{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:11:59Z","timestamp":1703722319927},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1977,9,1]],"date-time":"1977-09-01T00:00:00Z","timestamp":241920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1977,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Serum gastrin concentration was measured in 3 dogs after a meat meal; basal levels rose significantly after 10\u00a0minutes. After antrectomy with a Billroth I, and later a Billroth II anastomosis, the tests were repeated. Basal gastrin levels were unchanged but the rise after meat feeding was abolished. Four antrectomized dogs with a BII anastomosis and cannulae in both the duodenum and stomach were used to examine the effect of duodenal perfusion on serum gastrin. Whether the perfusate was 150\u00a0mM NaCl, 150\u00a0mM HCl or 0.1% acetylcholine, the mean serum gastrin levels did not differ significantly from basal levels. Transthoracic vagotomy in antrectomized dogs produced a significant rise in basal gastrin levels, but did not restore the response to a meat meal or duodenal perfusion<\/jats:bold>.<\/jats:p><jats:p><jats:bold>Parallel studies were conducted in 6 antrectomized, vagotomized patients who had undergone Roux\u2010en\u2010Y conversion for postgastrectomy bilious vomiting, and in 2 patients after total gastrectomy. Duodenal perfusion via duodenostomy tubes with 150\u00a0mM NaCl, 150\u00a0mM HCl, fat emulsion, and an amino acid mixture did not raise serum gastrin above basal levels<\/jats:bold>.<\/jats:p><jats:p><jats:bold>Since meat feeding and duodenal perfusion in antrectomized dogs and humans failed to stimulate a rise in serum gastrin, we conclude that the intestinal phase of gastric secretion is unlikely to be mediated by gastrin. The results following vagotomy in the dog suggest that extragastric basal gastrin release is vagally inhibited or that vagotomy interferes with the catabolic destruction of gastrin<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01556195","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T20:10:30Z","timestamp":1114632630000},"page":"639-645","source":"Crossref","is-referenced-by-count":1,"title":["Studies on the release of extra\u2010antral gastrin evidence of vagal inhibition in the dog"],"prefix":"10.1002","volume":"1","author":[{"given":"M. H.","family":"Wheeler","sequence":"first","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"},{"name":"Llandough Hospital Nr. Penarth. S. Glam. CF6 1XX Cardiff Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bhattacherjee","sequence":"additional","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Psaila","sequence":"additional","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"McLeish","sequence":"additional","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Poxom","sequence":"additional","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Owens","sequence":"additional","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. G.","family":"Clendinnen","sequence":"additional","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Alexander\u2010Williams","sequence":"additional","affiliation":[{"name":"Surgical Units University Hospital of Wales Cardiff"},{"name":"General Hospital Birmingham"},{"name":"Royal Infirmary Bristol Great Britain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527109180667"},{"key":"e_1_2_1_3_1","first-page":"95","volume-title":"Proceedings of Nobel Symposium XVI","author":"Nilsson G.","year":"1973"},{"key":"e_1_2_1_4_1","first-page":"841","article-title":"The intestinal phase of gastric secretion: a pharmacological profile of entero\u2010oxyntin","volume":"77","author":"Way L.W.","year":"1975","journal-title":"Surgery"},{"key":"e_1_2_1_5_1","first-page":"145","article-title":"Further evidence for an intestinal phase hormone that stimulates gastric acid secretion","volume":"80","author":"Orloff M.J.","year":"1976","journal-title":"Surgery"},{"key":"e_1_2_1_6_1","first-page":"500","article-title":"A comparison of insulin and food as stimuli for the differentiation of vagal and non\u2010vagal gastric pouches","volume":"1","author":"Jemerin E.E.","year":"1943","journal-title":"Gastroenterology"},{"key":"e_1_2_1_7_1","first-page":"91","volume-title":"Statistical Methods","author":"Snedecor G.W.","year":"1968"},{"key":"e_1_2_1_8_1","first-page":"847","article-title":"The technique and indications for balloon catheter duodenostomy","volume":"69","author":"Alexander\u2010Williams J.","year":"1976","journal-title":"Proc. R. Soc. Med."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197502000-00012"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32409-6"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(73)80157-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80540-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(71)80141-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(71)80140-3"},{"key":"e_1_2_1_15_1","first-page":"826","article-title":"Physiological characteristics of the intestinal phase of gastric secretion","volume":"62","author":"Way L.W.","year":"1972","journal-title":"Gastroenterology"},{"key":"e_1_2_1_16_1","first-page":"285","article-title":"Fonctions gastro\u2010intestinales","volume":"17","author":"Leconte P.","year":"1900","journal-title":"Etude Physiol. Cellule"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1925.sp000343"},{"key":"e_1_2_1_18_1","first-page":"118","article-title":"Humoral mediation of the intestinal phase of gastric secretion and of acid hypersecretion associated with portacaval shunts","volume":"66","author":"Orloff M.J.","year":"1969","journal-title":"Surgery"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32802-1"},{"key":"e_1_2_1_20_1","first-page":"314","article-title":"Gastrin release from duodenum and jejunum in dogs","volume":"23","author":"Becker H.D.","year":"1972","journal-title":"Surg. Forum"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80315-0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527209180950"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(74)80169-1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1973.12096740"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(64)80052-4"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01556195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01556195\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01556195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T11:33:22Z","timestamp":1703676802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01556195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1977,9]]}},"alternative-id":["10.1007\/BF01556195"],"URL":"https:\/\/doi.org\/10.1007\/bf01556195","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,9]]}}}