{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:40:19Z","timestamp":1683070819812},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[1978,8,1]],"date-time":"1978-08-01T00:00:00Z","timestamp":270777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Wochenschr"],"published-print":{"date-parts":[[1978,8]]},"DOI":"10.1007\/bf01489717","type":"journal-article","created":{"date-parts":[[2005,4,14]],"date-time":"2005-04-14T11:30:45Z","timestamp":1113478245000},"page":"825-833","source":"Crossref","is-referenced-by-count":1,"title":["Altersabh\ufffdngigkeit immunologischer Untersuchungsverfahren zur Feststellung einer Immundefizienz","Agedependence of immunological methods for detecting an immunodeficiency state"],"prefix":"10.1007","volume":"56","author":[{"given":"P. A.","family":"B\ufffdrkle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"T\ufffdnnesmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sch\ufffdfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Federlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-3083.1974.tb01285.x","volume":"3","author":"F. Aiuti","year":"1974","unstructured":"Aiuti, F., Cerottini, J.C., Coombs, R.A., Cooper, M., Dickler, H.B., Fr\u00f8land, S.S., Fudenberg, H.H., Greaves, M.F.: Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood. Report of a WHO\/IARC-sponsored Workshop on human B and T cells. Scand. J. Immunol.3, 521 (1974)","journal-title":"Scand. J. Immunol."},{"issue":"Suppl 97","key":"CR2","first-page":"77","volume":"21","author":"A. B\u00f6yum","year":"1968","unstructured":"B\u00f6yum, A.: Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest.21, (Suppl 97) 77?89 (1968)","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-3083.1974.tb01244.x","volume":"3","author":"G. Brown","year":"1974","unstructured":"Brown, G., Greaves, M.F.: Enumeration of absolute numbers of T and B lymphocytes in human blood. Scand. J. Immunol.3, 161 (1974)","journal-title":"Scand. J. Immunol."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"964","DOI":"10.4049\/jimmunol.105.4.964","volume":"105","author":"C.E. Buckley","year":"1970","unstructured":"Buckley, C.E., Dorsey, F.C.: The effect of aging on human serum immunoglobulin concentrations. J. Immunol.105, 964 (1970)","journal-title":"J. Immunol."},{"key":"CR5","first-page":"153","volume":"151","author":"P.A. B\u00fcrkle","year":"1976","unstructured":"B\u00fcrkle, P.A., T\u00f6nnesmann, E., Ahnefeld, S., Nobbe, F., Federlin, K.: Erfahrungen mit dem DNCB-Hauttest bei gesunden Personen verschiedener Altersgruppen. Z. Immunit\u00e4tsforsch.151, 153 (1976)","journal-title":"Z. Immunit\u00e4tsforsch."},{"key":"CR6","doi-asserted-by":"crossref","unstructured":"Burnet, F.M.: Immunological Surveillance, Oxford 1970","DOI":"10.1016\/B978-0-08-017481-5.50012-2"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jama.1967.03120070067008","volume":"199","author":"R.J. Cammarata","year":"1967","unstructured":"Cammarata, R.J., Rodnan, G.P., Fennell, R.H.: Serum anti-gamma-globulin and antinuclear factors in the aged. Jama199, 455 (1967)","journal-title":"Jama"},{"key":"CR8","first-page":"69","volume-title":"Methods in Immunology","author":"D.H. Campbell","year":"1964","unstructured":"Campbell, D.H., Garvey, J.S., Cremer, N.E., Sussdorf, D.H.: Methods in Immunology. New York-Amsterdam: W.A. Benjamin, Inc., p 69?71, 1964"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0008-8749(74)90085-9","volume":"12","author":"E.D. Carosella","year":"1974","unstructured":"Carosella, E.D., Mochanko, K., Braun, M.: Rosette-forming T-cells in human peripheral blood at different ages. Cell. Immunol.12, 323 (1974)","journal-title":"Cell. Immunol."},{"key":"CR10","first-page":"325","volume":"12","author":"W.J. Catalona","year":"1972","unstructured":"Catalona, W.J., Taylor, P.T., Chretien, P.B.: Quantitative dinitrochlorobenzene contact sensitization in a normal population. Clin. Exp. Immunol.12, 325 (1972)","journal-title":"Clin. Exp. Immunol."},{"key":"CR11","first-page":"463","volume":"149","author":"G. Cohnen","year":"1975","unstructured":"Cohnen, G., Augener, W., Reuter, A., Brittinger, G.: Peripheral blood T and B lymphocytes in men in different age groups. Z. Immunit\u00e4tsforsch.149, 463 (1975)","journal-title":"Z. Immunit\u00e4tsforsch."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0140-6736(75)91794-8","volume":"I","author":"E. Diaz-Jouanen","year":"1975","unstructured":"Diaz-Jouanen, E., Williams, R.C., Strickland, R.G.: Age-related changes in T and B cells. LancetI, 688 (1975)","journal-title":"Lancet"},{"key":"CR13","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-85851-2","volume-title":"Cancer Incidence in five continents. (Union internationale contre le cancer)","author":"R. Doll","year":"1970","unstructured":"Doll, R., Muir, C., Waterhouse, J.: Cancer Incidence in five continents. (Union internationale contre le cancer) Berlin-Heidelberg-New York: Springer Verlag (Geneva) (1970)"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000245437","volume":"15","author":"H. Droller","year":"1973","unstructured":"Droller, H., Middleton, R.S.W., Selvaraj, V.T., Timothy, O.R.: Delayed cellular immunity response as measured by tuberculin testing of an elderly population. Gerontol. Clin.15, 84 (1973)","journal-title":"Gerontol. Clin."},{"key":"CR15","first-page":"657","volume":"17","author":"B.S.I. Foad","year":"1974","unstructured":"Foad, B.S.I., Adams, L.E., Yamauchi, Y., Litwin, A.: Phytomitogen responses of peripheral blood lymphocytes in young and older subjects. Clin. Exp. Immunol.17, 657 (1974)","journal-title":"Clin. Exp. Immunol."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0140-6736(74)91593-1","volume":"II","author":"Gajl-Peczalska","year":"1974","unstructured":"Gajl-Peczalska, Hallgren, H., Kersey, J.H., Zusman, J., Yunis, E.J.: B-Lymphocytes during ageing. LancetII, 163 (1974)","journal-title":"Lancet"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/1097-0142(197510)36:4<1289::AID-CNCR2820360415>3.0.CO;2-P","volume":"36","author":"G.C. Gast de","year":"1975","unstructured":"de Gast, G.C., The, T.H., Schraffordt-Koops, H., Huiges, H.A., Oldhoff, J., Nieweg, H.O.: Humoral and cell-mediated immune response in patients with malignant melanoma. Cancer36, 1289 (1975)","journal-title":"Cancer"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000211395","volume":"10","author":"P. Goullet","year":"1964","unstructured":"Goullet, P., Kaufmann, H.: Etudes sur la r\u00e9ponse immunitaire selon l'\u00e2ge chez le rat. Gerontologia, Basel10, 76 (1964\/1965)","journal-title":"Gerontologia, Basel"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/220293a0","volume":"220","author":"M.F. Greaves","year":"1968","unstructured":"Greaves, M.F., Roitt, I.M., Rose, M.E.: Effect of bursectomy and thymectomy on the response of chicken peripheral blood lymphocytes to phytohaemagglutinin. Nature, Lond.220, 293 (1968)","journal-title":"Nature, Lond."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000211939","volume":"18","author":"L.J. Greenberg","year":"1972","unstructured":"Greenberg, L.J., Yunis, E.J.: Immunologic control of aging: a possible primary event. Gerontologia18, 247 (1972)","journal-title":"Gerontologia"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000211530","volume":"12","author":"O. Haferkamp","year":"1966","unstructured":"Haferkamp, O., Schlettwein-Gsell, D., Schwick, H.G., St\u00f6riko, K.: Serum protein in an aging population with particular reference to evaluation of immune globulins and antibodies. Gerontologia (Basel)12, 30 (1966)","journal-title":"Gerontologia"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.4049\/jimmunol.111.4.1101","volume":"111","author":"H.M. Hallgren","year":"1973","unstructured":"Hallgren, H.M., Buckley, C.E., III, Gilbertsen, V.A., Yunis, E.J.: Lymphocyte phytohaemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J. Immunol.111, 1101 (1973)","journal-title":"J. Immunol."},{"key":"CR23","first-page":"203","volume":"15","author":"D.H. Heilman","year":"1973","unstructured":"Heilman, D.H., Gambril, M.R., Leichner, J.P.: The effect of hydrocortisone on the incorporation of tritiated thymidine by human blood lymphocytes cultured with phytohaemagglutinin and pokeweed mitogen. Clin. Exp. Immunol.15, 203 (1973)","journal-title":"Clin. Exp. Immunol."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00000441-194001000-00009","volume":"199","author":"J.M.S. Hwang","year":"1940","unstructured":"Hwang, J.M.S., Krumbhaar, E.B.: The amount of lymphoid tissue of the human appendix and its weight at different age periods. Amer. J. Med. Sci.199, 75 (1940)","journal-title":"Amer. J. Med. Sci."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/231323b0","volume":"231","author":"D.G. Jos\u00e9","year":"1971","unstructured":"Jos\u00e9, D.G., Good, R.A.: Absence of enhancing antibody in cell mediated immunity to tumor heterografts in protein deficient rats. Nature (London)231, 323 (1971)","journal-title":"Nature"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/00000441-193903000-00007","volume":"197","author":"E.B. Krumbhaar","year":"1939","unstructured":"Krumbhaar, E.B., Lippincott, S.W.: The postmortem weight of ?normal? human spleen at different ages. Amer. J. Med. Sci.197, 344 (1939)","journal-title":"Amer. J. Med. Sci."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","volume":"2","author":"G. Mancini","year":"1965","unstructured":"Mancini, G., Carbonara, A.O., Heremans, J.F.: Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry2, 235 (1965)","journal-title":"Immunochemistry"},{"key":"CR28","first-page":"75","volume":"19","author":"H. Mellstedt","year":"1975","unstructured":"Mellstedt, H.: In vitro activation of human T and B lymphocytes by pokeweed mitogen. Clin. Exp. Immunol.19, 75 (1975)","journal-title":"Clin. Exp. Immunol."},{"key":"CR29","first-page":"441","volume":"25","author":"L.A. Moroz","year":"1973","unstructured":"Moroz, L.A., Krygier, V., Kotoulas, A.O.: Normal human IgG with antibody activity for keyhole limpet haemocyanin. Immunology25, 441 (1973)","journal-title":"Immunology"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.7326\/0003-4819-77-3-431","volume":"77","author":"D.L. Morton","year":"1972","unstructured":"Morton, D.L., Haskell, C.M., Pilch, Y.H., Sparks, F.C., Winters, W.D.: Recent advances in oncology. Ann. Intern. Med.77, 431 (1972)","journal-title":"Ann. Intern. Med."},{"key":"CR31","first-page":"364","volume-title":"Progress in Immunology II, Vol. 3","author":"J.J. Oppenheim","year":"1974","unstructured":"Oppenheim, J.J., Bendixen, G.: Techniques for assessing delayed hypersensitivity in vitro. L. Brent and J. Holborow (Eds.) Progress in Immunology II, Vol. 3, p 364. Amsterdam: North Holland Publishing Company 1974"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/215193a0","volume":"215","author":"A.V. Pisciotta","year":"1967","unstructured":"Pisciotta, A.V., Westring, D.W., De Prey, C., Walsh, B.: Mitogenic effect of phytohaemagglutinin at different ages. Nature, Lond.215, 193 (1967)","journal-title":"Nature, Lond."},{"key":"CR33","first-page":"84","volume":"22","author":"J. Radl","year":"1975","unstructured":"Radl, J., Sepers, J.M., Skvaril, F., Morell, A., Hijmans, W.: Immunoglobulin patterns in humans over 95 years of age. Clin. Exp. Immunol.22, 84 (1975)","journal-title":"Clin. Exp. Immunol."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1126\/science.152.3721.535","volume":"152","author":"W.O. Rieke","year":"1966","unstructured":"Rieke, W.O.: Lymphocytes from thymectomized rats: Immunologic, proliferative and metabolic properties. Science152, 535 (1966)","journal-title":"Science"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0140-6736(74)91755-3","volume":"II","author":"I.C. Roberts-Thomson","year":"1974","unstructured":"Roberts-Thomson, I.C., Whittingham, S., Younchaiyud, U., Mackay, I.R.: Ageing, immune response and mortality. LancetII, 368 (1974)","journal-title":"Lancet"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/B978-0-08-010402-7.50009-6","volume-title":"Aging process of population","author":"E. Rosset","year":"1964","unstructured":"Rosset, E.: Aging process of population. Pergamon Press, Oxford-London-Edinburgh-New York-Paris-Frankfurt, p 88 (1964)"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0140-6736(68)92893-6","volume":"II","author":"M.J. Rowley","year":"1968","unstructured":"Rowley, M.J., Buchanan, H., Mackay, J.R.: Reciprocal change with age in antibody to extrinsic and intrinsic antigens. LancetII, 24 (1968)","journal-title":"Lancet"},{"key":"CR38","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-05749-0","volume-title":"Angewandte Statistik","author":"L. Sachs","year":"1974","unstructured":"Sachs, L.: Angewandte Statistik. Springer Verlag, Berlin-Heidelberg-New York (1974)"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0021-8707(69)90026-4","volume":"44","author":"J. Salvaggio","year":"1969","unstructured":"Salvaggio, J., Castro-Murillo, E., Kundur, V.: Immunologic response of atopic and normal individuals to keyhole limpet haemocyanin. J. Allergy44, 344 (1969)","journal-title":"J. Allergy"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM197509042931013","volume":"293","author":"J.E. Sokal","year":"1975","unstructured":"Sokal, J.E.: Measurement of delayed skin-test responses. New Engl. J. Med.293, 501 (1975)","journal-title":"New Engl. J. Med."},{"key":"CR41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4049\/jimmunol.74.4.306","volume":"74","author":"A.B. Stavitsky","year":"1955","unstructured":"Stavitsky, A.B., Arquilla, E.R.: Micromethods for the study of protein and antibodies. Procedure and applications of haemagglutination and haemagglutination inhibition reactions with bis-diazotized benzidine and protein-conjugated red blood cells. J. Immunol.74, 306 (1955)","journal-title":"J. Immunol."},{"key":"CR42","first-page":"67","volume":"63","author":"O. Thomsen","year":"1929","unstructured":"Thomsen, O., Kettel, K.: Die St\u00e4rke der menschlichen Isoagglutinine und entsprechender Blutk\u00f6rperchenrezeptoren in verschiedenen Lebensaltern. Z. Immunit\u00e4tsforsch.63, 67 (1929)","journal-title":"Z. Immunit\u00e4tsforsch."},{"key":"CR43","first-page":"289","volume":"15","author":"G.B. Thurman","year":"1973","unstructured":"Thurman, G.B., Strong, D.M., Ahmed, A., Green, S.S., Sell, K.W., Harkman, R.J., Bach, F.H.: Human mixed lymphocyte cultures: Evaluation of a microculture technique utilizing the multiple automated sample harvester (MASH). Clin. Exp. Immunol.15, 289 (1973)","journal-title":"Clin. Exp. Immunol."},{"key":"CR44","unstructured":"T\u00f6nnesmann, E.: Beitrag zur Testung des sog. Immunstatus bei Normalpersonen und Patienten mit Morbus Crohn. Inaug. Diss. Ulm 1976"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"605","DOI":"10.7326\/0003-4819-77-4-605","volume":"77","author":"T.A. Waldmann","year":"1972","unstructured":"Waldmann, T.A., Strober, W., Blaese, R.M.: Immunodeficiency disease and malignancy. Ann. Intern. Med.77, 605 (1972)","journal-title":"Ann. Intern. Med."},{"key":"CR46","first-page":"137","volume":"79","author":"R.L. Walford","year":"1973","unstructured":"Walford, R.L., Tittor, W.: Einfl\u00fcsse des lymphatischen Systems auf den Alterungsvorgang. Verh. Dtsch. Ges. Inn. Med.79, 137 (1973)","journal-title":"Verh. Dtsch. Ges. Inn. Med."},{"key":"CR47","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0019-2791(64)90030-8","volume":"1","author":"W.O. Weigle","year":"1964","unstructured":"Weigle, W.O.: Immunochemical properties of haemocyanin. Immunochemistry1, 295 (1964)","journal-title":"Immunochemistry"}],"container-title":["Klinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01489717.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01489717\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01489717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:10:44Z","timestamp":1683069044000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01489717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,8]]},"references-count":47,"journal-issue":{"issue":"16","published-print":{"date-parts":[[1978,8]]}},"alternative-id":["BF01489717"],"URL":"https:\/\/doi.org\/10.1007\/bf01489717","relation":{},"ISSN":["0023-2173","1432-1440"],"issn-type":[{"value":"0023-2173","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,8]]}}}