{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:38:52Z","timestamp":1779377932738,"version":"3.53.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"S12","license":[{"start":{"date-parts":[[1987,12,1]],"date-time":"1987-12-01T00:00:00Z","timestamp":565315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1987,12]]},"DOI":"10.1007\/bf01312464","type":"journal-article","created":{"date-parts":[[2005,3,25]],"date-time":"2005-03-25T19:15:13Z","timestamp":1111778113000},"page":"S51-S56","source":"Crossref","is-referenced-by-count":52,"title":["Possible mode of action of 5-aminosalicylic acid"],"prefix":"10.1007","volume":"32","author":[{"given":"B. M.","family":"Peskar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. W.","family":"Dreyling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Schaarschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Goebell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","first-page":"555","volume":"181","author":"MA Peppercorn","year":"1972","unstructured":"Peppercorn MA, Goldman P: The role of intestinal bacteria in the metabolism of salicylazosulfapyridin. J Pharmacol Exp Ther 181: 555?562, 1972","journal-title":"J Pharmacol Exp Ther"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/cpt1972134539","volume":"13","author":"H Schroeder","year":"1972","unstructured":"Schroeder H, Campbell DES: Absorption, metabolism and excretion of salicylazosulfapyridine in man. Clin Pharmacol Ther 13: 539?551, 1972","journal-title":"Clin Pharmacol Ther"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0016-5085(73)80035-6","volume":"64","author":"MA Peppercorn","year":"1973","unstructured":"Peppercorn MA, Goldman P: Distribution studies of salizylazosulphapyridine and its metabolites. Gastroenterology 64: 240?245, 1973","journal-title":"Gastroenterology"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2165\/00003088-197601060-00002","volume":"1","author":"KM Das","year":"1976","unstructured":"Das KM, Dubin R: Clinical pharmacokinetics of sulphasalazine. Clin Pharmacokinet 1: 406?425, 1976","journal-title":"Clin Pharmacokinet"},{"key":"CR5","first-page":"892","volume":"2","author":"AH Azad Kahn","year":"1977","unstructured":"Azad Kahn AH, Piris J, Truelove SC: An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet 2: 892?895, 1977","journal-title":"Lancet"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/gut.21.7.632","volume":"21","author":"PAM Hees van","year":"1977","unstructured":"van Hees PAM, Bakker JH, van Tongeren JHM: Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in patients with idiopathic proctitis: A study to determine the active therapeutic moiety of sulphasalazine. Gut 21: 632?653, 1977","journal-title":"Gut"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1056\/NEJM198012253032602","volume":"303","author":"U Klotz","year":"1980","unstructured":"Klotz U, Maier K, Fischer C, Heinkel K: Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative colitis and Crohn's disease. N Engl J Med 303: 1499?1502, 1980","journal-title":"N Engl J Med"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/bmj.287.6399.1099","volume":"287","author":"VC Neumann","year":"1983","unstructured":"Neumann VC, Grindulis KA, Hubball S, McConkey B, Wright V: Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial. Br Med J 287: 1099?1102, 1983","journal-title":"Br Med J"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1136\/bmj.287.6399.1102","volume":"287","author":"T Pullar","year":"1983","unstructured":"Pullar T, Hunter JA, Capell HA: Sulphasalazine in rheumatoid arthritis: A double blind comparison of sulphasalazine with placebo and sodium aurothiomalate. Br Med J 287: 1102?1104, 1983","journal-title":"Br Med J"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.0954-6820.1963.tb17422.x","volume":"173","author":"A Hanngren","year":"1963","unstructured":"Hanngren A, Hansson E, Svartz N, Ullberg S: Distribution and metabolism of salicyl-azosulphapyridine II. A study with S35-salicyl-azosulphapyridine and S35-sulphapyridine. Acta Med Scand 173: 391?399, 1963","journal-title":"Acta Med Scand"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/gut.15.12.960","volume":"15","author":"B West","year":"1974","unstructured":"West B, Lendrum R, Hill MJ, Walker G: Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with in patients with inflammatory bowel disease. Gut 15: 960?965, 1974","journal-title":"Gut"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/00365528109182016","volume":"16","author":"A Krook","year":"1981","unstructured":"Krook A: Effect of metronidazole and sulfasalazine on the normal human faecal flora. Scand J Gastroenterol 16: 587?594, 1981","journal-title":"Scand J Gastroenterol"},{"key":"CR13","first-page":"855","volume":"13","author":"J Harris","year":"1974","unstructured":"Harris J, Archampong EQ, Clark CG: The effect of salazopyrin on water and electrolyte transport in the human colon measuredin vivo andin vitro. Gut 13: 855, 1974","journal-title":"Gut"},{"key":"CR14","first-page":"217","volume":"33","author":"A Rubenstein","year":"1978","unstructured":"Rubenstein A, Das KM, Melamed J, Murphy RA: Comparative analysis of systemic immunological parameters in ulcerative colitis and idiopathic proctitis: Effects of sulphasalazinein vitro andin vivo. Clin Exp Immunol 33: 217?224, 1978","journal-title":"Clin Exp Immunol"},{"key":"CR15","first-page":"506","volume":"1","author":"ATMM Ali","year":"1982","unstructured":"Ali ATMM, Basran GS, Morley J: Mode of action of sulphasalazine: An alternative view. Lancet 1: 506?507, 1982","journal-title":"Lancet"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0162-3109(86)90030-5","volume":"11","author":"RP MacDermott","year":"1986","unstructured":"MacDermott RP, Kane MG, Steele LL, Stenson WF: Inhibition of cytotoxicity by sulfasalazine. I. Sulfasalazine inhibits spontaneous cell-mediated cytotoxicity by peripheral blood and intestinal mononuclear cells from control and inflammatory bowel disease patients. Immunopharmacology 11: 101?109, 1986","journal-title":"Immunopharmacology"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0162-3109(86)90031-7","volume":"11","author":"F Shanahan","year":"1986","unstructured":"Shanahan F, Niederlehner A, MacDermott RP, Stenson WF, Kane MG, Targan S: Inhibition of cytotoxicity by sulfasalazine. II. Sulfasalazine and sulfapyridine inhibit different stages of the NK and NKCF lytic process. Immunopharmacology 11: 111?118, 1986","journal-title":"Immunopharmacology"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3109\/00365527809181381","volume":"13","author":"M Lau Laursen","year":"1978","unstructured":"Lau Laursen M: The influence of salicylazosulfapyridine on the immune response to antigenic tumor cells inoculated into the caecal lumen of C3H mice. Scand J Gastroenterol 13: 991?997, 1978","journal-title":"Scand J Gastroenterol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1136\/bmj.286.6377.1547","volume":"286","author":"JP Delamere","year":"1983","unstructured":"Delamere JP, Farr M, Grindulis KA: Sulphasalazine-induced selective IgA deficiency in rheumatoid arthritis. Br Med J 286: 1547?1548, 1983","journal-title":"Br Med J"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.0954-6820.1979.tb13545.x","volume":"206","author":"L Molin","year":"1979","unstructured":"Molin L, Stendahl O: The effect of sulfasalazine and its active components on human polymorphonuclear leukocyte function in relation to ulcerative colitis. Acta Med Scand 206: 451?457, 1979","journal-title":"Acta Med Scand"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/gut.22.8.642","volume":"22","author":"JM Rhodes","year":"1981","unstructured":"Rhodes JM, Bartholomew TC, Jewell DP: Inhibition of leukocyte motility by drugs used in ulcerative colitis. Gut 22: 642?647, 1981","journal-title":"Gut"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0006-2952(84)90233-8","volume":"33","author":"WF Stenson","year":"1984","unstructured":"Stenson WF, Mehta J, Spilberg I: Sulfasalazine inhibition of binding ofn-formyl-methionyl-leucyl-phenylalanine (FMLP) to its receptors on human neutrophils. Biochem Pharmacol 33: 407?412, 1984","journal-title":"Biochem Pharmacol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0016-5085(73)80120-9","volume":"64","author":"JL Franklin","year":"1973","unstructured":"Franklin JL, Rosenberg IH: Impaired folic acid absorption in inflammatory bowel disease: Effects of salicylazosulfapyridine. Gastroenterology 64: 517?525, 1973","journal-title":"Gastroenterology"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1172\/JCI108921","volume":"61","author":"J Selhub","year":"1978","unstructured":"Selhub J, Dhar GJ, Rosenberg IH: Inhibition of folate enzymes by sulfasalazine. J Clin Invest 61: 221?224, 1978","journal-title":"J Clin Invest"},{"key":"CR25","first-page":"779","volume":"97","author":"CL Baum","year":"1981","unstructured":"Baum CL, Selhub J, Rosenberg IH: Antifolate actions of sulfasalazine on intact lymphocytes. J Lab Clin Med 97: 779, 1981","journal-title":"J Lab Clin Med"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-2952(86)90517-4","volume":"35","author":"W Roediger","year":"1986","unstructured":"Roediger W, Schapel G, Lawson M, Radcliffe B, Nance S: Effect of 5-aminosalicylic acid (5-ASA) and other salicylates on short-chain fat metabolism in the colonic mucosa?pharmacological implications for ulcerative colitis. Biochem Pharmacol 35: 221?225, 1986","journal-title":"Biochem Pharmacol"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1136\/gut.25.12.1399","volume":"25","author":"DS Rampton","year":"1984","unstructured":"Rampton DS, Hawkey CJ: Prostaglandins and ulcerative colitis. Gut 25: 1399?1413, 1984","journal-title":"Gut"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0016-5085(84)80015-3","volume":"86","author":"P Sharon","year":"1984","unstructured":"Sharon P, Stenson WF: Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 86: 453?460, 1984","journal-title":"Gastroenterology"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0016-5085(86)90684-0","volume":"97","author":"K Lauritsen","year":"1986","unstructured":"Lauritsen K, Laursen LS, Bukhave K, Rask-Madsen J: Effects of the topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibriumin vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology 97: 837?844, 1986","journal-title":"Gastroenterology"},{"key":"CR30","first-page":"A542","volume":"26","author":"BM Peskar","year":"1985","unstructured":"Peskar BM, Dreyling KW, May B, Thieves M, Morgenroth K, et al. Increased formation of leukotriene B4 and sulfidopeptide-leukotrienes by rectal mucosa of patients with Crohn's disease and ulcerative colitis. Gut 26: A542-A543, 1985","journal-title":"Gut"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF01965001","volume":"18","author":"BM Peskar","year":"1986","unstructured":"Peskar BM, Dreyling KW, Peskar BA, May B, Goebell H: Enhanced formation of sulfidopeptide-leukotrienes in ulcerative colitis and Crohn's disease: Inhibition by sulfasalazine and 5-aminosalicylic acid. Agents and Actions 18: 381?383, 1986","journal-title":"Agents and Actions"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1172\/JCI110474","volume":"69","author":"WF Stenson","year":"1982","unstructured":"Stenson WF, Lobos E: Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils. J Clin Invest 69: 494?497, 1982","journal-title":"J Clin Invest"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/0006-2952(85)90570-2","volume":"34","author":"MK Bach","year":"1985","unstructured":"Bach MK, Brashler JR: Johnson MA: Inhibition by sulfasalazine of LTC synthetase and of rat liver glutathione Stransferase. Biochem Pharmacol 34: 2695?2704, 1985","journal-title":"Biochem Pharmacol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/BF01314051","volume":"30","author":"CJ Hawkey","year":"1985","unstructured":"Hawkey CJ, Boughton-Smith NK, Whittle BJR: Modulation of human colonic arachidonic acid metabolism by sulfasalazine. Dig Dis Sci 30: 1161?1165, 1985","journal-title":"Dig Dis Sci"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0016-5085(85)80132-3","volume":"88","author":"P Sharon","year":"1985","unstructured":"Sharon P, Stenson WF: Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease. Gastroenterology 88: 55?62, 1985","journal-title":"Gastroenterology"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(82)80715-1","volume":"146","author":"U Aehringhaus","year":"1982","unstructured":"Aehringhaus U, Woelbling RH, Koenig W, Patrono C, Peskar BM, Peskar BA: Release of leukotriene C4 from human polymorphonuclear leukocytes as determined by radioimmunoassay. FEBS Lett 146: 111?114, 1982","journal-title":"FEBS Lett"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0005-2760(86)90145-1","volume":"878","author":"KW Dreyling","year":"1986","unstructured":"Dreyling KW, Hoppe U, Peskar BA, Morgenroth K, Kozuschek W, Peskar BM: Leukotriene synthesis by human gastroinestinal tissues. Biochim Biophys Acta 878: 184?193, 1986","journal-title":"Biochim Biophys Acta"},{"key":"CR38","first-page":"339","volume-title":"Advances in Prostaglandins, Thromboxane and Leukotriene Research. Vol 17","author":"KW Dreyling","year":"1987","unstructured":"Dreyling KW, Hoppe U, Peskar BA, Schaarschmidt K, Peskar BM: Leukotrienes in Crohn's disease: Effect of sulfasalazine and 5-aminosalicylic acid.In Advances in Prostaglandins, Thromboxane and Leukotriene Research. Vol 17, B Samuelsson, R Paoletti, P Ramwell (eds). New York, Raven Press, 1987, pp 339?343"},{"key":"CR39","first-page":"261","volume-title":"Inflammation Mechanisms and Control","author":"JR Vane","year":"1972","unstructured":"Vane JR: Prostaglandins in the inflammatory response.In Inflammation Mechanisms and Control. IH Lepow, PA Ward (eds). New York, Academic Press, 1972, pp 261?275"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.6301011","volume":"220","author":"B Samuelsson","year":"1983","unstructured":"Samuelsson B: Leukotrienes. Mediators of immediate hypersensitivity reactions and inflammation. Science 220: 568?575, 1983","journal-title":"Science"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(81)90235-X","volume":"2","author":"T Schlenker","year":"1981","unstructured":"Schlenker T, Peskar BM: Dual effect of sulphasalazine on colonic prostaglandin synthetase. Lancet 2: 815, 1981","journal-title":"Lancet"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1476-5381.1980.tb10865.x","volume":"68","author":"JRS Hoult","year":"1980","unstructured":"Hoult JRS, Moore PK: Effects of sulphasalazine and its metabolites on prostaglandin synthesis, inactivation and actions on smooth muscle. Br J Pharmacol 68: 719?730, 1980","journal-title":"Br J Pharmacol"},{"key":"CR43","first-page":"A444","volume":"23","author":"BM Peskar","year":"1982","unstructured":"Peskar BM, Schlenker T, Weiler H: Effect of sulphasalazine (SASP) and 5-aminosalicylic acid (5-ASA) on the human colonic prostaglandin system. Gut 23: A444, 1982","journal-title":"Gut"},{"key":"CR44","first-page":"185","volume-title":"New Trends in Pathophysiology and Therapy of the Large Bowel","author":"BM Peskar","year":"1983","unstructured":"Peskar BM: Effects of sulphasalazine and 5-aminosalicylic acid on the human colonic prostaglandin system.In New Trends in Pathophysiology and Therapy of the Large Bowel. L Barbara, M Miglioli, SF Phillips (eds). Amsterdam, Elsevier, 1983, pp 185?196"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0016-5085(19)31672-5","volume":"75","author":"P Sharon","year":"1978","unstructured":"Sharon P, Ligumsky M, Rachmilewitz D, Zor U: Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology 75: 638?640, 1978","journal-title":"Gastroenterology"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0140-6736(81)90502-X","volume":"2","author":"JRS Hoult","year":"1981","unstructured":"Hoult JRS, Page H: 5-aminosalicylic acid, a cofactor for colonic prostacyclin synthesis? Lancet 2: 255, 1981","journal-title":"Lancet"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0016-5085(79)91355-6","volume":"77","author":"T Gilat","year":"1979","unstructured":"Gilat T, Ratan J, Rosen P, Peled J: Prostaglandins and ulcerative colitis. Gastroenterology 77: 1083, 1979","journal-title":"Gastroenterology"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0090-6980(81)90087-3","volume":"21","author":"DS Rampton","year":"1981","unstructured":"Rampton DS, Sladen GE: Prostaglandin synthesis inhibitors in ulcerative colitis: Flurbiprofen compared with conventional treatment. Prostaglandins 21: 417?425, 1981","journal-title":"Prostaglandins"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/S0016-5085(84)80164-X","volume":"86","author":"K Lauritsen","year":"1984","unstructured":"Lauritsen K, Hansen J, Ryde M, Rask-Madsen J: Colonic azoidisalicylate metabolism determined byin vivo dialysis in healthy volunteers and patients with ulcerative colitis. Gastroenterology 86: 1496?1500, 1984","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01312464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01312464\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01312464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T14:12:03Z","timestamp":1586182323000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01312464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12]]},"references-count":49,"journal-issue":{"issue":"S12","published-print":{"date-parts":[[1987,12]]}},"alternative-id":["BF01312464"],"URL":"https:\/\/doi.org\/10.1007\/bf01312464","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12]]}}}