{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:32:02Z","timestamp":1759541522729},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1977,5,1]],"date-time":"1977-05-01T00:00:00Z","timestamp":231292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1977,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>In an experimental study, the serosa of the ileum of rats was injured with silver nitrate, and the effect of topical application of a dexamethasone solution on subsequent formation of intraperitoneal adhesions was compared to the effect of saline irrigation (controls). There was a highly significant difference<\/jats:bold> (<jats:italic>p<\/jats:italic>&lt;<jats:bold>0.01) in the incidence and grade of adhesions observed 1 and 4 weeks postoperatively between the control and dexamethasone\u2010treated rats. Furthermore, adhesive intestinal strictures were observed in the control rats, but not in the animals that received dexamethasone. Administration of dexamethasone at the time of laparotomy and again 1 week postoperatively was most effective in preventing adhesions<\/jats:bold>.<\/jats:p><jats:p><jats:bold>In a clinical trial, topical application of dexamethasone at the time of laparotomy for recurrent adhesive intestinal obstruction in 34 patients was associated with a 9% incidence of further recurrence of adhesive obstruction over a 1\u20136 year follow\u2010up period, compared to a 31% incidence of recurrent obstruction in 13 similar patients who received only saline irrigation. Intraperitoneal administration of dexamethasone at the time of laparotomy and for the first 2\u00a0days postoperatively in 5 patients was followed by no recurrence of obstruction<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01556870","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T19:36:52Z","timestamp":1114630612000},"page":"389-393","source":"Crossref","is-referenced-by-count":5,"title":["The role of topically applied dexamethasone in preventing peritoneal adhesions: Experimental and clinical studies"],"prefix":"10.1002","volume":"1","author":[{"given":"Jun\u2010ichi","family":"Shikata","sequence":"first","affiliation":[{"name":"Department of Surgery Bokuto General Hospital Tokyo Japan"},{"name":"Department of Surgery Teikyo University School of Medicine 2\u201011\u20101\u00a0Kaga, Itabashi\u2010ku 173 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Surgery Bokuto General Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"118","article-title":"The prophylaxis of peritoneal adhesion. 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