{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:16:47Z","timestamp":1758280607080},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1985,12,1]],"date-time":"1985-12-01T00:00:00Z","timestamp":502243200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[1985,12]]},"DOI":"10.1007\/bf00988607","type":"journal-article","created":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T21:25:57Z","timestamp":1111613157000},"page":"1653-1660","source":"Crossref","is-referenced-by-count":16,"title":["GABA-transaminase and glutamic acid decarboxylase changes in the brain of rats treated with pyrithiamine"],"prefix":"10.1007","volume":"10","author":[{"given":"Sharlene G.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith G.","family":"McGeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"321","volume":"78","author":"M. Sassaris","year":"1983","unstructured":"Sassaris, M., Meka, R., Miletello, G., Nance, C., andHunter, F. M. 1983 Neuropsychiatric syndromes after gastric partition. Am. J. Gastroenterol. 78:321?325.","journal-title":"Am. J. Gastroenterol."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/ajcn\/36.5.1067","volume":"36","author":"F. L. Iber","year":"1982","unstructured":"Iber, F. L., Blass, J. P., Brin, M., andLevy, C. M. 1982 Thiamin in the elderly?Relation to alcoholism and to neurological degenerative disease. Am. J. Clin. Nutr. 36:1067?1082.","journal-title":"Am. J. Clin. Nutr."},{"key":"CR3","first-page":"1","volume-title":"The biochemical lesion of thiamine deficiency","author":"R. A. Peters","year":"1967","unstructured":"Peters, R. A. 1967 The biochemical lesion of thiamine deficiency. Pages 1?18,in Wolstenholme, G. E. W., andO'Conner, M. (eds), J. A. Churchill Ltd., London."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-0186(82)90033-X","volume":"4","author":"R. F. Butterworth","year":"1982","unstructured":"Butterworth, R. F. 1982 Review?Neurotransmitter function in thiamin-deficiency encephalopathy. Neurochem. Internatl. 4:1?16.","journal-title":"Neurochem. Internatl."},{"key":"CR5","first-page":"537","volume":"217","author":"L. L. Barclay","year":"1981","unstructured":"Barclay, L. L., Gibson, G. E., andBlass, J. P. 1981 Impairment of behavior and acetylcholine metabolism in thiamine deficiency. J. Pharmacol. Exp. Ther. 217:537?543.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/145856a0","volume":"145","author":"P. J. G. Mann","year":"1940","unstructured":"Mann, P. J. G., andQuastel, J. H. 1940 Vitamin B1 and acetylcholine formation in isolated brain. Nature 145:856?857.","journal-title":"Nature"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1212\/WNL.28.7.691","volume":"28","author":"A. Plaitakis","year":"1978","unstructured":"Plaitakis, A., Nicklas, W. J., andBerl, S. 1978 Thiamine deficiency: Selective impairment of the cerebellar serotonergic system. Neurology 28:691?698.","journal-title":"Neurology"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1093\/jn\/107.10.1902","volume":"107","author":"C. V. Vorhees","year":"1977","unstructured":"Vorhees, C. V., Schmidt, D. E., Barrett, R. J., andSchenker, S. 1977 Effects of thiamin deficiency on acetylcholine levels and utilization in vivo in rat brain. J. Nutr. 107:1902?1908.","journal-title":"J. Nutr."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0361-9230(78)90078-3","volume":"3","author":"C. V. Vorhees","year":"1978","unstructured":"Vorhees, C. V., Schmidt, D. E., andBarrett, R. J. 1978 Effects of pyrithiamin and oxythiamin on acetylcholine levels and utilization in rat brain. Brain Res. Bull. 3:493?496.","journal-title":"Brain Res. Bull."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1093\/jn\/112.10.1906","volume":"112","author":"L. L. Barclay","year":"1982","unstructured":"Barclay, L. L., Gibson, G. E., andBlass, J. P. 1982 Cholinergic therapy of abnormal open-field behavior in thiamine deficient rats. J. Nutr. 112:1906?1913.","journal-title":"J. Nutr."},{"key":"CR11","first-page":"3112","volume":"236","author":"C. J. Gubler","year":"1961","unstructured":"Gubler, C. J. 1961 Studies on the physiological functions of thiamine. J. Biochem. 236:3112?3120.","journal-title":"J. Biochem."},{"key":"CR12","first-page":"367","volume-title":"Thiamin: 20 years of progress","author":"A. Plaitakis","year":"1982","unstructured":"Plaitakis, A., Hwang, E. C., Van Woert, M. H., Sziligyl, P. I. A., andBerl, S. 1982 Effect of thiamine deficiency on brain neurotransmitter systems. Pages 367?380,in Sable, H. Z., andGubler, C. J. (eds.), Thiamin: 20 years of progress, N.Y. Acad. Sci., New York."},{"issue":"Suppl","key":"CR13","first-page":"32","volume":"41","author":"A. Plaitakis","year":"1983","unstructured":"Plaitakis, A., andBerl, S. 1983 Thiamine deficiency: effect on brain serotonergic mechanisms (Abstr). J. Neurochem. 41 (Suppl):S32.","journal-title":"J. Neurochem."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-8993(79)90494-3","volume":"179","author":"M. H. Woert Van","year":"1979","unstructured":"Van Woert, M. H., Flaitakis, A., Hwang, E. C., andBerl, S. 1979 Effect of thiamine deficiency on brain serotonin turnover. Brain Res. 179:103?110.","journal-title":"Brain Res."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(85)91518-5","volume":"327","author":"R. S. Lee","year":"1985","unstructured":"Lee, R. S., Strahlendorf, H. K., andStrahlendorf, J. C. 1985 Enhanced sensitivity of cerebellar Purkinje cells to applied serotonin in thiamine deficiency. Brain Res. 327:249?258.","journal-title":"Brain Res."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0014-2999(70)90074-9","volume":"12","author":"H. Iwata","year":"1970","unstructured":"Iwata, H., Nishikawa, T., andBaba, A. 1970 Catecholamine accumulation in tissues of thiamine deficient rats after inhibition of monoamine oxidase. Eur. J. Pharmac. 12:253?256.","journal-title":"Eur. J. Pharmac."},{"key":"CR17","first-page":"464","volume-title":"Thiamin: 20 years of progress","author":"R. F. Butterworth","year":"1982","unstructured":"Butterworth, R. F. 1982 Regional amino acid neurotransmitter distribution in thiamine deficiency. Pages 464?465,in Sable, H. Z., andGubler, C. J. (eds.), Thiamin: 20 years of progress, N.Y. Acad. Sci., New York."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1471-4159.1979.tb05191.x","volume":"37","author":"E. Hamel","year":"1979","unstructured":"Hamel, E., Butterworth, R. F., andBarbeau, A. 1979 Effect of thiamine deficiency on levels of putative amino acid transmitters in the affected regions of rat brain. J. Neurochem. 37:575?577.","journal-title":"J. Neurochem."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0006-8993(79)91053-9","volume":"171","author":"A. Plaitakis","year":"1979","unstructured":"Plaitakis, A., Nicklas, W. J., andBerl, S. 1979 Alterations in uptake and metabolism of aspartate and glutamate in brain of thiamine-deficient animals. Brain Res. 171:489?502.","journal-title":"Brain Res."},{"key":"CR20","first-page":"160","volume":"4","author":"R. F. Butterworth","year":"1978","unstructured":"Butterworth, R. F., Hamel, E., andBarbeau, A. 1978 Role of aspartic and glutamic acid in the ataxia produced by thiamine deficiency. Soc. Neurosci. Absts. 4:160.","journal-title":"Soc. Neurosci. Absts."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1017\/S0317167100119675","volume":"6","author":"R. F. Butterworth","year":"1979","unstructured":"Butterworth, R. F., Hamel, E., Lauderville, F., andBarbeau, A. 1979 Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia. Can. J. Neurol. Sci. 6:217?222.","journal-title":"Can. J. Neurol. Sci."},{"issue":"Suppl","key":"CR22","first-page":"28","volume":"41","author":"E. G. McGeer","year":"1983","unstructured":"McGeer, E. G., andThompson, S. G. 1983 GABA-transaminase (GABA-T) and glutamic acid decarboxylase (GAD) changes in brain of rats treated with pyrithiamine (Abstr). J. Neurochem. 41 (Suppl):S28.","journal-title":"J. Neurochem."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1471-4159.1976.tb04437.x","volume":"26","author":"P. L. McGeer","year":"1976","unstructured":"McGeer, P. L., andMcGeer, E. G. 1976 Enzymes associated with the metabolism of catecholamines, acetylcholine and GABA in human controls and patients with Parkinson's desease and Huntington's chorea. J. Neurochem. 26:65?76.","journal-title":"J. Neurochem."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1471-4159.1965.tb06759.x","volume":"12","author":"N. H. Gelder Van","year":"1965","unstructured":"Van Gelder, N. H. 1965 The histochemical demonstration of ?-aminobutyric acid metabolism by a reduction of a tetrazolium salt. J. Neurochem. 12:231?237.","journal-title":"J. Neurochem."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/cne.902180209","volume":"218","author":"T. Nagai","year":"1983","unstructured":"Nagai, T., McGeer, P. L., andMcGeer, E. G. 1983 Distribution of GABA-T-intensive neurons in the rat forebrain and midbrain. J. Comp. Neurol. 218:220?238.","journal-title":"J. Comp. Neurol."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-8993(82)91277-X","volume":"251","author":"S. R. Vincent","year":"1982","unstructured":"Vincent, S. R., Kimura, H., andMcGeer, E. G. 1982 GABA-transaminase in the basal ganglia: A pharmacohistochemical study. Brain Res. 251:93?104.","journal-title":"Brain Res."},{"issue":"Suppl","key":"CR27","first-page":"31","volume":"41","author":"R. F. Butterworth","year":"1983","unstructured":"Butterworth, R. F. 1983 Amino acid neurotransmitter function in thiamine deficiency encephalopathy (Abstr). J. Neurochem. 41 (Suppl):S31.","journal-title":"J. Neurochem."},{"key":"CR28","first-page":"229","volume-title":"Thiamine","author":"P. E. Dreyfus","year":"1976","unstructured":"Dreyfus, P. E. 1976 Thiamine deficient encephalopathy: thoughts on its pathogenesis. Pages 229?239,in Gubler, C. J., Fujiwara, M., andDreyfus, P. M. (eds.), Thiamine, John Wiley & Sons, New York."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-3-642-68214-8_13","volume-title":"Geriatrics 1","author":"E. G. McGeer","year":"1982","unstructured":"McGeer, E. G., andMcGeer, P. L. 1982 Neurotransmitters in normal aging. Pages 263?282,in Platt, D. (ed), Geriatrics 1, Springer-Verlag, Berlin Heidelberg."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF00691499","volume":"59","author":"H. Aikawa","year":"1983","unstructured":"Aikawa, H., Suzuki, K., andIwasaki, Y. 1983 Ultrastructural observations on the thalamic neuronal inclusions in young mice. Acta Neuropath. (Berl.) 59:316?318.","journal-title":"Acta Neuropath. (Berl.)"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.2042-7158.1962.tb11049.x","volume":"14","author":"P. J. G. Bhatgat","year":"1962","unstructured":"Bhatgat, P. J. G., andLockett, M. F. 1962 The synthesis of acetylcholine by acetone dried powders from the brains of normal and of thiamine deficient rats. J. Pharm. Pharmacol. 14:37?40.","journal-title":"J. Pharm. Pharmacol."},{"key":"CR32","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1471-4159.1973.tb07581.x","volume":"21","author":"C. P. Heinrich","year":"1973","unstructured":"Heinrich, C. P., Standler, H., andWeiser, H. 1973 The effects of thiamine deficiency on the acetylcoenzyme A and acetylcholine levels in the rat brain. J. Neurochem. 21:1273?1281.","journal-title":"J. Neurochem."},{"key":"CR33","first-page":"285","volume":"25","author":"T. S. Reddy","year":"1982","unstructured":"Reddy, T. S. 1982 Effect of thiamine deficiency on 2?,3?-cyclic nucleotide 3?-phosphohydrolase activity in rat CNS. Nutr. Reports Internl. 25:285?7.","journal-title":"Nutr. Reports Internl."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0006-8993(78)91095-8","volume":"151","author":"O. Sacchi","year":"1978","unstructured":"Sacchi, O., Ladinsky, H., Prigioni, I., Consolo, S., Peri, G., andPerri, V. 1978 Acetylcholine turnover in the thiamine-depleted superior cervical ganglion of the rat. Brain Res. 151:609?614.","journal-title":"Brain Res."},{"key":"CR35","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1471-4159.1980.tb03710.x","volume":"35","author":"E. J. Thornber","year":"1980","unstructured":"Thornber, E. J., Dunlop, R. H., andGawthorne, J. M. 1980 Thiamin deficiency in the lamb: changes in thiamin phosphate esters in the brain. J. Neurochem. 35:713?717.","journal-title":"J. Neurochem."},{"issue":"Suppl","key":"CR36","first-page":"31","volume":"41","author":"Y. Dunant","year":"1983","unstructured":"Dunant, Y., andEder, L. 1983 Functional relationships between thiamine and acetylcholine (Abstr). J. Neurochem. 41 (Suppl):S31.","journal-title":"J. Neurochem."},{"key":"CR37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/264186a0","volume":"264","author":"L. Eder","year":"1976","unstructured":"Eder, L., Hirt, L., andDunant, Y. 1976 Possible involvement of thiamine in acetylcholine release. Nature 264:186?188.","journal-title":"Nature"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00988607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00988607\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00988607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T05:35:27Z","timestamp":1706074527000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00988607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1985,12]]}},"alternative-id":["BF00988607"],"URL":"https:\/\/doi.org\/10.1007\/bf00988607","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}