{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:11:43Z","timestamp":1770991903154,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[1997,3]]},"DOI":"10.1007\/bf01214668","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T19:08:10Z","timestamp":1109358490000},"page":"161-166","source":"Crossref","is-referenced-by-count":12,"title":["Expression of epidermal growth factor receptor in gestational trophoblastic diseases"],"prefix":"10.1007","volume":"123","author":[{"given":"Prabha","family":"Balaram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molykutty","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. N.","family":"Rajalekshmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balaraman","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnan","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01214668_CR1","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/0002-9378(89)90676-5","volume":"161","author":"A Berchuck","year":"1989","unstructured":"Berchuck A, Soisson AP, Olt GJ, Soper JT, et al (1989) Epidermal growth factor receptor expression in normal and malignant endometrium. Am J Obstet Gynecol 161: 1247\u20131252","journal-title":"Am J Obstet Gynecol"},{"key":"BF01214668_CR2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0002-9378(92)91858-8","volume":"166","author":"F Bisonnette","year":"1992","unstructured":"Bisonnette F, Cook C, Geoghegan T, Steflen M, et al (1992) Transforming growth factor-\u03b1 and epidermal growth factor messenger ribonucleic acid and protein levels in human placentas from early, mid, and late gestation. Am J Obstet Gynecol 166: 192\u2013199","journal-title":"Am J Obstet Gynecol"},{"key":"BF01214668_CR3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0092-8674(94)90564-9","volume":"78","author":"KL Carraway","year":"1994","unstructured":"Carraway KL, Cantley LC (1994) A New acquaintance for ErbB3 and ErbB4: a role for receptor heterodimerisation in growth signalling. Cell 78: 5\u20138","journal-title":"Cell"},{"key":"BF01214668_CR4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ijc.2910530206","volume":"53","author":"O Engebraaten","year":"1993","unstructured":"Engebraaten O, Bjerkvig R, Pedersen PH, Laerum OD (1993) Effects of EGF, bFGF, NGF and PDGF on cell proliferative, migratory and invasive capacities of human brain-tumour biopsies in vitro. Int J Cancer 53: 209\u2013214","journal-title":"Int J Cancer"},{"key":"BF01214668_CR5","first-page":"3442","volume":"44","author":"SL Fitzpatrick","year":"1984","unstructured":"Fitzpatrick SL, La Chance MP, Schulz GS (1984) Characterisation of epidermal growth factor receptor and action on human breast cancer cells in culture. Cancer Res 44: 3442\u20133447","journal-title":"Cancer Res"},{"key":"BF01214668_CR6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF00666180","volume":"29","author":"SB Fox","year":"1994","unstructured":"Fox SB, Smith K, Hollyer J, Greenall M, Hastrich D, Harris AL (1994) The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients. Breast Cancer Res Treat 29: 41\u201349","journal-title":"Breast Cancer Res Treat"},{"key":"BF01214668_CR7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ijc.2910520322","volume":"52","author":"SM Game","year":"1992","unstructured":"Game SM, Huelsen A, Patel V, Donnelly M, Yeudall WA, Stone A, Fusenig NE, Prime SS (1992) Progressive abrogation of TGF-\u03b21 and EGF growth control is associated with tumour progression in ras-transfected human keratinocytes. Int J Cancer 52: 461\u2013470","journal-title":"Int J Cancer"},{"key":"BF01214668_CR8","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1097\/00007611-197811000-00006","volume":"71","author":"KD Hatch","year":"1978","unstructured":"Hatch KD, Shingleton HM, Austin JM (1978) Southern Regional Trophoblastic Disease Centre. South Med J 71: 1334\u20131339","journal-title":"South Med J"},{"key":"BF01214668_CR9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1172\/JCI111463","volume":"74","author":"FJ Hender","year":"1984","unstructured":"Hender FJ, Ozanne BW (1984) Human squamous cell lung cancer express increased epidermal growth factor receptors. J Clin Invest 74: 647\u2013651","journal-title":"J Clin Invest"},{"key":"BF01214668_CR10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1507\/endocrj1954.30.601","volume":"30","author":"Y Hirata","year":"1983","unstructured":"Hirata Y, Uchihashi M, Fujita T, Matsukura S, et al (1983) Characteristics of specific binding of epidermal growth factor (EGF) on human tumour cell lines. Endocrinol Jpn 30: 601\u2013607","journal-title":"Endocrinol Jpn"},{"key":"BF01214668_CR11","first-page":"431","volume":"21","author":"M John","year":"1993","unstructured":"John M, Balaram P, Rajalekshmy TN, Abraham E, et al (1993) Profile of gestational trophoblastic disease in Kerala, India. Med Sci Res 21: 431\u2013432","journal-title":"Med Sci Res"},{"key":"BF01214668_CR12","first-page":"483","volume":"5","author":"P Kesavan","year":"1990","unstructured":"Kesavan P, Das P, Kern J, Das M (1990) Regulation of stability and synthesis of EGF-receptor mRNAs encoding for intact and truncated receptor forms. Oncogene 5: 483\u2013488","journal-title":"Oncogene"},{"key":"BF01214668_CR13","first-page":"21","volume":"13","author":"JGM Klijn","year":"1992","unstructured":"Klijn JGM, Berns PMJJ, Schmitz PIM, Foekens JA (1992) The clinical significance of epidermal growth factor receptor in human breast cancer: review of 5232 patients. Endocrine Rev 13: 21\u201327","journal-title":"Endocrine Rev"},{"key":"BF01214668_CR14","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0002-9378(12)90766-8","volume":"165","author":"C Ladines-Llave","year":"1991","unstructured":"Ladines-Llave C, Maruo T, Manalo AS, Mochizuki M (1991) Cytologic localization of epidermal growth factor and its receptor in developing human placenta varies over the course of pregnancy. Am J Obstet Gynecol 165: 1377\u20131382","journal-title":"Am J Obstet Gynecol"},{"key":"BF01214668_CR15","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1002\/1097-0142(19930615)71:12<4118::AID-CNCR2820711251>3.0.CO;2-H","volume":"71","author":"CA Ladines-Llave","year":"1993","unstructured":"Ladines-Llave CA, Maruo T, Manalo AM, Mochizuki M (1993) Decreased expression of epidermal growth factor and its receptor in the malignant transformation of trophoblasts. Cancer 71: 4118\u20134123","journal-title":"Cancer"},{"key":"BF01214668_CR16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/1097-0142(19930715)72:2<519::AID-CNCR2820720231>3.0.CO;2-#","volume":"72","author":"RJ Lelle","year":"1993","unstructured":"Lelle RJ, Talavera F, Gretz H, Roberts JA, Menon KMJ (1993) Epidermal growth factor receptor expression in three different human endometrial cancer cell lines. Cancer 72: 519\u2013525","journal-title":"Cancer"},{"key":"BF01214668_CR17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0002-9378(87)90086-X","volume":"156","author":"T Maruo","year":"1987","unstructured":"Maruo T, Mochizuki M (1987) Immunohistochemical localization of epidermal growth factor receptor and myc oncogene product in human placenta: Implication for trophoblast proliferation and differentiation. Am J Obstet Gynecol 156: 721\u2013727","journal-title":"Am J Obstet Gynecol"},{"key":"BF01214668_CR18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0002-9378(77)90562-2","volume":"128","author":"CP Morrow","year":"1977","unstructured":"Morrow CP, Kletzky OA, DiSaia PJ, Townsend DE, et al (1977) Clinical and laboratory correlates of molar pregnancy and trophoblastic disease. Am J Obstet Gynecol 128: 424\u2013428","journal-title":"Am J Obstet Gynecol"},{"key":"BF01214668_CR19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/41.2.8093455","volume":"41","author":"J Muhlhauser","year":"1993","unstructured":"Muhlhauser J, Crescimanno C, Kaufmann P, Hofler H, et al (1993) Differentiation and proliferation patterns in human trophoblast revealed by c-erb-2 oncogene product and EGFR. J Histochem Cytochem 41: 165\u2013173","journal-title":"J Histochem Cytochem"},{"key":"BF01214668_CR20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/1097-0142(19910701)68:1<142::AID-CNCR2820680126>3.0.CO;2-X","volume":"68","author":"H Mukaida","year":"1991","unstructured":"Mukaida H, Toi M, Hirai Y, Yamashita Y, Toge T, et al (1991) Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer. Cancer 68: 142\u2013148","journal-title":"Cancer"},{"key":"BF01214668_CR21","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/bjc.1995.239","volume":"71","author":"JC Newby","year":"1995","unstructured":"Newby JC, A'Hern RP, Leek RD, Smith IE, Harris AL, Dowsett M (1995) Immunohistochemical assay for epidermal growth factor receptor on paraffin-embedded sections: validation against ligand binding assay and clinical relevance in breast cancer. Br J Cancer 71: 1237\u20131242","journal-title":"Br J Cancer"},{"key":"BF01214668_CR22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ijc.2910420108","volume":"42","author":"S Nicholson","year":"1988","unstructured":"Nicholson S, Sainsbury JRC, Needham GK, Chambers P, et al (1988) Quantitative assays of epidermal growth factor receptor in human breast cancer: cut-off points of clinical relevance. Int J Cancer 42: 36\u201341","journal-title":"Int J Cancer"},{"key":"BF01214668_CR23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00666178","volume":"29","author":"N Normanno","year":"1994","unstructured":"Normanno N, Clardello F, Brand R, Salmon DS (1994) Epidermal growth factor related peptides in the pathogenesis of human breast cancer. Breast Cancer Res Treat 29: 11\u201327","journal-title":"Breast Cancer Res Treat"},{"key":"BF01214668_CR24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0090-8258(88)90046-7","volume":"30","author":"F Parrazini","year":"1988","unstructured":"Parrazini F, Mangili G, Belloni C, La Vecchia, et al (1988) The problem of identification of prognostic factors for persistent trophoblastic disease. Gynecol Oncol 30: 57\u201362","journal-title":"Gynecol Oncol"},{"key":"BF01214668_CR25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00666177","volume":"29","author":"T Rajkumar","year":"1994","unstructured":"Rajkumar T, Gullick WJ (1994) The type 1 growth factor receptors in human breast cancer. Breast Cancer Res Treat 29: 3\u20139","journal-title":"Breast Cancer Res Treat"},{"key":"BF01214668_CR26","first-page":"1398","volume":"I","author":"JRC Sainsbury","year":"1987","unstructured":"Sainsbury JRC, Fandon JR, Needham GK, Malcom AJ, Harris AL (1987) Epidermal growth factor receptor status as predictor of early recurrence of an death from breast cancer. Lancet I: 1398\u20131402","journal-title":"Lancet"},{"key":"BF01214668_CR27","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1126\/science.7618085","volume":"269","author":"M Sibilia","year":"1995","unstructured":"Sibilia M, Wagner EF (1995) Strain dependent epithelial defects in mice lacking the EGF receptor. Science 269: 234\u2013238","journal-title":"Science"},{"key":"BF01214668_CR28","first-page":"5810","volume":"49","author":"K Smith","year":"1989","unstructured":"Smith K, Fennelly JA, Neal DE, Hall RR, Harris AL (1989) Characterisation and quantitation of the epidermal growth factor receptor in invasive and superficial bladder tumours. Cancer Res 49: 5810\u20135818","journal-title":"Cancer Res"},{"key":"BF01214668_CR29","unstructured":"WHO Scientific Group (1983) Gestational trophoblastic diseases. WHO Tech Rep Ser 692"},{"key":"BF01214668_CR30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1349-7006.1990.tb02644.x","volume":"81","author":"H Yamazaki","year":"1990","unstructured":"Yamazaki H, Ohba Y, Tamaoki N, Shibuya M (1990) A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors. Jpn J Cancer Res 81: 773\u2013779","journal-title":"Jpn J Cancer Res"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01214668.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01214668\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01214668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T09:55:35Z","timestamp":1556790935000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01214668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["BF01214668"],"URL":"https:\/\/doi.org\/10.1007\/bf01214668","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}