{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:14:38Z","timestamp":1760980478899},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article summarizes 15 years of clinical and laboratory studies that have continued the search for a biochemical basis for the development and resolution of symptomatic benign fibrocystic disease. The clinical response to diet modifications is presented along with simultaneous laboratory tissue and serum studies. An ongoing study of the clinical response to complete and total methylxanthine abstention, especially caffeine, is presented in the initial part of the article. Following the clinical observations, is a series of laboratory studies, some of which actually preceded the clinical investigation and, in fact, pointed out that a beneficial clinical response might occur in some women following complete abstention. In the last paragraph, we present current information that may identify which women are susceptible to fibrocystic breast disease development.<\/jats:p>","DOI":"10.1007\/bf01658414","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T12:53:49Z","timestamp":1115556829000},"page":"680-684","source":"Crossref","is-referenced-by-count":13,"title":["Nonendocrine theories of the etiology of benign breast disease"],"prefix":"10.1002","volume":"13","author":[{"given":"John Peter","family":"Minton","sequence":"first","affiliation":[{"name":"Department of Surgery The Ohio State University College of Medicine 43210 Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Abou\u2010Issa","sequence":"additional","affiliation":[{"name":"Department of Surgery The Ohio State University College of Medicine 43210 Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(79)80037-X"},{"key":"e_1_2_1_3_1","first-page":"299","article-title":"Biochemical and clinical studies on methylxanthine\u2010related fibrocystic breast disease","volume":"90","author":"Minton J.P.","year":"1981","journal-title":"Surgery"},{"key":"e_1_2_1_4_1","first-page":"652","article-title":"Biochemical subgrouping of benign breast disease to define premalignant potential","volume":"90","author":"Minton J.P.","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_1_5_1","first-page":"665","article-title":"In vivo and in vitro effects of caffeine on cyclic nucleotide metabolism in mammary tissue","volume":"40","author":"Abou\u2010Issa H.","year":"1981","journal-title":"Fed. 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