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The increased availability of potent gastric acid antisecretory agents such as histamine H<jats:sub>2<\/jats:sub>\u2010receptor antagonists and more recently the H<jats:sup>+<\/jats:sup>K<jats:sup>+<\/jats:sup>\u2010ATPase inhibitors such as omeprazole and lansoprazole have made it possible to medically control acid secretion in all patients. Increased understanding of the variation in antisecretory drug dosage between individual patients has led to identification of criteria to ensure effective antisecretory control and to the recognition of subgroups of patients who require special monitoring. Effective regimens for parenteral antisecretory control during surgery have been established. The importance of parathyroidectomy in patients with multiple endocrine neoplasia type I with ZES and the possible usefulness of highly selective vagotomy have been investigated. We review here the new data that led to increased understanding in each of these areas from our studies and studies by others.<\/jats:p>","DOI":"10.1007\/bf01655106","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T03:39:28Z","timestamp":1115523568000},"page":"468-480","source":"Crossref","is-referenced-by-count":69,"title":["Control of gastric acid hypersecretion in the management of patients with Zollinger\u2010Ellison syndrome"],"prefix":"10.1002","volume":"17","author":[{"given":"David C.","family":"Metz","sequence":"first","affiliation":[{"name":"Digestive Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Pisegna","sequence":"additional","affiliation":[{"name":"Digestive Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaly A.","family":"Fishbeyn","sequence":"additional","affiliation":[{"name":"Digestive Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard V.","family":"Benya","sequence":"additional","affiliation":[{"name":"Digestive Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Digestive Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195510000-00015"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196409000-00013"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)90932-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90501-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.10.8.603"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196806132782402"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197506192922505"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01654904"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198009000-00018"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)40287-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-1-59"},{"key":"e_1_2_1_13_1","first-page":"931","volume-title":"The Pancreas: Biology, Pathobiology and Disease","author":"Jensen R.T.","year":"1993"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198410000-00002"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(85)80024-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711053171907"},{"key":"e_1_2_1_17_1","first-page":"117","volume-title":"Peptic Ulcer and Other Acid\u2010Related Diseases","author":"Jensen R.T.","year":"1991"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90780-1"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-1-52"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01318525"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(85)80024-X"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90600-5"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-6-668"},{"key":"e_1_2_1_24_1","first-page":"90","article-title":"Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with gastric hypersecretory states","volume":"77","author":"Jensen R.T.","year":"1984","journal-title":"Am. 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