{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:57:53Z","timestamp":1791115073963,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1984,5,1]],"date-time":"1984-05-01T00:00:00Z","timestamp":452217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem J"],"published-print":{"date-parts":[[1984,5]]},"DOI":"10.1007\/bf01041351","type":"journal-article","created":{"date-parts":[[2005,1,30]],"date-time":"2005-01-30T17:48:36Z","timestamp":1107107316000},"page":"507-519","source":"Crossref","is-referenced-by-count":25,"title":["Immunological and histochemical analysis of regional variations of epidermal Langerhans cells in normal human skin"],"prefix":"10.1007","volume":"16","author":[{"given":"J. A.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Biggerstaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Sloane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. F.","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","first-page":"435","volume":"122","author":"T. M. Alyassin","year":"1976","unstructured":"Alyassin, T. M. &Toner, P. G. (1976) Langerhans cells in the human oesophagus.J. Anat. 122, 435?45.","journal-title":"J. Anat."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/1523-1747.ep12543542","volume":"74","author":"P. R. Bergstresser","year":"1980","unstructured":"Bergstresser, P. R., Toews, G. B., Gilliam, J. N. &Streilein, J. W. (1980) Unusual numbers and distributions of Langerhans cells in skin with unique immunologic properties.J. Invest. Dermatol. 74, 312?4.","journal-title":"J. Invest. Dermatol."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00000372-197900130-00007","volume":"1","author":"B. Berman","year":"1979","unstructured":"Berman, B. &France, D. S. (1979) Histochemical analysis of Langerhans' cells.Am. J. Dermatopathol. 1, 215?21.","journal-title":"Am. J. Dermatopathol."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/jid.1961.80","volume":"37","author":"M. S. Birbeck","year":"1961","unstructured":"Birbeck, M. S., Breathnach, A. S. &Everall, J. D. (1961) An electron microscopic study of basal melanocytes and high level clear cells (Langerhans cells) in vitiligo.J. Invest. Dermatol. 37, 51?63.","journal-title":"J. Invest. Dermatol."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/jid.1967.153","volume":"49","author":"J. Brown","year":"1967","unstructured":"Brown, J., Winkelmann, R. K. &Wolff, K. (1967) Langerhans cells in vitiligo: a qualitative study.J. Invest. Dermatol. 49, 386?90.","journal-title":"J. Invest. Dermatol."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/1523-1747.ep12506352","volume":"78","author":"A. Chu","year":"1982","unstructured":"Chu, A., Eisinger, M., Lee, J. S., Takezaki, S., Kung, P. C. &Edelson, R. L. (1982) Immunoelectron microscope identification of Langerhans cells using a new antigenic marker.J. Invest. Dermatol. 78, 177?80.","journal-title":"J. Invest. Dermatol."},{"key":"CR7","first-page":"139","volume":"26","author":"M. Elleder","year":"1977","unstructured":"Elleder, M., Povysil, C., Rozkovcova, J. &Cihula, J. (1977) Alpha-d-mannosidase activity in Histiocytosis X.Virchows Arch. (Pathol) 26, 139?45.","journal-title":"Virchows Arch. (Pathol)"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/jid.1959.74","volume":"32","author":"J. Fan","year":"1959","unstructured":"Fan, J., Schoenfeld, R. J. &Hunter, R. (1959) A study of epidermal clear cells with special reference to their relationship to the cells of Langerhans.J. Invest. Dermatol. 32, 445?9.","journal-title":"J. Invest. Dermatol."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1073\/pnas.78.4.2541","volume":"78","author":"E. Fithian","year":"1981","unstructured":"Fithian, E., Kung, P., Goldstein, G., Rubenfeld, M., Fenoglio, C. &Edelson, R. (1981) Reactivity of Langerhans cells with hybridoma antibody.Proc. Natn. Acad. Sci, U.S.A. 78, 2541?4.","journal-title":"Proc. Natn. Acad. Sci, U.S.A."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/1523-1747.ep12541607","volume":"73","author":"F. Gschnait","year":"1979","unstructured":"Gschnait, F. &Brenner, W. (1979) Kinetics of epidermal Langerhans cells.J. Invest. Dermatol. 73, 566?9.","journal-title":"J. Invest. Dermatol."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/1523-1747.ep12261091","volume":"56","author":"L. H. Hutchens","year":"1971","unstructured":"Hutchens, L. H., Sagebiel, R. W. &Clarke, M. A. (1971) Oral epithelial dendritic cells of the Rhesus monkey-histologic demonstration, fine structure and quantitative distribution.J. Invest. Dermatol.,56, 325?6.","journal-title":"J. Invest. Dermatol."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/jid.1969.26","volume":"52","author":"K. Jimbow","year":"1969","unstructured":"Jimbow, K., Sato, S. &Kukita, A. (1969) Langerhans cells in the normal pilosebaceous system. An electron microscopic investigation.J. Invest. Dermatol. 52, 177?80.","journal-title":"J. Invest. Dermatol."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2340\/0001555557289296","volume":"57","author":"L. Juhlin","year":"1977","unstructured":"Juhlin, L. &Shelley, W. B. (1977) New staining techniques for the Langerhans cell.Acta derm. venereol. (Stockh) 57, 289?96.","journal-title":"Acta derm. venereol. (Stockh)"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/268248a0","volume":"268","author":"L. Klareskog","year":"1977","unstructured":"Klareskog, L., Tjernlund, U. M., Forsum, W. &Peterson, P. A. (1977) Epidermal Langerhans cells express Ia antigens.Nature 268, 248?50.","journal-title":"Nature"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2340\/0001555553425428","volume":"53","author":"P. Lisi","year":"1973","unstructured":"Lisi, P. (1973) Investigation of Langerhans cells in pathological human epidermis.Acta derm. venereol. (Stockh) 53, 425?8.","journal-title":"Acta derm. venereol. (Stockh)"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/978-3-642-67234-7","volume-title":"Enzyme Histochemistry. A Laboratory Manual","author":"Z. Lojda","year":"1979","unstructured":"Lojda, Z., Gossrau, R. &Schiebler, T. H. (1979)Enzyme Histochemistry. A Laboratory Manual, 1st edn, p. 98. Berlin, Heidelberg, New York: Springer-Verlag.","edition":"1st edn"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2133.1975.tb03120.x","volume":"92","author":"I. C. Mackenzie","year":"1975","unstructured":"Mackenzie, I. C. &Squier, C. A. (1975) Cytochemical identification of ATPase positive Langerhans cells in EDTA-separated sheets of mouse epidermis.Br. J. Dermatol. 92, 523?33.","journal-title":"Br. J. Dermatol."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/eji.1830090307","volume":"9","author":"A. J. Mcmichael","year":"1979","unstructured":"Mcmichael, A. J., Pilch, J. R., Galfre, G., Mason, D. Y., Fabre, J. W. &Milstein, C. (1979) A human thymocyte antigen defined by a hybridoma myeloma monoclonal antibody.Eur. J. Immunol. 9, 205?10.","journal-title":"Eur. J. Immunol."},{"key":"CR19","first-page":"465","volume":"45","author":"G. F. Murphy","year":"1981","unstructured":"Murphy, G. F., Bhan, A. K., Sato, S., Harrist, T. J. &Mihm, M. C. (1981) Characterization of Langerhans cells by the use of monoclonal antibodies.Lab. Invest. 45, 465?8.","journal-title":"Lab. Invest."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1399-0039.1981.tb00686.x","volume":"17","author":"J. J. Nordlund","year":"1981","unstructured":"Nordlund, J. J. &Ackles, A. (1981) A method for quantifying Langerhans cells in epidermal sheets of human and murine skin.Tissue Antigens 17, 217?25.","journal-title":"Tissue Antigens"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1177\/29.8.7024402","volume":"29","author":"B. A. Ponder","year":"1981","unstructured":"Ponder, B. A. &Wilkinson, M. M. (1981) Inhibition of endogenous tissue alkaline phosphatase with the use of alkaline phosphatase conjugates in immunohistochemistry.J. Histochem. Cytochem. 29, 981?4.","journal-title":"J. Histochem. Cytochem."},{"key":"CR22","first-page":"327","volume":"25","author":"E. Rausch","year":"1977","unstructured":"Rausch, E., Kaiserling, E. &Goos, M. (1977) Langerhans cells and interdigitating reticulum cells in the thymus-dependent region of human dermatopathic lymphadenitis.Virchows Arch. (Pathol) 25, 327?43.","journal-title":"Virchows Arch. (Pathol)"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/jid.1967.5","volume":"48","author":"P. A. Riley","year":"1967","unstructured":"Riley, P. A. (1967) A study of the distribution of epidermal dendritic cells in pigmented and non-pigmented skinJ. Invest. Dermatol. 48, 28?38.","journal-title":"J. Invest. Dermatol."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/10520298109067287","volume":"56","author":"P. G. Robins","year":"1981","unstructured":"Robins, P. G. &Brandon, D. R. (1981) A modification of the adenosine triphosphatase method to demonstrate epidermal Langerhans cells.Stain Technol. 56, 87?9.","journal-title":"Stain Technol."},{"key":"CR25","first-page":"1. 31","volume-title":"The Epidermis in Disease","author":"G. Rowden","year":"1981","unstructured":"Rowden, G., Chespak, L. W., &More, N. (1981) Epidermal Langerhans cell morphology and distribution after topical nitrogen mustard treatment. InThe Epidermis in Disease (edited byMarks, R. andChristophers, E.), p. 1. 31. Philadelphia: Lippincott (Medical)."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2133.1979.tb05578.x","volume":"100","author":"G. Rowden","year":"1979","unstructured":"Rowden, G., Phillips, T. M. &Lewis, M. G. (1979) Ia antigen on indeterminate cells of the epidermis. Immunoelectron microscopic studies of surface antigen.Br. J. Dermatol. 100, 531?42.","journal-title":"Br. J. Dermatol."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-4362.1981.tb04329.x","volume":"20","author":"J. H. Saurat","year":"1981","unstructured":"Saurat, J. H. (1981) Cutaneous manifestations of graft versus host disease.Int. J. Dermatol. 20, 249?56.","journal-title":"Int. J. Dermatol."},{"key":"CR28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/1523-1747.ep12506298","volume":"69","author":"J. Schweizer","year":"1977","unstructured":"Schweizer, J. &Marks, F. (1977) A developmental study of the distribution and frequency of Langerhans cells in relation to formation of patterning in mouse tail epidermis.J. Invest. Dermatol. 69, 198?204.","journal-title":"J. Invest. Dermatol."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/261046a0","volume":"261","author":"W. B. Shelley","year":"1976","unstructured":"Shelley, W. B. &Juhlin, L. (1976) Langerhans cells form a reticulo-epithelial trap for external contact antigens.Nature 261, 46?7.","journal-title":"Nature"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/1523-1747.ep12482139","volume":"66","author":"I. Silberberg","year":"1976","unstructured":"Silberberg, I., Baer, R. L. &Rosenthal, S. A. (1976) The role of Langerhans cells in allergic contact hypersensitivity: review of findings in man and guinea pig.J. Invest. Dermatol. 66, 210?17.","journal-title":"J. Invest. Dermatol."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0008-8749(76)90105-2","volume":"25","author":"I. Silberberg-Sinakin","year":"1976","unstructured":"Silberberg-Sinakin, I., Thorbecke, G. J., Baer, R. L., Rosenthal, S. A. &Berezowsky, V. (1976) Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes.Cell Immunol. 25, 137?51.","journal-title":"Cell Immunol."},{"key":"CR32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/268245a0","volume":"268","author":"G. Stingl","year":"1977","unstructured":"Stingl, G., Wolff-Schreiner, E. C. H., Pichler, W. J., Gschnait, F., Knapp, W. &Wolff, K. (1977) Epidermal Langerhans cells bear Fc and C3 receptors.Nature 268, 245?6.","journal-title":"Nature"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/jcp.35.3.327","volume":"35","author":"J. A. Thomas","year":"1982","unstructured":"Thomas, J. A., Janossy, G., Chilosi, M., Pritchard, J. &Pincott, J. R. (1982) Combined immunological and histochemical analysis of skin and lymph node lesions in histiocytosis X.J. Clin. Pathol. 35, 327?37.","journal-title":"J. Clin. Pathol."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4049\/jimmunol.124.1.445","volume":"124","author":"G. B. Toews","year":"1980","unstructured":"Toews, G. B., Bergstresser, P. R. &Streilein, J. W. (1980) Epidermal Langerhans cell density dertermines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB.J. Immunol. 124, 445?53.","journal-title":"J. Immunol."},{"key":"CR35","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/jid.1967.82","volume":"48","author":"K. Wolff","year":"1967","unstructured":"Wolff, K. &Winkelmann, R. K. (1967) Quantitative studies on the Langerhans cell population in guinea pig epidermis.J. Invest. Dermatol. 48, 504?13.","journal-title":"J. Invest. Dermatol."},{"key":"CR36","first-page":"625","volume":"98","author":"A. S. Zelickson","year":"1968","unstructured":"Zelickson, A. S. &Mottaz, J. H. (1968) Epidermal dendritic cells. A quantitative study.Arch. Dermatol. 98, 625?9.","journal-title":"Arch. Dermatol."}],"container-title":["The Histochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01041351.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01041351\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01041351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T13:43:31Z","timestamp":1705844611000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01041351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["BF01041351"],"URL":"https:\/\/doi.org\/10.1007\/bf01041351","relation":{},"ISSN":["0018-2214","1573-6865"],"issn-type":[{"value":"0018-2214","type":"print"},{"value":"1573-6865","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}