{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:02:15Z","timestamp":1766466135852},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Thirty\u2010seven patients with primary aldosteronism were treated by unilateral total adrenalectomy during a 7\u2010year period (1981\u20131987). The 37 patients were classified into 3\u00a0groups on the basis of adrenal pathology: unilateral solitary adenoma, 23 cases (group 1); unilateral adenomas, 3 cases (group 2); and adenoma with multiple macro\u2010 or microscopic nodules, 11 cases (group 3). The preoperative conditions of the patients (age, duration of hypertension, plasma renin activity, plasma aldosterone concentration, and serum potassium concentration), postoperative sequential changes of hormone levels, and outcome of hypertension were compared among the groups in order to determine whether the differences of adrenal pathology would affect the postoperative course. The preoperative parameters excluding age at surgery did not differ significantly among the 3\u00a0groups. The mean age in group 3, however, was slightly higher than in groups 1 and 2 (47.8 versus 42.8 versus 42.7 years)<\/jats:bold>.<\/jats:p><jats:p><jats:bold>Postoperative hormonal changes were also similar, particularly in groups 1 and 3, staying within the normal range throughout the follow\u2010up period (mean, 31\u00a0months; range, 3\u201386\u00a0months). However, postoperative improvement of hypertension showed marked differences, being significantl retarded in patients with multinodular lesions (group 3), about half of whom remained hypertensive even after 1 year. Nodular lesions other than adenoma(s) were, therefore, thought not to contribute to hormonal excess but to result from intractable hypertension<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01658518","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T13:03:12Z","timestamp":1115557392000},"page":"330-334","source":"Crossref","is-referenced-by-count":23,"title":["Clinical significance of associated nodular lesions of the adrenal in patients with aldosteronoma"],"prefix":"10.1002","volume":"14","author":[{"given":"Yukio","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women's Medical College 8\u20101\u00a0Kawada\u2010cho, Shinjuku\u2010ku 162 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women's Medical College 8\u20101\u00a0Kawada\u2010cho, Shinjuku\u2010ku 162 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women's Medical College 8\u20101\u00a0Kawada\u2010cho, Shinjuku\u2010ku 162 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaya","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women's Medical College 8\u20101\u00a0Kawada\u2010cho, Shinjuku\u2010ku 162 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1990,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070160037008"},{"key":"e_1_2_1_3_1","first-page":"257","article-title":"The evolution of primary aldosteronism 1954\u20131967","volume":"62","author":"Conn J.W.","year":"1967","journal-title":"Harvey Lect."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5950.135"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/978-1-4612-5222-1","volume-title":"Manual of Endocrine Surgery","author":"Edis A.J.","year":"1984"},{"key":"e_1_2_1_6_1","first-page":"99","article-title":"The nodular adrenal","volume":"1","author":"Neville A.M.","year":"1978","journal-title":"Invest. 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