{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:45:44Z","timestamp":1792640744941,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[1996,5]]},"DOI":"10.1007\/bf01409982","type":"journal-article","created":{"date-parts":[[2005,4,3]],"date-time":"2005-04-03T15:31:01Z","timestamp":1112542261000},"page":"109-114","source":"Crossref","is-referenced-by-count":25,"title":["Autoantibodies and target antigens in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides"],"prefix":"10.1007","volume":"16","author":[{"given":"J. A.","family":"Savige","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. R. C.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(85)91147-X","volume":"1","author":"FJ Woude van der","year":"1985","unstructured":"van der Woude FJ, Rasmussen N, Lobatto ZS, et al. (1985) Auto-antibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1:425?429","journal-title":"Lancet"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(87)90591-5","volume":"1","author":"COS Savage","year":"1987","unstructured":"Savage COS, Winearls CG, Johnes S, et al. (1987) Prospective study of radio-immunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet 1 1389?1393","journal-title":"Lancet"},{"key":"CR3","first-page":"467","volume":"220","author":"COS Savage","year":"1985","unstructured":"Savage COS, Winearls CG, Evans DJ, et al. (1985) Microscopic polyarteritis: presentation, pathology and prognosis. Q J Med 220:467?483","journal-title":"Q J Med"},{"key":"CR4","first-page":"435","volume":"208","author":"AJ Pinching","year":"1983","unstructured":"Pinching AJ, Lockwood CM, Pussell BA, et al. (1983) Wegener's granulomatosis: observations on 18 patients with severe renal disease. Q J Med 208:435?460","journal-title":"Q J Med"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/978-1-4757-9182-2_68","volume":"336","author":"O Hergesell","year":"1993","unstructured":"Hergesell O, Egbring R, Andrassy K (1993) Presence of anticardiolipin antibodies (ACA) discriminates between Wegener's granulomatosis (WG) and microscopic polyarteritis (MPA). Adv Exp Med Biol 336:393?396","journal-title":"Adv Exp Med Biol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0046-8177(87)80340-4","volume":"18","author":"TL Wahls","year":"1987","unstructured":"Wahls TL, Bonsib SM, Schuster VL (1987) Co-existent Wegener's granulomatosis and antiglomerular basement membrane disease. Hum Pathol 18:202?205","journal-title":"Hum Pathol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/ki.1990.72","volume":"37","author":"DRW Jayne","year":"1990","unstructured":"Jayne DRW, Marshall PD, Jones SJ, et al. (1990) Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis. Kidney Int 37:965?970","journal-title":"Kidney Int"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2249.1990.tb05431.x","volume":"82","author":"G Frampton","year":"1990","unstructured":"Frampton G, Jayne DRW, Perry GJ, et al. (1990) Autoantibodies to endothelial cells and neutrophil cytoplasmic antigens in systemic vasculitis. Clin Exp Immunol 82:227?232","journal-title":"Clin Exp Immunol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1172\/JCI114335","volume":"84","author":"R Goldschmeding","year":"1989","unstructured":"Goldschmeding R, van der Schoot DE, ten Bokken Huinink D, et al. (1989) Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. J Clin Invest 84:1577?1587","journal-title":"J Clin Invest"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJM198806233182504","volume":"318","author":"RJ Falk","year":"1988","unstructured":"Falk RJ, Jennette JC (1988) Antineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotising and crescentic glomerulonephritis. N Engl J Med 318:1651?1657","journal-title":"N Engl J Med"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1398-9995.1980.tb01768.x","volume":"35","author":"A Wiik","year":"1980","unstructured":"Wiik A (1980) Granulocyte-specific antinuclear antibodies. Allergy 35:263?289","journal-title":"Allergy"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0091-6749(05)80067-3","volume":"86","author":"A Saxon","year":"1990","unstructured":"Saxon A, Shanhan F, Landers C, et al. (1990) A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 86:202?210","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 4","key":"CR13","first-page":"F24","volume":"8","author":"DGI Scott","year":"1990","unstructured":"Scott DGI, Sharrack BR, Webb FWS (1990) Antineutrophil cytoplasmic antibodies and rheumatoid arthritis. Clin Exp Rheumatol 8:F24 [Suppl 4]","journal-title":"Clin Exp Rheumatol"},{"key":"CR14","first-page":"380","volume":"91","author":"L Nassberger","year":"1990","unstructured":"Nassberger L, Jonsson H, Sjoholm AG, et al. (1990) Autoantibodies against neutrophil cytoplasmic compounds in systemic lupus erythematosus and in hydralazine-induced lupus. Clin Exp Immunol 91:380?393","journal-title":"Clin Exp Immunol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2249.1995.tb03471.x","volume":"99","author":"MH Zhao","year":"1995","unstructured":"Zhao MH, Jones SJ, Lockwood CM (1995) Bactericidal\/permeability-increasing protein (BPI) is an important antigen for antineutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Clin Exp Immunol 99:49?56","journal-title":"Clin Exp Immunol"},{"key":"CR16","first-page":"201A","volume":"18","author":"BK Flesch","year":"1991","unstructured":"Flesch BK, Lampe M, Rautman ET, et al. (1991) Antielastase, cathepsin G and lactoferrin antibodies in sera with cANCA or with atypical fluorescence staining pattern. Am J Kidney Dis 18:201A","journal-title":"Am J Kidney Dis"},{"key":"CR17","first-page":"41A","volume":"101S","author":"M-H Zhao","year":"1995","unstructured":"Zhao M-H, Lockwood CM (1995) Azurocidin is a novel ANCA antigen in vasculitis. Clin Exp Immunol 101S:41A","journal-title":"Clin Exp Immunol"},{"key":"CR18","first-page":"12","volume":"97","author":"A Wiik","year":"1988","unstructured":"Wiik A (1988) Delineation of a standard procedure for indirect immunofluorescence of ANCA. APMIS 97:12","journal-title":"APMIS"},{"key":"CR19","first-page":"738","volume":"62","author":"S Loizou","year":"1985","unstructured":"Loizou S, McCrea JD, Rudge AC, et al. (1985) Measurement of anticardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA) standardisation and quantitation of results. Clin Exp Immunol 62:738?745","journal-title":"Clin Exp Immunol"},{"key":"CR20","first-page":"1","volume":"46","author":"AE Gharavi","year":"1987","unstructured":"Gharavi AE, Harris EN, Asherson RA, et al. (1987) Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Clin Exp Immunol 46:1?6","journal-title":"Clin Exp Immunol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2249.1990.tb05433.x","volume":"82","author":"JA Savige","year":"1990","unstructured":"Savige JA, Gallicchio M, Georgiou T, Davies DJ (1990) Diverse target antigens recognised by circulating antibodies in antineutrophil cytoplasm antibody-associated renal vasculitides. Clin Exp Immunol 82:238?243","journal-title":"Clin Exp Immunol"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2249.1994.tb06519.x","volume":"95","author":"GJ Jennings","year":"1994","unstructured":"Jennings GJ, Chang L, Savige JA (1994) Antiproteinase 3 antibodies: their detection and characterisation. Clin Exp Immunol 95:251?256","journal-title":"Clin Exp Immunol"},{"key":"CR23","first-page":"55","volume":"66:","author":"KJ Parleviet","year":"1988","unstructured":"Parleviet KJ, Henzen-Logmans SC, Oe PL, et al. (1988) Antibodies to components of neutrophil cytoplasm: a new diagnostic tool in patients with Wegener's granulomatosis and systemic vasculitis. Q J Med 66:55?63","journal-title":"Q J Med"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0272-6386(12)80876-6","volume":"18","author":"WL Gross","year":"1991","unstructured":"Gross WL, Schmitt WH, Csernok E (1991) Antineutrophil cytoplasmic autoantibody-associated diseases: a rheumatologist's perspective. Am J Kidney Dis 18:175?179","journal-title":"Am J Kidney Dis"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1136\/bmj.281.6244.836","volume":"281","author":"AJ Pinching","year":"1980","unstructured":"Pinching AJ, Rees AJ, Pussell BA, et al. (1980) Relapses in Wegener's granulomatosis: the role of infection. BMJ 281:836?838","journal-title":"BMJ"},{"key":"CR26","first-page":"199A","volume":"18","author":"DE Roberts","year":"1991","unstructured":"Roberts DE, Peebles CL, Tan EM (1991) The influence of antinuclear autoantibodies (ANA) on the detection of antimyeloperoxidase autoantibodies and the clinical spectrum associated with their occurrence. Am J Kidney Dis 18:199A","journal-title":"Am J Kidney Dis"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000168822","volume":"15","author":"S Cohney","year":"1995","unstructured":"Cohney S, Savige JA, Stewart MR (1995) Lupus anticoagulant associated with ANCA-associated polyarteritis. Am J Nephrol 15:157?160","journal-title":"Am J Nephrol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1056\/NEJM197406132902403","volume":"290","author":"J Klassen","year":"1974","unstructured":"Klassen J, Elwood C, Grossberg A, et al. (1974) Evolution of membranous nephropathy into anti-glomerular basement membrane glomerulonephritis. N Engl J Med 290:1340?1344","journal-title":"N Engl J Med"},{"key":"CR29","first-page":"209A","volume":"18","author":"SM Bonsib","year":"1991","unstructured":"Bonsib SM, Goeken JA, Kemp JD, et al. (1991) Co-expression of anti-neutrophil cytoplasmic antibody (ANCA) in antiglomerular basement membrane mediated diseases. Am J Kidney Dis 18:209A","journal-title":"Am J Kidney Dis"},{"key":"CR30","first-page":"208A","volume":"18","author":"DJ Donoghue","year":"1991","unstructured":"Donoghue DJ, Vanhille P, Lesavre P, et al. (1991) Antimyeloperoxidase antibodies in antiglomerular basement membrane disease. Am J Kidney Dis 18:208A","journal-title":"Am J Kidney Dis"},{"key":"CR31","first-page":"209A","volume":"18","author":"X Bosch","year":"1991","unstructured":"Bosch X, Mirapeix E, Font J, et al. (1991) Detection and prognostic implication of ANCA in antiGBM disease. Am J Kidney Dis 18:209A","journal-title":"Am J Kidney Dis"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4757-9182-2_36","volume":"336","author":"S Hauschild","year":"1993","unstructured":"Hauschild S, Schmitt WH, Csernok E, et al. (1993) ANCA in systemic vasculitides, rheumatic disorders and inflammatory bowel diseases. Adv Exp Med Biol 336:245?251","journal-title":"Adv Exp Med Biol"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1365-2249.1996.d01-654.x","volume":"104","author":"MP Stoffel","year":"1996","unstructured":"Stoffel MP, Csernok E, Herzberg C, Johnston T, Carroll SF, Gross WL (1996) Antineutrophil cytoplasmic antibodies (ANCA) directed against bactericidal\/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders. Clin Exp Immunol 104:54?59","journal-title":"Clin Exp Immunol"},{"key":"CR34","first-page":"46A","volume":"93","author":"S Hauschild","year":"1993","unstructured":"Hauschild S, Schwarting K, Csernok E, et al. (1993) ANCA fine specificities and disease activity in IBD. Clin Exp Immunol 93:46A","journal-title":"Clin Exp Immunol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/978-1-4757-9182-2_63","volume":"336","author":"M Braun","year":"1993","unstructured":"Braun M, Csernok E, Schmitt WH, et al. (1993) Incidence and specificity of pANCA in rheumatic diseases. Adv Exp Med 336:371?373","journal-title":"Adv Exp Med"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/art.1780351210","volume":"35","author":"IEM Coremans","year":"1992","unstructured":"Coremans IEM, Hagen EC, Daha MR, et al. (1992) Antilactoferrin antibodies in patients with rheumatoid arthritis are associated with vasculitis. Arthritis Rheum 35:1466?1475","journal-title":"Arthritis Rheum"},{"key":"CR37","first-page":"33A","volume":"93","author":"MG Braun","year":"1993","unstructured":"Braun MG, Csernok E, Schmitt W, et al. (1993) Antineutrophil antibodies (ANCA) and extra-articular involvement in rheumatoid arthritis (RA). Clin Exp Immunol 93:33A","journal-title":"Clin Exp Immunol"},{"key":"CR38","first-page":"30A","volume":"93","author":"D Metzger","year":"1993","unstructured":"Metzger D, Rother E, Melchers I, et al. (1993) Autoantibodies against neutrophil cytoplasmic antigens (ANCA): specificity and MHC association in rheumatoid arthritis (RA). Clin Exp Immunol 93:30A","journal-title":"Clin Exp Immunol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/rheumatology\/31.3.185","volume":"31","author":"C Juby","year":"1992","unstructured":"Juby C, Johnston C, Davis P, et al. (1992) Antinuclear and antineutrophil cytoplasmic antibodies (ANCA) in the sera of patients with Felty's syndrome. Br J Rheumatol 31:185?188","journal-title":"Br J Rheumatol"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0896-8411(91)90163-7","volume":"4","author":"P Gueirard","year":"1991","unstructured":"Gueirard P, Delpech A, Gilbert D, et al. (1991) Antimyeloperoxidase antibodies: immunological characteristics and clinical associations. J Autoimm 4:517?527","journal-title":"J Autoimm"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/rheumatology\/31.10.669","volume":"31","author":"SS Lee","year":"1992","unstructured":"Lee SS, Lawton JWM, Chan CE, et al. (1992) Antilactoferrin antibody in systemic lupus erythematosus. Br J Rheumatol 31:669?673","journal-title":"Br J Rheumatol"},{"key":"CR42","first-page":"202A","volume":"18","author":"C Pozzi","year":"1991","unstructured":"Pozzi C, Radice A, Rota S, et al. (1991) Clinical significance of antilactoferrin antibodies in renal disease. Am J Kidney Dis 18:202A","journal-title":"Am J Kidney Dis"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/978-1-4757-9182-2_66","volume":"336","author":"RA Sinico","year":"1992","unstructured":"Sinico RA, Pozzi C, Radice A, et al. (1992) ANCA specificity for lactoferrin in systemic lupus erythematosus. Adv Exp Med Biol 336:385?387","journal-title":"Adv Exp Med Biol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01409982.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01409982\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01409982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T10:04:24Z","timestamp":1556877864000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01409982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["BF01409982"],"URL":"https:\/\/doi.org\/10.1007\/bf01409982","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}