{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:20:56Z","timestamp":1779236456698,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"S11","license":[{"start":{"date-parts":[[1985,11,1]],"date-time":"1985-11-01T00:00:00Z","timestamp":499651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1985,11]]},"DOI":"10.1007\/bf01309391","type":"journal-article","created":{"date-parts":[[2005,3,25]],"date-time":"2005-03-25T23:12:29Z","timestamp":1111792349000},"page":"83S-94S","source":"Crossref","is-referenced-by-count":27,"title":["Prostaglandins and histological changes in the gastric mucosa"],"prefix":"10.1007","volume":"30","author":[{"given":"Eric R.","family":"Lacy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0016-5085(79)90002-7","volume":"77","author":"A Robert","year":"1979","unstructured":"Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433?443, 1979","journal-title":"Gastroenterology"},{"key":"CR2","first-page":"507","volume":"2","author":"A Robert","year":"1975","unstructured":"Robert A: Antisecretory, anti-ulcer, cytoprotective and diarrheogenic properties of prostaglandins. Adv Prostaglandin Thromboxane Res 2:507?520, 1975","journal-title":"Adv Prostaglandin Thromboxane Res"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0016-5085(79)90235-X","volume":"77","author":"A Robert","year":"1979","unstructured":"Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761?767, 1979","journal-title":"Gastroenterology"},{"key":"CR4","first-page":"G601","volume":"245","author":"TA Miller","year":"1983","unstructured":"Miller TA: Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 245:G601?623, 1983","journal-title":"Am J Physiol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0016-5085(82)80198-4","volume":"83","author":"ER Lacy","year":"1982","unstructured":"Lacy ER, Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 83:619?625, 1982","journal-title":"Gastroenterology"},{"key":"CR6","first-page":"49","volume-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","author":"ER Lacy","year":"1984","unstructured":"Lacy ER, Ito S: Ethanol-induced insult to the superficial rat gastric epithelium: A study of damage and rapid repair.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract A Allen, G, Flemstr\u00f6m, A Garner, W, Silen, LA Turnberg (eds). New York, Raven Press, 1984, pp 49?56"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02892800","volume":"38","author":"GP Morris","year":"1981","unstructured":"Morris GP, Wallace JL: The roles of ethanol and of acid in the production of gastric mucosal erosions in rats. Virchows Arch (Cell Pathol) 38:23?38, 1981","journal-title":"Virchows Arch (Cell Pathol)"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0016-5085(84)80068-2","volume":"87","author":"PH Guth","year":"1984","unstructured":"Guth PH, Paulsen G, Nagata H: Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection. Gastroenterology 87:1083?1090, 1984","journal-title":"Gastroenterology"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1139\/y82-247","volume":"60","author":"JL Wallace","year":"1982","unstructured":"Wallace JL, Morris GP, Krausse EJ, Greaves SE: Reduction by cytoprotective agents of ethanol-induced damage to rat gastric mucosa: a correlated morphological and physiological study. Can J Physiol Pharmacol 60:1686?1699, 1982","journal-title":"Can J Physiol Pharmacol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0016-5085(85)80189-X","volume":"88","author":"T Ohno","year":"1985","unstructured":"Ohno T, Ohtsuki H, Okabe S: Effect of 16, 16-dimethyl prostaglandin E2 on ethanol-induced and aspirin-induced gastric damage in the rat. Scanning electron microscopic study. Gastroenterology 88:353?361, 1985","journal-title":"Gastroenterology"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0016-5085(85)80188-8","volume":"88","author":"A Tarnawski","year":"1985","unstructured":"Tarnawski A, Hollander D, Stachura J, Krause WJ, Gergely H: Prostaglandin protection of the gastric mucosa against alcohol injury?a dynamic time-related process. Gastroenterology 88:334?352, 1985","journal-title":"Gastroenterology"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0016-5085(85)80186-4","volume":"88","author":"BJR Whittle","year":"1985","unstructured":"Whittle BJR, Steel G: Evaluation of the protection of rat gastric mucosa by a prostaglandin analogue using cellular enzyme markers and histologic techniques. Gastroenterology 88:315?327,1985","journal-title":"Gastroenterology"},{"key":"CR13","first-page":"57","volume-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","author":"A Robert","year":"1984","unstructured":"Robert A: Role of endogenous and exogenous prostaglandins in mucosal protection.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A Allen, G Flemstr\u00f6m, A Garner, W Silen, LA Turnberg (eds). New York, Raven Press, 1984, pp 57?63"},{"key":"CR14","first-page":"381","volume-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","author":"A Robert","year":"1984","unstructured":"Robert A: Cytoprotection: What it is and what it is not.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract A Allen G Flemstr\u00f6m, A Garner, W Silen, LA Turnberg (eds). New York, Raven Press, 1984, pp 381?382"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0016-5085(85)80187-6","volume":"88","author":"A Robert","year":"1985","unstructured":"Robert A, Lancaster C, Davis JP, Field SO, Sinha AJW, Thornburgh BA: Cytoprotection by prostaglandin occurs in spite of penetration of absolute ethanol into the gastric mucosa. Gastroenterology 88:328?333, 1985","journal-title":"Gastroenterology"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0016-5085(85)80178-5","volume":"88","author":"S Ito","year":"1985","unstructured":"Ito S, Lacy ER: Morphology of rat gastric mucosal damage, defense and restitution in the presence of luminal ethanol. Gastroenterology 88:250?260, 1985","journal-title":"Gastroenterology"},{"key":"CR17","first-page":"57","volume-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","author":"S Ito","year":"1984","unstructured":"Ito S, Lacy ER: Characteristics of ethanol induced lesions in rat gastric mucosa.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A Allen, G Flemstr\u00f6m, A Garner, W Silen, LA Turnberg (eds). New York. Raven Press, 1984, pp 57?63"},{"key":"CR18","first-page":"573","volume":"51","author":"ER Lacy","year":"1984","unstructured":"Lacy ER, Ito S: Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab Invest 51:573?583, 1984","journal-title":"Lab Invest"},{"issue":"Suppl. 110)","key":"CR19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/00365528509095834","volume":"20","author":"ER Lacy","year":"1985","unstructured":"Lacy ER: Gastric mucosal resistance to a repeated ethanol insult. Scand J Gastroenterol 20 (Suppl. 110):63?72, 1985","journal-title":"Scand J Gastroenterol"},{"issue":"Suppl 101)","key":"CR20","first-page":"87","volume":"19","author":"S Ito","year":"1984","unstructured":"Ito S, Lacy ER, Rutten MJ, Critchlow J, Silen W: Rapid repair of injured gastric mucosa. Scand J Gastroenterol 19 (Suppl 101):87?96, 1984","journal-title":"Scand J Gastroenterol"},{"key":"CR21","first-page":"253","volume-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","author":"PH Guth","year":"1984","unstructured":"Guth PH: Local metabolism and circulation in mucosal defense.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A Allen, G Flemstr\u00f6m, A Garner, W Silen, LA Turnberg (eds) New York, Raven Press, 1984, pp 253?258"},{"key":"CR22","first-page":"G171","volume":"244","author":"MJ Rutten","year":"1983","unstructured":"Rutten MJ, Ito S: Morphology and electrophysiology of guinea pig gastric mucosal repairin vitro. Am J Physiol 244:G171-G182, 1983","journal-title":"Am J Physiol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/0016-5085(82)90077-4","volume":"82","author":"K Svanes","year":"1982","unstructured":"Svanes K, Ito S: Takeuchi K, Silen W: Restitution of the surface epithelium ofin vitro frog gastric mucosa after damage with hyperosmolar sodium chloride. Gastroenterology 82:1409?1426, 1982","journal-title":"Gastroenterology"},{"key":"CR24","first-page":"627","volume":"15","author":"HF Helander","year":"1983","unstructured":"Helander HF: Morphological studies on the margin of gastric corpus wounds in the rat. J Submicrosc Cytol 15:627?643, 1983","journal-title":"J Submicrosc Cytol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0016-5085(81)90723-X","volume":"80","author":"H Blom","year":"1981","unstructured":"Blom H, Helander HF: Quantitative ultrastructural studies on parietal cell regeneration in experimental ulcers in rat gastric mucosa. Gastroenterology 80:334?343, 1981","journal-title":"Gastroenterology"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/aja.1001090204","volume":"109","author":"SF Townsend","year":"1961","unstructured":"Townsend SF: Regeneration of the gastric mucosa in rats. Am J Anat 109:133?147, 1961","journal-title":"Am J Anat"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0016-5085(66)80027-6","volume":"50","author":"HW Davenport","year":"1966","unstructured":"Davenport HW: Fluid produced by the gastric mucosa during damage by acetic and salicylic acids. Gastroenterology 50:487?499, 1966","journal-title":"Gastroenterology"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF02890313","volume":"46","author":"GP Morris","year":"1984","unstructured":"Morris GP, Harding RK, Wallace JL: A functional model for extracellular mucus in the rat. Virchows Arch (Cell Pathol) 46:239?251, 1984","journal-title":"Virchows Arch (Cell Pathol)"},{"key":"CR29","first-page":"33","volume-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","author":"K Svanes","year":"1984","unstructured":"Svanes K, Critchlow J, Takeuchi K, Magee D, Ito S, Silen W: Factors influencing reconstitution of frog gastric mucosa: role of prostaglandins.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A Allen, G Flemstr\u00f6m, A Garner, W Silen, LA Turnberg (eds). New York, Raven Press, 1984, pp 33?39"},{"key":"CR30","first-page":"287","volume-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","author":"S Szabo","year":"1984","unstructured":"Szabo S, Trier JS: Pathogenesis of acute gastric mucosal injury: Sulfhydryls as a protector, adrenal cortex as a modulator, and vascular endothelium as a target.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A Allen, G Flemstr\u00f6m, A Garner, W Silen, LA Turnberg (eds). New York, Raven Press, 1984, pp 287?292"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0016-5085(75)80280-0","volume":"68","author":"WP Ritchie Jr","year":"1975","unstructured":"Ritchie WP Jr: Acute gastric mucosal damage induced by bile salts, acid, and ischemia. Gastroenterology 68:699?707, 1975","journal-title":"Gastroenterology"},{"key":"CR32","first-page":"150","volume":"91","author":"WA Mersereau","year":"1982","unstructured":"Mersereau WA, Hinchey EJ: Role of gastric mucosal folds in formation of focal ulcers in the rat. Surgery 91:150?155, 1982","journal-title":"Surgery"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3181\/00379727-145-38012","volume":"145","author":"K Pinar","year":"1974","unstructured":"Pinar K, Schult WJ, Barboirak JJ: Histologic study of gastric lesions of food-restricted rats. Proc Soc Exp Biol Med 145:1353?1358, 1974","journal-title":"Proc Soc Exp Biol Med"},{"key":"CR34","first-page":"154","volume":"70","author":"FE Moody","year":"1971","unstructured":"Moody FE, Aldrete JS: Hydrogen permeability of canine gastric secretory epithelium during the formation of acute superficial erosions. Surgery 70:154?160, 1971","journal-title":"Surgery"},{"key":"CR35","first-page":"1110","volume":"82","author":"C Lancaster","year":"1982","unstructured":"Lancaster C, Nezamis JE, Robert A: Dissolution of gastric mucosal folds does not explain cytoprotection by prostaglandins. Gastroenterology 82:1110, 1982","journal-title":"Gastroenterology"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0016-5085(85)80176-1","volume":"88","author":"S Szabo","year":"1985","unstructured":"Szabo S, Trier JS, Brown A, Schnoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88:228?236, 1985","journal-title":"Gastroenterology"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0016-5085(83)80131-0","volume":"84","author":"KM Takeuchi","year":"1983","unstructured":"Takeuchi KM, Magee J, Critchlow J, Matthews J, Silen W: Studies of the pH gradient and thickness of frog gastric mucus gel. Gastroenterology 84:331?340, 1983","journal-title":"Gastroenterology"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF01072421","volume":"23","author":"JP Bolton","year":"1978","unstructured":"Bolton JP, Palmer D, Cohen MM: Stimulation of mucus and non-parietal cell secretion by E2 prostaglandins. Am J Dig Dis 23:359?364, 1978","journal-title":"Am J Dig Dis"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2362.1979.tb00928.x","volume":"9","author":"C Johansson","year":"1979","unstructured":"Johansson C, Kollberg B: Stimulation by intragastrically administered E2 prostaglandins of human gastric mucus output. Eur J Clin Invest 9:229?232, 1979","journal-title":"Eur J Clin Invest"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3109\/00365528109182025","volume":"16","author":"H Ruppin","year":"1981","unstructured":"Ruppin H, Person B, Robert A, Domschke W: Gastric cytoprotection in man by prostaglandin E2. Scand J Gastroenterol 16:647?652, 1981","journal-title":"Scand J Gastroenterol"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/0016-5085(81)90139-6","volume":"80","author":"M Bickel","year":"1981","unstructured":"Bickel M, Kauffman GL Jr: Gastric gel mucus thickness: Effect of distension, 16,16-dimethyl prostaglandin E2 and carbenoxolone. Gastroenterology 80:770?775, 1981","journal-title":"Gastroenterology"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0016-5085(83)80128-0","volume":"84","author":"JT Lamont","year":"1983","unstructured":"Lamont JT, Ventola AS, Maull EA, Szabo S: Cysteamine and prostaglandin F2? stimulate gastric mucin release. Gastroenterology 84:306?313, 1983","journal-title":"Gastroenterology"},{"key":"CR43","first-page":"G388","volume":"2425","author":"S McQueen","year":"1983","unstructured":"McQueen S, Hutton D, Allen A, Garner A: Gastric and duodenal surface mucus gel thickness in rat: Effects of prostaglandins and damaging agents. Am J Physiol 2425:G388-G393, 1983","journal-title":"Am J Physiol"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0016-5085(84)80115-8","volume":"86","author":"A Robert","year":"1984","unstructured":"Robert A, Bottcher W, Golanska E, Kauffman GL Jr: Lack of correlation between mucus gel thickness and gastric cytoprotection in rats. Gastroenterology 86:670?674, 1984","journal-title":"Gastroenterology"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0016-5085(79)90228-2","volume":"77","author":"CA Zalewsky","year":"1979","unstructured":"Zalewsky CA, Moody FG: Mechanisms of mucus release in exposed canine gastric mucosa. Gastroenterology 77:719?729, 1979","journal-title":"Gastroenterology"},{"key":"CR46","first-page":"G370","volume":"242","author":"RD Specian","year":"1982","unstructured":"Specian RD, Neutra MR: Regulation of intestinal goblet cell secretion. I. Role of parasympathetic stimulation. Am J Physiol 242:G370-G379, 1982","journal-title":"Am J Physiol"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0016-5085(85)80177-3","volume":"88","author":"J Critchlow","year":"1985","unstructured":"Critchlow J, Magee D, Ito S, Takeuchi K, Silen W: Requirements for restitution of the surface epithelium of frog stomach after mucosal injury. Gastroenterology 88:237?249, 1985","journal-title":"Gastroenterology"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"G113","DOI":"10.1152\/ajpcell.1983.245.1.C113","volume":"245","author":"A Robert","year":"1983","unstructured":"Robert A, Nezamis JE, Lancaster C, Davis JP, Field SO, Hanchar AJ: Mild irritants prevent gastric necrosis through ?adaptive cytoprotection? mediated by prostaglandins. Am J Physiol 245:G113-G121, 1983","journal-title":"Am J Physiol"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3181\/00379727-126-32532","volume":"126","author":"HW Davenport","year":"1967","unstructured":"Davenport HW: Ethanol damage to canine oxyntic glandular mucosa. Proc Soc Exp Biol Med 126:657?662, 1967","journal-title":"Proc Soc Exp Biol Med"},{"key":"CR50","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/BF02236042","volume":"15","author":"VP Dinoso","year":"1978","unstructured":"Dinoso VP, Chey WY, Siplet H, Lorber SH: Effects of ethanol on the gastric mucosa of the Heidenhain pouch of dogs. Dig Dis Sci 15:809?816, 1978","journal-title":"Dig Dis Sci"},{"key":"CR51","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0016-5085(19)32927-0","volume":"67","author":"GL Eastwood","year":"1974","unstructured":"Eastwood GL, Kirchner JP: Changes in the fine structure of mouse gastric epithelium produced by ethanol and urea. Gastroenterology 67:71?84, 1974","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01309391.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01309391\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01309391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T14:19:30Z","timestamp":1586182770000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01309391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":51,"journal-issue":{"issue":"S11","published-print":{"date-parts":[[1985,11]]}},"alternative-id":["BF01309391"],"URL":"https:\/\/doi.org\/10.1007\/bf01309391","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}