{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T17:25:51Z","timestamp":1708968351811},"reference-count":35,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,4,1]]},"abstract":"<jats:p>By using the proton microprobe technique we have investigated the elemental composition of both pancreatic \u03b2-cells and exocrine pancreas from fed and 24 h or 48 h starved obese hyperglycemic mice. Among the 15 elements measured in the \u03b2-cells both Ca and Fe increased while Mg and S decreased significantly after 24 h of starvation, the effects being more pronounced after 48 h. When animals were starved for 48 h there was a decrease in the contents of Cl, Rb and Cu, whereas that of Al and Mn increased with 152 and 55%, respectively. There was an initial decrease in Na after 24 h of starvation, which was followed by an increase after 48 h. This is in contrast to Cd, which first increased and then decreased to a value lower than that obtained in the fed animal. The content of K showed a small decrease and that of Pb showed an increase only in the 24 h starved group. In the \u03b2-cells the contents of Zn and P did not change subsequent to starvation. In the exocrine pancreas Na, Cl and P decreased after 24 h of starvation and except for Na, the decrease was maintained when the starvation period was increased to 48 h. After 24 h there was a significant, though transient, increase in K, Mg and Rb. With regard to the contents of Zn, Cu and S there was a progressive decrease as the starvation continued. In contrast to the endocrine pancreas the content of Al in the exocrine pancreas did not change after 48 h of starvation. There was no change in islet insulin content subsequent to starvation. The extent to which the observed changes in \u03b2-cell elemental composition is involved in the impaired insulin release associated with starvation, merits further investigations.<\/jats:p>","DOI":"10.1007\/bf01119194","type":"journal-article","created":{"date-parts":[[2005,2,6]],"date-time":"2005-02-06T11:04:52Z","timestamp":1107687892000},"page":"73-84","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Starvation is associated with changes in the elemental composition of the pancreatic \u03b2-cell"],"prefix":"10.1042","volume":"11","author":[{"given":"L.","family":"Juntti-Berggren","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology, Biomedicum, University of Uppsala, Box 571, S-751 23 Uppsala, Sweden"},{"name":"The Rolf Luft Center for Diabetes Research, Department of Endocrinology, Karolinska Institute, Karolinska Hospital, Box 60500, S-104 01 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Lindh","sequence":"additional","affiliation":[{"name":"Department of Radiation Sciences, University of Uppsala, Box 531, S-751 21 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.-O.","family":"Berggren","sequence":"additional","affiliation":[{"name":"Department of Medical Cell Biology, Biomedicum, University of Uppsala, Box 571, S-751 23 Uppsala, Sweden"},{"name":"The Rolf Luft Center for Diabetes Research, Department of Endocrinology, Karolinska Institute, Karolinska Hospital, Box 60500, S-104 01 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI108574","volume":"58","author":"A. 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