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Particularly intriguing has been independently the discovery by two laboratories, that the resorptive cell of bone, the osteoclast, is capable of detecting changes in ambient calcium. A common theme amongst all these so called \u201ccalcium-responsive\u201d cells is that extracellular calcium increases elevate intracellular calcium levels, and this intracellular signal is either stimulatory or inhibitory to the functional response. But how these cells detect changes in the concentration of extracellular calcium, and how these recognition events are subsequently transformed into intracellular signals that regulate cell function are somewhat less clear. The commentary reveals some recent developments that seemingly provide insights into these mechanisms, with special reference to the osteoclast.<\/jats:p>","DOI":"10.1007\/bf01116610","type":"journal-article","created":{"date-parts":[[2005,2,6]],"date-time":"2005-02-06T11:03:44Z","timestamp":1107687824000},"page":"493-507","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["\u201cCalcium receptors\u201d on eukaryotic cells with special reference to the osteoclast"],"prefix":"10.1042","volume":"10","author":[{"given":"Mone","family":"Zaidi","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Sciences, Division of Biochemistry, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1085\/jgp.82.2.269","volume":"82","author":"J. 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