{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:26:43Z","timestamp":1771644403349,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1993,3]]},"DOI":"10.1007\/bf01316491","type":"journal-article","created":{"date-parts":[[2005,3,25]],"date-time":"2005-03-25T23:31:22Z","timestamp":1111793482000},"page":"403-409","source":"Crossref","is-referenced-by-count":31,"title":["Duodenal brush-border mucosal glucose transport and enzyme activities in aging man and effect of bacterial contamination of the small intestine"],"prefix":"10.1007","volume":"38","author":[{"given":"Jennifer L.","family":"Wallis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Lipski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Mathers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver F. W.","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry H.","family":"Hirst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"689","volume":"14","author":"PR Holt","year":"1985","unstructured":"Holt PR: The small intestine. Clin Gastroenterol 14:689?723, 1985","journal-title":"Clin Gastroenterol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/BF01391447","volume":"27","author":"JH Feibusch","year":"1982","unstructured":"Feibusch JH, Holt PR: Impaired absorptive capacity for carbohydrate in the ageing human. Dig Dis Sci 27:1095?1100, 1982","journal-title":"Dig Dis Sci"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/ageing\/16.5.294","volume":"16","author":"DM Beaumont","year":"1987","unstructured":"Beaumont DM, Cobden I, Sheldon WL, Laker MF, James OFW: Passive and active carbohydrate absorption by the ageing gut. Age Ageing 16:294?300, 1987","journal-title":"Age Ageing"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0047-6374(89)90023-7","volume":"48","author":"MT Vincenzini","year":"1989","unstructured":"Vincenzini MT, Iantomasi T, Stio M, Favilli F, Vanni P, Tonelli F, Treves C: Glucose transport during ageing by human intestinal brush-border membrane vesicles. Mech Ageing Dev 48:33?41, 1989","journal-title":"Mech Ageing Dev"},{"key":"CR5","first-page":"G328","volume":"249","author":"G Esposito","year":"1985","unstructured":"Esposito G, Faelli A, Tosco M, Orsenigo MN, Battistessa R: Age-related changes in rat intestinal transport ofd-glucose, sodium, and water. Am J Physiol 249:G328-G334, 1985","journal-title":"Am J Physiol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0005-2736(85)90509-7","volume":"816","author":"C Lindi","year":"1985","unstructured":"Lindi C, Marciani P, Faelli A, Esposito G: Intestinal sugar transport during ageing. Biochim Biophys Acta 816:411?414, 1985","journal-title":"Biochim Biophys Acta"},{"key":"CR7","first-page":"G208","volume":"251","author":"HJ Freeman","year":"1986","unstructured":"Freeman HJ, Quamme GA: Age-related changes in sodium-dependent glucose transport in the rat small intestine. Am J Physiol 251:G208-G217, 1986","journal-title":"Am J Physiol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0531-5565(87)90033-7","volume":"22","author":"WC Eastin","year":"1987","unstructured":"Eastin WC, Birnbaum LS: Intestinal absorption of two glucose analogues in rats of different ages. Exp Geroltol 22:351?357, 1987","journal-title":"Exp Geroltol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0047-6374(87)90089-3","volume":"39","author":"WG Doubek","year":"1987","unstructured":"Doubek WG, Armbrecht HJ: Changes in glucose transport over the lifespan of the rat. Mech Ageing Dev 39:91?102, 1987","journal-title":"Mech Ageing Dev"},{"key":"CR10","unstructured":"Hirst BH, Wallis JW: Sodium-coupledd-glucose uptake in adult and aged mouse and rat jejuna brush border membrane vesiclesin vitro. J Physiol 422:67P, 1990"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0047-6374(88)90121-2","volume":"46","author":"JS Thompson","year":"1988","unstructured":"Thompson JS, Crouse DA, Mann SL, Saxena SK, Sharp JG: Intestinal glucose uptake is increased in aged mice. Mech Ageing Dev 46:135?143, 1988","journal-title":"Mech Ageing Dev"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1136\/gut.29.11.1557","volume":"29","author":"F Raul","year":"1988","unstructured":"Raul F, Gosse F, Doffoel M, Darmenton P, Wessely JY: Age related increase of brush border enzyme activities along the small intestine. Gut 29:1557?1563, 1988","journal-title":"Gut"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0047-6374(89)90058-4","volume":"50","author":"P Darmenton","year":"1989","unstructured":"Darmenton P, Raul F, Doffoel M, Wessley J-Y: Age influence on sucrose hydrolysis and on monosaccharide absorption along the small intestine of rat. Mech Ageing Dev 50:49?55, 1989","journal-title":"Mech Ageing Dev"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0531-5565(77)90010-9","volume":"12","author":"F Moog","year":"1977","unstructured":"Moog F: The small intestine in old mice: growth, alkaline phosphatase and disaccharidase activities, and deposition of amyloid. Exp Gerontol 12:223?235, 1977","journal-title":"Exp Gerontol"},{"key":"CR15","first-page":"453","volume":"26","author":"K Rommel","year":"1972","unstructured":"Rommel K, B\u00f6hmer R: Beziehungen zwischen Lebensalter, intestinalen disaccharidasen und Monosaccharidabsorption der Ratte. Arzneim Forsch 26:453?457, 1972","journal-title":"Arzneim Forsch"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0047-6374(78)90068-4","volume":"7","author":"P H\u00f6hn","year":"1978","unstructured":"H\u00f6hn P, Gabbert H, Wagner R: Differentiation and aging of the rat intestinal mucosa. II. Morphological, enzyme-histochemical and disc electrophoretic aspects of the aging of the small intestinal mucosa. Mech Ageing Dev 7:217?226, 1978","journal-title":"Mech Ageing Dev"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/0016-5085(85)90204-5","volume":"89","author":"PR Holt","year":"1985","unstructured":"Holt PR, Tierney AR, Kolter DP: Delayed enzyme expression: A defect of aging rat gut. Gastroenterology 89:1026?1034, 1985","journal-title":"Gastroenterology"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0035-9203(85)90167-1","volume":"79","author":"BS Anand","year":"1985","unstructured":"Anand BS, Chaudhary A, Jyothi A, Yadev RS, Baveja UK: Experimental examination of the direct damaging effects ofG. lamblia on intestinal mucosal scrappings of mice. Trans R Soc Trop Med Hyg 79:613?617, 1985","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/gut.30.9.1213","volume":"30","author":"M Belosevic","year":"1989","unstructured":"Belosevic M, Faubert GM, Maclean JD: Disaccharidase activity in the small intestine of gerbils (Meriones unguiculatus) during primary and challenge infections withGiardia lamblia. Gut 30:1213?1219, 1989","journal-title":"Gut"},{"key":"CR20","first-page":"801","volume":"17","author":"HK Samra","year":"1988","unstructured":"Samra HK, Ganguly NK, Garg UC, Goyal J, Mahajan RC: Effect of excretory-secretory products ofGiardia lamblia on glucose and phenylalanine transport in the small intestine of Swiss albino mice. Biochem Int 17:801?812, 1988","journal-title":"Biochem Int"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0140-6736(77)90436-6","volume":"2","author":"SH Roberts","year":"1977","unstructured":"Roberts SH, James OFW, Jarvis EH: Bacterial overgrowth syndrome without ?blind loop?: A cause for malnutrition in the elderly. Lancet 2:1193?1195 1977","journal-title":"Lancet"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/bmj.287.6395.789","volume":"287","author":"A McEvoy","year":"1983","unstructured":"McEvoy A, Dutton J, James OFW: Bacterial contamination of the small intestine as an important cause of occult malabsorption in the elderly. Br Med J 287:789?793, 1983","journal-title":"Br Med J"},{"key":"CR23","first-page":"999","volume":"42","author":"NY Haboubi","year":"1988","unstructured":"Haboubi NY, Cowley PA, Lee GS: Small bowel bacterial overgrowth: A cause of malnutrition in the elderly? Eur J Clin Nutr 42:999?1005, 1988","journal-title":"Eur J Clin Nutr"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(71)80068-5","volume":"2","author":"H Fromm","year":"1971","unstructured":"Fromm H, Hofmann AF: Breath test for altered bile acid metabolism. Lancet 2:621?625, 1971","journal-title":"Lancet"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/bmj.3.5873.191","volume":"3","author":"OFW James","year":"1973","unstructured":"James OFW, Agnew JE, Bouchier IAD: Assessment of the14C-glycocholic acid breath test. Br Med J 3:191?195, 1973","journal-title":"Br Med J"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0140-6736(76)92779-3","volume":"1","author":"G Metz","year":"1976","unstructured":"Metz G, Gassull MA, Drasar BS, Jenkins DSA, Blendis LM: Breath hydrogen test for small bacterial contamination. Lancet 1:668?669, 1976","journal-title":"Lancet"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0009-8981(80)90004-2","volume":"108","author":"K Bartlett","year":"1980","unstructured":"Bartlett K, Dobson JV, Eastham E: A new method for the detection of hydrogen in breath and its application for acquired and inborn sugar malabsorption. Clin Chim Acta 108:189?194, 1980","journal-title":"Clin Chim Acta"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0006-291X(88)80819-2","volume":"156","author":"JM Harig","year":"1988","unstructured":"Harig JM, Soergel KH, Barry J, Ramaswamy K: Brush border membrane vesicles formed from human duodenal biopsies exhibit Na+-dependent concentrativel-leucine andd-glucose uptake. Biochem Biophys Res Commun 156:164?170, 1988","journal-title":"Biochem Biophys Res Commun"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/cvr\/18.6.384","volume":"18","author":"DJ Hearse","year":"1984","unstructured":"Hearse DJ: Microbiopsy metabolite and paired flow analysis: A new rapid procedure for homogenisation, extraction and analysis of high energy phosphates and other intermediates without any errors from tissue loss. Cardiovasc Res 18:384?390, 1984","journal-title":"Cardiovasc Res"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248?254, 1976","journal-title":"Anal Biochem"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/00365518409161400","volume":"44","author":"A Dahlqvist","year":"1984","unstructured":"Dahlqvist A: Assay of intestinal disaccharidases: Scand J Clin Lab Invest 44:169?172, 1984","journal-title":"Scand J Clin Lab Invest"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265?275, 1951","journal-title":"J Biol Chem"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9258(18)43072-4","volume":"164","author":"O Bessey","year":"1946","unstructured":"Bessey O, Lowry OH, Brock MJ: A method for the rapid determination of alkaline phosphatase. J Biol Chem 164:321?329, 1946","journal-title":"J Biol Chem"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/bj1720057","volume":"172","author":"W Haase","year":"1978","unstructured":"Haase W, Schafer A, Murer H, Kinne R: Studies on the orientation of brush border membrane vesicles. Biochem J 172:57?62, 1978","journal-title":"Biochem J"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/cs0510557","volume":"51","author":"TJ Peters","year":"1976","unstructured":"Peters TJ: Analytical subcellular fractionation of jejunal biopsy specimens: Methodology and characterization of the organelles in normal tissue. Clin Sci 51:557?574, 1976","journal-title":"Clin Sci"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00580831","volume":"373","author":"H L\u00fccke","year":"1978","unstructured":"L\u00fccke H, Berner W, Menge H, Murer H: Sugar transport by brush border membrane vesicles isolated from human small intestine. Pfluegers Arch 373:243?248, 1978","journal-title":"Pfluegers Arch"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/bj2370229","volume":"237","author":"MK Bluett","year":"1986","unstructured":"Bluett MK, Abumrad NN, Arab N, Ghishan FK: Aboral changes ind-glucose transport by human intestinal brush-border membrane vesicles. Biochem J 237:229?234, 1986","journal-title":"Biochem J"},{"key":"CR38","first-page":"G618","volume":"256","author":"JM Harig","year":"1989","unstructured":"Harig JM, Barry JA, Rajendran VM, Soergel KH, Ramaswamy K:d-Glucose andl-leucine transport by human intestinal brush-border membrane vesicles. Am J Physiol 256:G618-G623, 1989","journal-title":"Am J Physiol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/0016-5085(90)90288-C","volume":"98","author":"SP Shirazi-Beechey","year":"1989","unstructured":"Shirazi-Beechey SP, Davies AG, Tebbutt K, Dyer J, Ellis A, Taylor CJ, Fairclough P, Beechey RB: Preparation and properties of brush-border membrane vesicles from human small intestine. Gastroenterology 98:676?685, 1989","journal-title":"Gastroenterology"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/S0016-5085(83)80014-6","volume":"85","author":"N Triadou","year":"1983","unstructured":"Triadou N, Bataille J, Schmitz J: Longitudinal study of the human intestinal brush border membrane proteins. Distribution of the main disaccharidases and peptidases. Gastroenterology 85:1326?1332, 1983","journal-title":"Gastroenterology"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/00365528609034621","volume":"21","author":"K-\u00c5 J\u00f6nsson","year":"1986","unstructured":"J\u00f6nsson K-\u00c5, Bodemar G, Tagesson C, Walan A: Variation of disaccharidase activities in duodenal biopsy specimens. Scand J Gastroenterol 21:51?54, 1986","journal-title":"Scand J Gastroenterol"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0016-5085(86)90935-2","volume":"90","author":"C Guedon","year":"1986","unstructured":"Guedon C, Schmitz J, Lerebours E, Metayer J, Audran E, Hemet J, Colin R: Decreased brush border hydrolase activities without gross morphological changes in human intestinal mucosa after prolonged total parental nutrition of adults. Gastroenterology 90:373?378, 1986","journal-title":"Gastroenterology"},{"key":"CR43","first-page":"425","volume-title":"Carbohydrate Metabolism and Its Disorders, Vol 3","author":"G Semenza","year":"1981","unstructured":"Semenza G: Intestinal oligo- and disaccharidases.In Carbohydrate Metabolism and Its Disorders, Vol 3. PJ Randle, DF Steiner WJ Whelan (eds). London, Academic Press, 1981, pp 425?479"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000416401","volume":"57","author":"T Goda","year":"1988","unstructured":"Goda T, Koldovsky O: Dietary regulation of small intestinal disaccharidases. World Rev Nutr Diet 57:275?329, 1988","journal-title":"World Rev Nutr Diet"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/gut.31.7.770","volume":"31","author":"K Walshe","year":"1990","unstructured":"Walshe K, Healy MJ, Speekenbrink AB, Keane CT, Weir DG, O'Moore RR: Effects of an enteric anaerobic bacterial culture supernatant and deoxycholate on intestinal calcium absorption and disaccharidase activity. Gut 31:770?776, 1990","journal-title":"Gut"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01316491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01316491\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01316491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T11:46:14Z","timestamp":1625658374000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01316491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["BF01316491"],"URL":"https:\/\/doi.org\/10.1007\/bf01316491","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}