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Our experience and that of others with these various conditions demonstrates that the decision to perform splenectomy should be based on well\u2010defined and often strictly limited indications. Except for idiopathic splenomegaly, the presence and severity of secondary hypersplenism or severely symptomatic splenomegaly should be well documented. In each case, the potential for palliation and known mean duration of expected response must be weighed against the increased morbidity and mortality of splenectomy (as compared to operation for \u201cprimary\u201d hypersplenism)<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01655279","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T02:24:16Z","timestamp":1115519056000},"page":"437-443","source":"Crossref","is-referenced-by-count":7,"title":["Splenectomy for splenomegaly and secondary hypersplenism"],"prefix":"10.1002","volume":"9","author":[{"given":"William W.","family":"Coon","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Michigan Hospitals Ann Arbor Michigan USA"},{"name":"Section of General Surgery University of Michigan Hospitals D2214, Medical Professional Building 48109 Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,6]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Coon W.W.:The limited role of splenectomy in patients with leukemia. 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