{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:52:01Z","timestamp":1792147921965,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1979,3,1]],"date-time":"1979-03-01T00:00:00Z","timestamp":289094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1979,3]]},"DOI":"10.1007\/bf01308429","type":"journal-article","created":{"date-parts":[[2005,3,25]],"date-time":"2005-03-25T12:31:50Z","timestamp":1111753910000},"page":"197-202","source":"Crossref","is-referenced-by-count":57,"title":["Platelet function in chronic liver disease"],"prefix":"10.1007","volume":"24","author":[{"given":"M. H.","family":"Rubin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Weston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. G.","family":"Langley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1056\/NEJM196107132650202","volume":"265","author":"E Mandel","year":"1961","unstructured":"Mandel E, Lazerson J: Thombasthenia in liver disease. N Engl J Med 265:56?61, 1961","journal-title":"N Engl J Med"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1749-6632.1972.tb16302.x","volume":"201","author":"DP Thomas","year":"1972","unstructured":"Thomas DP: Abnormalities of platelet aggregation in patients with alcoholic cirrhosis. Ann NY Acad Sci 201:243?250, 1972","journal-title":"Ann NY Acad Sci"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/archinte.1976.03630030050009","volume":"136","author":"HS Ballard","year":"1976","unstructured":"Ballard HS, Marcus AJ: Platelet aggregation in portal cirrhosis. Arch Intern Med 136:316?319, 1976","journal-title":"Arch Intern Med"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/ajcp\/44.6.678","volume":"44","author":"BS Bull","year":"1965","unstructured":"Bull BS, Schneiderman MA, Brecher G: Platelet counts with the Coulter counter. Am J Clin Pathol 44:678?688, 1965","journal-title":"Am J Clin Pathol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1365-2141.1967.tb00768.x","volume":"13","author":"PM Manucci","year":"1967","unstructured":"Manucci PM, Sharp AA: Platelet volume and shape in relation to aggregation and adhesion. Br J Haematol 13: 604?618, 1967","journal-title":"Br J Haematol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1182\/blood.V34.2.204.204","volume":"34","author":"CH Mielke","year":"1969","unstructured":"Mielke CH, Kaneshiro MM, Maher IA, Weinner JM, Rapaport SI: The standardized normal Ivy bleeding time and its prolongation by aspirin. Blood 34:204?215, 1969","journal-title":"Blood"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2141.1965.tb06586.x","volume":"11","author":"RM Hardisty","year":"1965","unstructured":"Hardisty RM, Hutton RA: The kaolin clotting time of platelet-rich plasma: A test of platelet factor 3 availability. Br J Haematol 11:258?268, 1965","journal-title":"Br J Haematol"},{"key":"CR8","volume-title":"Practical Haematology","author":"JV Dacie","year":"1975","unstructured":"Dacie JV, Lewis SM: Practical Haematology, 5th edition. Edinburgh, Churchill Livingstone, 1975","edition":"5th edition"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0009-8981(63)90080-9","volume":"8","author":"C Vermylen","year":"1963","unstructured":"Vermylen C, De Vreker RA, Verstraete M: A rapid enzymatic method for assay of fibrinogen fibrin polymerisation time (FPT test). Clin Chim Acta 8:418?425, 1963","journal-title":"Clin Chim Acta"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1172\/JCI104953","volume":"43","author":"AP Fletcher","year":"1964","unstructured":"Fletcher AP, Biederman O, Moore D, Alkjaersig N, Sherry S: Abnormal plasminogen-plasmin system activity (fibrinolysis) in patients with hepatic cirrhosis: Its cause and consequences. J Clin Invest 43:681?695, 1964","journal-title":"J Clin Invest"},{"key":"CR11","first-page":"476","volume":"15","author":"M Kopec","year":"1966","unstructured":"Kopec M, Budzynski A, Stachurska J, Wegrzynowicz Z, Kowalski E: Studies on mechanism of interference by fibrinogen degradation products (FDP) with platelet function: Role of fibrinogen in platelet atmosphere. Thromb Diath Haemorrh 15:476?490, 1966","journal-title":"Thromb Diath Haemorrh"},{"key":"CR12","first-page":"339","volume":"183","author":"MH Rubin","year":"1977","unstructured":"Rubin MH, Weston MJ, Bullock G, Roberts J, Langley P, White YS, Williams R: Abnormal platelet function and ultrastructure in fulminant hepatic failure. Q J Med 183:339?352, 1977","journal-title":"Q J Med"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1172\/JCI106064","volume":"48","author":"S Karpatkin","year":"1969","unstructured":"Karpatkin S: Heterogeneity of human platelets. II Functional evidence suggestive of young and old platelets. J Clin Invest 48:1083?1087, 1969","journal-title":"J Clin Invest"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-0038-1649381","volume":"27","author":"AD Ginsburg","year":"1972","unstructured":"Ginsburg AD, Aster RH: Changes associated with platelet aging. Thromb Diath Haemorrh 27:407?415, 1972","journal-title":"Thromb Diath Haemorrh"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1182\/blood.V51.2.307.307","volume":"51","author":"S Karpatkin","year":"1978","unstructured":"Karpatkin S: Heterogeneity of human platelets VI. correlation of platelet function with platelet volume. Blood 51:307?315, 1978","journal-title":"Blood"},{"key":"CR16","first-page":"302","volume":"81","author":"NR Shulman","year":"1968","unstructured":"Shulman NR, Watkins SP, Itscoitz SB, Students AB: Evidence that the spleen retains the youngest and hemostatically most effective platelets. Trans Assoc Am Physicians 81:302?313, 1968","journal-title":"Trans Assoc Am Physicians"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2141.1975.tb00855.x","volume":"31","author":"ML Freedman","year":"1975","unstructured":"Freedman ML, Karpatkin S: Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes. Br J Haematol 31:255?262, 1975","journal-title":"Br J Haematol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1172\/JCI105380","volume":"15","author":"RH Aster","year":"1966","unstructured":"Aster RH: Pooling of platelets in the spleen: Role in the pathogenesis of ?hypersplenic thrombocytopenia.? J Clin Invest 15:645?657, 1966","journal-title":"J Clin Invest"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-89-2-200","volume":"89","author":"S Karpatkin","year":"1978","unstructured":"Karpatkin S, Freedman ML: Hypersplenic thrombocytopenia differentiated from increased peripheral destruction by platelet volume. Ann Intern Med 89:200?203, 1978","journal-title":"Ann Intern Med"},{"key":"CR20","unstructured":"Siemensma NP, Bathal PS, Penington DG: The effect of massive liver resection on platelet kinetics in the rat. J Lab Clin Med 86:817?833"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01308429.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01308429\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01308429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T14:02:59Z","timestamp":1586181779000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01308429"}},"subtitle":["Relationship to disease severity"],"short-title":[],"issued":{"date-parts":[[1979,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,3]]}},"alternative-id":["BF01308429"],"URL":"https:\/\/doi.org\/10.1007\/bf01308429","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,3]]}}}