{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T18:06:20Z","timestamp":1702317980196},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1985,2,1]],"date-time":"1985-02-01T00:00:00Z","timestamp":476064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmacokinetics and Biopharmaceutics"],"published-print":{"date-parts":[[1985,2]]},"DOI":"10.1007\/bf01073655","type":"journal-article","created":{"date-parts":[[2005,1,31]],"date-time":"2005-01-31T10:23:36Z","timestamp":1107167016000},"page":"41-53","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of theobromine and its metabolites in rabbits"],"prefix":"10.1007","volume":"13","author":[{"given":"Gian Luigi","family":"Traina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Bonati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1985,2,1]]},"reference":[{"key":"BF01073655_CR1","first-page":"1424","volume":"61","author":"W. R. Kreiser","year":"1978","unstructured":"W. R. Kreiser and R. A. Martin Jr. The determination of theobromine and caffeine in cocoa and chocolate products by HPLC.J. Assoc. Off. Anal. Chem. 61:1424\u20131427 (1978).","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"BF01073655_CR2","volume-title":"Encyclopedia of Chemical Technology, Vol. 6","author":"B. L. Zoumas","year":"1979","unstructured":"B. L. Zoumas and E. J. Finnegan. Chocolate and cocoa. In Kirk-Othmer,Encyclopedia of Chemical Technology, Vol. 6, 3rd. ed., Wiley & Sons, New York, 1979.","edition":"3rd. ed."},{"key":"BF01073655_CR3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/10408448209037495","volume":"9","author":"S. M. Tarka Jr.","year":"1982","unstructured":"S. M. Tarka, Jr. The toxicology of cocoa and methylxanthines: A review of the literature.CRC Crit. Rev. Toxicol. 9:275\u2013312 (1982).","journal-title":"CRC Crit. Rev. Toxicol."},{"key":"BF01073655_CR4","unstructured":"J. H. Andresky.Consumers Digest. Sept.\u2013Oct: 31 (1981)."},{"key":"BF01073655_CR5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02021187","volume":"4","author":"G. Czok","year":"1974","unstructured":"G. Czok. Concerning the question of the biological effectiveness of methylxanthines in cocoa products.Z. Ernaehrungswiss. 4:165 (1974).","journal-title":"Z. Ernaehrungswiss."},{"key":"BF01073655_CR6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.nu.02.070182.001543","volume":"2","author":"P. B. Dews","year":"1982","unstructured":"P. B. Dews. Caffeine.Ann. Rev. Nutr. 2:323\u2013341 (1982).","journal-title":"Ann. Rev. Nutr."},{"key":"BF01073655_CR7","unstructured":"C. I. Miles. Biological effects of caffeine. FDA status.Food Technol. 48\u201350 (Sept. 1983)."},{"key":"BF01073655_CR8","volume-title":"Caffeine","year":"1984","unstructured":"P. B. Dews. Ed.,Caffeine, Springer-Verlag, Berlin, 1984."},{"key":"BF01073655_CR9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0300-483X(84)90143-4","volume":"30","author":"M. Bonati","year":"1984","unstructured":"M. Bonati, R. Latini, B. Sadurska, E. Riva, F. Galletti, J. F. Borzelleca, S. Tarka, M. J. Arnaud, and S. Garattini. I. Kinetics and metabolism of theobromine in male rats.Toxicology 30:327\u2013341 (1984).","journal-title":"Toxicology"},{"key":"BF01073655_CR10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0300-483X(84)90144-6","volume":"30","author":"R. Latini","year":"1984","unstructured":"R. Latini, M. Bonati, F. Gaspari, G. L. Traina, L. Jiritano, A. Bortolotti, J. E. Borzelleca, S. Tarka, M. J. Arnaud, and S. Garattini. II. Kinetics and metabolism of theobromine in male and female non-pregnant and pregnant rabbits.Toxicology 30:343\u2013354 (1984).","journal-title":"Toxicology"},{"key":"BF01073655_CR11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/cpt1978233296","volume":"23","author":"D. D. Drouillard","year":"1978","unstructured":"D. D. Drouillard, E. S. Vesell, and B. H. Dvorchik. Studies on theobromine disposition in normal subjects. Alterations induced by dietary abstention from or exposure to methylxanthines.Clin Pharmacol. Ther. 23:296\u2013302 (1978).","journal-title":"Clin Pharmacol. Ther."},{"key":"BF01073655_CR12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0041-008X(83)90321-6","volume":"67","author":"C. A. Shively","year":"1983","unstructured":"C. A. Shively and S. M. Tarka Jr., Theobromine metabolism and pharmacokinetics in pregnant and nonpregnant Sprague-Dawley rats.Toxicol. Appl. Pharmacol. 67:376\u2013382 (1983).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"BF01073655_CR13","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/clpt.1983.212","volume":"34","author":"S. M. Tarka Jr.","year":"1983","unstructured":"S. M. Tarka Jr., M. J. Arnaud, B. H. Dvorchik, and E. S. Vesell. Theobromine kinetics and metabolic disposition.Clin. Pharmacol. Ther. 34:546\u2013555 (1983).","journal-title":"Clin. Pharmacol. Ther."},{"key":"BF01073655_CR14","first-page":"1","volume":"1","author":"H. Cornish","year":"1981","unstructured":"H. Cornish, M. Brabec, S. Tarka, G. Miller, L. Radulovic, and R. P. Wit. A comparative study of the metabolism of theobromine in mammalian species.Toxicologist 1:1 (1981).","journal-title":"Toxicologist"},{"key":"BF01073655_CR15","first-page":"10","volume-title":"The Rabbit in Experimental Physiology","author":"H. M. Kaplan","year":"1962","unstructured":"H. M. Kaplan.The Rabbit in Experimental Physiology, Scholar's Library, New York, 1962, pp. 10\u201311."},{"key":"BF01073655_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-4274(80)90077-6","volume":"7","author":"M. Bonati","year":"1980","unstructured":"M. Bonati, R. Latini, E. Marzi, R. Cantoni, and G. Belvedere. [2-C]Caffeine metabolism in control and 3-methylcholanthrene induced rate liver microsomes by high pressure liquid chromatography.Toxicol. Lett. 7:1\u20137 (1980).","journal-title":"Toxicol. Lett."},{"key":"BF01073655_CR17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0010-468X(83)90006-5","volume":"16","author":"G. Sacchi Landriani","year":"1983","unstructured":"G. Sacchi Landriani, V. Guardabasso, and M. Rocchetti. nl-fit: A microcomputer program for non-linear fitting.Comput. Programs Biomed. 16:35\u201342 (1983).","journal-title":"Comput. Programs Biomed."},{"key":"BF01073655_CR18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0010-468X(82)90084-8","volume":"14","author":"M. Rocchetti","year":"1982","unstructured":"M. Rocchetti and M. Recchia. spbs: Statistical programs for biological sciences-Minicomputer software for applying routine biostatistical methods.Comput. Programs Biomed. 14:7\u201320 (1982).","journal-title":"Comput. Programs Biomed."},{"key":"BF01073655_CR19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1476-5381.1967.tb01947.x","volume":"29","author":"A. J. Cummings","year":"1967","unstructured":"A. J. Cummings, B. K. Martin, and G. S. Park. Kinetic considerations relating to the accrual and elimination of drug metabolites.Br. J. Pharmac. Chemother. 29:136\u2013149 (1967).","journal-title":"Br. J. Pharmac. Chemother."},{"key":"BF01073655_CR20","volume-title":"Fundamentals of Clinical Pharmacokinetics","author":"J. G. Wagner","year":"1979","unstructured":"J. G. Wagner.Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publ., Hamilton, Ill, 1979."},{"key":"BF01073655_CR21","volume-title":"Clinical Pharmacokinetics: Concepts and Applicatins","author":"M. Rowland","year":"1980","unstructured":"M. Rowland and T. N. Tozer.Clinical Pharmacokinetics: Concepts and Applicatins, Lea & Fibiger, Philadelphia, 1980."},{"key":"BF01073655_CR22","doi-asserted-by":"crossref","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics","author":"M. Gibaldi","year":"1982","unstructured":"M. Gibaldi and D. Perrier.Pharmacokinetics, 2nd. ed., Marcel Dekker, New York, 1982.","edition":"2nd. ed."},{"key":"BF01073655_CR23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0021-9258(18)70714-X","volume":"228","author":"H. H. Cornish","year":"1957","unstructured":"H. H. Cornish and A. A. Christman. A study of the metabolism of theobromine, theophylline, and caffeine in man.J. Biol. Chem. 228:315\u2013323 (1957).","journal-title":"J. Biol. Chem."},{"key":"BF01073655_CR24","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1021\/jf60223a039","volume":"27","author":"M. J. Arnaud","year":"1979","unstructured":"M. J. Arnaud and C. Welsch. Metabolic pathway of theobromine in the rat and identification of two new metabolites in human urine.J. Agric. Food Chem. 27:524\u2013527 (1979).","journal-title":"J. Agric. Food Chem."},{"key":"BF01073655_CR25","first-page":"385","volume-title":"IXth International Colloquium in the Science and Technology of Coffee, vol. 1","author":"M. J. Arnaud","year":"1981","unstructured":"M. J. Arnaud and C. Welsch. Caffeine metabolism in human subjects. InIXth International Colloquium in the Science and Technology of Coffee, vol. 1. Association Scientifique Internationale du Caf\u00e9, Paris, pp. 385\u2013396, 1981."}],"container-title":["Journal of Pharmacokinetics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01073655.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01073655\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01073655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T12:39:25Z","timestamp":1625402365000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01073655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,2]]}},"alternative-id":["BF01073655"],"URL":"https:\/\/doi.org\/10.1007\/bf01073655","relation":{},"ISSN":["0090-466X"],"issn-type":[{"value":"0090-466X","type":"print"}],"subject":[],"published":{"date-parts":[[1985,2]]}}}