{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:18:02Z","timestamp":1752549482324},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1988,4,1]],"date-time":"1988-04-01T00:00:00Z","timestamp":575856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is epidemiological evidence of an association between cigarette smoking and peptic ulcer disease. Patients who are smokers and treated with H<jats:sub>2<\/jats:sub>\u2010receptor antagonists have a higher recurrence rate than equally treated nonsmokers. To study whether this is also a fact among surgically treated patients, we investigated 306 patients operated on with parietal cell vagotomy (PCV) from 1971 to 1980. Sixty\u2010two percent were cigarette smokers and among these, 16% were female compared to 33% in the nonsmoking group (<jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>&lt;<jats:bold>0.01). An ulcer recurrence rate of 24% was found among smokers with a primarily duodenal ulcer disease compared to 7% in nonsmokers (<\/jats:bold><jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>&lt;<jats:bold>0.01). In the group of patients with pyloric\/prepyloric ulcer disease, a 34% ulcer recurrence rate was reported in the smoking group compared to a 5% ulcer recurrence rate among nonsmokers (<\/jats:bold><jats:bold><jats:italic>p<\/jats:italic><\/jats:bold>&lt;<jats:bold>0.01). Before surgery, basal and pentagastrin\u2010stimulated acid output were significantly higher in the smoking group, but, postoperatively, no significant differences were seen. This implies that factors other than gastric acid secretion must be the cause of the higher ulcer recurrence rate in smokers<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01658075","type":"journal-article","created":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T05:43:22Z","timestamp":1115617402000},"page":"277-280","source":"Crossref","is-referenced-by-count":4,"title":["Increased ulcer relapse rate after PCV in smokers"],"prefix":"10.1002","volume":"12","author":[{"given":"Hans","family":"Graffner","sequence":"first","affiliation":[{"name":"Department of Surgery University of Lund Lund Sweden"},{"name":"Department of Surgery Helsingborg Hospital Helsingborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Lindell","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Lund Lund Sweden"},{"name":"Department of Surgery Helsingborg Hospital Helsingborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,4]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"65","article-title":"Effect of cigarette smoking on gastrointestinal physiology and non\u2010neoplastic digestive disease","volume":"6","author":"Kikendall J.W.","year":"1984","journal-title":"J. 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(Abstract)","volume":"19","author":"Deakin M.","year":"1985","journal-title":"Br. Soc. 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