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Following initial mucosal attachment, EPEC secrete \u2018signalling\u2019 proteins and expresss a surface adhesin, intimin, to produce \u2018attaching &amp; effacing\u2019 lesions in the enterocyte brush border membrane characterised by localised destruction of brush border microvilli, intimate bacterial adhesion and cytoskeletal reorganisation and accretion beneath attached bacteria. The pathophysiology of EPEC diarrhoea is also complex and probably results from a combination of epithelial cell responses including both electrolyte secretion and structural damage.<\/jats:p>","DOI":"10.1007\/bf01204350","type":"journal-article","created":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T15:37:56Z","timestamp":1108741076000},"page":"469-479","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cellular responses to enteropathogenic<i>Escherichia coli<\/i>infection"],"prefix":"10.1042","volume":"15","author":[{"given":"Stuart","family":"Knutton","sequence":"first","affiliation":[{"name":"Institute of Child Health, University of Birmingham, Fancis Road, Birmingham B16 8ET, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/00005176-198302030-00023","volume":"2","author":"M. M. 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