{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:44:05Z","timestamp":1783633445434,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Since the syndrome of primary hyperaldosteronism was described by Jerome Conn in 1955, over 300 patients with this disorder have been identified in the medical centers of Vanderbilt University and the University of Michigan. The most frequent cause of this endocrinopathy has been a solitary adenoma of the adrenal cortex (72%); bilateral adrenocortical hyperplasia has been the cause of primary hyperaldosteronism in 27% of cases; less frequently, the cause has been multiple and\/or bilateral adenomas (1%). During the last 4 years in these 2\u00a0medical centers, we have encountered 3 patients who have had biochemically proven primary hyperaldosteronism due to adrenocortical carcinoma. Each of these unusual cases is summarized with review of the recent literature<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01655546","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T03:02:04Z","timestamp":1115521324000},"page":"646-652","source":"Crossref","is-referenced-by-count":17,"title":["Primary hyperaldosteronism caused by adrenocortical carcinoma"],"prefix":"10.1002","volume":"10","author":[{"suffix":"Jr.","given":"H. William","family":"Scott","sequence":"first","affiliation":[{"name":"Departments of Surgery, Pathology, and Nuclear Medicine Vanderbilt University Nashville Tennessee"},{"name":"University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Sussman","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Pathology, and Nuclear Medicine Vanderbilt University Nashville Tennessee"},{"name":"University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Page","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Pathology, and Nuclear Medicine Vanderbilt University Nashville Tennessee"},{"name":"University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman W.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Pathology, and Nuclear Medicine Vanderbilt University Nashville Tennessee"},{"name":"University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton D.","family":"Gross","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Pathology, and Nuclear Medicine Vanderbilt University Nashville Tennessee"},{"name":"University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Pathology, and Nuclear Medicine Vanderbilt University Nashville Tennessee"},{"name":"University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1986,8]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3","article-title":"Primary aldosteronism: A new clinical syndrome","volume":"45","author":"Conn J.W.","year":"1955","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_3_1","first-page":"145","volume-title":"Functional Pathology of the Adrenal Gland","author":"Symington T.","year":"1969"},{"key":"e_1_2_1_4_1","first-page":"56","volume-title":"Principles and Management of Urologic Cancer","author":"Mostofi F.K.","year":"1979"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(55)90163-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49969-1"},{"key":"e_1_2_1_7_1","first-page":"163","article-title":"Primary aldosteronism and malignant adrenocortical neoplasia","volume":"86","author":"Salassa R.M.","year":"1974","journal-title":"Trans. Am. Clin. Climatol. Assn."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-3-316"},{"key":"e_1_2_1_9_1","unstructured":"Page D.L. DeLellis R.A. Hough A.J. Jr.:Tumors of the adrenal. Washington D.C. AFIP and UAREP(in press)."}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01655546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01655546\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01655546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01655546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T17:37:57Z","timestamp":1703698677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01655546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1007\/BF01655546"],"URL":"https:\/\/doi.org\/10.1007\/bf01655546","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}