{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:31:06Z","timestamp":1760297466730},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1007\/bf01575444","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T16:15:46Z","timestamp":1114618546000},"page":"127-134","source":"Crossref","is-referenced-by-count":7,"title":["IL-2 gene therapy of solid tumors: an approach for the prevention of signal transduction defects in T cells"],"prefix":"10.1007","volume":"74","author":[{"given":"K. S.","family":"Zier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gansbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/369357a0","volume":"369","author":"D Pardoll","year":"1994","unstructured":"Pardoll D (1994) A new look for the 1990s. Nature 369:357\u2013358","journal-title":"Nature"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.180.1.1","volume":"180","author":"AN Houghton","year":"1994","unstructured":"Houghton AN (1994) Cancer antigens: immune recognition of self and altered self. J Exp Med 180:1\u20134","journal-title":"J Exp Med"},{"key":"CR3","doi-asserted-by":"crossref","unstructured":"Boon T, Cerottini J-C, Van den Eynde B, van der Bruggen P, Van Pel A. Tumor antigens recognized by T lymphocytes. Ann Rev Immunol 12:337\u2013365","DOI":"10.1146\/annurev.iy.12.040194.002005"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0092-8674(05)80059-5","volume":"71","author":"L Chen","year":"1994","unstructured":"Chen L, Ashe S, Brady WA, Hellstrom I, Hellstrom KE, Ledbetter JA, McGown P, Linsley PS (1994) Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71:1093\u20131102","journal-title":"Cell"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1073\/pnas.90.12.5687","volume":"90","author":"S Baskar","year":"1993","unstructured":"Baskar S, Ostrand-Rosenberg S, Nabavi N, Nadler LM, Freeman GJ, Glimcher LH (1993) Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated MCH class II molecules. Proc Natl Acad Sci 90:5687\u20135690","journal-title":"Proc Natl Acad Sci"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1084\/jem.179.2.523","volume":"179","author":"L Chen","year":"1994","unstructured":"Chen L, McGowan P, Ashe S, Johnston J, Li Y, Hellstrom I, Hellstrom KE (1994) Tumor immunogenicity determines the effect of B7-1 costimulation on T cell mediated tumor immunity. J Exp Med 179:523\u2013532","journal-title":"J Exp Med"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1126\/science.7678351","volume":"259","author":"SE Townsend","year":"1993","unstructured":"Townsend SE, Allison J (1993) Tumor rejection after direct costimulation of CD8+ T cell by B7-transfected melanoma cells. Science 259:368\u2013370","journal-title":"Science"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/08830188909044783","volume":"4","author":"AJT George","year":"1989","unstructured":"George AJT, Stevenson FK (1989) Prospect for the treatment of B cell tumors using idiotypic vaccination. Intern Rev Immunol 4:271\u2013310","journal-title":"Intern Rev Immunol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0065-230X(08)60827-1","volume":"60","author":"D Sulizeanu","year":"1993","unstructured":"Sulizeanu D (1993) Immunosuppressive factors in human cancers. Adv Cancer Res 60:247\u2013267","journal-title":"Adv Cancer Res"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0952-7915(92)90036-E","volume":"4","author":"MJ Browning","year":"1992","unstructured":"Browning MJ, Bodmer WF (1992) MHC antigens and cancer: Implications for T-cell surveillance. Curr Opin Immunol 4:613\u2013618","journal-title":"Curr Opin Immunol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1056\/NEJM197812072992305","volume":"299","author":"S Broder","year":"1978","unstructured":"Broder S, Waldmann H (1978) The suppressor cell network in cancer. New Engl J Med 299:1281\u20131284","journal-title":"New Engl J Med"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1126\/science.1465616","volume":"258","author":"H Mizoguchi","year":"1992","unstructured":"Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW, Ochoa AC (1992) Alterations in signal transduction molecules in T lymphocytes from tumor bearing mice. Science 258:1795\u20131798","journal-title":"Science"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.4049\/jimmunol.153.11.5176","volume":"153","author":"S Salvadori","year":"1994","unstructured":"Salvadori S, Gansbacher B, Pizaimenti A, Zier K. (1994) Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2 secreting tumors. J Immunol 153:5176\u20135182","journal-title":"J Immunol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0167-5699(93)90051-L","volume":"14","author":"DM Pardoll","year":"1993","unstructured":"Pardoll DM (1993) Cancer vaccines. Immunol Today 14:310\u2013316","journal-title":"Immunol Today"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00001622-199411000-00014","volume":"6","author":"F Rosenthal","year":"1994","unstructured":"Rosenthal F, Zier KS, Gansbacher B (1994) Human tumor vaccines and genetic engineering of tumors with cytokine and histocompatibility genes to enhance immunogenicity. Curr Opin Oncol 6:611\u2013615","journal-title":"Curr Opin Oncol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.1532456","volume":"255","author":"F Letourneur","year":"1992","unstructured":"Letourneur F, Klausner RD (1992) Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science 255:79\u201382","journal-title":"Science"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0022-1759(85)90416-8","volume":"84","author":"KS Zier","year":"1985","unstructured":"Zier KS (1985) Generation of antigen specific CTL directed against class II molecules expressed by activated T cells. J Immunol Methods 84:73\u201384","journal-title":"J Immunol Methods"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1146\/annurev.iy.12.040194.003511","volume":"12","author":"G Berke","year":"1994","unstructured":"Berke G (1994) The binding and lysis of target cells by cytotoxic lymphocytes: molecular and cellular aspects. Ann Rev Immunol 12:735\u2013773","journal-title":"Ann Rev Immunol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0167-5699(94)90080-9","volume":"15","author":"CH June","year":"1994","unstructured":"June CH, Bluestone JA, Nadler L, Thompson CB (1994) The B7 and CD28 receptor families. Immunol Today 15:321\u2013331","journal-title":"Immunol Today"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.2540528","volume":"244","author":"T Lindsten","year":"1989","unstructured":"Lindsten T, June CH, Ledbetter JA, Stella GT, Thompson CB (1989) Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339\u2013343","journal-title":"Science"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0952-7915(93)90054-V","volume":"5","author":"MK Jenkins","year":"1993","unstructured":"Jenkins MK, Johnson JG (1993) Molecules involved in T cell costimulation. Curr Opin Immunol 5:361\u2013367","journal-title":"Curr Opin Immunol"},{"key":"CR22","first-page":"402","volume-title":"Immunology and allergy clinics of american: human cancer immunology II","author":"PO Livingston","year":"1991","unstructured":"Livingston PO (1991) Active specific immunotherapy in the treatment of cancer. In: Oettgen HF (ed) Immunology and allergy clinics of american: human cancer immunology II, vol 11. Saunders: London, pp 402\u2013423"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00000658-199310000-00006","volume":"218","author":"SA Rosenberg","year":"1993","unstructured":"Rosenberg SA, Anderson WF, Blaese M, Hwu P, Yannelli JR, Topakian SL, Schwawrtzentruber KJ, Weber JS, Ettingausen SE, Parkinson DN, White DE (1993) The development of gene therapy for the treatment of cancer. Ann Surg 218:455\u2013463","journal-title":"Ann Surg"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0167-5699(94)90131-7","volume":"15","author":"MP Colombo","year":"1993","unstructured":"Colombo MP, Forni G (1993) Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now? Immunol Today 15:48\u201351","journal-title":"Immunol Today"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.4049\/jimmunol.149.11.3627","volume":"149","author":"T Cavallo","year":"1992","unstructured":"Cavallo T, Giovarelli M, Gulino A, Vacca A, Stoppacciaro A, Modesti A, Forni A (1992) Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by the IL-2 gene. J Immunol 149:3627\u20133635","journal-title":"J Immunol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1073\/pnas.92.10.4711","volume":"92","author":"W Schmidt","year":"1995","unstructured":"Schmidt W, Schweighoffer T, Herbst E, Maass G, Berger M, Schilcher G, Schaffner G, Birnstiel ML (1995) Cancer vaccines: the interleukin 2 dosage effect. Proc Natl Acad Sci 92:4711\u20134714","journal-title":"Proc Natl Acad Sci"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.8493530","volume":"260","author":"RC Mulligan","year":"1993","unstructured":"Mulligan RC (1993) The basic science of gene therapy. Science 260:926\u2013932","journal-title":"Science"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1084\/jem.172.4.1217","volume":"172","author":"B Gansbacher","year":"1990","unstructured":"Gansbacher B, Zier K, Daniels B, Cronin K, Bannerji R, Gilboa E (1990) IL-2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 172:1217\u20131224","journal-title":"J Exp Med"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1126\/science.1948050","volume":"254","author":"PT Golumbek","year":"1991","unstructured":"Golumbek PT, Lazenby AJ, Levitzky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM (1991) Treatment of established renal cancer engineered to secrete interleukin-4. Science 254:713\u2013716","journal-title":"Science"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1084\/jem.177.4.1127","volume":"177","author":"J Connor","year":"1993","unstructured":"Connor J, Bannerji R, Saito S, Heston W, Fair W, Gilboa E (1993) Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells. J Exp Med 177:1127\u20131134","journal-title":"J Exp Med"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1073\/pnas.90.8.3539","volume":"90","author":"G Dranoff","year":"1993","unstructured":"Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky HI, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC (1993) Vaccination with irradiated tumor cells engineered to secrete murine ganulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci 90:3539\u20133543","journal-title":"Proc Natl Acad Sci"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.4049\/jimmunol.150.4.1458","volume":"150","author":"A Porgardor","year":"1993","unstructured":"Porgardor A, Bannerji R, Watanabe Y, Feldman M, Gilboa E, Eisenbach L (1993) Anti-metastatic vaccination of tumorbearing mice with two types of IFN-\u03b3 gene inserted tumors cells. J Immunol 150:1458\u20131470","journal-title":"J Immunol"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(89)90925-2","volume":"57","author":"RI Tepper","year":"1989","unstructured":"Tepper RI, Pattengale PK, Leder P (1989) Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell 57:503\u2013512","journal-title":"Cell"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0092-8674(90)90591-2","volume":"60","author":"E R Fearon","year":"1990","unstructured":"Fearon E R, Pardoll D M, Itaya T, Golumbek P, Levitsky HI, Simons JW, Karasuyama H, Vogelstein B, Frost P (1990) Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 60:397\u2013403","journal-title":"Cell"},{"key":"CR35","first-page":"7820","volume":"50","author":"B Gansbacher","year":"1990","unstructured":"Gansbacher B, Bannerji R, Daniels B, Zier K, Cronin K, Gilboa E (1990) Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long-lasting antitumor immunity. Cancer Res 50:7820\u20137825","journal-title":"Cancer Res"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1126\/science.1948050","volume":"254","author":"PT Golumbek","year":"1991","unstructured":"Golumbek PT, Lazenby A J, Levitzky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM (1991) Treatment of established renal cancer engineered to secrete interleukin-4. Science 254:713\u2013716","journal-title":"Science"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.173.5.1047","volume":"173","author":"T Blankenstein","year":"1991","unstructured":"Blankenstein T, Qin ZH, Uberia K, Muller W, Rosen H, Volk HD, T Diamantstein (1991) Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer. J Exp Med 173:1047\u20131052","journal-title":"J Exp Med"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.4049\/jimmunol.146.9.3227","volume":"146","author":"AL Asher","year":"1991","unstructured":"Asher AL, Mule JJ, Kasid A, Restifo NP, Salo JC, Reichert CM, Jaffe G, Fendly B, Kriegler M, Rosenberg SA (1991) Murine tumor cells transduced with the gene for tumor necrosis factor alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors. J Immunol 146:3227\u20133234","journal-title":"J Immunol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1084\/jem.174.6.1291","volume":"174","author":"H Hock","year":"1991","unstructured":"Hock H, Dorsch M, Diamantstein T, Blankenstein T (1991) Interleukin-7 induces CD4+ T cell-dependent tumor rejection. J Exp Med 174:1291\u20131298","journal-title":"J Exp Med"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/eji.1830210350","volume":"21","author":"V Ley","year":"1991","unstructured":"Ley V, Langlade-Demoyen P, Kourilsky P, Larsson-Scared E-L (1991) Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo. Eur J Immunol 21:851\u2013854","journal-title":"Eur J Immunol"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1084\/jem.173.4.889","volume":"173","author":"M Colombo","year":"1991","unstructured":"Colombo M, Ferrari G, Stoppacciaro A, Parenza M, Rodolfo M, Mavilio F, Parmiani G (1991) Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med 173:889\u2013897","journal-title":"J Exp Med"},{"key":"CR42","first-page":"3679","volume":"52","author":"A Porgador","year":"1992","unstructured":"Porgador A, Tzehoval E, Katz A, Vadai E, Revel M, Feldman M, Eisenbach L. (1992) Interleukin-6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers therapeutic competence against metastatic cells. Cancer Res 52:3679\u20133686","journal-title":"Cancer Res"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1089\/hum.1995.6.10-1299","volume":"6","author":"S Salvadori","year":"1995","unstructured":"Salvadori, S, Gansbacher, B, Wernick, I, Tirelli, S, Zier, K (1995) B7-1 transfected tumor cells induce a response in syngeneic hosts in vivo, but fail to stimulate naive allogeneic cells in vitro. Human Gene Ther 6:1299\u20131306","journal-title":"Human Gene Ther"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1126\/science.7513904","volume":"264","author":"AYC Huang","year":"1994","unstructured":"Huang AYC, Golumbek P, Ahmadzadeh M, Jaffee E, Pardoll D, Levitsky H (1994) Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264:961\u2013965","journal-title":"Science"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/eji.1830190504","volume":"19","author":"ME Sanders","year":"1989","unstructured":"Sanders ME, Makgoba MW, June CH, Young HA, Shaw S (1989) Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation. Eur J Immunol 19:803\u2013807","journal-title":"Eur J Immunol"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jlb.55.2.265","volume":"55","author":"N Isakov","year":"1994","unstructured":"Isakov N, Wange RL, Samelson LE (1994) The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor mediated signal transduction pathway. J Leuk Biol 55:265\u2013271","journal-title":"J Leuk Biol"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.iy.11.040193.001333","volume":"11","author":"T Minami","year":"1993","unstructured":"Minami T, Kono T, Miyazaki T, Taniguchi T (1993) The IL-2 receptor complex: its function, and target genes. Ann Rev Immunol 11:245\u2013268","journal-title":"Ann Rev Immunol"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"24913","DOI":"10.1016\/S0021-9258(19)73981-7","volume":"267","author":"LE Samelson","year":"1992","unstructured":"Samelson LE, Klausner RD (1992) Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J Biol Chem 267:24913\u201324916","journal-title":"J Biol Chem"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/1074-7613(94)90038-8","volume":"1","author":"S Oers van","year":"1994","unstructured":"van Oers S, Killeen N, Weiss A (1994) ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity 1:675\u2013685","journal-title":"Immunity"},{"key":"CR50","doi-asserted-by":"crossref","unstructured":"Salvadori S, Zier K (1996) The molecular basis of T cell dysfunction in cancer is influenced by paracrine secretion of tumor-derived IL-2. J Immunol (in press)","DOI":"10.4049\/jimmunol.156.8.2927"},{"key":"CR51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(94)90334-4","volume":"76","author":"A Weiss","year":"1994","unstructured":"Weiss A, Littman DR (1994) Signal transduction by lymphocyte antigen receptors. Cell 76:263\u2013274","journal-title":"Cell"},{"key":"CR52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/357161a0","volume":"357","author":"TJ Molina","year":"1992","unstructured":"Molina TJ, Kishihara K, Siderovski DP, van Ewijk W, Narendran W, Timms E, Wakeham A, Paige CJ, Jartmann KU, Veillette A, Davidson D, Mak TW (1992) Profound block in thymocyte development in mice lacking p56lek. Nature 357:161\u2013164","journal-title":"Nature"},{"key":"CR53","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0092-8674(92)90309-Z","volume":"70","author":"MW Appelby","year":"1992","unstructured":"Appelby MW, Gross JA, Cooke, MP Levin SD, Qian X, Perlmutter RM (1992) Defective T cell receptor signaling in mice lacking the thymic isoform of p59-fyn. Cell 70:751\u2013763","journal-title":"Cell"},{"key":"CR54","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(92)90598-7","volume":"71","author":"AC Chan","year":"1992","unstructured":"Chan AC, Iwashima M, Turck CW, Weiss A (1992) ZAP-70: a 70 kD protein-tyrosinase that associates with the TCR \u03b6 chain. Cell 71:649\u2013662","journal-title":"Cell"},{"key":"CR55","doi-asserted-by":"crossref","first-page":"19797","DOI":"10.1016\/S0021-9258(19)36584-6","volume":"268","author":"RL Wange","year":"1993","unstructured":"Wange RL, Malek SN, Desiderio S, Samelson LE (1993) Tandem SH2 domains of ZAP-70 bind to the T cell antigen receptor zeta and CD\u03b5 from activated Jurkat T cells. J Biol Chem 268:19797\u201319801","journal-title":"J Biol Chem"},{"key":"CR56","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0092-8674(94)90368-9","volume":"76","author":"E Arpaia","year":"1994","unstructured":"Arpaia E, Shahar M, Dadi H, Cohen D, Roifman CM (1994) Defective T cell receptor signaling and CD8+ thymic selection in humans lacking ZAP-70 kinase. Cell 76:947\u2013958","journal-title":"Cell"},{"key":"CR57","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.8202712","volume":"264","author":"ME Elder","year":"1994","unstructured":"Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TE (1994) Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264:1596\u20131599","journal-title":"Science"},{"key":"CR58","doi-asserted-by":"crossref","first-page":"20031","DOI":"10.1016\/S0021-9258(20)80690-5","volume":"268","author":"R Taichman","year":"1993","unstructured":"Taichman R, Merida I, Torigoe T, Gaulton GN, Reed JC (1993) Evidence that protein tyrosine kinase p56lck regulates the activity of phosphatidylinositol-3\u2032-kinase in IL-2 dependent T cells. J Biol Chem 268:20031\u201320036","journal-title":"J Biol Chem"},{"key":"CR59","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1084\/jem.179.6.1799","volume":"179","author":"LM Karnitz","year":"1994","unstructured":"Karnitz LM, Sutor SL, Abraham RT (1994) The src-family kinase, fyn, regulates the activation of phosphatidylinositol-3-kinase in an IL-2 dependent line. J Exp Med 179:1799\u20131808","journal-title":"J Exp Med"},{"key":"CR60","first-page":"91","volume-title":"Lymphocyte activation","author":"GN Gaulton","year":"1994","unstructured":"Gaulton GN, Williamson P (1994) Interleukin-2 and the interleukin-2 receptor complex. In: Samelson LE (ed) Lymphocyte activation. Karger, Basel, pp 91\u2013114"},{"key":"CR61","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1084\/jem.179.3.1071","volume":"179","author":"KE Truitt","year":"1994","unstructured":"Truitt KE, Hicks CM, Imboden JB (1994) Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med 179:1071\u20131076","journal-title":"J Exp Med"},{"key":"CR62","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/intimm\/6.5.769","volume":"6","author":"A August","year":"1994","unstructured":"August A, Dupont B (1994) CD28 of T lymphocytes associates with Pl 3-kinase. Int Immunol 6:769\u2013774","journal-title":"Int Immunol"},{"key":"CR63","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/smim.1993.1041","volume":"5","author":"GB Mills","year":"1993","unstructured":"Mills GB, Schmandt R, Gibson S, Leung B, Hill M, May C, Shi YF, Branch DR, Radvanyi L, Truitt KE, Imboden J (1993) Transmembrane signaling by the IL-2 receptor: progress and conundrums. Semin Immunol 5:345\u2013364","journal-title":"Semin Immunol"},{"key":"CR64","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0167-5699(95)80134-0","volume":"16","author":"MI Pastor","year":"1995","unstructured":"Pastor MI, Reif K, Cantrell DA (1995) The regulation and function of p21ras during T-cell activation and growth. Immunol Today 16:159\u2013164","journal-title":"Immunol Today"},{"key":"CR65","unstructured":"Reed JC, Nowell PC (1988) Mechanisms of interleukin 2 action: IL-2-inducible gene expression in T lymphocytes. In: Smith KA (ed) Interleukin 2, pp 137\u2013151"},{"key":"CR66","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/370151a0","volume":"370","author":"JA Johnston","year":"1994","unstructured":"Johnston JA, Kawamura M, Kirken RA, Chen Y, Blake T, Shibuya D, Ortaldo J, McVicar D, O'Shea J (1994) Phosphorylation and activation of the Jak-3 kinase in response to interleukin-2. Nature 370:151\u2013153","journal-title":"Nature"},{"key":"CR67","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/370153a0","volume":"370","author":"BA Witthuhn","year":"1994","unstructured":"Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN (1994) Involvement of the Jak-3 kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153\u2013157","journal-title":"Nature"},{"key":"CR68","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1002\/j.1460-2075.1994.tb06898.x","volume":"13","author":"C Beadling","year":"1994","unstructured":"Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA (1994) Activation of JAK kinases and STAT proteins by interleukin-2 and interferon \u03b1, but not the T cell antigen receptor, in human T lymphocytes. EMBO J 13: 5605\u20135615","journal-title":"EMBO J"},{"key":"CR69","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/1074-7613(95)90140-X","volume":"2","author":"H Hou","year":"1995","unstructured":"Hou H, Schindler U, Henzel WJ, Wong SC, McKnight SL (1995) Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321\u2013329","journal-title":"Immunity"},{"key":"CR70","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","volume":"264","author":"JE Darnell","year":"1994","unstructured":"Darnell JE, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415\u20131421","journal-title":"Science"},{"key":"CR71","first-page":"613","volume":"53","author":"JH Finke","year":"1993","unstructured":"Finke JH, Zea AH, Stanley J, Longo DL, Mizoguchi H, Tubbs RR, Wiltrout RH, O'Shea JJ, Kudoh S, Bukowsky R, Ochoa AC (1993) Loss of T-cell receptor chain and p56lck in T-cells infiltrating human renal cell carcinoma. Cancer Res 53:613\u20135616","journal-title":"Cancer Res"},{"key":"CR72","first-page":"5610","volume":"53","author":"H Nakagomi","year":"1993","unstructured":"Nakagomi H, Peterson M, Magnusson I, Juhlin C, Matsuda M, Mellstedt H, Taupin J-L, Vivier E, Anderson P, Kiessling, R (1993) Decreased expression of the signal-transducing \u03b6 chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res 53:5610\u20135612","journal-title":"Cancer Res"},{"key":"CR73","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/ijc.2910590607","volume":"59","author":"F Farace","year":"1994","unstructured":"Farace F, Angevin E, Vanderplancke J, Escudier B, Triebel F (1994) The decreased expression of CD3 \u03b6 chains in cancer patients is not reversed by IL-2 administration. Int J Cancer 59:752\u2013755","journal-title":"Int J Cancer"},{"key":"CR74","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1084\/jem.181.5.1881","volume":"181","author":"T Aoe","year":"1995","unstructured":"Aoe T, Okamoto Y, Saito T (1995) Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Med 181:1881\u20131886","journal-title":"J Exp Med"},{"key":"CR75","first-page":"2969","volume":"54","author":"P Ghosh","year":"1994","unstructured":"Ghosh P, Sica A, Young HA, Ye J, Franco JL, Wiltrout RH, Longo DL, Rice NR, Komschlies KL (1994) Alterations in NkB\/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy. Cancer Res 54:2969\u20132972","journal-title":"Cancer Res"},{"key":"CR76","first-page":"5424","volume":"54","author":"X Li","year":"1994","unstructured":"Li X, Liu J, Park JK, Hamilton TA, Rayman P, Klein E, Edinger M, Tubbs R, Bukowski R, Finke J (1994) T cells from renal carcinoma patients exhibit an abnormal pattern of kBspecific DNA-binding activity: a preliminary report. Cancer Res 54:5424\u20135429","journal-title":"Cancer Res"},{"key":"CR77","first-page":"165","volume":"1","author":"S Salvadori","year":"1994","unstructured":"Salvadori S, Gansbacher B, Zier KS (1994) Functional differences are associated with abnormal signal transduction in T cells of mice inoculated with parental but not IL-2 secreting tumor cells. Cancer Gene Ther 1:165\u2013170","journal-title":"Cancer Gene Ther"},{"key":"CR78","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0167-5699(96)80567-6","volume":"17","author":"K Zier","year":"1995","unstructured":"Zier K, Gansbacher B, Salvadori S (1995) Preventing abnormalities in signal transduction of T cells in cancer: the promise of cytokine gene therapy. Immunol Today 17:39\u201345","journal-title":"Immunol Today"},{"key":"CR79","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1084\/jem.171.3.801","volume":"171","author":"CR Mackay","year":"1990","unstructured":"Mackay CR, Marston WL, Dudler L (1990) Naive and memory T cell show distinct pathways of lymphocyte recirculation. J Exp Med 171:801\u2013817","journal-title":"J Exp Med"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01575444.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01575444\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01575444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T02:02:02Z","timestamp":1683079322000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01575444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["BF01575444"],"URL":"https:\/\/doi.org\/10.1007\/bf01575444","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}