{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:09:52Z","timestamp":1762322992552},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1993,7,1]],"date-time":"1993-07-01T00:00:00Z","timestamp":741484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Studies have shown that the duodenum is a more common site (30\u201340%) of primary gastrinomas than previously reported. These tumors are often occult to conventional exploration, and their detection requires duodenotomy and meticulous evaluation of the mucosa by eversion and direct palpation. Furthermore, tumors as small as 1 to 2\u00a0mm may be associated with lymph node metastases. Seven patients with duodenal gastrinomas treated during a 2\u2010year period are reported. Four had sporadic Zollinger\u2010Ellison syndrome (ZES), and three had multiple endocrine neoplasia type I (MEN\u2010I) syndrome. All seven patients had malignant duodenal gastrinomas as proved by metastatic lymph nodes and in one case a large liver metastasis as well. Local excision of the tumor, lymph node excisions, and in one case liver lobectomy resulted in eugastrinemia in the 4 with sporadic ZES. Two of the three with MEN\u2010I were also eugastrinemic after similar procedures, with the addition of distal pancreatectomy. Duodenotomy is considered an essential procedure in sporadic ZES patients when no pancreatic tumor is found and in all MEN\u2010I\/ZES patients, regardless of the pancreatic findings. Regional lymph node excisions are essential when a duodenal tumor has been found<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01655104","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T03:39:28Z","timestamp":1115523568000},"page":"455-462","source":"Crossref","is-referenced-by-count":71,"title":["Duodenal gastrinomas, duodenotomy, and duodenal exploration in the surgical management of Zollinger\u2010Ellison syndrome"],"prefix":"10.1002","volume":"17","author":[{"given":"Norman W.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Surgery University of Michigan Medical Center Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Pasieka","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical Center Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Fukuuchi","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical Center Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(64)90002-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1972.04180040061011"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199001000-00002"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198904000-00002"},{"key":"e_1_2_1_6_1","first-page":"1108","article-title":"Management of islet cell tumors in patients with multiple endocrine neoplasia: a prospective study","volume":"106","author":"Sheppard B.C.","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_1_7_1","first-page":"246","article-title":"Transhepatic portal vein catheterization for localization of sporadic and MEN\u2010I gastrinomas: a ten year experience","volume":"107","author":"Vinik A.I.","year":"1990","journal-title":"Surgery"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003153221103"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910915)68:6<1329::AID-CNCR2820680624>3.0.CO;2-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198809000-00006"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90029-1"},{"key":"e_1_2_1_12_1","first-page":"1081","article-title":"The surgical treatment of gastrinoma in MEN\u2010I syndrome patients","volume":"106","author":"Thompson N.W.","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_1_13_1","first-page":"1113","article-title":"Extrapancreatic gastrinomas","volume":"98","author":"Thompson N.E.","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01654938"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198802000-00008"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01655104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01655104\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01655104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T18:45:01Z","timestamp":1704998701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01655104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1007\/BF01655104"],"URL":"https:\/\/doi.org\/10.1007\/bf01655104","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}