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The terminology and concepts of fibrocystic disease and its many alternative terms have been discarded.<\/jats:p><jats:p>Cysts arise as an aberration of normal lobular involution (ANDI) associated with active secretion of apocrine epithelium under hormonal stimulation. They are readily managed in most cases by aspiration alone. Multiple recurrent cysts may constitute a considerable nuisance and justify short\u2010term therapy with danazol. There is increasing evidence that multiple recurrent cysts are associated with a small, but significant increase in breast cancer risk.<\/jats:p>","DOI":"10.1007\/bf01658419","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T12:53:49Z","timestamp":1115556829000},"page":"711-714","source":"Crossref","is-referenced-by-count":12,"title":["Breast macrocysts"],"prefix":"10.1002","volume":"13","author":[{"given":"Leslie E.","family":"Hughes","sequence":"first","affiliation":[{"name":"University Department of Surgery University of Wales College of Medicine Heath Park CF4 4XN Cardiff Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel J.","family":"Bundred","sequence":"additional","affiliation":[{"name":"University Department of Surgery University of Wales College of Medicine Heath Park CF4 4XN Cardiff Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,11]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Illustrations of Diseases of the Breast","author":"Cooper A.P.","year":"1829"},{"key":"e_1_2_1_3_1","first-page":"761","article-title":"La Maladie Kystique des Mammelles","volume":"3","author":"Reclus P.","year":"1883","journal-title":"Revue de Chirurgie"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91204-9"},{"key":"e_1_2_1_5_1","first-page":"757","article-title":"Cystic disease of the breast. 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