{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T04:16:54Z","timestamp":1778991414294,"version":"3.51.4"},"reference-count":17,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,6,1]]},"abstract":"<jats:p>We report the effects of tetracycline analogues on cytosolic Ca2+ transients resulting from application of ionic nickel (Ni2+), a potent surrogate agonist of the osteoclast Ca2+ \u201creceptor\u201d. Preincubation with minocycline (1 mg\/l) or a chemically modified tetracycline, 4-dedimethyl-aminotetracycline (CMT-1) (1 or 10 mg\/l), resulted in a significant attenuation of the magnitude of the cytosolic [Ca2+] response to an application of 5 mM-[Ni2+]. Preincubation with doxycycline (1 or 10 mg\/l) failed to produce similar results. In addition, application of minocycline alone (0.1\u2013100 mg\/l) resulted in a 3.5-fold elevation of cytosolic [Ca2+]. The results suggest a novel action of tetracyclines on the osteoclast Ca2+ \u201creceptor\u201d.<\/jats:p>","DOI":"10.1007\/bf01149961","type":"journal-article","created":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T12:56:17Z","timestamp":1108558577000},"page":"169-174","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tetracyclines modulate cytosolic Ca2+ responses in the osteoclast associated with \u201cCa2+ receptor\u201d activation"],"prefix":"10.1042","volume":"13","author":[{"given":"Christopher M. R.","family":"Bax","sequence":"first","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijai S.","family":"Shankar","sequence":"additional","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S. M.","family":"Towhidul Alam","sequence":"additional","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget E.","family":"Bax","sequence":"additional","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baljit S.","family":"Moonga","sequence":"additional","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.-H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Physiological Laboratory, Cambridge University, Cambridge, CB2 3EG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mone","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry R.","family":"Rifkin","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, New York University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","reference":[{"key":"CR1","first-page":"85","volume-title":"Biological Mechanisms of Tooth Movement and Craniofacial Adaptation","author":"B. Rifkin","year":"1992","unstructured":"Rifkin, B., Golub, L. M., Sanavi, F., Vernillo, A. T., Kleckner, A. P., McNamara, T. F., Auszmann, J. M. and Ramamurthy, N. S. (1992) In:Biological Mechanisms of Tooth Movement and Craniofacial Adaptation. (Ed: Davidovitch, Z.) Ohio University College of Dentistry, Columbus. pp 85?90."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/BF01946671","volume":"40","author":"B. C. Gomes","year":"1984","unstructured":"Gomes, B. C., Golub, L. M. and Ramamurthy, N. S. (1984)Experientia 40:1273?1275.","journal-title":"Experientia"},{"key":"CR3","first-page":"27","volume":"68","author":"L. M. Golub","year":"1990","unstructured":"Golub, L. M., Ramamurthy, N. S., Kaneko, H., Sasaki, T., Rifkin, B. and McNamara, T. F. (1990)Res. Comm. Chem. Pathol. Pharmacol. 68:27?40.","journal-title":"Res. Comm. Chem. Pathol. Pharmacol."},{"key":"CR4","first-page":"28","volume":"14","author":"R. A. Greenwald","year":"1987","unstructured":"Greenwald, R. A., Golub, L. M., Lavietes, B., Ramamurthy, N. S., Gruber, B., Laskin, R. S. and McNamara, T. F. (1987)J. Rheumatol. 14:28?31.","journal-title":"J. Rheumatol."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jor.1100060512","volume":"6","author":"R. A. Greenwald","year":"1988","unstructured":"Greenwald, R. A., Simonson, B. G., Moak, S. A., Rush, S. W., Ramamurthy, N. S., Laskin, R. S. and Golub, L. M. (1988)J. Orthop. Res. 6:695?703.","journal-title":"J. Orthop. Res."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/0006-291X(89)91143-1","volume":"163","author":"M. Zaidi","year":"1989","unstructured":"Zaidi, M., Datta, H. K., Moonga, B. S., Patchell, A. and MacIntyre, I. (1989)Biochem. Biophys. Res. Commun. 163:1461?1465.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"14342","DOI":"10.1016\/S0021-9258(18)71683-9","volume":"264","author":"A. Malgaroli","year":"1989","unstructured":"Malgaroli, A., Meldolesi, J., Zambonin-Zallone, A. and Teti, A. (1989)J. Biol. Chem. 264:14342?14347.","journal-title":"J. Biol. Chem."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/jcp.1041490310","volume":"149","author":"M. Zaidi","year":"1991","unstructured":"Zaidi, M., Kerby, J., Huang, C. L.-H., Alam, A. S. T., Rathod, H., Chambers, T. J. and Moonga, B. S. (1991)J. Cell. Physiol. 149:422?427.","journal-title":"J. Cell. Physiol."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/jbmr.5650071111","volume":"7","author":"H. J. Donahue","year":"1992","unstructured":"Donahue, H. J., Ijima, K., Goligorsky, M. S., Rubin, C. T. and Rifkin, B. R. (1992)J. Bone Min. Res. 7:1313?1318.","journal-title":"J. Bone Min. Res."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0006-291X(92)91284-W","volume":"187","author":"V. S. Shankar","year":"1992","unstructured":"Shankar, V. S., Bax, C. M. R., Alam, A. S. M. T., Bax, B. E., Huang, C. L.-H. and Zaidi, M. (1992)Biochem. Biophys. Res. Commun. 187:913?918.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/10454411910020030201","volume":"2","author":"L. M. Golub","year":"1991","unstructured":"Golub, L. M., Ramamurthy, N. S., McNamara, T. F., Greenwald, R. A. and Rifkin, B. R. (1991) Crit.Rev. Oral Biol. Med. 2:297?322.","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/path.1711360104","volume":"136","author":"T. J. Chambers","year":"1982","unstructured":"Chambers, T. J. and Magnus, C. J. (1982)J. Pathol. 136:27?39.","journal-title":"J. Pathol."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0006-291X(92)90527-R","volume":"183","author":"C. M. R. Bax","year":"1992","unstructured":"Bax, C. M. R., Shankar, V. S., Moonga, B. S., Huang, C. L.-H. and Zaidi, M. (1992)Biochem. Biophys. Res. Commun. 183:619?625.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"CR14","first-page":"264","volume-title":"The Extra Pharmacopoeia","author":"Martindale","year":"1989","unstructured":"Martindale: (1989). The Extra Pharmacopoeia (29th edition). Pharmaceutical Press. London, p 264.","edition":"29th edition"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1677\/joe.0.1260473","volume":"125","author":"M. Zaidi","year":"1990","unstructured":"Zaidi, M., Datta, H. K., Moonga, B. S. and MacIntyre, I. (1990)J. Endocrinol. 125:473?481.","journal-title":"J. Endocrinol."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1113\/expphysiol.1991.sp003554","volume":"76","author":"B. S. Moonga","year":"1991","unstructured":"Moonga, B. S., Datta, H. K., Bevis, P. J. R., MacIntyre, I., Huang, C. L.-H. and Zaidi, M. (1991)Exp. Physiol. 76:923?933.","journal-title":"Exp. Physiol."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0006-291X(90)92097-J","volume":"167","author":"M. Zaidi","year":"1990","unstructured":"Zaidi, M., Datta, H. K. and MacIntyre, I. (1990)Biochem. Biophys. Res. Commun. 167:807?812.","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/13\/3\/169\/468756\/bsr0130169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/13\/3\/169\/468756\/bsr0130169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T17:42:57Z","timestamp":1637084577000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/13\/3\/169\/52051\/Tetracyclines-modulate-cytosolic-Ca2-responses-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6,1]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,6,1]]}},"URL":"https:\/\/doi.org\/10.1007\/bf01149961","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6,1]]}}}