{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:25:54Z","timestamp":1791199554823,"version":"4.2.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1981,3,1]],"date-time":"1981-03-01T00:00:00Z","timestamp":352252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1981,3]]},"DOI":"10.1007\/bf01391638","type":"journal-article","created":{"date-parts":[[2005,4,2]],"date-time":"2005-04-02T10:12:36Z","timestamp":1112436756000},"page":"247-252","source":"Crossref","is-referenced-by-count":57,"title":["Is there an immune deficit in Whipple's disease?"],"prefix":"10.1007","volume":"26","author":[{"suffix":"III","given":"William O.","family":"Dobbins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01391638_CR1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00005792-197005000-00001","volume":"49","author":"H Maizel","year":"1970","unstructured":"Maizel H, Ruffin JM, Dobbins WO III: Whipple's disease: A review of 19 patients from one hospital and a review of the literature since 1950. Medicine 49:175\u2013205, 1970","journal-title":"Medicine"},{"key":"BF01391638_CR2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM197904193001607","volume":"300","author":"GE Feurle","year":"1979","unstructured":"Feurle GE, Yolk B, Waldherr R: Cerebral Whipple's disease with negative jejunal histology. N Engl J Med 300:907\u2013908, 1979","journal-title":"N Engl J Med"},{"key":"BF01391638_CR3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1177\/014107687907201116","volume":"72","author":"J Winfield","year":"1979","unstructured":"Winfield J, Dourmashkin RR, Gumpel JM: Diagnostic difficulties in Whipple's disease. J R Soc Med 72:859\u2013863, 1979","journal-title":"J R Soc Med"},{"key":"BF01391638_CR4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.7326\/0003-4819-89-1-64","volume":"89","author":"CM Mansbach II","year":"1978","unstructured":"Mansbach CM II, Shelburne FA, Stevens RD, Dobbins WO III: Lymph node bacilli-form bodies resembling those of Whipple's disease in a patient without intestinal involvement. Ann Intern Med 89:64\u201366, 1978","journal-title":"Ann Intern Med"},{"key":"BF01391638_CR5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ana.410010308","volume":"1","author":"PF Finelli","year":"1977","unstructured":"Finelli PF, McEntee WJ, Lessel S, Morgan TF, Copetto J: Whipple's disease with predominantly neuroophthalmic manifestations. Ann Neurol 1:247\u2013252, 1977","journal-title":"Ann Neurol"},{"key":"BF01391638_CR6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00685145","volume":"36","author":"SW Silbert","year":"1976","unstructured":"Silbert SW, Parker E, Horenstein S: Whipple's disease of the central nervous system. Acta Neuropathol 36:31\u201338, 1976","journal-title":"Acta Neuropathol"},{"key":"BF01391638_CR7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1001\/archinte.1969.00300110076015","volume":"123","author":"SM Switz","year":"1969","unstructured":"Switz SM, Casey TR, Bogaty GV: Whipple's disease and papilledema. Arch Intern Med 123:74\u201377, 1969","journal-title":"Arch Intern Med"},{"key":"BF01391638_CR8","first-page":"225","volume":"51","author":"WO Dobbins III","year":"1967","unstructured":"Dobbins WO III, Ruffin JM: A light and electron microscopic study of bacterial invasion in Whipple's disease. Am J Pathol 51:225\u2013242, 1967","journal-title":"Am J Pathol"},{"key":"BF01391638_CR9","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0140-6736(68)90239-0","volume":"1","author":"JD Maxwell","year":"1968","unstructured":"Maxwell JD, Ferguson A, McKay AM, Imrie RC, Watson WC: Lymphocytes in Whipple's disease. Lancet 1:887\u2013889, 1968","journal-title":"Lancet"},{"key":"BF01391638_CR10","first-page":"2127","volume":"48","author":"M Cerf","year":"1970","unstructured":"Cerf M, Hurez D, Marche CL, Debray C: Etude des plasmocytes de L'intestin grele au cours de la maladie de Whipple. Presse Med 48:2127\u20132129, 1970","journal-title":"Presse Med"},{"key":"BF01391638_CR11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0016-5085(19)33170-1","volume":"63","author":"A Groll","year":"1972","unstructured":"Groll A, Valberg LS, Simon JB, Eidinger D, Wilson B, Forsdyke DR: Immunological defect in Whipple's disease. Gastroenterology 63:943\u2013950, 1972","journal-title":"Gastroenterology"},{"key":"BF01391638_CR12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0016-5085(78)90421-3","volume":"75","author":"PM Kirkpatrick","year":"1978","unstructured":"Kirkpatrick PM, Kent SP, Minas A, Pritchett P: Whipple's disease: A case report with immunological studies. Gastroenterology 75:297\u2013301, 1978","journal-title":"Gastroenterology"},{"key":"BF01391638_CR13","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0016-5085(79)80067-0","volume":"77","author":"DF Keren","year":"1979","unstructured":"Keren DF, Weinrieb IF, Bertovich MJ, Brady PG: Whipple's disease \u2014 immunological studies. Gastroenterology 77:991\u2013996, 1979","journal-title":"Gastroenterology"},{"key":"BF01391638_CR14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2362.1979.tb00901.x","volume":"9","author":"GE Feurle","year":"1979","unstructured":"Feurle GE, D\u00f6rken B, Sch\u00f6pf E, Lenhard V: HLA B27 and defects in the T-cell system in Whipple's disease. Eur J Clin Invest 9:385\u2013389, 1979","journal-title":"Eur J Clin Invest"},{"key":"BF01391638_CR15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01102877","volume":"382","author":"I Babaryka","year":"1979","unstructured":"Babaryka I, Thorn L, Langer E: Epitheloid cell granulomata in the mucosa of the small intestine in Whipple's disease. Virch Arch A Pathol Anat Histol 382:227\u2013235, 1979","journal-title":"Virch Arch A Pathol Anat Histol"},{"key":"BF01391638_CR16","first-page":"659","volume":"64","author":"P Barbier","year":"1975","unstructured":"Barbier P, Balasse-Ketelbant, P, Kennes B: Maladie de Whipple\u2014etude electronique et immunologique. Arch Fr Mal Appl Dig 64:659\u2013666, 1975","journal-title":"Arch Fr Mal Appl Dig"},{"key":"BF01391638_CR17","first-page":"477","volume":"110","author":"SC Berens","year":"1969","unstructured":"Berens SC, Cohen RA, Schwabe AD: Case Reports: Diagnostic problems of partially treated Whipple's disease. Calif Med 110:477\u2013481, 1969","journal-title":"Calif Med"},{"key":"BF01391638_CR18","first-page":"207","volume":"25","author":"P Bienveno","year":"1976","unstructured":"Bienveno P, Groussin P, Metman EG, Medelsi M, Morand P: Maladie de Whipple avec localisations cardiaques. Ann Cardiol Angeiol 25:207\u2013216, 1976","journal-title":"Ann Cardiol Angeiol"},{"key":"BF01391638_CR19","unstructured":"Bloch HM, Hammersma T, Vorster L, Ziady F: Whipple's disease\u2014a case report. S Afr Med J 1105\u20131110, 1978"},{"key":"BF01391638_CR20","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/BF01468478","volume":"52","author":"K Buchholz","year":"1974","unstructured":"Buchholz K, Maintz J, Otto HF: Klinisch-immunologische und electronenmikroskopishe Untersuchungen bei Morbus Whipple. Klin Wochenschr 52:672\u2013677, 1974","journal-title":"Klin Wochenschr"},{"key":"BF01391638_CR21","first-page":"79","volume":"5","author":"JJ Canoso","year":"1978","unstructured":"Canoso JJ, Saini M, Harmos JA: Whipple's disease and anklylosing spondylitis simultaneous occurrence in HLA-B27 postive male. J Rheumatol 5:79\u201384, 1978","journal-title":"J Rheumatol"},{"key":"BF01391638_CR22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJM197109022851008","volume":"285","author":"Case Records of the Massachusetts General Hospital (Case 35-1971)","year":"1971","unstructured":"Case Records of the Massachusetts General Hospital (Case 35-1971). N Engl J Med 285: 567\u2013575, 1971","journal-title":"N Engl J Med"},{"key":"BF01391638_CR23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/pgmj.49.571.355","volume":"49","author":"M Cochran","year":"1973","unstructured":"Cochran M, Gallagher JC, Cook MG, Peacock M: Case Reports: Hypogammaglobulinemia with Whipple's disease. Postgrad Med J 49:355\u2013358, 1973","journal-title":"Postgrad Med J"},{"key":"BF01391638_CR24","first-page":"139","volume":"127","author":"A Cornet","year":"1976","unstructured":"Cornet A, Barbier J, Henry-Barbaud E, Malvy JP, Benisty J, Carnot F: Maladie de Whipple\u2014Localisations granulomateuses hepatiques decelees par ponction-biopse due foie. Ann Med Intern 127:139\u2013146, 1976","journal-title":"Ann Med Intern"},{"key":"BF01391638_CR25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0016-5085(19)33750-3","volume":"59","author":"AP Douglas","year":"1970","unstructured":"Douglas AP, Crabbe PA, Hobbs JR: Immunochemical studies of the serum intestinal secretions and intestinal mucosa in patients with adult celiac sprue disease and other forms of the celiac syndrome. Gastroenterology 59:414\u2013425, 1970","journal-title":"Gastroenterology"},{"key":"BF01391638_CR26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.0954-6820.1975.tb19519.x","volume":"198","author":"L Elsborg","year":"1975","unstructured":"Elsborg L, Gravgaard E, Jacobsen NO: Treatment of Whipple's disease with sulphamethoxazole-trimethoprim. Acta Med Scand 198:141\u2013143, 1975","journal-title":"Acta Med Scand"},{"key":"BF01391638_CR27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/pgmj.54.627.45","volume":"54","author":"MR Haeney","year":"1978","unstructured":"Haeney MR, Ross IN: Whipple's disease in a female with impaired cell-mediated immunity unresponsive to co-trimoxazole and levamisole therapy. Postgrad Med J 54:45\u201350, 1978","journal-title":"Postgrad Med J"},{"key":"BF01391638_CR28","first-page":"51","volume":"139","author":"DF Keren","year":"1976","unstructured":"Keren DF, Weisburger WR, Yardley JH, Salyer WR, Arthur RR, Charache P: Whipple's disease: Demonstration by immunofluorescence of similar bacterial antigens in macrophages from three cases. Johns Hopkins Med J 139:51\u201359, 1976","journal-title":"Johns Hopkins Med J"},{"key":"BF01391638_CR29","first-page":"325","volume":"98","author":"J Lamberty","year":"1974","unstructured":"Lamberty J, Varela PY, Font RG, Jarvis BW, Coover J: Whipple's disease\u2014light and electron microscopy study. Arch Pathol 98:325\u2013330, 1974","journal-title":"Arch Pathol"},{"key":"BF01391638_CR30","first-page":"9","volume":"1","author":"MF LeBodic","year":"1977","unstructured":"LeBodic MF, Delumeau G, Hamza H, Prost A, Leportz J, Lenne Y, Mussini-Montpellier J: Aspects immunologiques de la maladie de Whipple. Gastroenterol Clin Biol 1:9\u201321, 1977","journal-title":"Gastroenterol Clin Biol"},{"key":"BF01391638_CR31","first-page":"238","volume":"25","author":"G Lukacs","year":"1978","unstructured":"Lukacs G, Dobi S, Szabo M: A case of Whipple's disease with repeated operations for ileus and complete cure. Acta Hepato-Gastroenterol 25:238\u2013242, 1978","journal-title":"Acta Hepato-Gastroenterol"},{"key":"BF01391638_CR32","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/jama.1976.03270080038029","volume":"236","author":"LC Maas","year":"1976","unstructured":"Maas LC, Liu H, Gelzayd EA: Interior vena cava obstruction in Whipple's disease\u2014association with retroperitoneal lymphadenopathy. J Am Med Assoc 236:856\u2013857, 1976","journal-title":"J Am Med Assoc"},{"key":"BF01391638_CR33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0016-5085(19)33342-6","volume":"63","author":"FF Martin","year":"1972","unstructured":"Martin FF, Vilseck J, Dobbins WO III, Buckley CE III, Tyor MP: Immunological alterations in patients with treated Whipple's disease. Gastroenterology 63:6\u201318, 1972","journal-title":"Gastroenterology"},{"key":"BF01391638_CR34","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.0954-6820.1970.tb08041.x","volume":"188","author":"E Myhre","year":"1970","unstructured":"Myhre E, Skrede S, Gjone E: Dermatitis herpetiformis enteropathy and Whipple's disease. Acta Med Scand 188:301\u2013302, 1970","journal-title":"Acta Med Scand"},{"key":"BF01391638_CR35","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0002-9343(73)90264-7","volume":"55","author":"BM Pastor","year":"1973","unstructured":"Pastor BM, Geerken RG: Whipple's disease presenting as pleuropericarditis. Am J Med 55:827\u2013831, 1973","journal-title":"Am J Med"},{"key":"BF01391638_CR36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1001\/archinte.1972.00320030099012","volume":"129","author":"JR Rodarte","year":"1972","unstructured":"Rodarte JR, Garrison CO, Holley KE, Fontana RS: Whipple's disease simulating sarcoidosis. Arch Intern Med 129:479\u2013482, 1972","journal-title":"Arch Intern Med"},{"key":"BF01391638_CR37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.0954-6820.1978.tb08466.x","volume":"204","author":"P Tauris","year":"1978","unstructured":"Tauris P, Moesner J: Whipple's disease\u2014clinical and histopathological changes during treatment with sulphamethoxazole-trimethoprim. Acta Med Scand 204:423\u2013427, 1978","journal-title":"Acta Med Scand"},{"key":"BF01391638_CR38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000198017","volume":"15","author":"GN Tytgat","year":"1977","unstructured":"Tytgat GN, Boogendijk JL, Agenant D, Schellekens PT: Etiopathogenetic studies in a patient with Whipple's disease. Digestion 15:309\u2013321, 1977","journal-title":"Digestion"},{"key":"BF01391638_CR39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1445-5994.1977.tb03690.x","volume":"7","author":"R Clancy","year":"1977","unstructured":"Clancy R, Muckle TJ, de Jesus D, Stevens D: Characteristics of the immune response in a patient with Whipple's disease. Aust NZ J Med 7:294\u2013298, 1977","journal-title":"Aust NZ J Med"},{"key":"BF01391638_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00686137","volume":"13","author":"SS Schochet Jr","year":"1969","unstructured":"Schochet SS Jr, Lampert PW: Granulomatous encephalitis in Whipple's disease. Electron microscopic examinations. Acta Neuropathol 13:1\u201311, 1969","journal-title":"Acta Neuropathol"},{"key":"BF01391638_CR41","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1056\/NEJM197503202921210","volume":"292","author":"FS Kantor","year":"1975","unstructured":"Kantor FS: Infection, anergy and cell-mediated immunity. N Engl J Med 292:629\u2013634, 1975","journal-title":"N Engl J Med"},{"key":"BF01391638_CR42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1600-065X.1978.tb00408.x","volume":"40","author":"ER Unanue","year":"1978","unstructured":"Unanue ER: The regulation of lymphocyte functions by the macrophage. Immunol Rev 40:227\u2013255, 1978","journal-title":"Immunol Rev"},{"key":"BF01391638_CR43","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJM197911083011902","volume":"301","author":"EL Reinherz","year":"1979","unstructured":"Reinherz EL, Rubinstein A, Geha RS, Strelkauskas AJ, Rosen FS, Schlossman SF: Abnormalities of immunoregulatory T cells in disorders of immune function. N Engl J Med 301:1018\u20131022, 1979","journal-title":"N Engl J Med"},{"key":"BF01391638_CR44","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1084\/jem.149.3.632","volume":"149","author":"CO Elson","year":"1979","unstructured":"Elson CO, Heck JA, Strober W: T-cell regulation of murine IgA synthesis. J Exp Med 149:632\u2013643, 1979","journal-title":"J Exp Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01391638\/fulltext.html","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01391638.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01391638\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01391638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01391638.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T22:04:54Z","timestamp":1581977094000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01391638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,3]]}},"alternative-id":["BF01391638"],"URL":"https:\/\/doi.org\/10.1007\/bf01391638","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3]]}}}