{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:21:42Z","timestamp":1790918502899,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[1989,1]]},"DOI":"10.1007\/bf00969762","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T08:14:52Z","timestamp":1105517692000},"page":"81-84","source":"Crossref","is-referenced-by-count":5,"title":["In vitro localization of the protein synthesis defect associated with experimental phenylketonuria"],"prefix":"10.1007","volume":"14","author":[{"given":"Marc-Andr\ufffd","family":"Elsliger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges R.","family":"Th\ufffdriault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF00966321","volume":"3","author":"J. V. Hughes","year":"1978","unstructured":"Hughes, J. V., and Johnson, T. C. 1978. Abnormal amino acid metabolism and brain protein synthesis during neural development. Neurochem. Res. 3:381?399.","journal-title":"Neurochem. Res."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1212\/WNL.18.10.1003","volume":"18","author":"J. H. Menkes","year":"1968","unstructured":"Menkes, J. H. 1968. Cerebral proteolipids in phenylketonuria. Neurology 18:1003?1008.","journal-title":"Neurology"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1471-4159.1972.tb01357.x","volume":"19","author":"S. N. Shaw","year":"1972","unstructured":"Shaw, S. N., Peterson, N. A., and McKean, C. M. 1972. Impaired myelin formation in experimental hyperphenylalaninaemia. J. Neurochem. 19:479?485.","journal-title":"J. Neurochem."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1126\/science.168.3927.129","volume":"168","author":"K. Aoki","year":"1970","unstructured":"Aoki, K., and Siegel, F. L. 1970. Hyperphenylalaninaemia. Disaggregation of brain polyribosomes in young rats. Science 168:129?130.","journal-title":"Science"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/bj1510173","volume":"151","author":"F. Taub","year":"1975","unstructured":"Taub, F., and Johnson, T. C. 1975. The mechanism of polyribosome disaggregation in brain tissue by phenylalanine. Biochem. J. 151:173?180.","journal-title":"Biochem. J."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1471-4159.1976.tb04492.x","volume":"26","author":"S. Roberts","year":"1976","unstructured":"Roberts, S., and Morelos, B. S. 1976. Role of ribonuclease action in phenylalanine-induced disaggregation of rat cerebral polyribosomes. J. Neurochem. 26:387?400.","journal-title":"J. Neurochem."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/bj1170325","volume":"117","author":"H. C. Agrawal","year":"1970","unstructured":"Agrawal, H. C., Bone, A. H., and Davison, A. N. 1970. Effect of phenylalanine on protein synthesis in the developing rat brain. Biochem. J. 117:325?331.","journal-title":"Biochem. J."},{"key":"CR8","first-page":"48","volume":"14","author":"O. F. C. Lindroos","year":"1971","unstructured":"Lindroos, O. F. C., and Oja, S. S. 1971. Hyperphenylalaninaemia and the exchange of tyrosine in adult rat brain. Exptl. Brain Res. 14:48?60.","journal-title":"Exptl. Brain Res."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1471-4159.1976.tb06993.x","volume":"26","author":"J. V. Hughes","year":"1976","unstructured":"Hughes, J. V., and Johnson, T. C. 1976. The effects of phenylalanine on amino acid metabolism and protein synthesis in brain cellsin vitro. J. Neurochem. 26:1105?111.","journal-title":"J. Neurochem."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1471-4159.1968.tb06202.x","volume":"15","author":"C. M. McKean","year":"1968","unstructured":"McKean, C. M., Boggs, D. E., and Peterson, N. A. 1968. The influence of high phenylalanine and tyrosine on the concentrations of essential amino acids in brain. J. Neurochem. 15:235?241.","journal-title":"J. Neurochem."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1471-4159.1975.tb06972.x","volume":"25","author":"K. N. Antonas","year":"1975","unstructured":"Antonas, K. N., and Coulson, W. F. 1975. Brain uptake and protein incorporation of amino acids studied in rats subjected to prolonged hyperphenylalaninaemia. J. Neurochem. 25:309?314.","journal-title":"J. Neurochem."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1471-4159.1975.tb03652.x","volume":"24","author":"M. L. Vahvelainen","year":"1975","unstructured":"Vahvelainen, M. L., and Oja, S. S. 1975. Kinetic analysis of phenylalanine-induced inhibition of the saturable influx of tyrosine, tryptophan, leucine and histidine into brain cortex slices from adult and 7-day-old rats. J. Neurochem. 24:885?892.","journal-title":"J. Neurochem."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/bj1620527","volume":"162","author":"J. V. Hughes","year":"1977","unstructured":"Hughes, J. V., and Johnson, T. C. 1977. The effects of hyperphenylalaninaemia on the concentration of aminoacyl-transfer ribonucleic acidin vivo: A mechanism for inhibition of neural protein synthesis by phenylalanine. J. Biochem. 162:527?537.","journal-title":"J. Biochem."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0005-2787(78)90214-9","volume":"517","author":"J. V. Hughes","year":"1978","unstructured":"Hughes, J. V., and Johnson, T. C. 1978. Experimentally-induced and natural recovery from the effects of phenylalanine on brain protein synthesis. Biochim. Biophys Acta 517:473?485.","journal-title":"Biochim. Biophys Acta"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1471-4159.1971.tb11984.x","volume":"18","author":"F. L. Siegel","year":"1971","unstructured":"Siegel, F. L., Aoki, K., and Colwell, R. E. 1971. Polyribosome disaggregation and cell-free protein synthesis in preparations from cerebral cortex of HPA rats. J. Neurochem. 18:537?547.","journal-title":"J. Neurochem."},{"key":"CR16","unstructured":"Gauthier, D., and Murthy, M. R. V. 1988. Direct translation of brain polysomes in reticulocyte lysate. Med. Sci. Res. (in print)."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF00993241","volume":"12","author":"D. Gauthier","year":"1987","unstructured":"Gauthier, D., and Murthy, M. R. V. 1987. Efficacy of RNase inhibitors during brain polysome isolation. Neurochem. Res. 12:335?339.","journal-title":"Neurochem. Res."},{"key":"CR18","first-page":"343","volume":"63","author":"J. W. Cosgrove","year":"1981","unstructured":"Cosgrove, J. W., Brown, I. R. 1981. Characterization of an initiating cell-free protein synthesis system derived from rabbit brain. J. Neurochem. 63:343?56.","journal-title":"J. Neurochem."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/BF00966123","volume":"11","author":"J. W. Cosgrove","year":"1986","unstructured":"Cosgrove, J. W., Rapoport, S. I. 1986. Preparation of a cell-free extract from rat brain which can initiate protein synthesisin vitro. Neurochem. Res. 11:1289?1301.","journal-title":"Neurochem. Res."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1021\/bi00640a030","volume":"16","author":"A. Jim\u00e9nez","year":"1977","unstructured":"Jim\u00e9nez, A., Carrasco, L., V\u00e1zquez, D. 1977. Enzymic and nonenzymic translocation by yeast polysomes. Sites of action of a number of inhibitors. Biochemistry 16:4727?4730.","journal-title":"Biochemistry"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1432-1033.1976.tb10822.x","volume":"68","author":"M. Fresno","year":"1976","unstructured":"Fresno, M., Carrasco, L., and V\u00e1zquez, D. 1976. Initiation of the polypeptide chain by reticulocyte cell-free systems. Survey of different inhibitors of translation. Eur. J. Biochem. 68:355?364.","journal-title":"Eur. J. Biochem."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0003-2697(84)90218-5","volume":"136","author":"T. S. Nowak","year":"1984","unstructured":"Nowak, T. S., Carty, E. R., Lust, W. D., and Passonnean, J. V. 1984. Anin vitro amino acid incorporation for assessing the status ofin vivo protein synthesis. Anal. Biochem. 136:285?292.","journal-title":"Anal. Biochem."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/0006-291X(82)90701-X","volume":"104","author":"C. M. Mackie","year":"1982","unstructured":"Mackie, C. M., Buxton, D. B., and Mowbray, J. 1982. Aurintricarboxylic acid as both a stimulator and an inhibitor of cell-free protein synthesis by rat heart polyribosomes. Biochem. Biophys. Res. Comm. 104:750?757.","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"11927","DOI":"10.1016\/S0021-9258(19)86406-2","volume":"254","author":"J. E. Bergman","year":"1979","unstructured":"Bergman, J. E., and Lodish, H. F. 1979. A kinetic model of protein synthesis. Application to hemoglobin synthesis and translational control. J. Biol. Chem. 254:11927?11937.","journal-title":"J. Biol. Chem."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/j.1471-4159.1986.tb01759.x","volume":"446","author":"S. W. Fleming","year":"1986","unstructured":"Fleming, S. W., and Brown, I. R. 1986. Characterization of a translational inhibitor isolated from rabbit brain following intravenous administration of d-lysergic acid diethylamide. J. Neurochem. 446:1436?1443.","journal-title":"J. Neurochem."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1073\/pnas.71.10.4020","volume":"71","author":"C. Raffel","year":"1974","unstructured":"Raffel, C., Stein, S., and Kaempfer, R. 1974. Role for heme in mammalian protein synthesis: activation of an initiation factor. Proc. Natl. Acad. Sci. USA 71:4020?4024.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0021-9258(17)42476-8","volume":"261","author":"A. Benedetti De","year":"1986","unstructured":"De Benedetti, A., Baglioni, C. 1986. Activation of hemin-regulated initiation factor-2 kinase in heat-shocked HeLa cells. J. Biol. Chem. 261:338?342.","journal-title":"J. Biol. Chem."}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00969762.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00969762\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00969762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T22:43:47Z","timestamp":1625352227000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00969762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["BF00969762"],"URL":"https:\/\/doi.org\/10.1007\/bf00969762","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}