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The effect of ethanol administration (12 weeks) on 5\u2032-D activity in different tissues was also studied. Ethanol induced a 5\u2032-D activity increase in hypothesis and brain frontal cortex, when compared to control animals. No change in 5\u2032-D activity is observed in either pineal gland, Harderian gland, or brown adipose tissue. Since basal values of 5\u2032-D activity in hypophysis or brain frontal cortex are particularly dependent on serum thyroxine (T4) concentration, the effect of chronic ethanol administration on thyroid hormone levels was studied. Serum T4 levels in ethanol-treated animals were significantly decreased when compared to controls at any time point studied. However, no change in serum 3\u2032,3,5-triiodothyronine (T3) levels were found.<\/jats:p>","DOI":"10.1007\/bf01145961","type":"journal-article","created":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T13:13:44Z","timestamp":1108559624000},"page":"91-98","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of chronic ethanol administration on the rat pineal N-acetyltransferase and thyroxine type II 5\u2032-deiodinase activities"],"prefix":"10.1042","volume":"13","author":[{"given":"J.","family":"Jimenez","sequence":"first","affiliation":[{"name":"The University of Seville School of Medicine, Department of Medical Biochemistry and Molecular Biology, Avda Sanchez Pizjuan 4, 41009-Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Osuna","sequence":"additional","affiliation":[{"name":"The University of Seville School of Medicine, Department of Medical Biochemistry and Molecular Biology, Avda Sanchez Pizjuan 4, 41009-Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rubio","sequence":"additional","affiliation":[{"name":"The University of Seville School of Medicine, Department of Medical Biochemistry and Molecular Biology, Avda Sanchez Pizjuan 4, 41009-Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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