-title":"Transport phenomena in the nervous system: physiological and pathological aspects","author":"L. Battistin","year":"1976","unstructured":"Battistin, L. 1976. Cerebral permeability phenomena in epilepsy. Pages 465?477in Levi, G., Battistin, L., andLajtha, A. (eds.) Transport phenomena in the nervous system: physiological and pathological aspects. Plenum Press, New York."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF00964640","volume":"4","author":"L. Battistin","year":"1979","unstructured":"Battistin, L., Varotto, M., Tezzon, F., andPistollato, L. 1979. Levels and uptake of taurine in various brain regions after drug-induced generalized convulsions. Neurochem. Res. 4:457?464.","journal-title":"Neurochem. Res."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1016\/S0021-9258(18)94012-3","volume":"236","author":"C. F. Baxter","year":"1961","unstructured":"Baxter, C. F., andRoberts, E. 1961. Elevation of ?-aminobutyric acid in brain: selective inhibition of ?-aminobutyric-?-ketoglutaric acid transaminase. J. Biol. Chem. 236:3287?3294.","journal-title":"J. Biol. Chem."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0028-3908(72)90083-4","volume":"11","author":"J. Crossland","year":"1972","unstructured":"Crossland, J., andTurnbull, M. J. 1972. Gamma-aminobutyric acid and the barbiturate abstinence syndrome in rats. Neuropharmacol. 11:733?738.","journal-title":"Neuropharmacol."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1471-4159.1973.tb04263.x","volume":"21","author":"L. J. Fowler","year":"1973","unstructured":"Fowler, L. J. 1973. Analysis of the major amino acids of rat brain after in vivo inhibition of GABA transaminase by ethanolamine O-sulphate. J. Neurochem. 21:437?440.","journal-title":"J. Neurochem."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1471-4159.1969.tb08975.x","volume":"16","author":"Y. Godin","year":"1969","unstructured":"Godin, Y., Heiner, L., Mark, J., andMandel, P. 1969. Effects of di-n-propylacetate, an anticonvulsive compound, on GABA metabolism. J. Neurochem. 16:869?873.","journal-title":"J. Neurochem."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1471-4159.1969.tb06855.x","volume":"16","author":"L. T. Graham Jr.","year":"1969","unstructured":"Graham, L. T., Jr., andAprison, M. H. 1969. Distribution of some enzymes associated with the metabolism of glutamate, aspartate, ?-aminobutyrate and glutamine in cat spinal cord. J. Neurochem. 16:559?566.","journal-title":"J. Neurochem."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(76)90359-9","volume":"40","author":"R. W. Horton","year":"1976","unstructured":"Horton, R. W., Meldrum, B. S., Sawaya, M. C. B., andStephenson, J. D. 1976. Picrotoxin convulsions and GABA metabolism after injection of anticonvulsants in chicks. Eur. J. Pharmacol. 40:101?106.","journal-title":"Eur. J. Pharmacol."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0014-2999(77)90259-X","volume":"41","author":"R. W. Horton","year":"1977","unstructured":"Horton, R. W., Anlezark, G. M., Sawaya, M. C. B., andMeldrum, B. S. 1977. Monoamine and GABA metabolism and the anticonvulsant action of di-n-propylacetate and ethanolamine O-sulphate. Eur. J. Pharmacol. 41:387?397.","journal-title":"Eur. J. Pharmacol."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0006-2952(75)90422-0","volume":"24","author":"L. L. Iversen","year":"1975","unstructured":"Iversen, L. L., andKelly, J. S. 1975. Uptake and metabolism of ?-aminobutyric acid by neurones and glial cells. Biochem. Pharmacol. 24:933?938.","journal-title":"Biochem. Pharmacol."},{"key":"CR14","first-page":"32","volume-title":"Epileptic seizures, Behaviour, Pain","author":"W. Y. Koella","year":"1976","unstructured":"Koella, W. Y., Levin, P., andBaltzer, V. 1976. The pharmacology of carbamazepine and some other antiepileptic drugs. Pages 32?48,in W. Birkamayer (ed.) Epileptic seizures, Behaviour, Pain, Hans Huber, Berlin."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00498692","volume":"296","author":"W. Loscher","year":"1977","unstructured":"Loscher, W., andFrey, H. H. 1977. Effect of convulsant and anticonvulsant agents on level and metabolism of ?-aminobutyric acid in mouse brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 296:263?269.","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/j.1471-4159.1980.tb11250.x","volume":"34","author":"W. Loscher","year":"1980","unstructured":"Loscher, W. 1980. Effects of inhibitors of GABA transaminase on the synthesis, binding, uptake and metabolism of GABA. J. Neurochem. 34:1603?1608.","journal-title":"J. Neurochem."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(08)60205-6","volume":"17","author":"B. C. Meldrum","year":"1975","unstructured":"Meldrum, B. C. 1975. Epilepsy and ?-aminobutyric acid mediated inhibition. Intern. Rev. Neurobiol. 17:1?32.","journal-title":"Intern. Rev. Neurobiol."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1471-4159.1978.tb06538.x","volume":"30","author":"C. P. Miller","year":"1978","unstructured":"Miller, C. P., Martin, D. C., Mazumder, A., andWalters, J. R. 1978. Studies on the regulation of GABA synthesis: substrate-promoted dissociation of pyridoxal-5?-phosphate from GAD. J. Neurochem. 30:361?369.","journal-title":"J. Neurochem."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1471-4159.1981.tb01643.x","volume":"36","author":"P. N. Patsalos","year":"1981","unstructured":"Patsalos, P. N., andLascelles, P. T. 1981. Changes in regional brain levels of amino acid putative neurotransmitters after prolonged treatment with the anticonvulsant drugs diphenylhydantoin, phenobarbitone, sodium valproate, ethosuximide and sulthiame in the rat. J. Neurochem. 36:688?695.","journal-title":"J. Neurochem."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0014-2999(72)90119-7","volume":"17","author":"S. F. Saad","year":"1972","unstructured":"Saad, S. F., El Masry, A. M., andScott, P. M. 1972. Influence of certain anticonvulsants on the concentration of ?-aminobutyric acid in the cerebral hemispheres of mice. Eur. J. Pharmacol. 17:386?392.","journal-title":"Eur. J. Pharmacol."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2302\/kjm.13.211","volume":"13","author":"S. Saito","year":"1964","unstructured":"Saito, S., Toknriaga, Y., andKosima, K. 1964. Effect of several excitants and depressants on glutamic acid and its metabolite in rabbit and rat brain. Keio J. Med. 13:211?235.","journal-title":"Keio J. Med."},{"key":"CR22","first-page":"351","volume":"4","author":"M. Saladini","year":"1981","unstructured":"Saladini, M., Gabana, M. A., Bracco, F., Zanchin, G., Maggioni, F., andBattistin, L. 1981. Effect of antiepileptic drugs on the cerebral amino acid uptake in vitro. It. J. Neurol. Sci. 4:351?360.","journal-title":"It. J. Neurol. Sci."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1471-4159.1978.tb06258.x","volume":"31","author":"P. J. Schechter","year":"1978","unstructured":"Schechter, P. J., Tranier, Y., andGrove, J. 1978. Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anticonvulsant activity. J. Neurochem. 31:1325?1327.","journal-title":"J. Neurochem."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1126\/science.6101294","volume":"207","author":"J. F. Tallman","year":"1980","unstructured":"Tallman, J. F., Paul, S. M., Skolnick, P., andGallager, D. W. 1980. Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science 207:274?281.","journal-title":"Science"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0165-6147(80)90014-0","volume":"1","author":"A. J. Turner","year":"1980","unstructured":"Turner, A. J., andWhittle, S. R. 1980. Sodium valproate, GABA and epilepsy. Trends Pharmacol. Sci. 1:257?260.","journal-title":"Trends Pharmacol. Sci."},{"key":"CR26","first-page":"242","volume-title":"Inhibition in the nervous system and gamma-aminobutyric acid","author":"A. Vernadakis","year":"1960","unstructured":"Vernadakis, A., andWoodbury, D. M. 1960. Effects of diphenylhydantoin and adrenocortical steroids on free glutamic acid, glutamate and gamma-aminobutyric acid concentrations of the rat cerebral cortex. Pages 242?248,in E. Roberts (ed.) Inhibition in the nervous system and gamma-aminobutyric acid, Pergamon, Oxford."},{"key":"CR27","volume-title":"Antiepileptic drugs","author":"D. M. Woodbury","year":"1972","unstructured":"Woodbury, D. M., Penry, J. K., andSchmidt, R. 1972. Antiepileptic drugs. Raven Press, New York."}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00964170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00964170\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00964170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:58:55Z","timestamp":1625360335000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00964170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,2]]}},"alternative-id":["BF00964170"],"URL":"https:\/\/doi.org\/10.1007\/bf00964170","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,2]]}}}