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Five cell lines derived from patients with the repairdeficiency syndrome xeroderma pigmentosum (XP) were analyzed for the presence of these binding activities. Four of the cell lines were from the A-complementation group and one was from the D-complementation group of XP. The binding activity with preference for damaged DNA was present in all cell lines. The single-stranded-DNA-binding activity was present in the XP-D cell line but was absent or reduced in all of the four XP-A cell lines tested.<\/jats:p>","DOI":"10.1007\/bf01172877","type":"journal-article","created":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T19:27:34Z","timestamp":1108668454000},"page":"667-674","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cell lines from xeroderma pigmentosum complementation group A lack a single-stranded-DNA-binding activity"],"prefix":"10.1042","volume":"3","author":[{"given":"Urs","family":"Kuhnlein","sequence":"first","affiliation":[{"name":"Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., Canada V5Z 1L3"},{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada V6T 1W5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu Sing","family":"Tsang","sequence":"additional","affiliation":[{"name":"Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., Canada V5Z 1L3"},{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada V6T 1W5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Opal","family":"Lokken","sequence":"additional","affiliation":[{"name":"Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., Canada V5Z 1L3"},{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada V6T 1W5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvian","family":"Tong","sequence":"additional","affiliation":[{"name":"Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., Canada V5Z 1L3"},{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada V6T 1W5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Twa","sequence":"additional","affiliation":[{"name":"Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., Canada V5Z 1L3"},{"name":"Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada V6T 1W5"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0027-5107(81)90001-4","volume":"83","author":"AA Francis","year":"1981","unstructured":"Francis AA, Snyder RO, Dunn WC & Regan JD (1981) Mutation Res.83, 159?169.","journal-title":"Mutation Res."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-035408-5.50008-3","volume":"8","author":"EL Friedberg","year":"1979","unstructured":"Friedberg EL, Ehmann UK & Williams JI (1979) Adv. 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