{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:24:45Z","timestamp":1773278685863,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1989,2,1]],"date-time":"1989-02-01T00:00:00Z","timestamp":602294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1989,2]]},"DOI":"10.1007\/bf01536058","type":"journal-article","created":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T07:25:18Z","timestamp":1113895518000},"page":"238-245","source":"Crossref","is-referenced-by-count":7,"title":["Effects of mepirizole and basic antiinflammatory drugs on HCl-ethanolinduced gastric lesions in rats"],"prefix":"10.1007","volume":"34","author":[{"given":"Hironori","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoyo","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1254\/fpj.65.378","volume":"65","author":"T Akimoto","year":"1969","unstructured":"Akimoto T, Tsukada K, Yamasaki T, Kojima H, Kasahara A, Akashi A, Yamaguchi K, Oshima Y: Pharmacological studies of an antiinflammatory agent 1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (DA-398). Folia Pharmacol Jpn 65:378?409, 1969","journal-title":"Folia Pharmacol Jpn"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1254\/fpj.65.620","volume":"65","author":"K Tsurumi","year":"1969","unstructured":"Tsurumi K, Nosaki M, Hiramatsu Y, Hayashi M, Fujimura H: Pharmacological studies of 1-(4-methyl-6-methoxy-2-pyrimidinyl)-3-methyl-5-methoxypyrazole. Folia Pharmacol Jpn 65:620?642, 1969","journal-title":"Folia Pharmacol Jpn"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF01296923","volume":"27","author":"S Okabe","year":"1982","unstructured":"Okabe S, Ishihara Y, Inoo H, Tanaka H: Mepirizole-induced duodenal ulcers in rats and their pathogenesis. Dig Dis Sci 27:242?249, 1982","journal-title":"Dig Dis Sci"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/BF01308158","volume":"28","author":"Y Ishihara","year":"1983","unstructured":"Ishihara Y, Yamada Y, Hata Y, Okabe S: Species and strain differences in mepirizole-induced duodenal and gastric lesions. Dig Dis Sci 28:552?558, 1983","journal-title":"Dig Dis Sci"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1254\/jjp.36.121","volume":"36","author":"Y Kurebayashi","year":"1984","unstructured":"Kurebayashi Y, Asano M, Hashizume T, Akashi A: Gastric hyperacidity and duodenal ulcer formation induced by dulcerozine in rats. Jpn J Pharmacol 36:121?123, 1984","journal-title":"Jpn J Pharmacol"},{"key":"CR6","first-page":"155","volume":"271","author":"Y Kurebayashi","year":"1984","unstructured":"Kurebayashi Y, Asano M, Hashizume T, Akashi A: Dulcerozine-induced duodenal ulcers in rats: A simple, highlyreliable model for evaluating anti-ulcer agents. Arch Inter Pharmacodyn Ther 271:155?168, 1984","journal-title":"Arch Inter Pharmacodyn Ther"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.7280691","volume":"214","author":"S Szabo","year":"1981","unstructured":"Szabo S, Trier JS, Frankel PW: Sulfhydryl compounds may mediate gastric cytoprotection. Science 214:200?202, 1981","journal-title":"Science"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0016-5085(79)90002-7","volume":"77","author":"A Robert","year":"1979","unstructured":"Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433?443, 1979","journal-title":"Gastroenterology"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF01296755","volume":"27","author":"D Aures","year":"1982","unstructured":"Aures D, Guth PH, Paulsen G, Grossman MI: Effect of increased gastric mucosal histamine on alcohol-induced gastric damage in rats. Dig Dis Sci 27:347?352, 1982","journal-title":"Dig Dis Sci"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1254\/jjp.33.939","volume":"33","author":"T Mizui","year":"1983","unstructured":"Mizui T, Doteuchi M: Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jpn J Pharmacol 33:939?945, 1983","journal-title":"Jpn J Pharmacol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/BF01338524","volume":"25","author":"TK Chaudhury","year":"1980","unstructured":"Chaudhury TK, Robert A: Prevention of mild irritants of gastric necrosis produced in rats by sodium taurocholate. Dig Dis Sci 25:830?836, 1980","journal-title":"Dig Dis Sci"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/BF01296520","volume":"31","author":"I Szelenyi","year":"1986","unstructured":"Szelenyi I, Brune K: Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide. Dig Dis Sci 31:1207?1210, 1986","journal-title":"Dig Dis Sci"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/BF01314054","volume":"30","author":"K Takeuchi","year":"1985","unstructured":"Takeuchi K, Nobuhara Y: Inhibition of gastric motor activity by 16,16-dimethyl prostaglandin E2. A possible explanation of cytoprotection. Dig Dis Sci 30:1181?1188, 1985","journal-title":"Dig Dis Sci"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1254\/jjp.42.383","volume":"42","author":"H Tanaka","year":"1986","unstructured":"Tanaka H, Ueki S, Ohno T, Takeuchi K, Okabe S: Pathogenic mechanisms involved in mepirizole-induced duodenal damage in the rat. Jpn J Pharmacol 42:383?396, 1986","journal-title":"Jpn J Pharmacol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1254\/jjp.42.297","volume":"42","author":"K Takeuchi","year":"1986","unstructured":"Takeuchi K, Nishiwaki H, Okabe S: Cytoprotective action of mast cell stabilizers against ethanol-induced gastric lesions in rats. Jpn J Pharmacol 42:297?307, 1986","journal-title":"Jpn J Pharmacol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-2999(83)90370-9","volume":"91","author":"H Mattsson","year":"1983","unstructured":"Mattsson H, Anderson K, Larsson H: Omeprazole provides protection against experimentally induced gastric mucosal lesions. Eur J Pharmacol 91:111?114, 1983","journal-title":"Eur J Pharmacol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000199088","volume":"30","author":"MJ Ruwart","year":"1984","unstructured":"Ruwart MJ, Nezamis JE, Rush BD, Lancaster C, Davis JP, Nichols NM, Ochoa R: Timoprazole is an unique cytoprotective agent in the rat. Digestion 30:33?40, 1984","journal-title":"Digestion"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1254\/jjp.42.123","volume":"42","author":"S Okabe","year":"1986","unstructured":"Okabe S, Miyake H, Awane Y: Cytoprotective effects of NC-1300 and omeprazole on HCl-ethanol-induced gastric lesions in rats. Jpn J Pharmacol 42:123?133, 1986","journal-title":"Jpn J Pharmacol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0016-5085(82)80198-4","volume":"83","author":"ER Lacy","year":"1982","unstructured":"Lacy ER, Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 83:619?625, 1982","journal-title":"Gastroenterology"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0016-5085(85)80189-X","volume":"88","author":"T Ohno","year":"1985","unstructured":"Ohno T, Ohtsuki H, Okabe S: Effects of 16,16-dimethyl prostaglandin E2 on ethanol-induced and aspirin-induced gastric damage in the rat: Scanning electron microscopic study. Gastroenterology 88:353?361, 1985","journal-title":"Gastroenterology"},{"key":"CR21","first-page":"1230","volume":"80","author":"WA Mersereau","year":"1981","unstructured":"Mersereau WA, Hinchey EJ: Dissolution of mucosal folding by prostaglandin: An explanation of cytoprotection. Gastroenterology 80:1230, 1981","journal-title":"Gastroenterology"},{"key":"CR22","first-page":"389","volume":"30","author":"WA Mersereau","year":"1985","unstructured":"Mersereau WA, Lough JO, Hinchey EJ: Microvascular injury; secondary to deep corrosion of the crests of the gastric mucosal folds in 0.6 N HCl treated rats. Dig Dis Sci 30:389, 1985","journal-title":"Dig Dis Sci"},{"key":"CR23","first-page":"998","volume":"20","author":"M Nakanishi","year":"1970","unstructured":"Nakanishi M, Imamura H, Maruyama Y: Pharmacological investigations of 2-amino-3-ethoxycarbonyl-6-benzyl-4-5-6-7-tetrahydrothieno[2,3-c]pyridine. Arzneim Forsch (Drug Res) 20:998?1003, 1970","journal-title":"Arzneim Forsch (Drug Res)"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01536058\/fulltext.html","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01536058.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01536058\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01536058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:10:44Z","timestamp":1586218244000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01536058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["BF01536058"],"URL":"https:\/\/doi.org\/10.1007\/bf01536058","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2]]}}}