{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:14:35Z","timestamp":1764688475851},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[1991,1]]},"DOI":"10.1007\/bf01613190","type":"journal-article","created":{"date-parts":[[2005,4,30]],"date-time":"2005-04-30T09:10:09Z","timestamp":1114852209000},"page":"13-18","source":"Crossref","is-referenced-by-count":13,"title":["DNA methylation in the digestive tract of F344 rats during chronic exposure toN-methyl-N-nitrosourea"],"prefix":"10.1007","volume":"117","author":[{"given":"Hiroko","family":"Ohgaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara I.","family":"Ludeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kleihues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner K.","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schlatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.572989","volume":"205","author":"SC Boyd","year":"1979","unstructured":"Boyd SC, Sasame HA, Boyd MR (1979) High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis. Science 205:1010\u20131012","journal-title":"Science"},{"key":"CR2","doi-asserted-by":"crossref","unstructured":"Druckrey H, Preussmann R, Schm\u00e4hl D, M\u00fcller M (1961) Erzeugung von Magenkrebs durch Nitrosamide an Ratten. Naturwissenschaften 258\u2013259","DOI":"10.1007\/BF00639550"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/BF00631166","volume":"51","author":"H Druckrey","year":"1964","unstructured":"Druckrey H, Ivancovic S, Preussmann R (1964) Erzeugung von Hirntumoren bei Ratten durch Methylnitrosoharnstoff. Naturwissenschaften 51:144","journal-title":"Naturwissenschaften"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF00525737","volume":"69","author":"H Druckrey","year":"1965","unstructured":"Druckrey H, Ivankovic S, Preussmann R (1965) Selektive Erzeugung maligner Tumoren im Gehirn und R\u00fcckenmark von Ratten durchN-methyl-N-nitrosoharnstoff. Z Krebsforsch 69:389\u2013408","journal-title":"Z Krebsforsch"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00524152","volume":"69","author":"H Druckrey","year":"1967","unstructured":"Druckrey H, Preussmann R, Ivankovic S, Schm\u00e4hl D (1967) Organotrope carcinogene Wirkungen bei 65 verschiedenenN-Nitroso-Verbindungen an BD-Ratten. Z Krebsforsch 69:103\u2013201","journal-title":"Z Krebsforsch"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0076-6879(86)21050-2","volume":"121","author":"PL Ey","year":"1986","unstructured":"Ey PL, Ashman LK (1986) The use of alkaline phosphatase-conjugated anti-immunoglobulin with immunoblots for determining the specificity of monoclonal antibodies to protein mixtures. Methods Enzymol 121:497\u2013509","journal-title":"Methods Enzymol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1293\/tox.2.27","volume":"2","author":"M Fujita","year":"1989","unstructured":"Fujita M, Ishii T, Tsukahara Y, Shimozuma K, Nakano Y, Taguchi T, Hirota N (1989) Establishment of the optimum conditions for induction of stomach carcinoma in rats by continous oral administration ofN-methyl-N-nitrosourea. J Toxicol Pathol 2:27\u201332","journal-title":"J Toxicol Pathol"},{"key":"CR8","first-page":"634","volume":"78","author":"N Hirota","year":"1987","unstructured":"Hirota N, Aonuma T, Yamada S, Kawai T, Saito K, Yokoyama T (1987) Selective induction of glandular stomach carcinoma in F344 rats byN-methyl-N-nitrosourea. Jpn J Cancer Res 78:634\u2013638","journal-title":"Jpn J Cancer Res"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1471-4159.1973.tb12158.x","volume":"20","author":"P Kleihues","year":"1973","unstructured":"Kleihues P, Magee P (1973) Alkylation of rat brain nucleic acids byN-methyl-N-nitrosourea and methyl methanesulphonate. J Neurochem 20:595\u2013606","journal-title":"J Neurochem"},{"key":"CR10","first-page":"1839","volume":"53","author":"P Kleihues","year":"1974","unstructured":"Kleihues P, Margison GP (1974) Carcinogenicity ofN-methyl-N-nitrosourea: possible role of excision repair of O6-methylguanosine from DNA. J Natl Cancer Inst 53:1839\u20131941","journal-title":"J Natl Cancer Inst"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00524515","volume":"75","author":"P Kleihues","year":"1971","unstructured":"Kleihues P, Patzschke K (1971) Distribution ofN-[14C]methyl-N-nitrosourea in the rat after systemic application. Z Krebsforsch 75:193\u2013200","journal-title":"Z Krebsforsch"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1093\/carcin\/9.12.2271","volume":"9","author":"O Kobori","year":"1988","unstructured":"Kobori O, Schmerold I, Ludeke B, Ohgaki H, Kleihues P (1988) DNA methylation in rat stomach and duodenom following chronic exposure toN-methyl-N\u2032-nitro-N-nitrosoguamdine and the effect of dietary taurocholate. Carcinogenesis 9:2271\u20132274","journal-title":"Carcinogenesis"},{"key":"CR13","first-page":"5482","volume":"48","author":"M Koenigsmann","year":"1988","unstructured":"Koenigsmann M, Schmerold I, Jeltsch W, Ludeke B, Kleihues P, Wiessler M (1988) Organ and cell specificity of DNA methylation byN-nitrosomethylamylamine in rats. Cancer Res 48:5482\u20135486","journal-title":"Cancer Res"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1042\/bj1280117","volume":"128","author":"PD Lawley","year":"1972","unstructured":"Lawley PD, Shah SA (1972) Methylation of ribonucleic acid by the carcinogens dimethyl sulphate,N-methyl-N-nitrosourea andN-methyl-N\u2032-nitrp-N-nitrosoguanidme. Comparisons of analyses at the nucleoside and base levels. Biochem J 128:117\u2013132","journal-title":"Biochem J"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/carcin\/9.1.147","volume":"9","author":"BI Ludeke","year":"1988","unstructured":"Ludeke BI, Kleihues P (1988) Formation and persistence of O6-(2-hydroxyethyl)-2\u2032-deoxyguanosine in DNA of various rat tissues following a single dose ofN-nitroso-N-(2-hydroxyethyl)urea. An immuno-slot-blot study. Carcinogenesis 9:147\u2013151","journal-title":"Carcinogenesis"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/BF00390353","volume":"109","author":"A Maekawa","year":"1985","unstructured":"Maekawa A, Matsuoka C, Onodera H, Tanigawa H, Furuta K, Ogiu T, Mitsumori K, Hayashi Y (1985) Organspecific carcinogenicity ofN-methyl-N-nitrosourea in F344 and ACI\/N rats. J Cancer Res Clin Oncol 109:178\u2013182","journal-title":"J Cancer Res Clin Oncol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj1480521","volume":"148","author":"GP Margison","year":"1975","unstructured":"Margison GP, Kleihues P (1975) Chemical carcinogenesis in the nervous system. Preferential accumulation ofO 6-methylguanine in rat brain deoxyribonucleic acid during repetive administration ofN-methyl-N-nitrosourea. Biochem J 148:521\u2013525","journal-title":"Biochem J"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1021\/ja01204a027","volume":"69","author":"AF McKay","year":"1947","unstructured":"McKay AF, Wright GF (1947) Preparation and properties ofN-methyl-N\u2032-nitro-N-nitrosoguanidine. J Am Chem Soc 69:3028\u20133030","journal-title":"J Am Chem Soc"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/carcin\/6.2.263","volume":"6","author":"GJ Menkveld","year":"1985","unstructured":"Menkveld GJ, Van Der Laken CJ, Hermsen T, Kriek E, Scerer E, Den Engelase L (1985) Immunohistochemical localization ofO 6-ethyldeoxyguanosine and deoxyguanosin-8-yl-(acetyl) aminofluorene in liver sections of rats treated with diethylnitrosamine, ethylnitrosourea orN-acetylaminofluorene. Carcinogenesis (Lond) 6:263\u2013270","journal-title":"Carcinogenesis (Lond)"},{"key":"CR20","series-title":"IARC Scientific Publication 89","first-page":"75","volume-title":"Methods for detecting DNA damaging agents in cancer epidemiology and prevention","author":"R Montesano","year":"1988","unstructured":"Montesano R, Bresil H, Degan P, Martel-Planche G, Serres M, Wild CP (1988) Detection in human cells of alkylated macromolecules attributable to exposure to nitrosamines. In: Bartsch H, Hemminki K, O'Neill IK (eds) Methods for detecting DNA damaging agents in cancer epidemiology and prevention, IARC Scientific Publication 89. IARC, Lyon, pp 75\u201382"},{"key":"CR21","first-page":"53","volume":"96","author":"ASK Murthy","year":"1973","unstructured":"Murthy ASK, Vawter GF, Bhaktaviziam A (1973) Neoplasms in Wistar rats after anN-methyl-N-nitrosourea injection. Arch Pathol 96:53\u201357","journal-title":"Arch Pathol"},{"key":"CR22","first-page":"23","volume":"108","author":"P Nehls","year":"1984","unstructured":"Nehls P, Adamkiewiez J, Rajewsky MF (1984) Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA. J Cancer Res 108:23\u201329","journal-title":"J Cancer Res"},{"key":"CR23","first-page":"491","volume":"68","author":"T Ogiu","year":"1977","unstructured":"Ogiu T, Nakadate M, Furuta K, Maekawa A, Odashima S (1977) Induction of tumors of peripheral nervous system in female Donryu rats by continuous oral administration of 1-methyl-1-nitrosourea. Gann 68:491\u2013498","journal-title":"Gann"},{"key":"CR24","first-page":"27","volume-title":"Gastric cancer","author":"H Ohgaki","year":"1988","unstructured":"Ohgaki H, Sugimura T (1988) Experimental stomach cancer. In Douglass HO Jr (ed) Gastric cancer. Churchill Livingstone, New York, pp 27\u201354"},{"key":"CR25","first-page":"5275","volume":"48","author":"H Ohgaki","year":"1988","unstructured":"Ohgaki H, Tomihari M, Sato S, Kleihues P, Sugimura T (1988) Differential proliferative response of gastric mucosa during carcinogenesis induced byN-methyl-N\u2032-nitro-N-nitrosoguanidine in susceptible ACI rats, resistant Buffalo rats, and their hybrid F1 cross. Cancer Res 48:5275\u20135279","journal-title":"Cancer Res"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0304-3835(89)90018-9","volume":"46","author":"H Ohgaki","year":"1989","unstructured":"Ohgaki H, Szentirmay Z, Take M, Sugimura T (1989) Effects of 4-week treatment with gastric carcinogens and enhancing agents on proliferation of gastric mucosa cells in rats. Cancer Lett 46:117\u2013122","journal-title":"Cancer Lett"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1177\/29.12.7033366","volume":"29","author":"P Ordronneau","year":"1981","unstructured":"Ordronneau P, Lindstr\u00f6m PBM, Petrusz P (1981) Four unlabelled antibody bridge techniques: a comparison. J Histochem Cytochem 29:1397\u20131404","journal-title":"J Histochem Cytochem"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/bj1100049","volume":"110","author":"PF Swann","year":"1968","unstructured":"Swann PF (1968) The rate of breakdown of methyl methanesulphonate, dimethyl sulphate andN-methyl-N-nitrosourea in the rat. Biochem J 110:49\u201352","journal-title":"Biochem J"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/bj1100039","volume":"110","author":"PF Swann","year":"1968","unstructured":"Swann PF, Magee PN (1968) Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat byN-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate. Biochem J 110:39\u201347","journal-title":"Biochem J"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-2952(72)90277-8","volume":"21","author":"GP Wheeler","year":"1972","unstructured":"Wheeler GP, Bowdon BJ (1972) Comparison of the effects of cysteine upon the decomposition of nitrosoureas and of 1-methyl-3-nitro-1-nitrosoguanidine. Biochemical Pharmacol 21:265\u2013267","journal-title":"Biochemical Pharmacol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/carcin\/4.7.879","volume":"4","author":"O Wiestler","year":"1983","unstructured":"Wiestler O, Deimling A, Kobori O, Kleihues P (1983) Location ofN-methyl-N\u2032-nitro-N-nitrosoguanidine-induced gastrointestinal tumors correlates with thiol distribution. Carcinogenesis 4:879\u2013883","journal-title":"Carcinogenesis"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01613190.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01613190\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01613190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T14:14:57Z","timestamp":1557238497000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01613190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["BF01613190"],"URL":"https:\/\/doi.org\/10.1007\/bf01613190","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}