{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:03:46Z","timestamp":1778295826213,"version":"3.51.4"},"reference-count":229,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1979,9,1]],"date-time":"1979-09-01T00:00:00Z","timestamp":304992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1979,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prostaglandins and serotonin are vasoactive compounds with profound effects on the gastrointestinal tract. Both cause inhibition of gastric acid secretion (although serotonin stimulates gastric pepsin secretion), stimulation of intestinal motility, and conversion of small intestinal mucosa from absorption to secretion of water and electrolytes. Their effects on pancreatic and biliary function are still not clear.<\/jats:p><jats:p>Although prostaglandins appear to elicit their effects primarily by a paracrine mode of action, and serotonin is primarily a neurotransmitter (neurocrine), it is clear that even under normal conditions both can function as humoral agents. For example, we have shown that serotonin plays a physiologic role as a humoral inhibitor of gastric acid secretion. However, the effects of these agents become more pronounced in patients with humorally mediated diarrheogenic syndromes. Serotonin (and related indoles, particularly 5\u2010hydroxytryptophan) has been firmly implicated as a cause of diarrhea in patients with carcinoid syndrome; our recent studies suggest that the diagnosis can be more effectively made by measuring circulating immunoreactive serotonin concentrations than urinary excretion of 5\u2010HIAA; that some circulating serotonin escapes hepatic inactivation and, thus, large intestinal tumors can cause carcinoid syndrome in the absence of hepatic metastases; and that large amounts of serotonin are produced by some noncarcinoid diarrheogenic tumors, including medullary carcinomas of the thyroid and tumors associated with the WDHA syndrome. A large number of tumors of probable neural crest origin, including medullary thyroid carcinoma, carcinoids, and tumors associated with the WDHA syndrome, secrete large amounts of prostaglandins, particularly PGE<jats:sub>2<\/jats:sub>. The clinical response of at least some of the patients harboring these tumors to inhibitors of prostaglandin synthesis (particularly indomethacin) suggests that prostaglandins play a role in the etiology of these diarrheogenic syndromes.<\/jats:p>","DOI":"10.1007\/bf01654761","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T11:01:54Z","timestamp":1117191714000},"page":"565-577","source":"Crossref","is-referenced-by-count":42,"title":["Prostaglandins and serotonin: Nonpeptide diarrheogenic hormones"],"prefix":"10.1002","volume":"3","author":[{"given":"Bernard M.","family":"Jaffe","sequence":"first","affiliation":[{"name":"Department of Surgery Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Surgery Downstate Medical Center 450 Clarkson Avenue 11203 Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1979,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02233268"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)34024-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012315"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000197138"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)33598-X"},{"key":"e_1_2_1_7_1","first-page":"47","volume-title":"Prostaglandin Symposium of Worcester Foundation for Experimental Biology","author":"Robert A","year":"1968"},{"key":"e_1_2_1_8_1","first-page":"55","volume-title":"Prostaglandin Symposium of Worcester Foundation for Experimental Biology","author":"Shaw J.E.","year":"1968"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(75)90099-2"},{"key":"e_1_2_1_10_1","first-page":"107P","article-title":"Parameters of the control of acid secretion in the isolated blood\u2010perfused stomach","volume":"226","author":"Shaw J.E.","year":"1972","journal-title":"J. Physiol. (Lond."},{"issue":"546","key":"e_1_2_1_11_1","article-title":"Studies on the mode of action of cyclic 3\u2032,5\u2032\u2010AMP and prostaglandin E2 on rat gastric acid secretion and mucosal blood flow","volume":"46","author":"Whittle B.J.R.","year":"1972","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(73)90135-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80147-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197306000-00002"},{"issue":"464","key":"e_1_2_1_15_1","article-title":"A proposed role for PGE2 in genesis of stress\u2010induced gastric ulcers","volume":"52","author":"Daturi S.","year":"1974","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000197584"},{"key":"e_1_2_1_17_1","first-page":"946","article-title":"Prevention of bile\u2010induced acute erosive gastritis by prostaglandin E2, Maalox and cholestryamine","volume":"68","author":"Mann N.S.","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(75)90301-3"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527109181124"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-133-34509"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1973.tb17253.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-139-36318"},{"key":"e_1_2_1_23_1","first-page":"1268","article-title":"Decreased canine gastric mucosal blood flow induced by prostaglandin E1: a mechanism for its inhibitory effect on gastric secretion","volume":"56","author":"Wilson D.W.","year":"1969","journal-title":"Gastroenterology"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1959.tb01685.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/221874a0"},{"key":"e_1_2_1_26_1","first-page":"73A","article-title":"Adenyl cyclase activity of guinea pig gastric mucosa: stimulation by histamine and prostaglandins","volume":"49","author":"Perrier C.V.","year":"1970","journal-title":"J. Clin. Invest."},{"key":"e_1_2_1_27_1","first-page":"606A","article-title":"Evidence for separate histamine and prostaglandin sensitive adenylate cyclases (AC) in guinea pig gastric mucosa (GM)","volume":"22","author":"Wollin A.","year":"1974","journal-title":"Clin. Res."},{"key":"e_1_2_1_28_1","first-page":"122","article-title":"Prostaglandin E2, adenylate cyclase et secretion gastrique chez le chien","volume":"8","author":"Dozois R.R.","year":"1975","journal-title":"Biol. Gastroenterol."},{"key":"e_1_2_1_29_1","first-page":"329","article-title":"Interaction of dibutyryl cyclic AMP and PGE2 on stimulated gastric acid secretion in rats","volume":"33","author":"Hohnke L.A.","year":"1974","journal-title":"Fed. Proc."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.16.6.437"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-93-5-1148"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb00977.x"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/216873a0"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012316"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(74)90012-5"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(74)90329-5"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01073020"},{"key":"e_1_2_1_38_1","first-page":"873","article-title":"Gastric prostaglandin E (PGE) output during basal and stimulated acid secretion in normal subjects and patients with peptic ulcer","volume":"68","author":"Cheung L.Y.","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1975.tb07351.x"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(69)80119-8"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.5.3.230"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1968.01340050149024"},{"key":"e_1_2_1_43_1","first-page":"43","article-title":"Prostaglandins and gastric secretion in man","volume":"9","author":"Bennett A.","year":"1972","journal-title":"Adv. Biosci."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(74)80059-6"},{"key":"e_1_2_1_45_1","unstructured":"Schlegel W. Wenk K. Dollinger H.C.:Mucosal concentrations of prostaglandin PGA PGE PGF in gastric disease. Vth Int. Cong. Endocrinol. (Hamburg) July 18\u201324 1976."},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1976.230.2.351"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800601018"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80255-7"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80483-0"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1974.12096907"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(74)90367-1"},{"key":"e_1_2_1_52_1","first-page":"790","article-title":"A gastric anti\u2010secretory and anti\u2010ulcer prostaglandin with oral and long\u2010acting activity","volume":"64","author":"Lancaster R.A.","year":"1973","journal-title":"Gastroenterology"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(74)80015-8"},{"key":"e_1_2_1_54_1","first-page":"375","article-title":"Double\u2010blind trial of 15 (R)\u201015\u2010methyl prostaglandin E2 methyl ester in the relief of peptic ulcer pain","volume":"3","author":"Fung W.P.","year":"1974","journal-title":"Ann. Acad. Med."},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.18.8.636"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb08492.x"},{"key":"e_1_2_1_57_1","first-page":"56P","article-title":"The biological assay of prostaglandins A1 and A2","volume":"200","author":"Horton E.W.","year":"1969","journal-title":"J. Physiol. (Lond."},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb07142.x"},{"key":"e_1_2_1_59_1","first-page":"1004","article-title":"Effect of prostaglandin (PG) on electrical and motor activity of isolated colonic muscle","volume":"58","author":"Vanasin B.","year":"1970","journal-title":"Gastroenterology"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577106400106"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1969.216.2.386"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34371"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb08493.x"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.9.6.655"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90402-2"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)92012-1"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio238026a0"},{"key":"e_1_2_1_68_1","first-page":"635A","article-title":"Effect of prostaglandin E2 (PGE2) on sodium and chloride transport in rat jejunum","volume":"22","author":"Declusin R.","year":"1974","journal-title":"Clin. Res."},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(71)80003-3"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106159"},{"key":"e_1_2_1_71_1","first-page":"854","article-title":"Effects of prostaglandin E1 on net and unidirectional movements of water and electrolytes across jejunal mucosa in man","volume":"12","author":"Matuchansky C.","year":"1971","journal-title":"Gut"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(73)80065-4"},{"key":"e_1_2_1_73_1","first-page":"747","article-title":"The effect of prostaglandin E2 (PGE2) on net jejunal transport and mean transit time","volume":"66","author":"Mize B.F.","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/243169a0"},{"issue":"15","key":"e_1_2_1_75_1","article-title":"Studies on the site of production of diarrhoea induced by prostaglandins","volume":"46","author":"Cummings J.H.","year":"1974","journal-title":"Clin. Sci. Mol. Med."},{"key":"e_1_2_1_76_1","first-page":"754","article-title":"Differential response of the human small and large intestine to prostaglandin F2\u03b1","volume":"66","author":"Newman A.","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_1_77_1","first-page":"636C","article-title":"Effect of prostaglandin E1 on glucose absorption and on transintestinal movements of water and electrolytes in human jejunum","volume":"5","author":"Matuchansky C.","year":"1972","journal-title":"Biol. Gastroenterol."},{"key":"e_1_2_1_78_1","first-page":"86","article-title":"Effects of prostaglandin E1 on jejunal absorption in man","volume":"9","author":"Matuchansky C.","year":"1973","journal-title":"Digestion"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106599"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.16.10.759"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107606"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/235163a0"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/238273a0"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.3.280"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107635"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108368"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(77)80312-0"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071191"},{"key":"e_1_2_1_89_1","first-page":"272","article-title":"Choleretic effect of prostaglandin PGE1 and PGE2 in cats","volume":"12","author":"Krarup N.","year":"1975","journal-title":"Digestion"},{"key":"e_1_2_1_90_1","first-page":"361A","article-title":"The effect of prostaglandins A1 (PGA1) and E1 (PGE1) on canine hepatic bile flow","volume":"22","author":"Kaminski D.","year":"1974","journal-title":"Clin. Res."},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02326787"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009990"},{"key":"e_1_2_1_93_1","first-page":"263","article-title":"The effect of prostaglandin E1 on exocrine pancreatic secretion (in vivo and in vitro)","volume":"26","author":"Gabryelewicz A.","year":"1974","journal-title":"Pol. J. Pharmacol. Pharm."},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(71)80147-6"},{"key":"e_1_2_1_95_1","first-page":"767","article-title":"Synthetic prostaglandin analog and pancreatic secretion","volume":"66","author":"Rosenberg V.","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_1_96_1","first-page":"206","article-title":"Effect of a synthetic analogue of PGE2 on exocrine and endocrine pancreatic function in the rat","volume":"83","author":"Dodi G.","year":"1978","journal-title":"Surgery"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527709181688"},{"key":"e_1_2_1_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01077392"},{"key":"e_1_2_1_99_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108827"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01154a551"},{"key":"e_1_2_1_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb00048.x"},{"key":"e_1_2_1_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80488-X"},{"key":"e_1_2_1_103_1","first-page":"425","article-title":"Pharmacology of indolealkylamines","volume":"6","author":"Erspamer V.","year":"1954","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_1_104_1","first-page":"1","article-title":"The occurrence of biogenic monamines in the mammalian endocrine pancreas","volume":"314","author":"Cegrell L.","year":"1968","journal-title":"Acta Physiol. Scand. [Suppl.]"},{"key":"e_1_2_1_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02943247"},{"key":"e_1_2_1_106_1","first-page":"687","article-title":"Serotonin and the alimentary tract","volume":"2","author":"Thompson J.H.","year":"1971","journal-title":"Res. Comm. Pathol. Pharmacol."},{"key":"e_1_2_1_107_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-148-38729"},{"key":"e_1_2_1_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197611000-00018"},{"key":"e_1_2_1_109_1","first-page":"311","article-title":"Synthesis and uptake of 5\u2010hydroxytryptamine by the myenteric plexus of the guinea\u2010pig ileum: a histochemical study","volume":"178","author":"Robinson R.G.","year":"1971","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_110_1","doi-asserted-by":"publisher","DOI":"10.1515\/znb-1964-1209"},{"key":"e_1_2_1_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3680.197"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/169800b0"},{"key":"e_1_2_1_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/214196a0"},{"key":"e_1_2_1_114_1","first-page":"183","volume-title":"5\u2010Hydroxytryptamine","author":"Smith A.N.","year":"1968"},{"key":"e_1_2_1_115_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1959.sp006174"},{"key":"e_1_2_1_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(58)80101-8"},{"key":"e_1_2_1_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60512-8"},{"key":"e_1_2_1_118_1","first-page":"264","article-title":"Effect of serotonin on histamine\u2010stimulated secretion in canine Heidenhain pouches","volume":"21","author":"Sosin H.","year":"1962","journal-title":"Fed. Proc."},{"key":"e_1_2_1_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(68)90027-5"},{"key":"e_1_2_1_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196811000-00007"},{"key":"e_1_2_1_121_1","first-page":"1295","article-title":"Studies on the inhibition of gastric secretion by the small intestine","volume":"127","author":"Schuck M.","year":"1968","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_1_122_1","first-page":"32","article-title":"The effect of serotonin on human gastric and pancreatic secretion and bile flow","volume":"7","author":"Warner R.R.P.","year":"1959","journal-title":"Clin. Res."},{"key":"e_1_2_1_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)35480-0"},{"key":"e_1_2_1_124_1","first-page":"156","article-title":"Endogenous serotonin in the control of gastric acid secretion","volume":"82","author":"Jaffe B.M.","year":"1977","journal-title":"Surgery"},{"key":"e_1_2_1_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197708000-00002"},{"key":"e_1_2_1_126_1","first-page":"612","article-title":"Vliianie katekholaminov i serotonina na zheludochnuiu sekretsiiu","volume":"30","author":"Grechinishkin L.L.","year":"1967","journal-title":"Farmakol. Toksikol."},{"key":"e_1_2_1_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)35540-4"},{"key":"e_1_2_1_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(69)90069-5"},{"key":"e_1_2_1_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb00496.x"},{"key":"e_1_2_1_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1963.tb01306.x"},{"key":"e_1_2_1_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1963.tb01529.x"},{"key":"e_1_2_1_132_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1958.sp005940"},{"key":"e_1_2_1_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02003761"},{"key":"e_1_2_1_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(77)90160-5"},{"key":"e_1_2_1_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(78)90272-1"},{"key":"e_1_2_1_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90298-X"},{"key":"e_1_2_1_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1966.tb01882.x"},{"key":"e_1_2_1_138_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.7.3.208"},{"key":"e_1_2_1_139_1","first-page":"382","article-title":"Effect of iproniazid upon serotonin metabolism","volume":"17","author":"Kabakow B.","year":"1958","journal-title":"Fed. Proc."},{"key":"e_1_2_1_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(65)80089-0"},{"key":"e_1_2_1_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80054-6"},{"key":"e_1_2_1_142_1","first-page":"E85","article-title":"Effect of serotonin treatment on intestinal transport in the rabbit","volume":"232","author":"Donowitz M.","year":"1977","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01070754"},{"key":"e_1_2_1_144_1","first-page":"185","article-title":"Serotonin and choleresis","volume":"17","author":"Seferian V.","year":"1962","journal-title":"Therapie"},{"key":"e_1_2_1_145_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.9.5.546"},{"key":"e_1_2_1_146_1","first-page":"124","article-title":"Effect of biogenic amines on the choledochus of dogs","volume":"10","author":"Benslay D.N.","year":"1967","journal-title":"Physiologist"},{"key":"e_1_2_1_147_1","first-page":"854","article-title":"The effect of serotonin and serotonin precursor on pancreatic secretion in the dog","volume":"48","author":"Drapanas T.","year":"1960","journal-title":"Surgery"},{"key":"e_1_2_1_148_1","first-page":"79","article-title":"Some physiological observations on the exocrine pancreas. The effects of some agents on pancreatic secretion","volume":"31","author":"Nakano S.","year":"1968","journal-title":"Nagoya J. Med. Sci."},{"key":"e_1_2_1_149_1","first-page":"119","article-title":"The lymphatics, pancreatic ascites, and pancreatic inflammatory disease","volume":"53","author":"Dreiling D.A.","year":"1970","journal-title":"Gastroenterology"},{"key":"e_1_2_1_150_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.53.1.171"},{"key":"e_1_2_1_151_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1094131"},{"key":"e_1_2_1_152_1","first-page":"1","article-title":"Insulin secretion. Its regulation by monoamines and acid amyloglucosidase","volume":"372","author":"Lundquist I.","year":"1971","journal-title":"Acta Physiol. Scand. [Suppl.]"},{"key":"e_1_2_1_153_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.19.7.475"},{"key":"e_1_2_1_154_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-89-5-1295"},{"key":"e_1_2_1_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309896"},{"key":"e_1_2_1_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01221630"},{"key":"e_1_2_1_157_1","first-page":"339","article-title":"The effect of serotonin (5\u2010HT) on insulin secretion","volume":"25","author":"Lechin F.","year":"1975","journal-title":"Acta Physiol. Lat. Am."},{"key":"e_1_2_1_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01236311"},{"key":"e_1_2_1_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01236311"},{"key":"e_1_2_1_160_1","first-page":"182","article-title":"Pharmacological studies with the serotonin precursor, 5\u2010hydroxytryptophan","volume":"122","author":"Bogdanski D.F.","year":"1958","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_161_1","first-page":"74","article-title":"Inhibition of neurogenic vasoconstriction","volume":"11","author":"McCubbin J.W.","year":"1962","journal-title":"Circ. Res."},{"key":"e_1_2_1_162_1","first-page":"140","article-title":"Norepinephrine induced reflex vasodilation and vascular effects of serotonin","volume":"164","author":"Wellens D.","year":"1966","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"e_1_2_1_163_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.7.1.123"},{"key":"e_1_2_1_164_1","first-page":"624","article-title":"Direct effects of vasoactive agents on segmental resistance of the mesenteric and portal circulation","volume":"64","author":"Texter F.C.","year":"1964","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_165_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.27.149"},{"key":"e_1_2_1_166_1","first-page":"235","article-title":"Mesenteric vasodilator effect of 5\u2010hydroxytryptamine: possible enteric neuron mediation","volume":"221","author":"Fara J.","year":"1976","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"e_1_2_1_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1973.tb05419.x"},{"key":"e_1_2_1_168_1","first-page":"818","article-title":"Pressor amines and the carcinoid flush","volume":"58","author":"Levine R.J.","year":"1963","journal-title":"Arch. Intern. Med."},{"key":"e_1_2_1_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92907-1"},{"key":"e_1_2_1_170_1","first-page":"103","article-title":"The mechanism of facial flushes in the carcinoid syndrome","volume":"31","author":"Robertson J.I.S.","year":"1962","journal-title":"Q. J. Med."},{"key":"e_1_2_1_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90010-X"},{"key":"e_1_2_1_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)91528-6"},{"key":"e_1_2_1_173_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197010222831702"},{"key":"e_1_2_1_174_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197303000-00003"},{"key":"e_1_2_1_175_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107507"},{"key":"e_1_2_1_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(77)80257-6"},{"key":"e_1_2_1_177_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.10.12.980"},{"key":"e_1_2_1_178_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5974.11"},{"key":"e_1_2_1_179_1","first-page":"179","article-title":"Prostaglandin production by cells in vitro","volume":"9","author":"Jaffe B.M.","year":"1973","journal-title":"Adv. Biosci."},{"key":"e_1_2_1_180_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107196"},{"key":"e_1_2_1_181_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197610000-00015"},{"key":"e_1_2_1_182_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197401102900221"},{"key":"e_1_2_1_183_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197307122890225"},{"key":"e_1_2_1_184_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5989.165-b"},{"key":"e_1_2_1_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb06451.x"},{"key":"e_1_2_1_186_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-4684-7248-6_36","volume-title":"Gastrointestinal Hormones and Pathology of the Digestive Tract","author":"Jaffe B.M.","year":"1978"},{"key":"e_1_2_1_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91947-8"},{"key":"e_1_2_1_188_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1973.12096773"},{"key":"e_1_2_1_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32643-5"},{"key":"e_1_2_1_190_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197507242930401"},{"key":"e_1_2_1_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32655-1"},{"key":"e_1_2_1_192_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1106226"},{"key":"e_1_2_1_193_1","first-page":"591","volume-title":"Gastrointestinal Hormones","author":"Said S.I.","year":"1975"},{"key":"e_1_2_1_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(76)90025-1"},{"key":"e_1_2_1_195_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01072184"},{"key":"e_1_2_1_196_1","first-page":"675","article-title":"Occurrence of human pancreatic polypeptide in pancreatic endocrine tumors","volume":"85","author":"Larsson L.\u2010I.","year":"1976","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_197_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710132971508"},{"key":"e_1_2_1_198_1","first-page":"426","article-title":"Karzinoide: tumoren des dunndarms","volume":"1","author":"Oberndorfer S.","year":"1907","journal-title":"Frankf. Z. Pathol."},{"key":"e_1_2_1_199_1","first-page":"181","article-title":"Carcinoids (argentaffin\u2010cell tumors) and nerve hyperplasia of the appendicular mucosa","volume":"4","author":"Masson P.","year":"1928","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(52)90182-8"},{"key":"e_1_2_1_201_1","first-page":"4","article-title":"Metastasierendes dunndarmcarcinoid mit schweren, vorwiegend. Das rechte herz bettreffenden kloppenfehlern und pulmonalstenose\u2014ein eigen artiger symptomen komplex?","volume":"83","author":"Ister P.","year":"1953","journal-title":"Schweiz. Med. Wochenschr."},{"key":"e_1_2_1_202_1","first-page":"941","article-title":"Essential telangiectasia, pulmonic and tricuspid stenosis and neoplastic liver disease. A possible new clinical syndrome","volume":"42","author":"Rosenbaum F.F.","year":"1953","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(54)90152-0"},{"key":"e_1_2_1_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/172910a0"},{"key":"e_1_2_1_205_1","first-page":"140","volume-title":"The Clinical Chemistry of Monoamines, Vol. 2","author":"Gowenlock A.H.","year":"1962"},{"key":"e_1_2_1_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(55)91924-3"},{"key":"e_1_2_1_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90354-6"},{"key":"e_1_2_1_208_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5289.1390"},{"key":"e_1_2_1_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)90846-7"},{"key":"e_1_2_1_210_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196711232772101"},{"key":"e_1_2_1_211_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1956.184.2.265"},{"key":"e_1_2_1_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60303-8"},{"key":"e_1_2_1_213_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-99947-5"},{"key":"e_1_2_1_214_1","first-page":"282","article-title":"L'exploration biochimique des tumeurs carcinoides","volume":"31","author":"Dreux C.","year":"1973","journal-title":"Ann. Biol. Clin."},{"key":"e_1_2_1_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(72)90329-7"},{"key":"e_1_2_1_216_1","first-page":"21","article-title":"Humoral similarities of carcinoid tumors and medullary carcinomas of the thyroid","volume":"74","author":"Kaplan E.L.","year":"1973","journal-title":"Surgery"},{"key":"e_1_2_1_217_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196507292730504"},{"key":"e_1_2_1_218_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576605900707"},{"key":"e_1_2_1_219_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197305)31:5<1237::AID-CNCR2820310530>3.0.CO;2-K"},{"key":"e_1_2_1_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)32627-X"},{"key":"e_1_2_1_221_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1107341"},{"key":"e_1_2_1_222_1","first-page":"447","article-title":"Nonspecific islet\u2010cell tumour of the pancreas with diarrhea","volume":"31","author":"Espiner E.A.","year":"1962","journal-title":"Q. J. Med."},{"key":"e_1_2_1_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32655-1"},{"key":"e_1_2_1_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90951-6"},{"key":"e_1_2_1_225_1","first-page":"221","article-title":"Etude ultrastructurale des carcinoides bronchiques. II. Discussion","volume":"75","author":"Pariente R.","year":"1967","journal-title":"Presse Med."},{"key":"e_1_2_1_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90080-X"},{"key":"e_1_2_1_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(58)90616-0"},{"key":"e_1_2_1_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90952-8"},{"key":"e_1_2_1_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(65)80062-2"},{"key":"e_1_2_1_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(65)80063-4"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01654761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01654761\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01654761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T12:20:31Z","timestamp":1704975631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01654761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,9]]},"references-count":229,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,9]]}},"alternative-id":["10.1007\/BF01654761"],"URL":"https:\/\/doi.org\/10.1007\/bf01654761","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,9]]}}}