{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:07:01Z","timestamp":1790554021071,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1979,3,1]],"date-time":"1979-03-01T00:00:00Z","timestamp":289094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Autism Dev Disord"],"published-print":{"date-parts":[[1979,3]]},"DOI":"10.1007\/bf01531296","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T21:58:24Z","timestamp":1113861504000},"page":"95-103","source":"Crossref","is-referenced-by-count":50,"title":["Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome"],"prefix":"10.1007","volume":"9","author":[{"given":"Salvador","family":"Castells","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhaya","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand G.","family":"Winsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hurwic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Perel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Nyhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","first-page":"392","volume":"5","author":"E. M. Airaksinen","year":"1973","unstructured":"Airaksinen, E. M., & Kauko, K. Effect of probenecid on 5-hydroxyindoles in cerebrospinal fluid in Down's syndrome.Annals of Clinical Research, 1973,5, 392?394.","journal-title":"Annals of Clinical Research"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0024-3205(63)90132-2","volume":"2","author":"N. E. Anden","year":"1963","unstructured":"Anden, N. E., Roos, B. E., & Werdinius, B. The occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluoremetric method.Life Sciences, 1963,2, 448?458.","journal-title":"Life Sciences"},{"key":"CR3","first-page":"207","volume":"179","author":"A. H. Anton","year":"1971","unstructured":"Anton, A. H., & Sayre, D. F. The distribution on 5-hydroxyindoleacetic acid in various animals and its fluoremetric analysis in diverse biological material.Journal of Pharmacology and Experimental Therapeutics, 1971,179, 207?217.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0006-2944(69)90022-2","volume":"3","author":"B. Bakay","year":"1969","unstructured":"Bakay, B., Telfer, M. A., & Nyhan, W. L. Assay of hypoxanthine-guanine and adenine phosphoribosyl transferases. A simple screening test for the Lesch-Nyhan syndrome and related disorders of purine metabolism.Biochemical Medicine, 1969,3, 230?243.","journal-title":"Biochemical Medicine"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1139\/y65-105","volume":"43","author":"E. M. Boyd","year":"1965","unstructured":"Boyd, E. M., Dolman, M., Knight, L. M., & Sheppard, E. P. The chronic oral toxicity of caffeine.Canadian Journal of Physiology and Pharmacology, 1965,43, 995?1007.","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.22.5.479","volume":"22","author":"T. N. Chase","year":"1972","unstructured":"Chase, T. N., Ng, L. K. Y., & Watanabe, A. M. Parkinson's disease: Modification by 5-hydroxytryptophan.Neurology, 1972,22, 479?482.","journal-title":"Neurology"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1001\/archpsyc.1974.01760180085011","volume":"31","author":"D. J. Cohen","year":"1974","unstructured":"Cohen, D. J., Shaywitz, B. A., Johnson, W. T., & Bowers, M., Jr. Biogenic amines in autistic and atypical children.Archives of General Psychiatry, 1974,31, 845?853.","journal-title":"Archives of General Psychiatry"},{"key":"CR8","first-page":"278","volume":"140","author":"P. G. Dayton","year":"1963","unstructured":"Dayton, P. G., Yu. T. F., Chen, W., Berger, L., West, L. A., & Gutman, A. B. The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.Journal of Pharmacology and Experimental Therapeutics, 1963,140, 278?286.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/233272a0","volume":"233","author":"G. Dichiara","year":"1971","unstructured":"Dichiara, G., Camba, R., & Spano, P. F. Evidence for inhibition by brain serotonin of mouse killing behavior in rats.Nature, 1971,233, 272?273.","journal-title":"Nature"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0022-3476(73)80123-4","volume":"82","author":"V. Francke","year":"1973","unstructured":"Francke, V., Bakay, B., & Nyhan, W. L. Detection of heterozygous carriers of the Lesch-Nyhan syndrome by electrophoresis of hair root lysates.Journal of Pediatrics, 1973,82, 472?478.","journal-title":"Journal of Pediatrics"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/0024-3205(66)91026-5","volume":"5","author":"H. C. Guldberg","year":"1966","unstructured":"Guldberg, H. C., Ashcroft, G. W., & Crawford, T. B. B. Concentration of 5-hydroxyindolyl-acetic acid and homovanillic acid in the cerebrospinal fluid of the dog before and during treatment with probenecid.Life Sciences, 1966,5, 1571?1575.","journal-title":"Life Sciences"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(71)90607-X","volume":"35","author":"J. Korf","year":"1971","unstructured":"Korf, J., & Van Praag, H. M. Amine metabolism in the human brain: Further evaluation of the probenecid test.Brain Research, 1971,35, 221?230.","journal-title":"Brain Research"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0002-9343(64)90104-4","volume":"36","author":"M. Lesch","year":"1964","unstructured":"Lesch, M., & Nyhan, W. L. A familial disorder of uric acid metabolism and central nervous system function.American Journal of Medicine, 1964,36, 561?570.","journal-title":"American Journal of Medicine"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3758\/BF03335496","volume":"19","author":"L. L. Morgan","year":"1970","unstructured":"Morgan, L. L., Schneiderman, W., & Nyhan, W. L. Theophylline: Induction of self-biting in rabbits.Psychonomic Science, 1970,19, 37?38.","journal-title":"Psychonomic Science"},{"key":"CR15","first-page":"194","volume":"6","author":"N. H. Neff","year":"1964","unstructured":"Neff, N. H., Tozer, T. N., & Brodie, B. B. A specialized transport system to transfer 5-HIAA directly from brain to blood.Pharmacologist, 1964,6, 194.","journal-title":"Pharmacologist"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01543464","volume":"6","author":"W. L. Nyhan","year":"1976","unstructured":"Nyhan, W. L., Behavior in the Lesch-Nyhan syndrome.Journal of Autism and Childhood Schizophrenia, 1976,6, 235?252.","journal-title":"Journal of Autism and Childhood Schizophrenia"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1203\/00006450-196701000-00001","volume":"1","author":"W. L. Nyhan","year":"1967","unstructured":"Nyhan, W. L., Pesek, J., Sweetman, L., Carpenter, D. G., & Carter, C. H. Genetics of an x-linked disorder of uric acid metabolism and cerebral function.Pediatric Research, 1967,1, 5?13.","journal-title":"Pediatric Research"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/219502a0","volume":"219","author":"R. Olsson","year":"1968","unstructured":"Olsson, R., & Roos, B. E. Concentrations of 5-hydroxyindoleacetic acid and homovanillic acid in the cerebrospinal fluid after treatment with probenecid in patients with Parkinson's disease.Nature, 1968,219, 502?503.","journal-title":"Nature"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1471-4159.1965.tb04238.x","volume":"12","author":"S. Roberts","year":"1965","unstructured":"Roberts, S., & Morelos, B. S. Regulation of cerebral metabolism of amino acids?IV. Influence of amino acid levels on leucine uptake, utilization and incorporation into protein in vivo.Journal of Neurochemistry, 1965,12, 373?387.","journal-title":"Journal of Neurochemistry"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00456937","volume":"1","author":"B. E. Roos","year":"1969","unstructured":"Roos, B. E., & Sjostrom, R. 5-hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patients with manic-depressive psychosis.Pharmacologia Clinica, 1969,1, 153?155.","journal-title":"Pharmacologia Clinica"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1126\/science.155.3770.1682","volume":"155","author":"J. E. Seegmiller","year":"1967","unstructured":"Seegmiller, J. E., Rosenbloom, F. M., & Kelley, W. N. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis.Science, 1967,155, 1682?1684.","journal-title":"Science"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1212\/WNL.22.11.1201","volume":"22","author":"A. Y. Tourian","year":"1972","unstructured":"Tourian, A. Y. Administration of 5-hydroxy-L-tryptophan to individuals with Huntington's chorea.Neurology, 1972,22, 1201?1204.","journal-title":"Neurology"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1054-3589(08)60655-9","volume":"5","author":"L. Valzelli","year":"1967","unstructured":"Valzelli, L. Drugs and aggressiveness.Advances in Pharmacology, 1967,5, 79?108.","journal-title":"Advances in Pharmacology"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1212\/WNL.25.2.135","volume":"25","author":"M. H. Woert Van","year":"1975","unstructured":"Van Woert, M. H., & Sethy, V. H. Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486.Neurology, 1975,25 135?140.","journal-title":"Neurology"}],"container-title":["Journal of Autism and Developmental Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01531296\/fulltext.html","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01531296.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01531296\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01531296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T09:31:39Z","timestamp":1556875899000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01531296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,3]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,3]]}},"alternative-id":["BF01531296"],"URL":"https:\/\/doi.org\/10.1007\/bf01531296","relation":{},"ISSN":["0162-3257","1573-3432"],"issn-type":[{"value":"0162-3257","type":"print"},{"value":"1573-3432","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,3]]}}}